@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2533_HUMAN: (2015-12-09 )
MATGGQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPGLFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNIVHIFSAGSAAFITNSLMNPIWMVKTRMQLEQKVRGSKQMNTLQCARYVYQTEGIRGFYRGLTASYAGISETIICFAIYESLKKYLKEAPLASSANGTEKNSTSFFGLMAAAALSKGCASCIAYPHEVIRTRLREEGTKYKSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYELIVYLLEDRTQ
Atome Classification :
(20 SA)
--.........10........20-------........30........--40....-....50----------.......-.60.--.......70.--....-...---80----...-----.....---------------.90.-------.......100----....---....110------.....--------.------.------------.120.-----.-----....-----.130.-----..---...-.140......---..150......--------.--------160.--...-------------------.-..170.-....-------...--.180.---.....----.-190...-..-..200----.-.----.--...----.-.------.210..--...--------------------..220..--------.....230.---------------------..-----..---..240....-...250......--.260------.---....----.------..270.......280--.-..----.....290------...-----------------.---...300--........--310......-.----320--------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MATGGQQKE
N
T
L
L
H
L
FAGGCG-------GT
V
G
A
I
F
TC
P
L
E
V
I
K
T
R
L
--
Q
SS
R
L
A
-
L
R
T
V
Y
Y----------P
Q
V
H
L
G
T-ISGA--GMVRPTSV
T
P
--
G
L
F
Q
-
V
L
K
---
S
-----
I
L
E-----KE
G
P
K
---------------
S
L
F
R
-------GLGP
N
L
VGV-----APS
R
---
A
V
Y
F
A
C
-------
Y
S
K
A
K
--------
E
------Q------------FN
G
I
F
-----V-----PNS
N
-----
I
V
H
I
F-----SA---G
S
A
-
A
F
I
-
T
N
S
LMN---
P
I
W
M
V
K
T
R
M
Q
L
--------
E
--------
Q
K
VR--GSK-------------------Q-M
N
T
--
L
-
Q
C
A
R
-------
Y
V
Y
--QTE
G
I
---
R
G
F
Y
R
----
G
-
L
T
A
S
YA-G
I
-
S
E
T
------
I
-
I
----
C
--
F
A
I
----
Y
-
E
------
S
L
K
K
Y
L
--
K
EA--------------------PLASSAN--------GTEKNS
T
S
F
---------------------
F
G
-----
L
M
---
A
A
A
A
L
S
K
G
C
-
A
S
C
I
AY
P
H
E
V
I
R
--
T
R
-
L
------
R
---EEG
T
----
K
------
Y
K
S
F
V
Q
T
A
R
L
V
F
RE---E-
G
Y
----
L
A
F
Y
R
G
L
F
------
A
Q
L
-----------------
I
---
R
QIPN---
T
A
I
V
L
S
T
Y
--
E
L
I
V
Y
L
LED-R----TQ---------------------------------------------------------------------------------
6
PsiBlast_PDB
83.31
23%
-67
- C4 -
2C3E
4
ADT1_BOVIN
A:
[2-293]
-------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-------
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
--
Q
V
Q
H
A
S
-
K
Q
I
S
A
E
----------
K
Q
Y
K
----------------------
G
I
I
D
-
C
V
V
---
R
-----
I
P
K
-----
E
Q
G
F
L
---------------
S
F
W
R
-------
G
N
L
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
Y
K
--------
Q
------
I
------------
F
L
G
G
V
-----
D
-----
R
H
K
Q
-----
F
W
R
Y
F
A
G
N
L
A
S
G
---
G
A
A
-
G
A
T
-
S
L
C
F
V
Y
---
P
L
D
F
A
R
T
R
L
A
A
--------
D
V-------
G
K
G
A
--
A
Q
R
-------------------
E
-
F
T
G
--
L
G
N
C
I
T
-------
K
I
F
--
K
S
D
G
L
---
R
G
L
Y
Q
----
G
-
F
N
V
S
V
Q
-
G
I
----------
I
-
I
Y
R
A
A
Y
--
F
G
V
----
Y
-
D
------
T
A
K
G
M
L
--
P
D
--------------------------------------
P
K
N
V
H
I
I
---------------------
V
S
