@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK2_HUMAN: (2019-04-28 )
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
Atome Classification :
(10 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPHPRRYHSSERGSRG
S
Y
R
E
H
Y
R
S
R
K
H
K
R
R
RSRSWSSS
S
D
R
T
R
R
R
RREDS
Y
H
VRSRSSYDDRSSDR
R
V
Y
D
R
R
Y
CGSYRRNDYSRDRGDAYYDTDYRH
S
Y
E
YQREN
S
S
Y
R
S
Q
R
S
S
R
R
K
H
R
R
R
R
R
RSRTFSRSSSQHSSRRAKSVEDDAE
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
LGE
G
T
F
G
R
V
V
Q
C
V
D
HRRG
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
INEKDPDNK
N
L
C
V
Q
M
F
D
W
FDYHG
H
M
C
I
S
F
E
L
LG
L
S
T
F
D
FLKDNNYLPY
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
HDNKLTHTDLKPE
N
I
L
F
VNSD
Y
E
L
T
Y
NLEKK
R
D
E
R
S
V
K
S
T
A
V
R
V
V
DFGSATFDHEH
H
S
T
I
V
STRHYR
A
P
E
V
I
L
ELGWSQPC
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
QTHD
N
R
E
H
L
A
M
M
E
R
I
LGPI
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
YRGRLDWDENTSA
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
EYEPAKRL
T
L
G
E
A
L
Q
H
P
F
F
A
R
LRAEP
P
N
KLWDSSRDISR
5
PsiBlast_PDB
90.81
100%
-143
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[13-356]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
23
Blastp_CBE
88.91
99%
-140
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[10-356]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
3
PsiBlast_PDB
84.13
100%
-136
* C1 *
-
6FYK
1
CLK2_HUMAN
A:
[4-352]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
24
Blastp_CBE
83.89
100%
-133
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[4-352]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
25
Blastp_CBE
80.54
100%
-129
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[4-352]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
22
Blastp_CBE
77.49
99%
-130
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[8-354]
---------------------------------------------------------------------------------------------------------------------------------------
S
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
-----------------
1
PsiBlast_PDB
77.14
99%
-136
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[9-356]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
-------
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
---------------
4
PsiBlast_PDB
77.04
100%
-135
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
-----------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
21
Blastp_CBE
76.09
99%
-130
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[9-355]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
2
PsiBlast_PDB
71.19
99%
-135
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------