@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK4_HUMAN: (2019-05-23 )
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
Atome Classification :
(7 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSS
R
T
V
LAPGNDRNSDTHGTLGSGRSSDKGPSWSSR
S
L
G
A
R
C
R
N
S
I
ASCPEEQPHVG
N
Y
R
L
L
R
T
IGKGNF
A
K
V
K
L
A
R
H
I
LTG
R
E
V
A
I
K
I
I
DKTQL
N
P
S
S
L
Q
K
L
F
R
E
V
R
I
M
KGLNH
P
N
I
V
K
L
F
E
V
I
ETE
K
T
L
Y
L
V
M
EYASA
G
E
V
F
D
Y
L
V
SHGRM
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
QKN
I
V
H
R
DLKAE
N
L
L
LDAEA
N
I
K
I
A
DFGFSNEFTLGSK
L
D
T
FCGSPPYAA
P
E
LFQGKKYDGPE
V
D
I
W
S
L
G
V
I
L
Y
T
L
VSGSLPFDGH
N
L
K
E
L
R
E
R
V
LRGKYRV
P
F
Y
MST
D
C
E
S
I
L
R
R
F
L
VLN
P
A
K
R
C
T
L
E
Q
I
M
K
DK
W
I
NIGYEGEELKPYTE
P
E
E
DFGD
T
K
R
I
E
V
M
V
GMGY
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
L
L
LGRKTEEGGDRGAPG
L
A
L
A
R
V
RAPSDTTNGTSSSKGTSHSKGQRSSS
S
T
Y
H
R
Q
RRHSDFCGPSPAPLHPKRSPTST
G
E
A
E
L
K
E
ERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNP
N
K
A
EIPERRKDSTSTPNNL
P
P
S
M
M
TRRN
T
Y
V
CTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSG
E
R
S
RLARGST
I
R
STFHGGQ
V
R
DRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRP
T
T
N
L
F
T
K
L
T
S
K
L
T
R
R
VAD
E
P
E
RIGGPEV
T
S
C
HLPWDQTETAP
R
L
L
RF
P
W
S
V
K
LTSSR
P
P
E
A
L
M
A
A
L
R
Q
A
T
A
A
A
RCRCRQPQ
P
F
L
L
A
C
L
HGGAGGPEPLS
H
F
E
V
E
VCQLPRP
G
L
R
G
V
L
F
R
R
VA
G
T
A
L
A
F
R
T
L
V
T
R
I
SNDLEL
1
PsiBlast_PDB
80.74
100%
-120
- C3 -
-
5ES1
1
MARK4_HUMAN
A:
[12-328]
-----------------------------------------------------
P
H
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
E
A
N
I
K
I
A
D
F
G
F
S
N
-------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
V
P
F
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
K
W
I
N
I
G
Y
E
G
E
E
L
K
P
Y
T
E
P
E
E
D
F
G
D
T
K
R
I
E
V
M
V
G
M
G
Y
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
L
L
L
G
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
75.07
84%
-115
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[15-327]
--------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
G
-------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
75.03
84%
-118
- C3 -
-
5KZ8
1
MARK2_HUMAN
B:
[30-345]
-----------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.48
84%
-118
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[30-345]
-----------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
G
--------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.17
84%
-105
- C3 -
-
5EAK
1
MARK2_HUMAN
A:
[11-326]
----------------------------------------------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
G
F
S
-----------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.14
84%
-125
- C3 -
-
5KZ7
1
MARK2_HUMAN
A:
[30-345]
-----------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
74.02
84%
-123
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[30-345]
-----------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------