@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK18_HUMAN: (2019-05-18 )
MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
Atome Classification :
(3 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
K
M
K
N
F
K
R
R
FSLSVP
R
T
E
T
I
E
E
S
L
A
E
F
T
E
Q
F
N
Q
L
H
NRRNENLQLGPLGRD
P
P
Q
ECSTFSPTDSGEEPGQLSPG
V
Q
F
Q
R
R
QNQRRF
S
M
E
D
V
S
K
R
LSLPMDIR
L
P
Q
E
F
L
Q
K
L
QMESPDLP
K
P
L
S
R
M
S
R
RASLSDIG
F
G
K
L
E
T
Y
V
K
L
DKLGEGT
Y
A
T
V
FK
G
R
S
K
L
T
E
N
L
V
A
L
K
E
I
R
L
EHEEGAP
C
T
A
I
R
E
V
S
L
L
K
NLKHA
N
I
V
T
L
H
D
L
IHTDR
S
L
T
L
V
F
E
Y
L
D
S
D
L
K
Q
Y
L
D
HC
G
N
L
M
S
M
H
N
V
K
I
F
M
F
Q
L
L
R
G
L
A
Y
C
H
H
R
K
I
L
H
RDLKPQ
N
L
L
INERG
E
L
K
L
A
DFGLARAKSVPTKTYSN
E
V
V
T
L
W
YR
P
P
D
V
L
LGSTEYSTPID
M
W
G
V
G
C
I
H
Y
EMATGRPLFPG
S
T
V
K
E
E
L
H
L
I
F
R
L
LGTPTEETWPG
V
T
A
F
S
EFRTYSFPCYL
P
Q
P
L
I
NHAPRLDT
D
G
I
H
L
L
S
S
L
L
L
Y
ESKSRM
S
A
E
A
A
L
S
H
S
Y
F
R
S
L
G
E
R
V
H
Q
L
E
D
T
A
S
I
F
S
L
K
E
I
Q
L
QKDPGYRGLAFQQPGRGKNRRQSIF
21
Blastp_CBE
96.93
78%
-124
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-314]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
T
E
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
C
G
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
G
E
L
K
L
A
D
F
G
L
A
R
A
------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
R
A
E
A
L
L
S
H
A
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
S
--------------------
2
PsiBlast_PDB
96.23
77%
-111
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[1-313]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
T
E
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
C
G
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
R
A
E
A
L
L
S
H
A
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
---------------------
37
HHSearch
95.72
77%
-111
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-313]
-------------------------------------------------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
T
E
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
C
G
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
R
A
E
A
L
L
S
H
A
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
---------------------