@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK4_HUMAN: (2019-05-19 )
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
Atome Classification :
(8 SA)
.........10........20....-....30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MATSRYE
P
V
A
E
IGVGAYG
T
V
Y
KARD-PHSG
H
F
V
A
L
K
S
V
RVPNGGGGGGGL
P
I
S
T
V
R
E
V
A
L
L
R
R
L
E
A
FEHP
N
V
V
R
L
M
D
V
CATSRTD
R
E
I
K
V
T
L
V
F
E
HV
D
Q
D
L
R
T
Y
L
DKAPPPGL
P
A
E
T
I
K
D
L
M
R
Q
F
L
R
G
L
D
F
L
H
A
N
C
I
V
HRDLKPE
N
I
L
V
TSG
G
T
V
K
L
A
D
F
G
L
A
R
I
Y
S
Y
Q
M
A
L
T
P
V
V
V
T
L
W
YR
A
P
E
V
L
L
Q
STYAT
P
V
D
M
W
S
V
G
C
I
F
A
E
M
F
RRKPLFCGNS
E
A
D
Q
L
G
K
I
F
D
LIGLPPEDDWPRDVSLPRGAFPPRGPR
P
V
Q
S
V
V
P
E
M
E
E
S
G
A
Q
L
L
L
E
M
LTFNP
H
K
R
I
S
A
F
R
A
L
Q
H
S
Y
LHKDEGNPE
12
PsiBlast_PDB
73.85
69%
-46
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[10-305]
--
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
--------------
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---
11
PsiBlast_PDB
73.44
69%
-36
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[11-305]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
---
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
---
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---
13
PsiBlast_PDB
72.53
69%
-42
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[9-305]
-
A
D
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
-
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-------
Q
A
F
----
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---
21
Blastp_CBE
65.87
71%
-39
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[11-301]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
-------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
22
Blastp_CBE
65.79
71%
-39
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[11-301]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
-------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
--
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
19
PsiBlast_PDB
65.30
70%
-39
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[10-301]
--
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
-------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
-
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
20
PsiBlast_PDB
63.72
70%
-31
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[11-301]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
---------------
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
--------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
18
PsiBlast_PDB
59.88
69%
-62
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-304]
-------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
G
-
R
F
V
A
L
K
R
V
R
V
----
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
-------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
----------------
P
I
E
K
F
--
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
----