@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KSR2_HUMAN: (2019-04-30 )
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
Atome Classification :
(2 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDEENMTKSEEQQ
P
L
S
L
Q
K
A
L
Q
Q
C
E
L
V
Q
N
M
I
D
L
SIS
N
L
E
G
L
R
T
KCATSND
L
T
Q
K
E
I
R
T
L
E
S
K
L
V
K
Y
F
S
R
Q
LSC
K
K
K
V
A
L
Q
ERNAELDG
F
P
Q
L
R
H
W
F
R
I
V
D
V
R
K
E
V
L
E
EISPGQL
S
L
E
D
L
L
E
M
T
D
E
Q
V
C
E
T
V
E
K
YGA
N
R
E
E
C
A
R
L
N
A
S
L
S
C
L
R
N
V
HMSGGNLSKQ
D
W
T
I
QWPTTETGKENNPVCPPEP
T
P
W
I
R
T
HLSQSPRV
P
S
K
C
V
Q
H
Y
CHTSPTPGAP
V
Y
T
H
V
D
R
L
T
VDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTP
N
I
V
T
TVTPPGTPPMRKKNKLKPPGTPPPSS
R
K
L
I
H
LIP
G
F
T
A
L
HRSKSHEFQLGHRVDEAHTPKAKKKSK
P
L
N
L
K
I
HSSVGSCENI
P
S
Q
Q
RSP
L
L
S
E
R
S
L
R
S
F
F
VGHAPFLPSTPPVHTEANFSANTLSVPRWSPQI
P
R
R
D
L
G
N
S
I
K
H
R
F
ST
K
Y
W
M
S
Q
T
C
T
VCGKG
M
L
F
G
L
K
CKN
C
K
L
K
CHNKCTKEAPP
C
H
L
L
I
I
HRGDP
A
R
L
V
RTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSP
Q
C
T
R
QQKNFNL
P
A
S
H
Y
Y
K
Y
K
Q
Q
FIFPDVVPVPETPTRA
P
Q
V
I
L
H
PVTSNPILEGN
P
L
L
Q
I
E
VEPTSEN
E
E
VHDEAEESE
D
D
F
E
E
M
N
L
S
L
L
SARSFPRKASQ
T
S
I
F
L
QEWDI
P
F
E
Q
L
E
I
G
E
L
IGKGRFGQVY
H
G
R
W
H
G
E
V
A
I
R
L
I
D
IERD
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
TRHE
N
V
V
L
F
MGACMSP
P
H
L
A
I
I
T
S
L
CKG
R
T
L
Y
S
V
VRD
A
K
I
V
L
DV
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
AK
G
I
L
H
K
DLKSK
N
V
F
YDN
G
K
V
V
I
T
DF
G
L
F
S
I
S
G
V
L
Q
AGRRE
D
K
L
R
IQNG
W
L
C
H
L
A
P
E
I
I
R
Q
LSPDTEEDKLPFSKHSD
V
F
A
L
G
T
I
W
Y
E
LHAREWPFKTQPA
E
A
I
I
W
QMGTGMKP
N
L
S
QIGMG
K
E
I
S
D
I
L
L
F
C
WAFEQEER
P
T
F
T
K
L
M
D
M
L
E
K
L
P
K
RNRRLSHPGHFWKSAEL
1
PsiBlast_PDB
80.77
100%
-140
- C1 -
-
5KKR
1
B:
[19-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
T
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
---
F
G
Q
V
Y
H
G
R
W
H
G
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
N
G
K
V
V
I
T
D
F
G
L
F
S
I
S
G
V
L
Q
-----
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
---
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
K
T
Q
P
A
E
A
I
I
W
Q
M
G
T
G
M
K
P
N
L
S
Q
I
G
M
G
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
K
L
P
------------------
2
PsiBlast_PDB
80.59
100%
-136
- C1 -
-
2Y4I
1
B:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
G
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
--
K
V
V
I
T
D
F
G
L
F
S
----------
E
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
--
E
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
K
T
Q
P
A
E
A
I
I
W
Q
M
G
T
G
M
K
P
N
L
S
Q
I
G
M
G
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
K
L
-------------------