@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : WNK3_HUMAN: (2019-05-05 )
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
Atome Classification :
(10 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MATDSGDPASTEDSEKPDGISFENRVP
Q
V
A
A
T
L
T
V
E
A
R
LKEKNSTFSASG
E
T
V
E
R
K
R
F
F
R
K
SVEMTEDDKVAESSP
K
D
E
R
I
K
A
A
MNIP
R
V
D
KL
P
S
N
V
LRGGQE
V
K
Y
E
Q
CSK
S
T
S
E
I
S
K
D
C
F
K
EK
N
E
K
E
M
E
E
E
A
E
M
K
A
V
ATSPSG
R
F
L
K
F
D
I
ELGR
G
A
F
K
T
V
Y
KGLDTE
T
W
V
E
V
A
W
C
ELQDRKL
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
GLQHP
N
I
V
R
F
Y
D
S
W
E
S
I
LKGK
K
C
I
V
L
V
T
E
L
MTS
G
T
L
K
T
Y
L
K
R
FKVM
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
HTRTP
P
I
I
H
RDLKCD
N
I
F
I
TGPTG
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
VIGTPEFM
A
P
E
M
Y
E
E
H
YDES
V
D
V
Y
A
F
G
M
C
M
L
E
MATSEY
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
TSGIKPASFNKVT
D
P
E
V
K
E
I
I
E
G
C
I
RQNKSE
R
L
S
I
R
D
L
L
N
H
A
FFAEDTG
L
R
V
E
LAEEDDCSNS
S
L
A
L
R
L
W
VE
D
P
K
K
LKGKHKDN
E
A
I
E
F
S
F
NLETD
T
P
E
E
V
A
Y
E
M
V
K
SGFFHES
D
S
K
A
V
A
K
S
I
R
D
RVT
P
I
K
K
TREKKPA
G
C
L
E
E
R
R
D
S
Q
C
K
S
M
G
NVFPQPQNTTLPLAPAQQTGAE
C
E
E
T
E
V
D
Q
H
V
R
Q
Q
L
L
Q
R
K
P
Q
Q
H
C
S
SVTGDNLSEAGA
A
S
V
I
HSDTSSQP
S
V
A
YSSNQ
T
M
G
S
Q
M
V
S
NIPQAEVNVPGQIY
S
S
Q
Q
L
V
G
H
Y
Q
Q
V
S
G
L
Q
K
HSKLTQP
Q
I
L
P
L
VQGQ
S
T
V
L
P
V
H
VLGPTVVSQPQVSPL
T
V
QKVPQIKPVSQPVG
A
E
Q
Q
A
A
LL
K
P
D
L
V
R
S
L
N
Q
D
V
ATTKENVSSPDNPSGN
G
K
Q
D
R
I
K
Q
R
R
ASCPRPEKG
T
K
F
Q
L
T
V
L
Q
V
STSGD
N
M
V
E
C
Q
L
ETHN
N
K
M
V
T
F
K
F
DVDGD
A
P
E
D
I
A
D
Y
M
VED
N
F
V
L
E
S
E
K
E
K
F
V
E
E
L
R
A
I
V
G
Q
A
Q
E
I
L
H
V
H
FATERATGV
D
S
I
T
VDSNSSQTGSS
E
Q
V
Q
I
NSTSTQTSNESAPQSSPV
G
R
W
R
F
C
I
N
Q
T
IRNRETQSP
P
S
L
Q
H
S
M
S
AVPGRHPLPSPKNTSNKEISR
D
T
L
L
T
IENNPC
H
R
A
LFTSKSEHKDVVDG
K
I
S
E
CASVETKQ
P
A
I
L
Y
Q
VEDN
R
Q
I
M
A
PVTNSSSYST
T
S
V
R
AV
P
A
ECEGLTKQ
A
S
I
F
I
P
VYPCHQ
T
A
S
Q
A
D
A
L
M
SHPGESTQTSGN
S
L
T
T
L
A
FDQKPQT
L
S
VQQPAM
D
A
E
F
I
SQEGE
T
T
VNTEASSP
K
T
V
I
PTQTPGLEPTTLQP
T
T
VLESDGERPPKLEFAD
N
R
I
K
T
L
D
E
K
L
R
N
L
L
Y
Q
EH
S
I
S
SIYPESQKD
T
Q
SIDSPFSSSAEDTLSCPV
T
E
V
I
A
I
SHCGIKDSPVQSP
N
F
Q
Q
T
G
S
K
L
L
S
N
V
AASQPA
N
I
S
V
F
K
R
D
L
N
V
I
T
SV
P
S
E
L
C
L
H
E
MSSDASLPGDPEAYPAAVSSG
G
A
I
H
L
QTGG
G
Y
F
G
L
S
F
TCPSLKNPI
S
K
K
S
W
T
R
K
L
K
S
W
A
Y
R
L
R
Q
S
T
S
F
F
K
R
S
KVRQV
E
T
E
E
M
R
S
AIAPDPIPLTRESTA
D
T
R
A
L
N
R
C
K
AMSGSFQRG
R
F
Q
V
I
T
IPQQQSAKMTSFGI
E
H
I
S
V
FSETNHS
S
E
E
A
F
I
K
T
A
KS
Q
L
V
E
IEPATQNPKTSF
S
Y
E
K
L
Q
A
L
Q
E
T
C
K
ENKGVPKQGDN
F
L
S
FSAACETDVSSVT
P
E
K
E
F
E
E
TSATGSSMQS
G
S
E
L
L
L
K
E
R
E
I
LTAGKQPSSD
S
E
F
S
A
S
LAGSGK
S
V
AKTGPESNQCLPH
H
E
E
Q
A
Y
A
Q
T
Q
S
S
L
F
