@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MRCKG_HUMAN: (2019-05-24 )
MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP
Atome Classification :
(12 SA)
-.........10..-----.-...---...20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-M
E
R
R
L
R
A
L
E
Q
-
L
A-----R-GEA---GGCP
G
L
D
G
L
L
D
L
L
L
A
L
H
H
ELSSGP
L
R
R
E
R
S
V
A
Q
F
L
S
W
A
S
P
F
V
S
K
V
K
E
L
RLQRD
D
F
E
I
L
K
V
I
GRGAFG
E
V
T
V
V
R
QRDT
G
Q
I
F
A
M
K
M
L
H
K
W
E
M
L
K
R
A
E
T
A
C
F
R
EER
D
V
L
VKGDS
R
W
V
T
T
L
H
Y
A
FQDE
E
Y
L
Y
L
V
M
DYYAG
G
D
L
L
T
L
L
S
R
F
E
DRL
P
P
E
L
A
Q
F
Y
L
A
E
M
V
L
A
I
H
S
L
H
Q
L
G
Y
V
HRDVKPD
N
V
L
L
DVNG
H
I
R
L
ADFG
S
C
L
R
LNTNGMVDSSVAVGTPDYI
S
P
E
I
L
Q
A
M
E
EGKGHYGPQCDW
W
S
L
G
V
C
A
Y
E
L
LFGET
P
F
Y
A
E
S
L
V
E
T
Y
G
K
IMNH
E
D
HLQFPPDVPDVPA
S
A
Q
D
L
I
R
Q
L
L
C
R
Q
E
E
RLGRGG
L
D
D
FRNHPFFEGV
D
W
E
R
L
ASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHL
P
F
V
G
F
T
YTSGSHSPESS
S
E
A
W
A
A
L
E
R
K
L
Q
C
L
E
Q
E
K
V
E
L
S
R
K
H
Q
E
A
LHAPT
D
H
R
E
L
E
Q
L
R
K
E
V
Q
T
L
R
D
R
L
P
E
M
L
R
D
K
ASLSQTDGPPAGSPGQ
D
S
D
L
R
Q
E
L
D
R
L
H
R
E
L
A
EGRAGL
Q
A
Q
E
Q
E
L
C
R
AQG
Q
Q
E
E
L
L
Q
R
L
Q
E
A
Q
E
R
E
AA
T
A
S
Q
T
R
A
L
S
S
Q
L
E
E
A
R
A
A
Q
R
E
L
E
A
Q
V
S
S
L
S
R
Q
V
T
Q
L
Q
G
Q
W
E
Q
R
L
E
ESSQA
K
T
I
H
TASETNGMGPPEGG
P
Q
E
A
Q
L
R
K
E
V
A
A
L
R
E
Q
L
E
Q
A
HSHRPS
G
K
E
E
A
L
C
Q
L
Q
E
E
N
R
R
L
S
R
E
Q
E
R
L
E
A
E
L
A
Q
E
Q
E
S
K
Q
R
L
EGERRETES
N
W
E
A
Q
L
A
D
I
L
S
W
V
N
D
E
K
V
S
R
G
Y
L
Q
A
L
A
T
K
M
A
E
E
L
E
S
L
R
N
VGTQTLPARPL
D
H
Q
W
K
A
R
R
L
Q
K
M
E
A
S
A
R
L
E
L
Q
S
A
L
E
A
E
I
R
A
K
Q
G
L
Q
E
R
L
T
Q
V
Q
E
A
Q
L
Q
A
E
R
R
L
Q
E
A
E
K
Q
S
Q
A
L
Q
Q
E
L
A
M
L
R
E
E
L
RARGPVDTKPSNSL
I
P
F
LSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFP
S
P
T
K
C
L
R
C
T
S
L
M
L
G
LGRQGLGC
D
A
C
G
Y
F
CHTTCAPQAPPCPV
P
P
D
L
L
R
T
A
LGVHPETGTG
T
A
Y
E
G
FLSVPR
P
S
G
V
R
R
G
W
Q
R
V
F
A
A
LSDS
R
L
L
L
F
DAPD
L
R
LSPPSG
A
L
L
Q
V
L
DLRDPQFSATP
V
L
A
S
D
V
I
H
AQSRDL
P
R
I
F
RVTTSQLAVPPT
T
C
T
V
L
L
L
AESEG
E
R
E
R
W
L
Q
V
L
G
E
L
Q
R
L
L
LDARPRPR
P
V
Y
T
L
K
E
A
YDNGLPL
L
P
H
T
L
C
A
A
I
LD
Q
D
R
LALGTEE
G
L
F
V
I
H
LRSND
I
F
QVGEC
R
R
V
Q
Q
L
TLSPSA
G
L
L
V
V
L
CGRGP
S
V
R
L
F
A
L
A
E
LE
N
I
E
VAGAKIPESRG
C
Q
V
L
AAGSILQART
P
V
L
C
V
A
VKR
Q
V
L
C
Y
QLGPGP
G
P
W
Q
R
R
I
R
E
LQAP
A
T
V
Q
S
L
G
LLGDR
L
C
VGAAG
G
F
A
L
Y
P
L
L
NEAAPLALGAGLVPEELPPSRGG
L
G
E
A
L
G
A
V
E
L
S
L
S
E
F
L
L
L
F
TTA
G
I
Y
VDGAGRKSRGH
E
L
LWPAAPMGWGYAA
P
Y
L
T
V
FSENS
I
D
V
F
DV
R
R
A
E
W
V
QTVPLKKVRPLNPEG
S
L
F
L
Y
GT
E
K
V
R
L
T
Y
L
R
N
Q
LAEKDEFDIPDLT
D
N
S
R
R
Q
L
F
R
TKSK
R
R
F
F
F
RV
S
E
E
Q
Q
K
Q
Q
R
R
E
M
L
KD
P
F
V
R
SKLISPPTNF
N
H
L
V
H