-----
W
M
---
I
A
Q
T
V
T
-
A
V
-
A
G
L
V
S
Y
P
F
D
T
V
R
--
R
R
M
M
------
M
---
Q
S
G
R
----
K
GADIM-
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
---
E
-
G
P
----
K
A
F
F
K
G
A
W
------
S
N
V
-----------------
L
---
R
G
M
-
G
---
G
A
F
V
L
V
L
Y
--
D
E
I
-----------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.08
23%
-66
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-------
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
--
Q
V
Q
H
A
S
-
K
Q
I
S
A
E
----------
K
Q
Y
K
----------------------
G
I
I
D
-
C
V
V
---
R
-----
I
P
K
-----
E
Q
G
F
L
---------------
S
F
W
R
-------
G
N
L
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
Y
K
--------
Q
------
I
------------
F
L
G
G
V
-----
D
-----
R
H
K
Q
-----
F
W
R
Y
F
A
G
N
L
A
S
G
---
G
A
A
-
G
A
T
-
S
L
C
F
V
Y
---
P
L
D
F
A
R
T
R
L
A
A
--------
D
V-------
G
K
G
A
--
A
Q
R
-------------------
E
-
F
T
G
--
L
G
N
C
I
T
-------
K
I
F
--
K
S
D
G
L
---
R
G
L
Y
Q
----
G
-
F
N
V
S
V
Q
-
G
I
----------
I
-
I
Y
R
A
A
Y
--
F
G
V
----
Y
-
D
------
T
A
K
G
M
L
--
P
D
--------------------------------------
P
K
N
V
H
I
I
---------------------
V
S
-----
W
M
---
I
A
Q
T
V
T
-
A
V
-
A
G
L
V
S
Y
P
F
D
T
V
R
--
R
R
M
M
------
M
---
Q
S
G
R
----
K
GADIM-
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
---
E
-
G
P
----
K
A
F
F
K
G
A
W
------
S
N
V
-----------------
L
---
R
G
M
-
G
---
G
A
F
V
L
V
L
Y
--
D
E
I
-----------------------------------------------------------------------------------------------
9
HHSearch
81.37
22%
-52
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-------
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
--
Q
V
Q
H
A
S
-
K
Q
I
------------------------------
S
A
E
K
Q
Y
K
--
G
I
I
D
-
C
V
V
---
R
-----
I
P
K
-----
E
Q
G
F
L
---------------
S
F
W
R
-------
G
N
L
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
Y
K
--------
Q
------
I
------------
F
L
G
G
V
-----
D
RHKQ
F
W
R
Y
F
-----
A
G
N
L
A
-----
S
G
---
G
A
A
-
G
A
T
-
S
L
C
F
V
Y
---
P
L
D
F
A
R
T
R
L
A
A
--------
D
--------
V
G
K
G
AA
Q
R
E
-------------------
F
-
T
G
L
--
G
-
N
C
I
T
-------
K
I
F
--
K
S
D
G
L
---
R
G
L
Y
Q
----
G
-
F
N
V
S
V
Q
G
I
I
-
I
Y
R
------
A
-
A
----
Y
--
F
G
V
----
Y
-
D
------
T
A
K
G
M
L
--
P
D
P
--------------------
K
-------------------
N
V
H
I
---------------------
I
V
-----
S
W
---
M
I
A
Q
T
V
T
A
V
-
A
G
L
V
S
Y
P
F
D
T
V
R
--
R
R
-
M
------
M
---
M
Q
S
G
----
R
KGADIM
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
---
E
-
G
P
----
K
A
F
F
K
G
A
W
------
S
N
V
-----------------
L
---
R
G
M
G
----
G
A
F
V
L
V
L
Y
--
D
E
I
-----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.18
22%
-63
- C4 -
4C9Q
5
ADT3_YEAST
A:
[22-316]
-------
Q
Q
E
T
N
F
A
I
N
F
L
M
G
G
V
S
-------
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
--
Q
N
Q
D
-------------------
E
M
I
K
Q
G
T
-
L
D
----------
K
K
Y
S
--
G
I
V
D
-
C
F
K
---
R
-----
T
A
K
-----
Q
E
G
L
I
---------------
S
F
W
R
-------
G
N
T
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
I
K
L
M
FGFKKE-------
G
------------
Y
G
K
W
F