YSPSSPMSSDDESEIE
D
E
D
L
K
V
E
L
Q
R
L
R
E
K
H
I
Q
E
V
V
N
L
QTQQ
N
K
E
L
Q
E
L
Y
E
R
L
R
S
I
KDSKTQSTEIPLPPASPRR
P
R
S
F
K
S
K
L
R
SRP
Q
S
L
T
HVDN
G
I
VATG
K
S
C
L
I
N
ELEN
P
L
C
VESN
A
A
SCQQSPASKKGM
F
T
D
D
L
H
K
L
V
D
D
W
T
K
E
A
VGNSLIK
P
S
L
N
Q
L
K
Q
S
Q
HKLETENWNKVSENTPSTMG
Y
T
S
T
W
I
S
S
L
S
Q
I
RGAVPTSLPQGLSLPSFPGP
L
S
SYGMP
H
V
C
Q
YNAVAGAGY
P
V
Q
W
V
GISGTTQ
Q
S
V
V
I
PAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
1
PsiBlast_PDB
95.04
100%
-104
- C1 -
-
5O2C
5
WNK3_HUMAN
A:
[18-376]
-----------------------------------------------------------------------------------------------------------------------------------------
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
L
A
E
E
D
D
C
S
N
S
S
L
A
L
R
L
W
V
E
D
P
K
K
L
K
G
K
H
K
D
N
E
A
I
E
F
S
F
N
L
E
T
D
T
P
E
E
V
A
Y
E
M
V
K
S
G
F
F
H
E
S
D
S
K
A
V
A
K
S
I
R
D
R
V
T
P
I
K
K
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.81
100%
-127
- C1 -
-
5O2B
1
WNK3_HUMAN
A:
[3-285]
-----------------------------------------------------------------------------------------------------------------------------------
E
A
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
---
L
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
--------
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.30
99%
-127
- C1 -
-
5O1V
10
WNK3_HUMAN
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
74.22
100%
-131
- C1 -
-
5O2B
1
WNK3_HUMAN
B:
[6-277]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
---
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
----------
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
--
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
73.95
99%
-112
* C1 *
-
5O21
9
WNK3_HUMAN
B:
[6-279]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
73.22
99%
-110
- C1 -
-
5O26
1
WNK3_HUMAN
B:
[6-284]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
------
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
-----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.42
99%
-111
- C1 -
-
5O23
13
WNK3_HUMAN
A:
[7-276]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.39
99%
-108
- C1 -
-
5O26
2
WNK3_HUMAN
A:
[5-285]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
---
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
72.26
99%
-106
- C1 -
-
5O23
13
WNK3_HUMAN
B:
[3-279]
-----------------------------------------------------------------------------------------------------------------------------------
E
A
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.76
90%
-104
- C1 -
-
5W7T
1
WNK1_RAT
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
K
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------