@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL5_HUMAN: (2019-04-28 )
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK
Atome Classification :
(1 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKIP
N
I
G
N
V
M
N
K
F
E
I
L
G
V
VGEG
A
Y
G
V
V
L
K
C
RHKET
H
E
I
V
A
I
KKFKDSEE
N
E
E
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
RRG
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
EMPNGV
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
HKNDIVHRDIKPE
N
L
L
ISHN
D
V
L
K
L
CDFGFARNLSEGNNA
N
Y
T
E
Y
V
A
T
R
WYRSPE
L
L
L
GAPYGKSVD
M
W
S
V
G
C
I
LGELSDGQPLFP
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
LGPL
P
S
E
Q
M
K
L
FYSNPRFHGLRFPAVNH
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
LKLDPA
D
R
Y
L
T
E
Q
C
LNHPT
F
Q
T
Q
R
L
L
DRSPSRSAKRK
P
Y
H
VESSTLSNRNQAGKS
T
A
L
Q
S
HHRSNSK
D
I
Q
N
LSVGLPRADEGLPANESFLNGNLAGASLSP
L
H
T
K
T
YQASSQPGSTSKDLTNNNIPHLL
S
P
K
EAKSKT
E
F
D
FNIDPKPSEGPGT
K
Y
LKSNSR
S
Q
Q
N
R
H
S
F
M
E
SSQSKAGTLQPNEK
Q
S
R
H
S
Y
I
DTIPQSSRSPSYRTKAKSHGALSDSKSV
S
N
L
S
E
A
R
A
QIAEPSTSRYF
P
S
S
CLDLNSPTSPTPTRHSDT
R
T
LLSPSGRNNRNEGTLDSRRTTT
R
H
S
K
T
M
E
E
LKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHS
M
Y
V
T
R
D
K
V
RAKGLDGSLSIGQGMAARAN
S
L
Q
LLSPQPGEQLPP
E
M
T
V
A
R
S
S
V
K
E
T
S
REGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPV
P
R
R
VGSFYRVPSPRPDNSFHEN
N
V
S
T
R
V
SSLPSESSSGTNHSKRQPAFDPWKSPENI
S
H
S
E
Q
L
K
E
K
E
K
Q
G
F
F
R
S
M
K
K
K
K
KKSQTVPNSDSP
D
L
L
T
L
Q
K
S
IHSASTPSSRPKEWRP
E
K
I
S
D
L
QT
Q
S
Q
P
L
K
S
L
R
K
L
L
H
LSSASNHPASSDPRFQPL
T
A
Q
Q
TKNSFS
E
I
R
I
H
PLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQD
R
R
F
M
L
R
TTEQQG
E
Y
F
CCGDPKKPHTPCVPN
R
A
LHRPISSPAPY
P
V
L
Q
VRGTSMC
P
T
L
Q
V
RGTDAFSCPTQQS
G
F
S
F
F
V
R
H
V
M
R
E
A
L
I
H
R
A
QVN
Q
A
A
L
L
T
Y
HENAALTGK
1
PsiBlast_PDB
92.56
99%
-126
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[10-303]
--------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
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