-----
A
-----
G
N
----------
L
A
-----
S
G
---
G
A
A
-
G
A
L
-
S
L
L
F
V
Y
---
S
L
D
F
A
R
T
R
L
A
A
--------
D
--------
A
K
S
----
A
R
-------------------
Q
-
F
N
G
--
L
T
D
V
Y
K
-------
K
T
L
--
K
S
D
G
I
---
A
G
L
Y
R
----
G
-
F
M
P
S
V
V
-
G
I
----------
V
-
V
----
Y
--
R
G
L
----
Y
-
F
------
G
M
F
D
S
L
--
K
P
L
-------------------------------------
F
L
A
S
-------------------------------
F
L
---
L
G
W
V
V
T
T
G
A
-
S
T
C
-
S
Y
P
L
D
T
V
R
--
R
R
-
M
M
M
T
---
S
---
G
Q
A
V
----
K
------
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
---
E
-
G
V
----
G
S
L
F
K
G
C
G
------
A
N
I
-----------------
L
---
R
S
V
A
G
----
A
G
V
I
S
M
Y
--
D
Q
L
Q
M
I
L
F
G
-
K
---------------------------------------------------------------------------------------
18
Fugue
78.85
22%
-58
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-------
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
--
Q
V
Q
H
A
S
-
K
Q
I
S
A
E
----------
K
Q
Y
--------------------
K
--
G
I
I
D
-
C
V
V
---
R
-----
I
P
K
-----
E
Q
G
F
L
---------------
S
F
W
R
-------
G
N
L
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
Y
K
--------
Q
------
I
------------
F
L
G
G
V
DRHKQ
F
-----
W
R
Y
F
-----
A
G
N
L
A
-----
S
G
---
G
A
A
-
G
A
T
-
S
L
C
F
V
Y
---
P
L
D
F
A
R
T
R
L
A
A
--------
D
--------
V
G
K
G
--
A
A
Q
-------------------
R
-
E
F
T
G
L
G
-
N
C
I
T
-------
K
I
F
--
K
S
D
G
L
---
R
G
L
Y
Q
----
G
-
F
N
V
S
V
Q
-
G
I
-
I
I
Y
------
R
A
A
----
Y
--
F
G
V
----
Y
-
D
------
T
A
K
G
M
L
--
P
D
---------------------------------------
P
K
N
V
H
I
---------------------
I
V
-----
S
W
---
M
I
A
Q
T
V
T
A
V
-
A
G
L
V
S
Y
P
F
D
T
V
R
--
R
R
-
M
M
M
Q
SGR
K
---
G
A
D
I
----
M
------
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
---
E
-
G
P
----
K
A
F
F
K
G
A
W
------
S
N
V
-----------------
L
---
R
G
M
G
G
---
A
F
V
L
V
L
Y
D
--
E
I
------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.61
23%
-72
- C4 -
4C9H
5
ADT2_YEAST
A:
[21-312]
----------
S
N
F
L
I
D
F
L
M
G
G
V
S
-------
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
L
L
I
--
Q
N
Q
D
E
M
-
L
K
Q
------------------
G
T
-
L
D
----------
R
K
Y
A
--
G
I
L
D
-
C
F
K
---
R
-----
T
A
T
-----
Q
E
G
V
I
---------------
S
F
W
R
-------
G
N
T
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
I
K
--------
A
------
M
------------
F
G
--
F
-----
K
-----
K
E
E
G
-----
Y
A
K
W
F
A
G
N
L
A
S
G
---
G
A
A
-
G
A
L
-
S
L
L
F
V
Y
---
S
L
D
Y
A
R
T
R
L
A
A
--------
D
--------
S
------
A
R
-------------------
Q
-
F
N
G
--
L
I
D
V
Y
K
-------
K
T
L
--
K
S
D
G
V
---
A
G
L
Y
R
----
G
-
F
L
P
S
V
V
-
G
I
V
V
Y
R
------
G
-
L
----
Y
--
F
G
M
----
Y
-
D
------
S
L
K
----------------------------------------------
L
A
S
-------------------------------
F
L
---
L
G
W
V
V
T
T
G
A
-
S
T
C
-
S
Y
P
L
D
T
V
R
--
R
R
-
M
M
M
T
---
S
---
G
Q
A
V
----
K
------
Y
D
G
A
F
D
C
L
R
K
I
V
A
A
---
E
-
G
V
----
G
S
L
F
K
G
C
G
------
A
N
I
-----------------
L
---
R
G
V
A
G
----
A
G
V
I
S
M
Y
--
D
Q
L
Q
M
I
L
F
G
-
K
----
K
F
---------------------------------------------------------------------------------
