@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK19_HUMAN: (2019-04-27 )
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Atome Classification :
(8 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDYD
F
K
A
K
L
A
A
E
R
E
R
V
E
D
L
F
E
YEGCKVGRGTYG
H
V
Y
K
A
RRKDGK
D
E
K
E
Y
A
L
K
Q
IEGTGI
S
M
S
A
C
R
E
I
A
L
L
R
E
LKHP
N
V
I
A
L
Q
K
V
F
LSHSD
R
K
V
W
L
L
F
DYAE
H
D
L
W
H
I
I
K
F
H
RASKANKK
P
M
Q
L
P
R
S
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
HA
N
W
V
L
HRDLKPA
N
I
L
V
MGEGPERG
R
V
K
I
A
D
M
G
F
A
R
L
FNSPLKPLADLD
P
V
V
V
T
F
W
YR
A
P
E
L
L
L
GARH
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
LTSEP
I
F
H
C
R
QEDIKTSNPF
H
H
D
Q
L
D
R
I
F
S
V
MGFPADK
D
W
E
D
I
R
KMPEYP
T
L
Q
K
D
F
R
R
TTYA
N
S
S
L
I
K
Y
M
E
K
HKVKPD
S
K
V
F
L
L
L
Q
K
L
LTMDPTKRI
T
S
E
Q
ALQDPYFQEDPL
P
T
L
D
V
FAGCQIPY
P
K
R
E
FLNEDDPEEKGD
K
N
Q
Q
Q
Q
Q
N
QHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
20
PsiBlast_PDB
61.37
91%
-121
- C1 -
-
5HNB
6
CDK8_HUMAN
A:
[4-362]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
59.32
93%
-136
* C1 *
-
5FGK
10
CDK8_HUMAN
A:
[3-364]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
-------
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
-----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
-------
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.21
92%
-116
- C1 -
-
5IDP
3
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
---
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
55.55
93%
-118
- C1 -
-
5ICP
7
CDK8_HUMAN
A:
[3-364]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
--------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
53.42
93%
-127
- C1 -
-
5HBJ
2
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
--
L
F
N
S
P
L
----------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.42
92%
-125
- C1 -
-
5IDN
5
CDK8_HUMAN
A:
[3-365]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
-----
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
50.97
93%
-117
- C1 -
-
5HBE
4
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
----
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
---------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.27
91%
-115
- C1 -
-
5I5Z
2
CDK8_HUMAN
A:
[4-365]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
E
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
-----
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------