@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RIPK2_HUMAN: (2019-05-03 )
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Atome Classification :
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
G
E
A
I
C
S
ALPTIP
Y
H
K
L
A
D
L
R
Y
L
SRGASGTVSSARHA
D
W
R
V
Q
V
A
V
K
H
L
H
IHTPLL
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
LGICNE
P
E
F
L
G
I
V
T
E
YMPNG
S
L
N
E
L
L
H
RKTEYPDV
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
HNMT
P
P
L
L
H
HDLKT
Q
N
I
L
LDNEF
H
V
K
I
ADFGLS
K
W
R
M
M
S
L
SQSRSSKSAPEG
G
T
I
I
Y
MPPENYEPGQK
S
R
A
S
I
K
HDI
Y
S
Y
A
V
I
T
W
E
V
L
SRKQ
P
F
E
DVT
N
P
L
Q
I
M
YSVSQGHRPVINEESLPYDI
P
H
R
A
R
M
I
S
L
I
E
SGWAQNPDE
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
V
S
S
A
I
H
LCDK
K
K
M
E
L
S
L
NIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQD
N
D
F
L
S
R
KAQ
D
C
Y
F
M
K
L
HHCPGNHSWDSTISGSQ
R
A
A
FCDHKTTPC
S
S
A
IIN
P
L
STAG
N
S
E
RLQ
P
G
I
A
Q
Q
W
I
Q
S
K
R
E
D
I
V
N
Q
M
T
E
A
C
L
N
Q
S
L
D
A
L
L
S
R
D
L
I
MKEDYELVSTKPT
R
T
S
K
V
R
Q
L
L
DTTDI
Q
G
E
E
F
A
K
V
I
V
Q
K
L
KDNKQMGLQPYP
E
I
L
V
V
SRSPSL
N
L
LQNKSM
25
Blastp_CBE
96.32
100%
-135
- C2 -
-
5AR7
1
RIPK2_HUMAN
B:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
-----
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
---------------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
-
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
94.70
100%
-134
- C2 -
-
6ES0
1
RIPK2_HUMAN
B:
[5-315]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
--------
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
----------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.15
100%
-138
- C2 -
-
6ES0
1
RIPK2_HUMAN
A:
[5-316]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
-----------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
93.78
100%
-136
* C2 *
-
5J7B
1
RIPK2_HUMAN
B:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
--------
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
------------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.38
100%
-138
- C2 -
-
6HMX
1
RIPK2_HUMAN
A:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
-----
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
---------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.35
100%
-131
- C2 -
-
5AR5
1
RIPK2_HUMAN
A:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
----
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
-------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
93.21
100%
-140
- C2 -
-
5AR4
1
RIPK2_HUMAN
B:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
------
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.77
100%
-143
- C2 -
-
5J7B
1
RIPK2_HUMAN
A:
[21-326]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
-----
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
----
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
91.86
100%
-133
- C2 -
-
6FU5
1
RIPK2_HUMAN
B:
[5-316]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
----
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
91.60
100%
-135
- C2 -
-
5AR5
1
RIPK2_HUMAN
B:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
----
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
-----------------
T
I
I
Y
M
P
P
E
N
Y
E
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.22
100%
-133
- C2 -
-
6FU5
1
RIPK2_HUMAN
A:
[5-315]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
---
T
P
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.08
100%
-144
- C2 -
-
5AR4
1
RIPK2_HUMAN
A:
[21-326]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
-----
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
---------------------
T
I
I
Y
M
P
P
E
N
Y
E
------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
90.50
99%
-129
- C2 -
-
4C8B
1
RIPK2_HUMAN
B:
[26-333]
--------
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
-----
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.15
99%
-134
- C2 -
-
4C8B
2
RIPK2_HUMAN
A:
[25-333]
-------
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
89.64
100%
-139
- C2 -
-
5AR8
1
RIPK2_HUMAN
B:
[24-326]
-------
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
----------
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
-------------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.35
99%
-141
- C2 -
-
5NG2
1
RIPK2_HUMAN
A:
[9-302]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
N
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
M
--------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
87.73
100%
-148
- C2 -
-
5W5J
1
RIPK2_HUMAN
B:
[9-310]
---------
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
-
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
-----------
D
V
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
--
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
-----------------------
T
I
I
Y
M
P
P
E
N
Y
E
--------
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.46
100%
-148
- C2 -
-
5W5J
1
RIPK2_HUMAN
A:
[8-309]
--------
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
--------------------
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
-
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
-----------------------
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.96
100%
-150
- C2 -
-
5AR8
1
RIPK2_HUMAN
A:
[25-326]
--------
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
--------------
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
N
----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------