@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RIPK1_HUMAN: (2019-05-03 )
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQPDM
S
L
N
V
I
K
MKSSDF
L
E
SAELDSGGFG
K
V
S
L
C
F
HRTQ
G
L
M
I
M
K
T
VYKGPNCI
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
EEG
K
Y
S
L
V
M
E
Y
M
EKGN
L
M
H
V
L
K
A
EMSTPLSVK
G
R
I
I
L
E
I
I
E
G
M
C
Y
LHGKG
V
I
HKDLKPE
N
I
L
VDND
F
H
I
K
I
ADLG
L
A
S
F
K
M
W
S
KLN
N
E
E
H
N
E
L
R
E
VDGTAKKNG
G
T
L
Y
Y
M
A
P
E
HLNDVNAKPTEK
S
D
V
Y
S
F
A
V
V
L
W
A
I
FANKE
P
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
KSGNRP
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
WEANPEARPTFP
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
EYSN
E
N
A
V
V
K
R
M
Q
SLQ
L
D
C
V
AVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENE
P
S
L
Q
S
K
L
Q
DEAN
Y
H
L
YGSRMD
R
Q
T
K
QQPRQNVAYN
R
E
E
E
R
R
RRVSHDP
F
A
QQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQ
P
Q
V
L
Y
QNNGLYSSHGFGTRPLDPGTAGP
R
V
W
Y
RPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDE
S
I
K
Y
T
I
YNST
G
I
Q
I
G
A
Y
N
Y
M
E
IGGTS
S
S
LLDSTNTNFKEEP
A
A
K
Y
Q
A
I
FDNTTSL
T
D
K
H
L
D
P
I
R
E
N
L
G
K
H
W
K
N
C
A
R
KLGF
T
Q
S
Q
I
D
E
ID
H
D
Y
E
RD
G
L
K
E
K
V
Y
Q
M
L
Q
K
W
V
M
REGIKGA
T
V
G
K
L
A
Q
A
L
H
Q
C
S
R
I
D
L
L
S
S
L
I
YVSQN
1
PsiBlast_PDB
93.62
100%
-117
- C1 -
-
4NEU
1
RIPK1_HUMAN
A:
[15-322]
-----
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
C
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
C
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
----------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
89.00
99%
-117
- C1 -
-
4ITJ
1
RIPK1_HUMAN
B:
[7-294]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
------------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.54
98%
-133
- C1 -
-
4ITI
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
----------
G
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
-----
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
84.13
99%
-143
- C1 -
-
6C4D
1
RIPK1_HUMAN
D:
[8-296]
----
M
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
-------
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.00
98%
-141
- C1 -
-
5HX6
1
RIPK1_HUMAN
A:
[19-303]
---------
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
---
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
-----
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.88
98%
-134
- C1 -
-
4ITJ
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
--------
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
83.39
99%
-130
- C1 -
-
6C4D
1
RIPK1_HUMAN
B:
[10-297]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
------
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.32
98%
-127
- C1 -
-
6C4D
1
RIPK1_HUMAN
A:
[11-297]
-------
N
V
I
K
M
K
S
S
D
F
L
E
-------
G
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
-------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
82.60
99%
-128
- C1 -
-
4ITI
1
RIPK1_HUMAN
B:
[7-294]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
-------
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.72
98%
-120
- C1 -
-
6HHO
1
RIPK1_HUMAN
A:
[17-303]
-------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
---
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
81.39
99%
-141
* C1 *
-
5HX6
1
RIPK1_HUMAN
B:
[18-303]
--------
V
I
K
M
K
S
S
D
F
L
E
S
----------
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
------------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
80.41
99%
-134
- C1 -
-
6C4D
1
RIPK1_HUMAN
C:
[13-297]
---------
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
-----
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
----
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
79.99
98%
-136
- C1 -
-
6C3E
1
RIPK1_HUMAN
B:
[13-297]
---------
I
K
M
K
S
S
D
F
L
E
S
A
E
-------
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
-------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
L
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.87
98%
-132
- C1 -
-
6C3E
1
RIPK1_HUMAN
A:
[12-296]
--------
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
----
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
-----------------
G
T
L
Y
Y
M
A
P
E
H
L
------
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
L
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
77.67
99%
-132
- C1 -
-
5TX5
1
RIPK1_HUMAN
B:
[18-303]
--------
V
I
K
M
K
S
S
D
F
L
E
S
-----------
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
------------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------