2
PsiBlast_PDB
77.59
22%
-70
- C4 -
4C9J
4
ADT3_YEAST
A:
[25-316]
----------
T
N
F
A
I
N
F
L
M
G
G
V
S
-------
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
--
Q
N
Q
D
-------------------
E
M
I
K
Q
G
T
-
L
D
----------
K
K
Y
S
--
G
I
V
D
-
C
F
K
---
R
-----
T
A
K
-----
Q
E
G
L
I
---------------
S
F
W
R
-------
G
N
T
A
N
V
I
R
Y
-----
F
P
T
Q
---
A
L
N
F
A
F
-------
K
D
K
I
K
L
M
FGFKKE
E
------
G
------------
Y
G
K
W
F
-----
A
-----
G
N
----------
L
A
-----
S
G
---
G
A
A
-
G
A
L
-
S
L
L
F
V
Y
---
S
L
D
F
A
R
T
R
L
A
A
--------
D
--------
A
K
S
----
A
R
-------------------
Q
-
F
N
G
--
L
T
D
V
Y
K
-------
K
T
L
--
K
S
D
G
I
---
A
G
L
Y
R
----
G
-
F
M
P
S
V
V
-
G
I
----------
V
-
V
----
Y
--
R
G
L
----
Y
-
F
------
G
M
F
D
S
L
--
K
--------------------------------------------------------------------------
F
L
---
L
G
W
V
V
T
T
G
A
-
S
T
C
-
S
Y
P
L
D
T
V
R
--
R
R
-
M
M
M
T
---
S
---
G
Q
A
V
----
K
------
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
---
E
-
G
V
----
G
S
L
F
K
G
C
G
------
A
N
I
-----------------
L
---
R
S
V
A
G
----
A
G
V
I
S
M
Y
--
D
Q
L
Q
M
I
L
F
G
-
K
----
K
F
---------------------------------------------------------------------------------
8
HHSearch
63.35
22%
-64
- C4 -
2LCK
-
UCP2_MOUSE
A:
[14-302]
-------------
T
V
K
F
L
G
A
G
T
A
-------
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
V
R
L
--
Q
I
Q
G
E
S
-
Q
G
L
V
R
---------------------------
T
A
A
S
A
Q
Y
R
--
G
V
L
G
-
T
I
L
---
T
-----
M
V
R
-----
T
E
G
P
R
---------------
S
L
Y
N
-------
G
L
V
A
G
L
Q
R
Q
-----
M
S
F
A
---
S
V
R
I
G
L
-------
Y
D
S
V
K
--------
Q
------
F
------------
Y
T
K
G
S
-----
E
-----
H
A
G
I
-----
G
S
R
L
L
-----
A
G
---
S
T
T
-
G
A
L
-
A
V
A
V
A
Q
---
P
T
D
V
V
K
V
R
F
Q
A
--------
Q
--------
A
R
A
G
G-
G
R
R
-------------------
Y
-
Q
S
T
--
V
-
E
A
Y
K
-------
T
I
A
--
R
E
E
G
I
---
R
G
L
W
K
----
G
-
T
S
P
N
V
A
R
N
A
-
I
V
N
------
C
-
A
----
E
--
L
V
T
----
Y
-
D
------
L
I
K
D
T
L
--
L
K
A
--------------------
N
L
-----------------
M
T
D
D
L
---------------------
P
C
-----
H
F
---
T
S
A
F
G
A
G
F
C
-
T
T
V
I
A
S
P
V
D
V
V
K
--
T
R
-
Y
------
M
---
N
S
A
L
----
G
Q-----
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
---
E
-
G
P
----
R
A
F
Y
K
G
F
M
------
P
S
F
-----------------
L
---
R
L
G
S
W
---
N
V
V
M
F
V
T
Y
--
E
Q
L
K
R
A
L
M
A
-
A
----
Y
Q
---------------------------------------------------------------------------------
1
PsiBlast_PDB
62.45
24%
-52
- C4 -
2LCK
-
UCP2_MOUSE
A:
[15-292]
--------------
V
K
F
L
G
A
G
T
A
-------
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
V
R
L
--
Q
------------------------------
I
Q
G
E
SQ
G
L
V
R
T
A
A
S
A
Q
YR
G
V
L
G
-
T
I
L
---
T
-----
M
V
R
-----
T
E
G
P
R
---------------
S
L
Y
N
-------
G
L
V
A
G
L
Q
R
Q
-----
M
S
F
A
---
S
V
R
I
G
L
-------
Y
D
S
V
K
---------------
Q
------------
F
Y
T
K
G
-----
S
-----
E
H
A
G
-----
I
G
S
R
L
-----
L
A
---
G
S
T
T
G
A
L
-
A
V
A
V
A
Q
---
P
T
D
V
V
K
V
R
F
Q
A
--------
Q
--------
A
R
A
G
--
G
G
R
-------------------
R
Y
Q
S
T
--
V
-
E
A
Y
K
