@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK3_HUMAN: (2019-04-28 )
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
Atome Classification :
(8 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPV
L
S
A
R
R
R
E
L
A
D
HAGSGRRSGPSPTARSGPH
L
S
A
L
RAQPA
R
A
AHLSGR
G
T
Y
V
R
RDTAGGGPGQARPLGPP
G
T
S
L
L
GRGARRSGEGWCPGAFESGARAARPPSRVE
P
R
L
ATAASREGAGLP
R
A
E
VAAGSGRGARSGEWGLAAA
G
A
W
E
T
M
H
H
C
K
RYRSPEPDP
Y
L
S
Y
R
W
K
R
RRSYSREHEGRLRYPSRREPPPRRSRSRSHDRL
P
Y
Q
R
R
Y
R
E
RRDSDT
Y
R
CEERSPSFGEDYYGP
S
R
S
R
H
R
R
RSRERGPYR
T
R
K
H
A
H
H
C
H
K
R
R
TRSCSSASSR
S
Q
Q
SSKRSSRSVEDDKE
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
VGNLGE
G
T
F
G
K
V
V
E
C
L
D
H
ARG
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
KDKEN
K
F
L
C
V
L
M
S
D
W
F
N
FHG
H
M
C
I
A
F
E
L
LG
K
N
T
F
E
F
L
K
ENNFQPYPL
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
ENQLTHTDLKPE
N
I
L
F
VN
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
KSVKNT
S
I
R
V
A
DFGSATFDHEH
H
T
T
I
V
A
TRHYR
P
P
E
V
I
LELGWAQPC
D
V
W
S
I
G
C
I
L
F
E
Y
YRG
F
T
L
F
Q
THEN
R
E
H
L
V
M
M
E
K
I
LGPI
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
YKG
G
L
V
WDENSSDGR
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
LEFDPA
Q
R
I
T
L
A
E
A
L
L
H
P
F
FAGLTP
E
E
RSFHTSRNPSR
1
PsiBlast_PDB
86.14
99%
-131
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[31-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
-------
3
PsiBlast_PDB
79.53
99%
-125
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[31-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------
2
PsiBlast_PDB
77.84
99%
-128
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[32-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
--------
4
PsiBlast_PDB
77.42
99%
-124
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[5-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------
6
PsiBlast_PDB
75.84
100%
-126
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[4-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
--------
5
PsiBlast_PDB
75.67
100%
-126
* C1 *
-
6FYP
1
CLK3_HUMAN
A:
[11-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
--------
22
Blastp_CBE
75.02
99%
-122
- C1 -
-
6FT7
8
CLK3_HUMAN
B:
[5-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------
21
Blastp_CBE
72.31
99%
-123
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[33-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------