@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL1_HUMAN: (2019-05-19 )
MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
Atome Classification :
(4 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
K
Y
E
K
IGKIGEG
S
Y
G
V
V
F
K
CRNRDTG
Q
I
V
A
I
K
K
F
L
ESED
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
LKHP
N
L
V
N
L
L
E
V
F
R
RK
R
R
L
H
L
V
F
E
YC
D
H
T
V
L
H
E
L
D
R
Y
QRG
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
KHNCIHRDVKPE
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
LAGP
S
D
Y
Y
T
D
Y
V
A
T
R
WYRSPE
L
L
V
GDTQYGPP
V
D
V
W
A
I
G
C
V
F
A
E
L
LSGVPLWPGKS
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
FSTNQYFSGVKIPDPEDMEP
L
E
L
KFPNISY
P
A
L
G
L
L
K
G
C
LHMDPTQRL
T
C
E
Q
L
LH
H
P
Y
F
E
N
I
R
E
I
E
D
L
A
K
E
HNK
P
T
R
K
T
L
R
K
SRKHHCFTET
S
K
L
Q
Y
L
P
Q
LTGSSILPALDNK
K
Y
Y
CDTKKLNYRFPNI
25
HHSearch
96.51
99%
-136
- C1 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
Y
Q
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
1
PsiBlast_PDB
96.46
98%
-138
- C1 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
Y
Q
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
21
Blastp_CBE
96.28
98%
-136
- C1 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
Y
Q
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
22
Blastp_CBE
95.00
98%
-139
- C1 -
-
4AGU
1
CDKL1_HUMAN
B:
[4-293]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
Y
Q
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
-----------------------------------------------------------------