@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL2_HUMAN: (2019-05-19 )
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH
Atome Classification :
(5 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEKYENL
G
L
VGEGSY
G
M
V
M
K
CRNKDTG
R
I
V
A
I
K
K
F
L
ESD
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
KKK
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
LFPNGL
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
IGFCHSHN
I
I
HRDIKPE
N
I
L
VSQSG
V
V
K
L
CDFG
F
A
R
TLAAP
G
E
V
Y
T
D
Y
V
A
T
R
WYRAPE
L
L
V
GDVKYG
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
FMGEPLFPGDS
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
LI
P
R
H
Q
E
L
FNKNPVFAGVRLPEIKERE
P
L
E
R
RY
P
K
L
S
E
V
V
I
D
L
A
K
K
C
LHIDPDKR
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
QKDARNVSLSKKSQNRKKEKEK
D
D
S
L
V
E
ER
K
T
L
V
V
Q
DTNADPKIK
D
Y
K
L
F
K
I
KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTH
N
L
S
AVAPSINSGMGTE
T
I
P
IQ
G
Y
RVDEKTKKCSIPFVKPNRHSPS
G
I
Y
N
I
N
V
T
T
L
VSGPPLSDDSGADLPQMEHQH
2
PsiBlast_PDB
96.83
99%
-147
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-331]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
96.32
99%
-148
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[25-330]
-
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.90
99%
-166
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
94.48
99%
-164
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[25-325]
-
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
91.78
99%
-151
- C1 -
-
4BBM
3
CDKL2_HUMAN
B:
[24-331]
M
E
K
Y
E
N
L
G
-----
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
---------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
------
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------