@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ALK_HUMAN: (2019-05-18 )
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGA
I
G
L
L
W
L
L
P
L
L
L
S
T
A
AVGSGMGTGQRAGSPAAGPPLQPREPL
S
Y
S
R
L
Q
R
K
S
L
A
V
D
F
V
V
P
S
L
F
R
V
Y
A
R
D
LLLPPSSSELKAGRPEARGSLAL
D
C
A
P
L
L
R
LLGPAPGVSWTAGSPAP
A
E
A
R
T
L
S
R
V
L
KGG
S
V
R
K
L
R
R
A
K
Q
L
V
L
E
L
G
E
E
A
I
L
E
GCVGPP
G
E
A
A
V
G
L
L
Q
F
N
L
S
E
L
F
S
W
W
I
RQGE
G
R
L
R
I
R
LMP
E
K
K
A
S
E
VGREGR
L
S
A
A
IRASQ
P
R
L
L
F
Q
I
FGTGHSSLESPTNMPSPSP
D
Y
F
T
W
N
L
T
W
I
MKDSF
P
F
L
SHRSRYGLECSFDFPCELEYSP
P
L
H
D
L
RNQSWSWRRIP
S
E
E
ASQMDLLDGPGAERSKEMPRG
S
F
L
L
L
NTSADSKHT
I
L
S
P
W
M
RSSSE
H
C
T
L
A
V
S
V
H
RHLQPS
G
R
Y
I
A
Q
LLPH
N
E
A
A
R
E
I
L
L
MPTPGKHG
W
T
V
LQGRIGRPDN
P
F
R
V
A
L
E
Y
I
SSGNRS
L
S
A
V
D
F
F
A
LKNCSEGTSPGS
K
M
A
L
QSSFTCWN
G
T
V
L
QLGQAC
D
F
H
Q
D
CAQGE
D
E
S
Q
M
C
R
KLP
V
G
F
Y
C
NFEDGFCGWTQGTLSPHTPQ
W
Q
V
R
TLKDARFQDHQD
H
A
L
L
L
S
TTDVPASESA
T
V
TSATFPAPIKSS
P
C
E
L
R
M
S
W
L
I
R
G
V
LRG
N
V
S
L
V
L
V
ENKTGKEQG
R
M
V
W
H
V
A
A
YE
G
L
S
L
W
Q
W
M
V
L
P
L
LDV
S
D
R
F
W
L
Q
M
V
A
W
WGQG
S
R
A
I
V
A
F
D
N
I
S
I
S
L
D
C
Y
L
T
ISGED
K
I
L
QNTAPKSRNLFERNPNKELKPGENSPRQTPIFDP
T
V
H
W
L
F
TTCGASGPHGPT
Q
A
Q
CNNAYQNS
N
L
S
V
E
VGSEGPLK
G
I
Q
I
W
KVPAT
D
T
Y
S
I
SGYGAAGGKGGKN
T
M
MRSHG
V
S
V
L
G
I
F
NLEKD
D
M
L
Y
I
L
VGQQGEDACP
S
T
N
Q
L
I
Q
K
V
CIGENN
V
I
E
E
E
I
R
VNR
S
V
H
EWAGGGGGGGG
A
T
Y
V
F
KMKDGVP
V
P
L
I
I
A
AGGGGRAYGAKTDTF
H
P
E
RLENNS
S
V
L
G
LNGNSGAAGGGGGWNDNT
S
L
L
WAGK
S
L
QEGATGGH
S
C
P
Q
A
M
K
KWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDG
V
S
F
I
S
P
L
G
I
L
Y
T
P
A
L
K
V
MEGHG
E
V
N
I
K
H
Y
LNCSHCE
V
D
E
CHMDPES
H
K
V
I
C
F
CDHG
T
V
L
A
EDG
V
S
C
I
VSPTPEPHL
P
L
S
L
I
L
S
V
V
T
S
A
L
V
A
A
L
V
L
A
F
S
G
I
M
I
V
Y
R
R
K
H
Q
E
L
Q
A
M
Q
M
E
LQSP
E
Y
K
L
S
K
L
R
T
S
T
I
MTDYNP
N
Y
C
FAGKTS
S
I
S
D
L
K
EVPRKN
I
T
L
I
R
GLGHGAFGEVYEGQVSGMPNDP
S
P
L
Q
V
A
V
K
T
L
P
E
V
CSE
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
KF
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
MAGG
D
L
K
S
F
L
R
ETRPRPSQP
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
EN
H
F
I
H
R
D
IAAR
N
C
L
L
TCPGPG
R
V
A
KIGDF
G
M
A
R
D
I
Y
R
A
S
YYRKGG
C
A
MLPVKWM
P
P
E
A
F
M
E
G
I
FTSKTDT
W
S
F
G
V
L
L
W
E
I
F
SLGYMPYPSKS
N
Q
E
V
L
E
F
V
T
SGGRMDPPKNCP
G
P
V
Y
R
I
M
T
Q
C
W
QHQPEDRP
N
F
A
I
I
L
E
R
I
E
Y
CTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVP
P
L
L
V
S
Q
Q
A
K
R
E
EERSPAAPPPLPTTSSGKAAKKPT
A
A
E
I
S
V
RVPRGPAVEGG
H
V
N
M
A
FSQSN
P
P
S
E
L
H
K
VHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG
A
S
L
L
LEPSSLTANMKEV
P
L
F
R
LRHFPCGNVNYGYQQQGLPLEAATAPGAGH
Y
E
D
T
I
LKSKNSMNQPGP
15
PsiBlast_PDB
96.82
99%
-129
- C1 -
-
5IUI
1
A:
[6-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
----
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-----
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.98
99%
-125
- C1 -
-
3LCS
3
A:
[30-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
D
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
95.83
99%
-125
- C1 -
-
4FOD
2
A:
[8-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
T
I
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.67
100%
-130
- C1 -
-
3AOX
5
A:
[19-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
M
T
D
Y
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
95.40
99%
-129
- C1 -
-
4CMO
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.40
99%
-124
- C1 -
-
4MKC
3
A:
[50-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.18
99%
-121
- C1 -
-
3LCT
3
A:
[27-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
D
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
95.14
99%
-131
- C1 -
-
5AAA
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.99
99%
-122
- C1 -
-
3L9P
4
A:
[50-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-----
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
94.91
99%
-130
- C1 -
-
4CMU
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
94.26
99%
-133
- C1 -
-
5AA9
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
94.13
99%
-131
- C1 -
-
5AA8
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
94.12
99%
-130
- C1 -
-
4ANQ
1
A:
[24-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
94.04
99%
-132
- C1 -
-
4ANS
1
A:
[24-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
93.97
100%
-131
- C1 -
-
5FTO
1
A:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