-------
T
I
A
--
R
E
E
G
I
---
R
G
L
W
K
----
G
-
T
S
P
N
V
A
-
R
--
N
A
I
------
V
-
N
----
C
A
E
L
V
T
----
Y
-
D
------
L
I
K
D
T
L
--
L
K
A
--------------------
N
L
M
T
--
D
--------
D
L
P
C
H
F
T
S
A
---------------------
F
G
---------------
A
G
F
C
-
T
T
V
I
A
S
P
V
D
V
V
K
--
T
R
-
Y
------
M
---
N
S
A
L
G---
Q
------
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
---
E
-
G
P
----
R
A
F
Y
K
G
F
M
------
P
S
F
-----------------
L
---
R
L
G
S
W
---
N
V
V
M
F
V
T
Y
--
E
Q
L
K
R
A
L
M
A
-
A
----
Y
Q
---------------------------------------------------------------------------------
27
Fugue
62.22
14%
-72
- C1 -
1YT3
-
RND_ECOLI
A:
[1-375]
--
M
N
Y
Q
M
I
T
T
D
D
A
L
A
S
L
C
E
A
V
----------
R
A
F
P
A
I
A
L
D
T
E
F
V
R
T
R
T
--
Y
Y
P
Q
L
G
-
L
I
Q
L
F
D
----------
G
E
-
H
L
A
L
-
I
D
P
L
--
G
I
T
D
W
S
P
L
K
A
--
I
L
R
D
P
S
I
T
---
K
-----
F
L
H
AG---
S
E
D
L
E
---------------
V
F
L
N
-------
V
F
G
E
L
P
Q
P
L
-----
I
D
T
Q
---
I
L
A
A
F
C
GRPMSWG
F
A
S
M
V
--------
E
------
E
------------
Y
S
G
V
T
-----
L
-----
D
K
S
E
SRTDW
L
A
R
P
L
-----
T
E
---
R
Q
C
-
E
Y
A
-
A
A
D
V
W
Y
----
L
L
P
I
T
A
K
L
M
V
--------
E
--------
T
E
A
S
--
G
W
L
-------------------
P
-
A
A
L
--
D
-
E
C
R
L
-------
M
Q
M
--
R
R
Q
E
V
V
A
P
E
D
A
W
R
----
D
-
I
T
N
A
W
Q
-
L
R
-
T
R
Q
------
L
-
A
----
C
--
L
Q
L
----
L
A
D
------
W
R
L
R
K
A
--
R
E
R
--------------------
D
L
A
V
N
F
V
--------
V
R
E
E
H
L
W
S
V
---------------------
A
R
-----
Y
M
PGS
L
G
E
L
D
S
L
G
L
S
G
S
E
I
R
F
H
G
K
T
L
L
--
A
L
-
V
------
E
---
K
A
Q
T
----
L
------
P
E
D
A
L
P
Q
P
M
L
N
L
M
D
---
M
P
G
Y
----
R
K
A
F
K
A
I
K
------
S
L
I
-----------------
T
---
D
V
S
E
T
H
KI
S
A
E
L
L
A
S
R
--
R
Q
I
N
Q
L
L
N
W
-
H
W
KLK
P
Q
NNLPELISG
W
R
G
E
L
M
A
E
A
L
H
N
L
L
Q
EYPQ-----------------------------------------------------
23
Fugue
62.10
19%
-75
- C2 -
4Q9T
-
?
A:
[12-446]
--
T
K
I
L
T
E
T
E
K
Y
S
V
T
K
L
--------------
S
T
D
L
S
F
L
P
F
E
G
L
V
D
T
A
L
--
Q
K
A
L
V
N
D
L
D
H
I
Y
I
W
NYNSIQKDT
P
I
C
K
I
S
L
-
H
S
S
P
--
P
I
C
L
F
T
S
S
I
N
--
G
I
C
I
-
I
N
K
KNS
Q
-----
F
L
Y
-----
F
E
D
I
S
---------------
T
I
N
N
-------
L
A
H
V
L
D
L
K
L
-----
K
D
N
E
---
N
I
T
S
T
I
-------
N
C
E
P
-----------------------------------------------
S
G
-----
I
I
I
A
T
-----
S
L
---
G
R
V
-
L
F
I
-
T
I
K
D
S
T
---
G
K
P
K
L
E
L
K
Q
Q
L
--------
I
KPQNSFFF
R
N
L
D
--
S
S
K
-------------------
E
-
I
I
S
--
L
-
K
K
G
P
I
V
G
KG
E
R
L
L
Y
--
I
T
T
R
----
G
G
S
L
Q
----
I
-
W
Q
L
S
I
N
-
S
K
-
S
F
K
------
R
-
L
----
E
--
I
N
I
----
Y
-
E
------
H
V
L
D
S
L
--
Q
D
----------------------
L
Y
P
F
A
H
--------
G
T
L
A
F
L
D
S
H
PIYSDTSS
A
H
L
T
L
A
S
I
S
N
GN
E
I
Y
-----
Y
L
M
--
I
T
V
I
L
D
E
K
T
-
N
S
F
Q
I
F
S
I
Y
K
L
N
--
T
Y
-
F
------
T
---
K
S
T
V
DLNH
K
------
P
Q
L
F
I
P
N
A
L
D
S
I
V
S
P
T
L
S
-
V
Y
----
V
L
F
N
N
A
V
V
M
-----
T
Q
I
S
SKLDSSFPLRRK
W
E
D
I
I
---
R
F
N
K
D
---
V
E
I
I
G
S
G
Y
S
T
D
S
I
Y
V
I
C
K
D
M
G
----
V
L
K
I
A
S
H----------------------------------------------------------------------------
22
Fugue
60.26
16%
-92
- C5 -
4PG7
4
?
