@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARBK1_HUMAN: (2019-05-18 )
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
D
L
E
A
V
L
A
D
V
S
Y
L
M
A
M
E
KSKATPAARAS
K
K
I
LLP
E
P
S
I
R
S
V
M
Q
K
Y
L
E
DRGE
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
KLE
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
ACSHPFSKS
A
T
E
H
V
Q
G
HLGKKQV
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
SDKF
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
MNDF
S
V
H
R
I
IGRGGFGEVYGCRKADTG
K
M
Y
A
M
K
C
L
D
K
K
R
I
KMKQG
E
T
L
ALN
E
R
I
M
L
S
L
VSTGDC
P
F
I
V
C
M
S
Y
AFHT
P
D
K
L
S
F
I
L
D
LMNGG
D
L
H
Y
H
L
S
QHGVF
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
MHN
R
F
V
V
Y
R
DLK
P
A
N
I
L
LDEHG
H
V
R
I
S
D
L
G
L
ACDFSKKKPHASVGTHGYM
A
P
E
V
L
Q
K
GVAYDSSA
D
W
F
S
L
G
C
M
L
F
K
L
L
RGHS
P
F
R
QHKTK
D
K
H
E
I
D
R
M
T
L
T
M
A
V
ELPDSF
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
CLGR
G
A
Q
E
V
K
ESPFFRSLD
W
Q
M
V
F
L
QKYPPPLIPPRGEVNAADAFDIGSFDEEDTK
G
I
K
LLDS
D
Q
E
L
Y
R
NFPL
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
TINA
E
T
D
R
L
E
A
R
K
KAKNKQLGHEEDYAL
G
K
D
C
I
M
H
G
Y
M
S
KMG
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
LFPN
R
L
E
WRGEGEA
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
IKER
K
C
L
L
L
K
IRGG
K
Q
F
I
L
QCDSD
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
MKNKPRSP
V
V
ELSKV
P
L
V
QRGSANGL
18
PsiBlast_PDB
96.30
99%
-109
- C2 -
-
5UKL
1
ARBK1_HUMAN
A:
[2-642]
------------------------------
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
I
-----------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
A
P
------------------
20
PsiBlast_PDB
95.56
100%
-104
- C2 -
-
4MK0
2
ARBK1_HUMAN
A:
[1-639]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
6
PsiBlast_PDB
95.12
100%
-107
- C2 -
-
3KRW
1
ARBK1_HUMAN
A:
[29-670]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
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H
M
H
N
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F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
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H
G
H
V
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I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
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G
T
H
G
Y
M
A
P
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L
Q
K
G
V
A
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D
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S
A
D
W
F
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L
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C
M
L
F
K
L
L
R
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H
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Q
H
K
T
K
D
K
H
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I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
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V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
------------------
7
PsiBlast_PDB
94.79
100%
-104
- C2 -
-
3KRX
1
ARBK1_HUMAN
A:
[29-670]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
------------------
22
Blastp_CBE
94.71
98%
-104
- C2 -
-
5HE2
1
ARBK1_BOVIN
A:
[1-639]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------
S
F
D
E
E
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
5
PsiBlast_PDB
94.71
99%
-108
- C2 -
-
6C2Y
1
ARBK1_HUMAN
A:
[30-668]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
--
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
------------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
--
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
2
PsiBlast_PDB
94.60
100%
-103
- C2 -
-
4PNK
1
ARBK1_HUMAN
A:
[30-668]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
-------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
14
PsiBlast_PDB
94.36
98%
-113
- C2 -
-
3PVU
1
ARBK1_BOVIN
A:
[30-668]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
23
Blastp_CBE
94.09
98%
-107
- C2 -
-
5HE0
1
ARBK1_BOVIN
A:
[1-639]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
15
PsiBlast_PDB
94.00
98%
-109
- C2 -
-
3PVW
1
ARBK1_BOVIN
A:
[29-668]
----------------------------
S
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
---------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
16
PsiBlast_PDB
93.68
98%
-107
- C2 -
-
5UKM
1
ARBK1_BOVIN
A:
[31-669]
------------------------------
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
I
-----------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
--------------------
17
PsiBlast_PDB
93.63
99%
-105
- C2 -
-
5UKK
1
ARBK1_HUMAN
A:
[1-638]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
---------
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
----------------
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
----------------------
4
PsiBlast_PDB
93.63
100%
-105
- C2 -
-
5WG4
1
ARBK1_HUMAN
A:
[31-668]
------------------------------
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
--
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
----------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
---
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
--
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
21
Blastp_CBE
93.59
98%
-105
- C2 -
-
5HE3
1
ARBK1_BOVIN
A:
[1-641]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
------------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
-------------------
19
PsiBlast_PDB
93.42
99%
-109
- C2 -
-
5HE1
1
ARBK1_HUMAN
A:
[1-640]
----------------------------
S
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
-------------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
---
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
3
PsiBlast_PDB
93.27
100%
-104
- C2 -
-
5WG3
1
ARBK1_HUMAN
A:
[30-668]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
---
T
K
D
K
H
E
I
D
R
M
T
L
T
--
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
--------
E
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
------
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
--
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
24
Blastp_CBE
76.53
99%
-129
- C2 -
-
5UVC
1
ARBK1_HUMAN
A:
[39-545]
-----------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
-----
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
----------------------
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------------------
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
68.11
99%
-114
- C2 -
-
5UUU
2
ARBK1_HUMAN
A:
[40-547]
------------------------------
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
---------------------------------------------------------------------------------
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
-------------
E
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
I
S
E
R
W
Q
Q
E
V
A
E
T
V
F
D
T
I
N
A
E
T
D
R
L
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------