@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK1_HUMAN: (2019-05-19 )
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
Atome Classification :
(46 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRHSKRTYCPDWDDKDWDYGKWRSSS
S
H
K
R
R
KRSHSSAQENKRCKYN
H
S
KM
C
D
S
H
YLESRSIN
E
K
D
Y
H
S
R
R
Y
I
D
E
Y
R
N
D
Y
TQGCEPGHRQR
D
H
E
S
R
Y
QNHSSKSSGRSG
R
S
SYKSK
H
R
IHHSTSH
R
R
SH
G
K
S
H
R
R
K
RTRSVEDDEE
G
H
L
I
CQSGD
V
L
S
A
R
Y
E
I
V
D
T
LGE
G
A
F
G
K
V
V
E
C
I
DHKAGG
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
HLNTTDPN
S
T
F
R
C
V
Q
M
L
E
W
F
E
HHG
H
I
C
I
V
F
E
L
LGL
S
T
Y
D
F
I
K
ENG
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
HSNKLTHTDLKPE
N
I
L
F
V
QSDYTEAYNPKIKRDERTLINPD
I
K
V
V
DFGSATYDDEH
H
S
T
L
V
S
TRHYRAP
E
V
I
L
ALGWSQPC
D
V
W
S
I
G
C
I
L
I
E
Y
Y
LG
F
T
V
FPTHD
S
K
E
H
L
A
M
M
E
R
I
LGPL
P
K
H
M
I
Q
K
T
R
K
R
KYFHHDRLDWDEHSSA
G
R
Y
V
S
R
R
C
K
P
L
K
E
F
M
L
SQDV
E
H
E
R
L
F
D
L
I
Q
K
M
LEYDPAK
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
KSI
35
Blastp_CBE
97.28
99%
-143
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
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V
D
T
L
G
E
G
A
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K
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V
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I
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K
V
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F
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S
A
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P
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H
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S
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M
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P
A
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T
L
R
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A
L
K
H
P
F
F
D
L
L
K
K
--
22
Blastp_CBE
96.86
99%
-145
- C1 -
-
6Q8P
1
?
B:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
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A
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Y
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V
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T
L
G
E
G
A
F
G
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N
P
---
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V
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A
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--
R
H
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A
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S
-
25
Blastp_CBE
96.66
99%
-142
- C1 -
-
6I5K
3
?
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
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S
-
9
PsiBlast_PDB
96.33
99%
-139
- C1 -
-
6I5K
3
?
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
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--
10
PsiBlast_PDB
96.20
99%
-141
- C1 -
-
6I5L
3
?
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
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S
-
6
PsiBlast_PDB
96.10
99%
-141
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
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Q
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K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
26
Blastp_CBE
96.02
99%
-143
- C1 -
-
6I5K
5
?
B:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
24
Blastp_CBE
95.97
99%
-141
- C1 -
-
6I5L
2
?
B:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
28
Blastp_CBE
95.94
99%
-140
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
15
PsiBlast_PDB
95.87
99%
-142
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
---
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
21
Blastp_CBE
95.84
99%
-140
- C1 -
-
6Q8P
1
?
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
--
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
33
Blastp_CBE
95.60
99%
-137
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
31
Blastp_CBE
95.51
99%
-137
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
23
Blastp_CBE
95.34
99%
-141
- C1 -
-
6I5L
4
?
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
29
Blastp_CBE
95.00
99%
-142
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
51
HHSearch
94.99
100%
-141
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
27
Blastp_CBE
94.94
99%
-140
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
-
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
12
PsiBlast_PDB
94.89
99%
-139
- C1 -
-
6Q8K
2
?
A:
[3-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
I
11
PsiBlast_PDB
94.78
99%
-146
- C1 -
-
6I5H
7
?
A:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-----------
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
8
PsiBlast_PDB
94.29
99%
-138
- C1 -
-
6I5I
13
?
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
---
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
13
PsiBlast_PDB
93.97
99%
-138
- C1 -
-
6Q8P
1
?
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
34
Blastp_CBE
93.09
99%
-137
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[8-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
16
PsiBlast_PDB
92.89
87%
-141
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[5-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
G
M
D
G
M
H
V
A
V
K
I
V
K
N
V
G
R
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
F
R
C
V
Q
M
L
E
W
F
D
H
H
G
H
V
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
S
F
L
P
F
Q
I
D
H
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
H
H
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
K
S
D
Y
V
V
K
Y
N
---
K
R
D
E
R
T
L
K
N
T
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
Q
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
I
P
Q
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
N
Q
L
D
W
D
E
H
S
S
A
G
R
Y
V
R
R
R
C
K
P
L
K
E
F
M
L
C
H
D
E
E
H
E
K
L
F
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
P
F
F
D
L
L
K
---
14
PsiBlast_PDB
92.17
99%
-138
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
32
Blastp_CBE
90.37
99%
-148
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
---
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
---------------------
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
37
Blastp_CBE
90.27
66%
-131
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[5-350]
---------------------------------------------------------------------------------------------------------------------------------------
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
19
PsiBlast_PDB
90.12
66%
-143
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[13-356]
-----------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
38
Blastp_CBE
90.11
66%
-142
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[13-356]
-----------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
36
Blastp_CBE
90.01
66%
-134
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[5-350]
---------------------------------------------------------------------------------------------------------------------------------------
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
30
Blastp_CBE
89.72
99%
-143
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
----------------------
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
40
Blastp_CBE
89.52
67%
-134
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[15-355]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
17
PsiBlast_PDB
89.21
66%
-137
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[5-350]
---------------------------------------------------------------------------------------------------------------------------------------
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
41
Blastp_CBE
88.98
67%
-134
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[15-354]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
----
20
PsiBlast_PDB
88.96
66%
-138
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[15-355]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
-------
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
49
Blastp_CBE
88.53
62%
-138
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
39
Blastp_CBE
87.73
67%
-136
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
47
Blastp_CBE
87.69
62%
-135
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
18
PsiBlast_PDB
87.60
66%
-136
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
---------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
44
Blastp_CBE
87.40
62%
-130
- C1 -
-
6FT7
8
CLK3_HUMAN
B:
[6-348]
--------------------------------------------------------------------------------------------------------------------------------------
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
46
Blastp_CBE
86.63
62%
-133
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[33-369]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
43
Blastp_CBE
86.47
61%
-132
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[11-348]
-------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
42
Blastp_CBE
86.10
61%
-133
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[4-348]
------------------------------------------------------------------------------------------------------------------------------------
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
48
Blastp_CBE
85.88
62%
-134
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[32-369]
-------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
45
Blastp_CBE
85.71
62%
-132
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[6-348]
--------------------------------------------------------------------------------------------------------------------------------------
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
52
HHSearch
84.97
61%
-136
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[15-352]
-----------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
---
53
HHSearch
83.78
61%
-134
* C1 *
-
6FT7
7
CLK3_HUMAN
A:
[15-352]
-----------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
---