----
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
93.94
99%
-131
- C1 -
-
4CTC
1
A:
[10-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
93.90
99%
-131
- C1 -
-
2YFX
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
93.89
99%
-131
- C1 -
-
4CTB
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
93.75
99%
-127
- C1 -
-
5AAC
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
93.69
99%
-127
- C1 -
-
5A9U
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
93.66
99%
-130
- C1 -
-
4CLI
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
93.60
99%
-131
- C1 -
-
5AAB
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
93.60
99%
-132
- C1 -
-
4CD0
1
A:
[25-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
93.45
99%
-128
- C1 -
-
4CLJ
1
A:
[10-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
93.44
100%
-129
- C1 -
-
4Z55
3
A:
[22-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-----
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
93.33
99%
-125
- C1 -
-
5KZ0
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.22
99%
-129
- C1 -
-
4Z55
3
A:
[22-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-----
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
93.00
99%
-130
- C1 -
-
4CCU
1
A:
[9-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.69
99%
-125
- C1 -
-
4FOC
1
A:
[36-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
92.14
100%
-127
- C1 -
-
2XB7
1
A:
[3-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.97
99%
-124
- C1 -
-
4DCE
1
ALK_HUMAN
A:
[16-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
-----
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
91.75
99%
-132
- C1 -
-
4CNH
1
ALK_HUMAN
A:
[10-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
------
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
91.50
100%
-129
- C1 -
-
5FTQ
2
A:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
91.48
99%
-131
- C1 -
-
4CCB
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
---
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.44
99%
-123
- C1 -
-
4FNZ
1
A:
[10-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
-----
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
91.38
99%
-129
- C1 -
-
4DCE
1
B:
[17-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
Y
E
G
Q
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
91.30
99%
-131
- C1 -
-
4CMT
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
---
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
91.13
99%
-132
- C1 -
-
2XP2
1
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
---
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
90.93
99%
-130
- C1 -
-
4CNH
2
B:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
---
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
90.66
99%
-126
- C1 -
-
4TT7
5
A:
[2-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
---
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.20
99%
-125
- C1 -
-
4FOB
1
A:
[36-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
---
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
90.14
100%
-135
- C1 -
-
2XBA
1
A:
[3-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
-------
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.54
99%
-132
- C1 -
-
5IUH
1
A:
[10-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
-----
E
V
Y
E
G
Q
V
S
G
------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
---
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
89.43
100%
-134
- C1 -
-
5FTO
1
A:
[13-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
----
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
89.19
100%
-133
- C1 -
-
6MX8
1
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
--
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.88
99%
-127
- C1 -
-
5IUG
1
A:
[10-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.07
99%
-129
- C1 -
-
4FNY
1
A:
[20-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
81.21
99%
-126
- C1 -
-
5IMX
1
A:
[25-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
P
L
Q
V
A
V
K
T
L
---------
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.95
99%
-141
- C1 -
-
4JOA
1
A:
[41-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
------
V
Y
E
G
Q
V
S
--------
L
Q
V
A
V
K
T
L
P
---------
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------