@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TIE2_HUMAN: (2019-05-04 )
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Atome Classification :
(6 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
D
S
L
A
S
L
V
L
C
G
V
S
L
L
L
SGTVEG
A
M
D
L
I
L
INSLPLVSDAET
S
L
T
C
I
ASGWRPHE
P
I
TIG
R
D
F
E
A
L
M
N
QHQ
D
P
L
E
V
T
Q
D
V
T
R
E
W
A
K
K
V
V
W
K
R
E
K
ASKIN
G
A
Y
F
CEGRVRG
E
A
I
R
I
R
T
M
K
M
R
Q
Q
ASFL
P
A
T
L
T
M
T
VDKGDN
V
N
I
S
F
K
K
V
L
IKEE
D
A
V
I
YKNG
S
F
I
HSVPRHEVP
D
I
L
E
VHLPHAQPQDAGV
Y
S
A
R
YIG
G
N
L
F
T
S
A
F
T
R
L
I
V
R
R
C
E
A
QKWGP
E
C
N
H
L
C
T
A
C
MNNGVCHEDTG
E
C
ICPPGFM
G
R
T
C
E
K
A
C
E
L
H
T
F
G
R
T
C
K
E
RCS
G
Q
E
G
C
K
S
Y
V
F
CLPDPYGCSCATGWKGLQCNEACHPGFYGPDC
K
L
R
C
SCNN
G
E
M
C
D
R
F
Q
G
CLCSPGWQGL
Q
C
E
R
E
G
I
Q
R
MT
P
K
IVDLPD
H
I
E
VNSGKFNPICKASGWPLPTNE
E
M
T
L
VKPDG
T
V
LHPKDFNHTD
H
F
S
V
A
I
F
T
I
H
R
ILPPDS
G
V
W
V
C
S
V
N
T
V
A
G
M
VEKPF
N
I
S
V
K
V
LPKPLNAPNVIDTGH
N
F
A
V
I
NISSEPYFGDGPIKSK
K
L
L
YKPV
N
H
Y
E
A
W
Q
H
I
Q
V
T
N
E
I
V
T
L
N
YLEPR
T
E
Y
E
L
C
V
Q
L
V
RRGEGGEGHPGP
V
R
R
F
T
TASIGLPPPRGLNLLPKSQ
T
T
L
N
L
T
W
Q
PIFPSSED
D
F
Y
V
E
V
E
R
R
SVQKSDQQ
N
I
KVP
G
N
L
T
S
V
L
L
NNLH
P
R
E
Q
Y
V
V
R
A
R
VNTKAQGEWSEDL
T
A
W
T
L
S
DILPPQPEN
I
K
I
S
N
I
THS
S
A
V
I
S
W
T
I
LDG
Y
S
I
S
S
I
T
I
R
Y
K
VQGKNED
Q
H
V
D
V
K
I
KN
A
T
I
T
Q
Y
Q
LKGLEPET
A
Y
Q
V
D
I
F
A
ENNIGSSNPAFSH
E
L
V
TLPESQAPADLGG
G
K
M
L
L
I
A
I
LGSA
G
M
T
C
L
T
V
L
L
A
F
L
I
I
L
Q
L
K
R
A
N
V
Q
R
R
M
A
Q
A
F
Q
N
V
R
EEP
A
V
Q
FNS
G
T
L
A
L
NRKVKNNPDP
T
I
Y
P
V
LDWND
I
K
F
Q
DVIGEG
N
F
G
Q
V
L
K
A
R
I
K
KDGL
R
M
D
A
A
I
K
R
M
K
E
Y
ASKDD
H
R
D
F
A
G
E
L
E
V
L
C
KLGHHP
N
I
I
N
L
L
G
ACEHR
G
Y
L
Y
L
A
I
E
YAPHG
N
L
L
D
F
L
R
KSRVLETDP
A
F
A
IANSTAS
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
AR
N
I
LVG
E
N
Y
V
A
K
I
A
D
FGLSRG
Q
E
V
Y
V
K
K
TMGRL
P
V
R
W
M
A
I
ESL
N
Y
S
V
Y
T
TNS
D
V
W
S
Y
G
V
L
L
W
E
I
V
SLGGTPYCG
M
T
C
A
E
L
Y
E
KLPQGYRLEKPLNC
D
D
E
V
Y
D
L
M
R
Q
C
W
REKPYER
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
TYAGIDCSAEEAA
7
PsiBlast_PDB
62.12
100%
-124
- C2 -
-
3L8P
1
A:
[7-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
Y
P
V
L
D
W
N
D
I
K
F
Q
D
V
I
G
E
G
N
F
G
Q
V
L
K
A
R
I
K
K
D
G
L
R
M
D
A
A
I
K
R
M
-----------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
---
4
PsiBlast_PDB
61.37
99%
-120
- C2 -
-
2WQB
1
A:
[16-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
V
L
D
W
N
D
I
K
F
Q
D
V
I
G
E
G
--
G
Q
V
L
K
A
R
I
K
K
D
G
L
R
M
D
A
A
I
K
R
M
K
-------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
E
V
Y
V
K
K
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
----
21
Blastp_CBE
56.82
100%
-111
- C2 -
-
6MWE
1
B:
[9-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
V
L
D
W
N
D
I
K
F
Q
D
V
I
G
E
G
N
F
G
Q
V
L
K
A
R
I
K
K
D
G
L
R
M
D
A
A
I
K
R
--------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
E
V
---
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
E
--
8
PsiBlast_PDB
55.95
100%
-117
- C2 -
-
6MWE
1
TIE2_HUMAN
A:
[9-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
V
L
D
W
N
D
I
K
F
Q
D
V
I
G
E
G
N
F
G
Q
V
L
K
A
R
I
K
K
D
G
L
R
M
D
A
A
I
K
R
M
-------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
E
V
Y
--
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
E
--
6
PsiBlast_PDB
48.26
100%
-131
- C2 -
-
2OSC
1
A:
[30-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
R
I
------
M
D
A
A
I
K
R
M
K
----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
-----------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
--------
5
PsiBlast_PDB
45.98
99%
-137
- C2 -
-
4X3J
1
A:
[37-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
-------
R
M
D
A
A
I
K
----------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
--------
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
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N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
---------------
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
-------