@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAK1_HUMAN: (2019-05-17 )
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
K
F
F
D
S
R
R
EQGGSGLGSGSSGGGGSTSGLGSG
Y
I
G
R
VFGIGRQ
Q
V
T
V
D
E
V
L
AEG
G
F
A
I
V
F
L
V
RTSN
G
M
K
C
A
L
K
R
M
FVNNE
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
LSGHKN
I
V
G
Y
I
D
S
SINNVSSG
D
V
W
E
V
L
I
L
M
D
FCRGG
Q
V
V
N
L
M
N
Q
R
L
QTGFT
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QCKTP
I
I
HRD
L
K
V
E
N
I
L
L
HDRG
H
Y
V
L
C
DFGSATNKFQNPQTEG
V
N
A
V
E
D
E
I
K
K
YTTLSYRAP
E
M
V
N
LYS
G
K
I
I
T
TK
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
FTLPFGE
S
Q
V
A
I
CDG
N
F
TIPDNSRY
S
Q
D
M
H
C
L
I
R
Y
M
LEPDPDKRP
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
ECPIPNVQNSPIPAKLPEPVK
A
S
E
AAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNP
G
I
L
PIQPALTPRKRATVQPPPQAAGSSNQPG
L
L
ASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQAT
P
Q
H
Q
Q
Q
L
F
L
K
Q
Q
Q
Q
QQQPPPAQQQPA
G
T
F
Y
Q
Q
Q
Q
A
Q
T
Q
Q
F
QAVHPATQKPAIAQFPVVSQGG
S
Q
Q
Q
L
M
Q
N
F
Y
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
A
T
A
L
H
Q
Q
Q
L
M
T
Q
Q
A
A
L
QQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPK
T
Q
R
A
G
H
R
R
I
L
S
D
V
T
H
S
A
VFGVPAS
K
S
T
Q
L
L
Q
A
A
A
A
EASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDD
N
F
S
K
L
T
A
E
E
L
L
N
K
D
F
A
K
LGEGK
H
P
E
KLGG
S
A
E
S
LIPGFQSTQG
D
A
F
A
TTSFSAGT
A
E
KRKGGQTVDSGL
P
L
L
SVSDPFIPLQVPD
A
P
E
K
L
I
E
G
LKSPDTSLLLPDLLPMTDPFGST
S
D
A
V
I
E
K
A
D
V
A
V
E
S
LIPGLEPPVPQRLPS
Q
T
E
S
VTSNRTDSLTGEDS
L
L
D
CSLLSNP
T
T
D
L
L
E
E
FAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPI
P
V
L
I
TKNPQGGHSRNSSGSSES
S
L
P
N
L
A
R
S
L
L
L
V
D
Q
L
IDL
3
PsiBlast_PDB
96.40
100%
-142
- C3 -
-
4WSQ
2
AAK1_HUMAN
A:
[1-317]
----------------------------
G
L
G
S
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
E
P
V
K
A
S
E
A
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.95
100%
-143
- C3 -
-
5TE0
10
AAK1_HUMAN
A:
[2-320]
--------------------------
T
S
G
L
G
S
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
----
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
E
P
V
K
A
S
E
A
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
94.92
100%
-140
- C3 -
-
4WSQ
1
AAK1_HUMAN
B:
[5-314]
--------------------------------
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
E
P
V
K
A
S
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
91.41
100%
-151
- C3 -
-
4WSQ
2
AAK1_HUMAN
A:
[2-302]
-----------------------------
L
G
S
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.20
100%
-148
- C3 -
-
5L4Q
2
AAK1_HUMAN
A:
[7-309]
--------------------------------
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
----------
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
89.15
100%
-155
- C3 -
-
5TE0
10
AAK1_HUMAN
A:
[3-298]
---------------------------
S
G
L
G
S
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
----
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
88.93
100%
-154
- C3 -
-
5L4Q
2
AAK1_HUMAN
B:
[7-307]
--------------------------------
G
Y
I
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
----
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
----------
N
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.90
77%
-152
- C3 -
-
4W9W
7
BMP2K_HUMAN
A:
[4-306]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.45
77%
-143
- C3 -
-
5I3O
1
BMP2K_HUMAN
A:
[1-302]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
86.28
77%
-145
- C3 -
-
5I3O
1
BMP2K_HUMAN
B:
[1-302]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
85.91
77%
-143
- C3 -
-
5I3R
1
BMP2K_HUMAN
B:
[1-302]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.80
77%
-140
- C3 -
-
5I3R
1
BMP2K_HUMAN
A:
[1-302]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.63
77%
-151
- C3 -
-
4W9X
3
BMP2K_HUMAN
A:
[7-307]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
----
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
-
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.38
77%
-150
- C3 -
-
5IKW
1
BMP2K_HUMAN
A:
[7-303]
------------------------------------
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
84.06
78%
-153
- C3 -
-
4W9W
7
BMP2K_HUMAN
A:
[6-295]
--------------------------------------
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
-
S
D
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
83.31
78%
-148
- C3 -
-
5I3O
1
BMP2K_HUMAN
A:
[2-291]
-------------------------------------
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
-
S
D
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
G
E
S
Q
V
A
I
C
D
G
N
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------