A:
[20-446]
----------
H
M
K
K
L
N
I
A
L
L
G
L
G
--------
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
--
Q
D
T
L
N
K
-
D
I
V
I
K
H
----------
I
L
V
R
D
K
S
-
K
K
R
P
--
L
N
I
S
Q
Y
H
L
T
E
--
D
V
N
E
-
I
L
N
---
D
DSLD
I
I
V
E
VMGGI
E
P
T
V
D
---------------
W
L
R
T
-------
A
L
K
N
K
K
H
V
I
-----
T
A
N
K
DLL
A
V
H
L
K
L
-------
L
E
D
L
A
--------
E
E
N
G
V
A
L
K
------------
F
E
A
S
V
-----
A
-----
G
G
P
N
-----
N
I
S
K
F
-----
M
G
ILN
G
T
S
-
N
F
I
-
L
S
K
M
T
K
EQT
T
F
E
E
A
L
D
E
A
K
R
L
GFAEADP
T
--------
D
D
V
E
--
G
V
D
-------------------
A
-
A
R
K
--
V
-
V
I
T
S
-------
Y
L
S
FN
Q
V
I
K
L
---
N
D
V
K
R
RGIS
G
-
V
T
L
T
D
I
-
N
V
-
A
D
Q
L
G
Y
K
I
K
L
-
I
----
G
--
K
G
I
----
Y
-
E
NG
K
V
N
A
S
V
E
P
T
L
I
D
K
K
H
--------------------
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
D
A
V
G
D
T
M
F
---------------------
Y
G
K
G
A
G
S
L
A
---
T
G
S
A
V
V
S
D
L
-
L
N
V
A
L
F
F
E
S
T
L
P
--
P
H
-
F
------
E
---
L
K
T
D
----
K
------
T
R
E
M
E
K
S
N
F
F
V
V
V
N
HV-
K
-
G
S
----
I
E
N
F
E
N
E
L
------
K
A
I
-----------------
L
PFH
R
S
L
R
V
---
A
N
Y
D
N
Q
S
Y
--
A
A
V
I
V
G
L
E
S
-
S
----
P
E
E
L
I
T
K
H
GYEVD
K
V
Y
P
V
E
GV--------------------------------------------------------------
26
Fugue
59.37
18%
-57
* C3 *
2PNN
1
TRPV1_RAT
A:
[11-258]
-------
L
Y
D
R
R
S
I
F
D
A
V
A
Q
S
N
C
-------
Q
--------
E
L
E
S
L
L
P
F
L
--
Q
R
S
K
K
R
-
L
T
D
------------------------
S
--
E
F
K
D
P
E
T
-----
G
K
T
C
-
L
L
K
---
A
M
----
L
N
L
-----
H
N
G
Q
N
---------------
D
T
I
A
-------
L
L
L
D
V
A
R
K
T
-----
D
S
L
K
---
Q
F
V
N
A
S
-------
Y
T
D
S
---------------------------------
Y
-----
Y
-----
K
G
Q
T
-----
A
L
H
I
A
-----
I
E
---
R
R
N
M
T
L
V
-
T
L
L
V
E
N
----------
G
A
D
V
--------
Q
--------
A
A
A
N
--
G
---------------------------------
D
-------
F
F
K
--
K
T
K
G
R
---
P
G
F
Y
F
----
G
E
L
P
L
S
L
A
-
A
C
-
T
N
Q
-----------------------
L
-
A
------
I
V
K
F
L
L
--
Q
N
S
--------------------
W
--
Q
P
A
D
--------
I
S
A
R
D
S
V
------------------------
G
-----
N
T
---
V
L
H
A
L
V
E
V
A
-
D
N
T
V
D
N
T
K
F
V
T
S
M
Y
N
E
-
I
------
L
---
I
L
G
A
----
K
------
L
H
P
T
L
K
L
E
E
I
T
N
R
----------------
K
G
L
T
------
P
L
A
-----------------
L
---
A
A
S
S
G
---
K
------
I
--
G
V
L
A
Y
I
L
Q
R
-
E
----
I
H
---------------------------------------------------------------------------------
21
Fugue
57.36
15%
-66
- C3 -
4OBX
2
COQ5_YEAST
A:
[23-257]
-----
S
V
A
N
R
Y
D
L
M
N
D
V
M
S
L
G
--------------
I
H
R
L
W
K
D
H
F
I
N
K
L
--
D
A
G
K
R
P
-
N
S
T
T
P
L
----------
N
F
I
D
V
A
G
-
G
S
G
------------
D
--
I
A
F
G
-
L
L
D
---
H
-----
A
E
S
-----
K
F
G
D
T
---------------
E
-------------
S
T
M
D
I
V
-----
D
I
N
P
---
D
M
L
K
E
G
-------
E
K
R
A
M
--------
E
------
Q
--------------
G
K
Y
-----
F
-----
K
D
