@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAPK2_HUMAN: (2019-05-17 )
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAEKQKHDG
R
V
K
I
G
H
Y
V
LGDTLGVG
T
F
G
K
V
K
IGEHQLT
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
FRHP
H
I
I
K
L
Y
Q
V
ISTP
T
D
F
F
M
V
M
E
Y
VSG
G
E
L
F
D
Y
I
C
KHG
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
HRDLKPE
N
V
L
L
DAHMNA
K
I
A
D
F
G
L
S
N
MMSDG
E
F
L
R
TSCGSPNYAA
P
E
VISGRLYAGPE
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
CGTLPFDDE
H
V
P
T
L
F
K
K
IRG
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
QVDPL
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
YLFPEDPSYDANVI
D
D
E
A
V
K
E
V
C
E
KFEC
T
E
S
E
V
M
N
S
L
YSGDP
Q
D
Q
L
A
V
A
Y
H
L
I
ID
N
R
R
I
M
N
Q
A
S
E
F
Y
LASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKS
L
A
V
K
K
A
K
W
H
LGIRSQSK
P
Y
D
I
M
A
E
V
Y
R
A
M
K
QLD
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
RKNPVTG
N
Y
V
K
M
S
L
Q
L
Y
L
VDN
R
S
Y
L
L
D
FKSI
D
D
E
V
V
E
QRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSG
S
L
TGSLTGS
T
L
S
SVSPRLGS
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
LAR
5
PsiBlast_PDB
91.98
99%
-132
- C3 -
-
6B2E
3
AAPK2_HUMAN
A:
[22-564]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
G
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
-----
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
A
----------------------
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
8
PsiBlast_PDB
86.79
74%
-124
- C3 -
-
4RER
3
AAPK1_HUMAN
A:
[1-540]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
D
P
S
Y
S
----
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-----
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
T
----------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
17
PsiBlast_PDB
84.48
71%
-123
- C3 -
-
6C9H
3
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
--------------
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
----------------
T
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
19
PsiBlast_PDB
80.61
71%
-134
- C3 -
-
6C9G
2
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
---------------------------------------------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
18
PsiBlast_PDB
80.09
71%
-134
- C3 -
-
6C9F
2
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
D
----------------------------------------------------------------------------------------------------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
16
PsiBlast_PDB
78.34
80%
-129
- C3 -
-
4CFH
2
AAPK1_RAT
A:
[29-489]
---------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
D
----------------------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-
S
F
L
D
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
-------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
I
----------------------------------------------------------------------------
14
PsiBlast_PDB
77.24
73%
-130
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
-------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
---------------------------------------------------------
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
11
PsiBlast_PDB
77.06
73%
-134
- C3 -
-
4QFS
2
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
---------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
10
PsiBlast_PDB
77.06
73%
-132
- C3 -
-
4QFR
2
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
---------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
15
PsiBlast_PDB
77.05
73%
-134
- C3 -
-
6E4W
2
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
---------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
13
PsiBlast_PDB
76.81
73%
-135
- C3 -
-
6E4T
2
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
---------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
9
PsiBlast_PDB
76.69
73%
-129
- C3 -
-
4QFG
1
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
---------------------------------------------------------------------------------------------------------------------------
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
-------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
12
PsiBlast_PDB
76.61
73%
-131
- C3 -
-
5KQ5
2
?
A:
[12-503]
---------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
--------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
----------------------------------------------------------
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
7
PsiBlast_PDB
76.35
74%
-111
- C3 -
-
4REW
2
AAPK1_HUMAN
A:
[1-540]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
------
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
--------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
------------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
26
Blastp_CBE
66.71
99%
-142
- C3 -
-
3AQV
1
AAPK2_HUMAN
A:
[4-276]
------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
63.14
99%
-147
- C3 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-274]
------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
K
I
A
D
F
G
L
S
----------------
N
Y
A
A
P
E
------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------