@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FGFR4_HUMAN: (2019-04-29 )
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
L
L
L
A
L
L
G
V
L
LSVPGP
P
V
L
S
LEASEEVELEPCLAP
S
L
E
Q
Q
E
Q
E
L
T
V
ALGQ
P
V
R
L
C
CGRAERGGH
W
Y
KEGSRLAPAGRVRGWRG
R
L
E
I
A
S
FLPEDAG
R
Y
L
C
L
ARG
S
M
I
V
L
Q
N
L
T
L
I
TGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWT
H
P
Q
R
M
E
K
K
L
HAVPAG
N
T
V
K
F
RCPAAGNPT
P
T
I
R
W
LKDGQAFHGENRI
G
G
I
R
L
R
H
Q
H
W
S
L
V
M
E
S
VVPSDRG
T
Y
T
C
L
V
ENA
V
G
S
I
R
Y
N
Y
L
L
D
V
L
ERSPHR
P
I
L
QAGLPAN
T
T
A
VVG
S
D
V
E
L
L
C
K
V
YSDA
Q
P
H
I
Q
W
L
K
H
I
VINGSSFGADGF
P
Y
V
Q
V
L
K
TADINSS
E
V
E
V
L
Y
L
RNVSAEDAG
E
Y
T
C
LAGNSIG
L
S
Y
Q
S
A
W
L
T
VLPEEDPTWTAAAPEA
R
Y
T
D
I
I
L
YAS
G
S
L
A
L
A
V
L
L
L
L
A
G
L
YRGQALHGRHPRP
P
A
T
V
Q
K
L
S
RFPL
A
R
Q
F
SLESGSSGKSS
S
S
L
V
R
G
V
R
LSSS
G
P
A
L
L
A
G
L
V
SLDLPL
D
P
L
W
EFPRD
R
L
V
LGKPLGE
G
C
F
G
Q
V
V
R
A
E
AFGMDPARPDQA
S
T
V
A
V
K
M
L
KDNASD
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
GR
H
K
N
I
I
N
L
L
G
V
CTQEG
P
L
Y
V
I
V
ECAAKG
N
L
R
E
F
L
R
ARRPPGPDLSPDGPRSSEGPL
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
AAR
N
V
L
VTEDNV
M
K
I
A
D
F
G
L
A
RGVH
H
I
D
Y
Y
K
KTSNGRL
P
V
K
WM
A
P
E
A
L
F
D
R
V
Y
THQ
S
D
V
W
S
F
G
I
L
L
W
E
I
F
TLGGSPYPGI
P
V
E
E
L
F
S
L
L
REGHRMDRPPHC
P
P
E
L
Y
G
L
M
R
E
C
W
HAAPSQR
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
Y
L
D
L
R
L
T
FGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
12
PsiBlast_PDB
75.19
99%
-141
- C1 -
-
4QRC
1
A:
[24-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
D
L
S
P
D
G
P
R
S
S
E
G
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
14
PsiBlast_PDB
71.45
99%
-143
- C1 -
-
4UXQ
1
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
17
PsiBlast_PDB
64.38
96%
-142
- C1 -
-
4XCU
1
A:
[5-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
---------
S
S
E
G
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
---------------------------------------------------
16
PsiBlast_PDB
58.55
100%
-163
- C1 -
-
5NWZ
1
FGFR4_HUMAN
A:
[8-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
D
L
----------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
--------------------------------------------------
22
Blastp_CBE
56.96
100%
-167
- C1 -
-
5NUD
1
B:
[3-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
--------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
------------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
21
Blastp_CBE
56.79
100%
-167
* C1 *
-
5NWZ
1
B:
[8-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
--------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
--------------------------------------------------
15
PsiBlast_PDB
56.42
100%
-164
- C1 -
-
5NUD
1
FGFR4_HUMAN
A:
[7-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
---------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
-------------------------------------------------
5
PsiBlast_PDB
51.56
100%
-150
- C1 -
-
4TYJ
2
A:
[5-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
---------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
-------------------------------------------------
4
PsiBlast_PDB
46.69
100%
-143
- C1 -
-
4TYI
1
A:
[5-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
--------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
--------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
7
PsiBlast_PDB
45.62
99%
-158
- C1 -
-
4QQ5
1
A:
[15-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
-----
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
8
PsiBlast_PDB
45.34
99%
-159
- C1 -
-
4R6V
1
A:
[15-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
-----
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
1
PsiBlast_PDB
44.66
99%
-160
- C1 -
-
4QQC
1
A:
[15-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
-----
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
10
PsiBlast_PDB
39.55
99%
-159
- C1 -
-
5XFF
1
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
6
PsiBlast_PDB
29.89
99%
-148
- C1 -
-
5JKG
1
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------
9
PsiBlast_PDB
28.79
99%
-159
- C1 -
-
5XFJ
1
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------