P
R
-----
V
R
F
L
V
-----
S
N
---
G
E
K
-
L
E
E
-
I
D
S
D
S
K
---
D
I
Y
T
V
S
F
G
I
R
N
--------
F
---------------
T
D
-------------------
I
-
Q
K
G
--
L
-
N
T
A
Y
-------
R
V
L
--
K
P
G
------
G
I
F
Y
----
C
-
L
E
F
S
--------
K
------
I
-
E
----
N
--
P
L
M
----
D
-
F
------
A
Y
Q
Q
W
A
--
K
V
L
--------------------
P
V
M
G
S
M
I
--------
A
N
D
Y
D
S
Y
Q
Y
---------------------
L
V
-----
E
S
---
I
E
R
F
P
D
-----------
Q
E
T
F
K
--
S
M
-
I
------
E
---
K
A
G
----------------
F
K
S
A
G
Y
E
S
L
T
---
F
-
G
I
----
C
A
I
H
W
G
I
K
------
V
-------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
56.78
12%
-62
* C5 *
6MHT
2
MTH1_HAEPH
A:
[1-327]
MI
E
I
K
D
K
Q
L
T
G
L
R
F
I
D
L
F
A
G
-
L
G
-------
G
F
R
L
A
L
E
S
C
G
A
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
-
Y
E
M
N
F
G
-----------
E
K
P
E
G
D
-
I
T
Q
V
--
N
E
K
T
I
P
D
H
D
I
--
L
C
A
G
-
F
P
C
---
Q
-----
A
F
S
-----
I
S
G
K
Q
KGFEDSRGT
L
F
F
D
I
A
R
I
V
R
-------
E
K
K
P
K
V
V
F
M
-----
E
N
V
K
---
N
F
A
S
H
D
-------
N
G
N
T
L
--------
E
------
V
------------
V
K
N
T
M
-----
N
-----
E
L
D
Y
-----
S
F
H
A
K
-----
V
L
---
N
A
L
-
D
Y
G
-
I
P
Q
K
R
E
---
R
I
Y
M
I
C
F
R
N
D
L
--------
N
--------
I
Q
----
N
F
Q
-------------------
F
-
P
K
P
--
F
-
E
L
N
T
-------
F
V
K
--
D
L
L
L
P
---
D
S
E
V
E
----
H
-
L
V
I
D
R
K
-
D
L
-
V
M
T
------
N
-
Q
----
E
--
I
E
Q
----
T
-
T
------
P
K
T
V
R
L
--
G
I
V
--------------------
G
K
G
G
Q
G
E
--------
R
I
Y
S
T
R
G
I
A
---------------------
I
T
-----
L
S
---
A
Y
G
G
G
I
F
A
K
-
T
G
G
Y
L
V
N
-------------------------------------
G
K
---
T
R
K
L
H
P
R
E
---
C
-
A
R
----
V
M
G
Y
P
D
S
Y
KVHPS
T
S
Q
A
-----------------
Y
---
K
Q
F
G
N
---
S
V
V
I
N
V
L
Q
--
Y
I
A
Y
N
I
G
S
S
-
L
----
N
F
KPY------------------------------------------------------------------------------
24
Fugue
55.94
14%
-85
- C3 -
1UOK
-
?
?:
[1-479]
---
M
E
K
Q
W
W
K
E
S
V
V
Y
Q
I
Y
P
R
S
F
M
DSNGDGI
G
D
L
R
G
I
I
S
-
K
L
D
Y
L
K
-
E
L
--
G
I
D
V
I
W
-
L
S
P
V
Y
E
S---------
P
N
D
D
N
G
Y
D
I
S
D
Y
--
C
K
I
M
N
E
F
G
T
M
--
E
D
W
D
-
E
L
L
---
H
-----
E
M
H
-----
E
R
N
M
K
---------------
L
M
M
D
L
VVNHTS
D
E
H
N
W
F
I
E
S
R
KSKD
N
K
Y
R
---
D
Y
Y
I
W
R
-------
P
G
K
E
G
--------
K
------
E
PNN
W
G
A
AFSGSA
W
Q
Y
D
E
-----
M
-----
T
D
E
Y
-----
Y
L
H
L
F
-----
S
K
---
K
Q
P
-
D
L
N
W
D
N
E
K
V
R
---
Q
D
V
Y
E
M
M
K
F
W
L
--------
E
--------
K
G
I
D
--
G
F
R
MDVINFISKEEGLPTVETE
E
-
E
G
Y
--
V
-
S
G
H
K
-------
H
F
M
--
N
G
P
N
I
---
H
K
Y
L
H
----
E
-
M
N
E
E
V
L
-
S
H
-
Y
D
I
------
M
-
T
----
V
--
G
E
M
PGVT
T
-
E
------
E
A
K
L
Y
T
--
G
E
E
RKELQ
M
V
F
Q
FEHMDLDSGEG
G
K
W
D
V
K
P
--------
C
S
L
L
T
L
K
E
N
---------------------
L
T
-----
K
W
---
Q
K
A
L
E
H
T
G
W
-
N
S
L
Y
W
N
N
H
D
Q
P
R
--
V
V
-
S
------
R
F
G
N
D
G
M
Y
----
R
------
I
