@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MERTK_HUMAN: (2019-05-01 )
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGP
A
P
L
P
L
L
L
G
L
F
L
P
A
L
W
R
R
A
I
T
E
A
R
EEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
P
A
L
M
FSPTQPGRPHTGNVAIPQVTSVESKPLPP
L
A
F
KHTV
G
H
I
I
L
SEHK
G
V
K
F
N
C
S
ISVPNIYQDT
T
I
S
W
W
KD
G
K
E
L
L
G
A
H
H
A
I
T
QFYPDD
E
V
T
A
I
I
A
S
F
S
I
T
S
V
Q
RSDNG
S
Y
I
C
K
M
K
INNEEIVSD
P
I
Y
I
E
VQGLPHFTKQPESMNVTRN
T
A
F
N
L
T
C
Q
AVGPPE
P
V
N
I
F
W
VQNSSRVNEQPEKSP
S
V
L
TVPGL
T
E
M
A
V
F
S
C
EAHNDKG
L
T
VSKG
V
Q
I
N
I
K
AIPSPP
T
E
V
S
I
RNSTA
H
S
I
L
I
S
WVPGFDGYSPFRN
C
S
I
Q
V
K
EADPLSNG
S
V
M
I
F
NTSAL
P
H
L
Y
Q
I
K
Q
L
Q
A
L
A
NY
S
I
G
V
S
C
M
N
E
I
G
W
S
AVS
P
W
I
L
A
STTEGAPSV
A
P
L
N
V
T
V
F
L
NESSDNV
D
I
R
WMKPPTKQQDGE
L
V
G
Y
R
I
S
H
V
W
Q
SAGI
S
K
E
L
L
E
E
VGQNGS
R
A
R
I
S
V
Q
V
HN
A
T
C
T
V
R
I
A
A
V
TRGGVGPFSD
P
V
K
I
F
I
PAHGWVDYAPSSTPAPGNAD
P
V
L
I
I
F
G
C
F
C
G
F
I
L
I
G
L
I
L
Y
I
S
L
A
I
R
K
R
V
Q
ETKFGNAFTE
E
D
S
E
L
V
V
N
Y
I
A
K
K
S
F
C
R
R
A
I
E
L
T
L
H
SLGV
S
E
E
L
Q
N
K
L
E
D
V
V
IDRN
L
L
I
L
G
K
I
LGEGEFG
S
V
MEGNLKQEDGT
S
L
K
V
A
V
K
T
M
KLDNS
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
KDFSH
P
N
V
I
R
L
L
G
V
C
I
E
MSSQGIPK
P
M
V
I
L
P
FMKYG
D
L
H
T
Y
L
L
Y
S
R
LETGPKHI
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
SNR
N
F
L
H
R
D
L
A
A
RNCMLRDD
M
T
V
C
V
A
DFGLSKKIYSGDYYRQGRIAKM
P
V
K
W
I
A
I
E
S
L
A
D
R
VYTSKSD
V
W
A
F
G
V
T
M
W
E
I
A
TRGMTPYPGVQN
H
E
M
Y
D
Y
L
LHGHRLK
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
WRTDPLDR
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
PDVRNQA
D
V
I
Y
V
N
T
Q
L
LESSEGLAQGSTLA
P
L
D
LNIDP
D
S
I
I
ASCTPR
A
A
I
S
V
V
T
A
EVHDSKPHE
G
R
Y
I
LNGG
S
E
E
W
E
D
L
TSAPS
A
A
V
TAEKNSVLP
G
E
R
L
V
RNGVSWSHSSMLPLGSSL
P
D
E
L
L
FADDSSEGSEVLM
10
PsiBlast_PDB
95.28
99%
-165
- C1 -
-
5U6C
1
MERTK_HUMAN
A:
[23-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
M
R
L
L
G
V
C
I
E
M
----
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
V
---------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
93.59
98%
-165
- C1 -
-
3BRB
2
B:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.33
100%
-176
- C1 -
-
5K0K
1
MERTK_HUMAN
A:
[26-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.33
100%
-172
- C1 -
-
5K0X
1
MERTK_HUMAN
A:
[25-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.92
100%
-183
- C1 -
-
3TCP
1
MERTK_HUMAN
A:
[26-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.98
100%
-168
- C1 -
-
4MHA
1
MERTK_HUMAN
A:
[29-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
85.87
98%
-177
- C1 -
-
3BPR
1
D:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.87
100%
-176
- C1 -
-
3BPR
1
MERTK_HUMAN
A:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
84.91
99%
-181
- C1 -
-
5U6C
1
B:
[26-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
---------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
M
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
-----------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
82.62
98%
-180
- C1 -
-
3BPR
1
MERTK_HUMAN
B:
[25-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
-------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.88
100%
-181
- C1 -
-
2P0C
2
MERTK_HUMAN
A:
[24-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
--
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
80.32
98%
-181
- C1 -
-
2P0C
1
B:
[24-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.08
100%
-175
- C1 -
-
4MH7
1
MERTK_HUMAN
A:
[26-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
-----------------
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
80.04
98%
-174
- C1 -
-
5K0K
1
B:
[26-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
--
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
----------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
-----------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
79.38
98%
-175
- C1 -
-
3TCP
1
B:
[25-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
78.98
98%
-175
* C1 *
-
5K0X
1
B:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
--
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
------------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
75.43
98%
-171
- C1 -
-
4MHA
1
B:
[26-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------------------
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
-----------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.75
100%
-177
- C1 -
-
4M3Q
1
MERTK_HUMAN
A:
[27-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
-------------------
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.10
99%
-177
- C1 -
-
5TD2
1
MERTK_HUMAN
A:
[1-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
----------------
A
A
C
M
K
D
F
S
H
P
N
V
M
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.95
99%
-171
- C1 -
-
5TC0
1
MERTK_HUMAN
A:
[28-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------------------
D
F
S
H
P
N
V
M
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
E
-------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
70.70
98%
-188
- C1 -
-
4M3Q
1
B:
[26-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
N
L
K
-----
S
L
K
V
A
V
K
T
M
------------
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------