@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK5_HUMAN: (2019-05-19 )
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
Atome Classification :
(10 SA)
.........10........20........30........40........50........60........70........80........90........100........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230......-.240.......250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
K
Y
E
K
L
E
K
IGEGTYG
T
V
F
KAKNRET
H
E
I
V
A
L
K
R
V
RLDDDDEGV
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
HK
N
I
V
R
L
H
D
V
LHSDK
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
SCNGDL
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
LG
F
C
HSR
N
V
L
H
RDLKPQ
N
L
L
INRNG
E
L
K
L
A
D
FG
L
A
R
AFGI
P
V
R
C
Y
S
A
E
V
V
T
L
W
YRPPD
V
L
F
G
A
K
L
Y
S
T
SIDMWS
A
G
C
I
F
A
E
L
A
NAGRPLFPGN
D
V
D
D
Q
L
K
R
I
F
R
L
LGTP
T
E
E
QWPSMTKLPDYKP-YPMYPA
T
T
S
L
V
N
V
VPKLNAT
G
R
D
L
L
Q
N
L
L
KCNPVQRI
S
A
E
E
A
LQHPYFSDFCPP
25
HHSearch
95.36
100%
-105
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-292]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
3
PsiBlast_PDB
95.13
99%
-105
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-292]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
1
PsiBlast_PDB
93.50
99%
-111
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[1-292]
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
24
HHSearch
91.10
100%
-106
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---
23
Blastp_CBE
91.10
100%
-106
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---
6
PsiBlast_PDB
89.77
100%
-102
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
---
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---
21
Blastp_CBE
86.77
99%
-121
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-288]
-----
K
L
E
K
I
G
-----
T
V
F
K
A
------
E
I
V
A
L
K
R
V
R
--------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
G
D
L
D
P
-
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
-
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
----
10
PsiBlast_PDB
84.31
60%
-123
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-286]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
-
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
---------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
-
N
F
T
V
Y
E
P
L
P
W
E
S
F
L
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----
7
PsiBlast_PDB
79.60
60%
-118
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-286]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
-
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
-
N
F
T
V
Y
E
P
L
P
W
E
S
F
L
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----
11
PsiBlast_PDB
74.32
60%
-38
- C1 -
-
6Q4G
1
?
A:
[9-300]
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P