E
S
A
K
M
L
A
T
V
L
H
M
M
---
K
-
G
T
----
P
Y
I
Y
Q
G
E
E
------
I
G
M
-----------------
T
---
N
V
R
F
E
---
S
I
D
E
Y
R
D
I
--
E
T
L
N
M
Y
K
E
K
-
V
----
M
E
RGED
I
E
K
V
M
Q
S
I
Y
I
KGRDNARTPMQWDDQNHAGFTTGEPWITVNPNYKEIN
V
K
Q
A
I
Q
N
KDS
I
F
Y
Y
Y
K
K
L
I
E
L
R
K
N
N
EIVVY
11
HHSearch
54.08
23%
-46
- C4 -
1OKC
9
ADT1_BOVIN
A:
[110-293]
----------
R
Y
F
A
G
N
L
A
S
G
G
A
A
-------
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
--
A
A
D
V
G
K
-
G
A
--------------------------------
A
Q
R
E
F
T
--
G
L
G
N
-
C
I
T
---
K
-----
I
F
K
-----
S
D
G
L
R
---------------
G
L
Y
Q
-------
G
F
N
V
S
V
Q
G
I
-----
I
I
Y
R
---
A
A
Y
F
G
V
-------
Y
D
T
A
K
--------
G
------
M
------------
L
P
D
P
K
-----------
N
V
H
I
-----
I
V
S
W
M
-----
I
A
---
Q
T
V
-
T
A
V
-
A
G
L
V
S
Y
---
P
F
D
T
V
R
R
R
M
M
M
--------
Q
--------
S
G
R
K
GA
D
I
M
-------------------
Y
-
T
G
T
--
V
-
D
C
W
R
-------
K
I
A
--
K
D
E
G
P
---
K
A
F
F
K
----
G
-
A
W
S
N
V
L
R
G
M
-
G
-
G
------
A
-
F
----
V
--
L
V
L
----
Y
-
D
------
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
50.49
26%
-46
- C4 -
2LCK
-
UCP2_MOUSE
A:
[114-302]
----------
A
G
I
G
S
R
L
L
A
G
S
T
T
-------
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
--
Q
A
Q
A
R
A
-
G
G
---------------------------------
G
R
R
Y
Q
--
S
T
V
E
-
A
Y
K
---
T
-----
I
A
R
-----
E
E
G
I
R
---------------
G
L
W
K
-------
G
T
S
P
N
V
A
R
N
-----
A
I
V
N
---
C
A
E
L
V
T
-------
Y
D
L
I
K
--------
D
------
T
------------
L
L
K
A
N
L----
M
-----
T
D
D
L
-----
P
C
H
F
T
-----
S
A
---
F
G
A
-
G
F
C
-
T
T
V
I
A
S
---
P
V
D
V
V
K
T
R
Y
M
N
--------
S
--------
A
L
G
-----
Q
-------------------
Y
-
H
S
A
--
G
-
H
C
A
L
-------
T
M
L
--
R
K
E
G
P
---
R
A
F
Y
K
----
G
-
F
M
P
S
F
L
R
L
G
-
S
W
N
------
V
-
V
----
M
--
F
V
T
----
Y
-
E
------
Q
L
K
R
A
L
--
M
A
A
--------------------
Y
Q
S
R
E
A
P
--------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
46.51
19%
-28
- C4 -
3J9X
-
?
A:
[32-82]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
A
Q
--
Q
N
-
F
------
Q
---
T
N
V
P
----
K
------
F
T
S
V
N
E
N
V
S
A
V
L
T
Q
---
Y
-
G
I
TG
P
N
R
A
I
Y
Q
G
F
G
------
L
K
V
-----------------
A
---
R
A
L
N
R
---
I
G
S
G
P
A
L
V
--
N
M
I
N
G
L
K
G
Y
-
Y
----
I
S
---------------------------------------------------------------------------------
7
PsiBlast_PDB
39.68
26%
-47
- C4 -
1MC0
1
PDE2A_MOUSE
A:
[274-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
R
----
G
-
V
D
D
S
T
G
-
F
R
-
T
R
N
------
I
-
L
----
C
--
F
P
I
----
K
-
N
------
E
N
Q
E
V
I
--
G
V
A
--------------------
E
L
V
N
K
I
N
--------
G
P
---
W
F
S
K
---------------------
F
D
-----
E
D
---
L
A
T
A
F
S
I
Y
C
-
G
--
I
S
I
A
H
S
L
L
Y
--
K
K
-
V
------
N
---
E
--
A
----
Q
------
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------