@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK9_HUMAN: (2019-05-19 )
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAKQYDSVECPF
C
D
E
V
S
K
Y
E
K
L
A
K
IGQG
T
F
G
E
V
F
K
A
R
H
RKT
G
Q
K
V
A
L
K
K
V
L
M
ENEKEGFP
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
HE
N
V
V
N
L
I
E
I
CRTKASPYNRCK
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
DMKA
A
N
V
L
I
TRDG
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
AKNSQPNRYT
N
R
V
V
T
L
W
YR
P
P
E
L
LLGERDYGPPIDLWG
A
G
C
I
M
A
E
M
WTRSPIMQGN
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
SI
T
P
E
VWPNVD
N
Y
E
L
Y
E
K
L
E
L
VKG
Q
K
R
K
V
K
D
R
L
K
A
Y
VRDP
Y
A
L
D
L
I
D
K
L
L
VL
D
P
A
Q
RIDSDDALNHDFFWSDPM
P
S
D
L
K
G
M
L
S
T
H
L
T
S
M
F
E
Y
LAPPRRKGS
Q
I
T
Q
QSTNQSRNPATTN
Q
T
E
F
E
RVF
17
PsiBlast_PDB
95.81
99%
-137
- C1 -
-
4BCG
2
CDK9_HUMAN
A:
[8-328]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
4
PsiBlast_PDB
94.84
99%
-129
- C1 -
-
3MIA
1
CDK9_HUMAN
A:
[8-340]
-------
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
M
L
S
T
H
L
T
S
M
F
E
Y
L
A
--------------------------------
11
PsiBlast_PDB
92.45
99%
-127
- C1 -
-
3MY1
3
CDK9_HUMAN
A:
[7-328]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
-------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
15
PsiBlast_PDB
91.50
99%
-132
- C1 -
-
4BCI
1
CDK9_HUMAN
A:
[6-327]
----
Y
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
---------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
12
PsiBlast_PDB
91.06
99%
-133
- C1 -
-
3LQ5
1
CDK9_HUMAN
A:
[7-328]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
--
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
9
PsiBlast_PDB
91.01
99%
-143
- C1 -
-
3BLQ
1
CDK9_HUMAN
A:
[8-326]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
-------
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
------
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
-----------------------------------------------
16
PsiBlast_PDB
90.93
99%
-127
- C1 -
-
4BCJ
1
CDK9_HUMAN
A:
[7-327]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
-------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
G
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
10
PsiBlast_PDB
90.02
99%
-133
- C1 -
-
3BLR
1
CDK9_HUMAN
A:
[8-327]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
-----
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
13
PsiBlast_PDB
87.69
99%
-142
- C1 -
-
3TNH
1
CDK9_HUMAN
A:
[9-329]
-------
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
-------
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
---------------
K
V
K
D
R
L
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
K
G
M
L
--------------------------------------------