VGPANGRPGARDKSPAPEEKGRVARGSGPQRP
H
S
F
S
E
A
L
RRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLS
P
A
T
S
L
M
Q
V
SERPRSLPLSPELESSP
42
HHSearch
95.90
68%
-127
- C2 -
-
5OTE
2
MRCKB_HUMAN
A:
[28-412]
-------------------------------
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
--
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
----------
I
L
P
P
G
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
95.88
68%
-122
- C2 -
-
5OTF
3
MRCKB_HUMAN
A:
[28-411]
-------------------------------
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
--------
E
I
L
P
P
G
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
84.63
68%
8
- C2 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
-
F
I
-----
L
D
G
P
A
QTN
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
L
G
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.74
66%
6
- C2 -
-
5OTF
3
MRCKB_HUMAN
A:
[8-409]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
--------
E
I
L
P
P
G
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.35
69%
7
- C2 -
-
4AW2
5
MRCKA_RAT
A:
[3-405]
--
E
V
R
L
R
Q
L
E
Q
F
I
L
-----
D
-
G
P
A
QTN
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
L
G
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.21
66%
8
- C2 -
-
4UAK
2
MRCKB_HUMAN
A:
[8-409]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
---------------
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.61
66%
7
- C2 -
-
5OTE
2
MRCKB_HUMAN
A:
[8-409]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
--
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
----------
I
L
P
P
G
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.48
66%
1
- C2 -
-
4UAL
2
MRCKB_HUMAN
A:
[8-409]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
---
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
--
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
---------
I
L
P
P
--
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
81.99
67%
5
- C2 -
-
3TKU
3
MRCKB_HUMAN
B:
[22-423]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-------------------
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.44
66%
3
- C2 -
-
3QFV
2
MRCKB_HUMAN
A:
[6-407]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.08
66%
9
- C2 -
-
3TKU
3
MRCKB_HUMAN
A:
[22-423]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
81.05
67%
6
- C2 -
-
3QFV
3
MRCKB_HUMAN
B:
[6-407]
----
R
L
K
K
L
E
Q
-
L
L
LDGPW
R
-
N
E
S
---
A
--
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
L
G
Q
N
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
------------------
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------