@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S40A1_HUMAN: (2015-12-11 )
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
Atome Classification :
(20 SA)
.........10........20........30........40........50..-......60---........70........80........90........100.......110........120......--.130.......140---........150..------.....160.......170....-...180...-....190......-.200------......------..210.......220...-....230.......240........250.......260.......270.......280.......290.....-..300--.........310......-.320.......330-..-.....340.--------------------------......350.......360......--.370.----......380..----.....390.......400.......410.......420.......430.......440.......450.......460-.......-.470-----.......480.......490.........500.--......510.......520.......530.......540..-----...-..550.......560.......570
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRAGDHNRQRG
C
C
G
S
L
A
D
Y
L
T
S
A
K
F
L
L
Y
LGHS
L
S
T
W
G
D
R
M
W
H
F
A
V
S
V
F
L
V
E
L
-YGNS
L
L
L
T
---
A
V
Y
G
L
V
V
A
G
S
V
L
V
L
G
A
I
I
G
D
WVDKNA
R
L
K
V
A
Q
T
S
L
V
V
Q
N
V
S
V
I
L
C
G
I
I
L
M
-
M
V
F
L
H
K
H
E
L
L
T
M
Y
H
G
W
V
--
L
T
S
C
Y
I
L
I
I
T
I
A
N
----
I
A
N
LAST
A
T
A
I
T
I
------QR
D
W
I
V
V
V
AGE
D
R
S
K
L
A
N
M
N
A
T
-
I
R
R
I
D
Q
L
T
N
-
I
L
A
P
M
A
V
G
Q
I
M
TF-GS
P
-------
V
I
G
C
G
F------IS
G
W
N
L
V
S
M
C
V
E
Y
V
L
L
W
K
-
V
Y
QKTP
A
L
A
VKAGLK-
E
E
E
T
E
L
K
Q
L
NLHKDTEPKPLEG
T
H
L
MGVKDS
N
I
H
E
L
E
HEQEP
T
C
A
S
Q
M
A
E
P
F
R
T
F
R
D
-
G
W
V
----
S
Y
YNQP
V
F
L
A
G
M
G
L
A
F
L
Y
-
M
T
V
LG
F
D
C
ITTG
Y
A
-YT-QGL
S
G
S
I
L
S
--------------------------
I
L
M
G
A
S
A
I
T
G
I
M
G
T
V
A
F
T
W
L
R
R
KCG--
L
V
R
T
G
----
L
I
S
G
L
A
Q
L
S
C
L
----
I
L
C
V
I
S
V
FMPGSPLDLSVS
P
F
E
D
I
R
S
R
FIQGESITPTKIPE
I
T
T
E
I
Y
MSNGSNSANIVPETSPESV
P
I
I
S
V
S
L
L
F
A
G
--
V
I
A
A
R
IG-LW
S
F
-----
D
L
T
V
T
Q
L
L
Q
E
N
V
I
E
S
E
R
G
--
I
I
N
G
V
Q
N
S
M
N
Y
L
L
--
D
L
L
H
F
I
M
V
ILAPNPE
A
F
G
L
L
V
L
I
S
V
S
F
V
A
M
G
H
I
M
Y
F
R
F
A
Q
N
-----TLG-N
K
L
F
ACGP
D
A
K
E
V
R
K
ENQANTSVV
32
Fugue
76.80
19%
-89
- C1 -
2QUB
-
?
A:
[1-615]
--------
S
H
M
G
I
F
S
Y
K
D
L
D
E
N
A
S
K
A
L
F
S
D
A
L
A
I
S
T
Y
A
Y
H
N
I
D
N
G
F
D
E
G
Y
H
Q
T
G
F
G
L
G
L
P
L
T
---
L
I
T
A
L
I
--
G
S
T
Q
S
Q
G
G
L
P
G
L
P
W
N
P
D
S
E
-
Q
A
A
Q
E
A
V
N
N
A
G
W
S
V
I
S
---
A
T
Q
-
L
G
Y
A
G
K
T
D
A
R
G
T
Y
Y
G
E
T
AG
Y
T
T
A
Q
A
E
V
L
G
K
Y
D
----
S
E
G
-
N
L
T
A
I
G
I
S
F
R
G
TSGP
R
E
S
L
I
G
D
T
I
G
D
V
I
N
D
L
L
A
G
F
G
P
-
K
G
Y
A
D
G
Y
T
L
-
K
A
F
G
N
L
L
G
D
V
A
K
F
-
A
Q
A
H
GLSGED
V
V
V
S
G
H
S-----
L
G
G
L
A
V
N
S
M
A
A
Q
S
D
A
N
W
G
G
F
Y
A
Q
S
N
Y
V
A
F
A
S
P
T
Q
Y
E
A
G
G
K
V
I
N
I
G
Y
E
N
D
P
V
F
R
A
L
D
G
T
S
L
-
T
L
P
S
L
G
V
H
D
A
P
H
T
S
A
T
N
N
I
V
N
F
N
D
H
Y
A
S
--
D
-
A
W
N
LLPF
S
I
L
N
I
P
T
W
L
S
H
--
L
P
F
F
Y
-
Q
D
G
L
M
R
V
L
N
S
E
F
Y
S
-
L
T
-
D
K
D
S
T
I
I
V
S
NLSNVTRGN
T
W
V
E
DLNRNA
E
T
H
S
G
P
T
F
I
I
G
S
D
G
N
D
L
I
K
G
G
K
G
N
D
Y
L
E
G
R
D
G
D
D
I
F
R
D
A
G
G
Y
N
L
I
A
G
G
K
G
H
N
I
F
D
TQQ
A
L
K
N
T
E
V
A
Y
D
G
N
T
L
Y
L
R
-----
D
A
K
G
G
I
T
L
A
D
D
I
S
T
L
R
S
K
E
T
S
W
L
I
F
N
K
E
V
D
H
Q
V
T
A
A
G
L
K
S
D
S
G
L
K
A
Y
A
A
A
T
G
G
D
G
D
D
V
L
Q
A
R
S
H
D
A
W
L
F
GNAGN
D
T
L
I
G
H
A
G
G
N
L
T
F
V
G
G
S
G
D
D
I
L
K
G
V
G
N
G
N
T
F
L
F
S
G
D
F
G
R
D
Q
L
Y
G
F
N
A
S
----
D
K
L
V
F
I
G
T
E
G
-
A
S
G
N
I
R
D
Y
A
T
Q
Q
N
D
D
L
V
L
A
F
G
H
S
Q
V
T
L
I
G
V
S
L
D
H
I
S
T
D
Q
---
V
V
L
A
19
HHSearch
50.64
15%
-123
- C3 -
3WDO
-
?
A:
[8-168]
--------------------
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
---
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
-------
S
--
D
------
S
I
W
G
--
I
---
I
L
G
R
A
L
Q
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
------
S
D
--
L
T
-----
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
-
L
G
L
-------
H
A
L
F
W
M
------
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
-
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
-
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
-
F
G
S
----
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
-
V
F
C
V
G
L
I
V
V
A
E
I
V
L
-
W
N
-
A
Q
T
Q
F
W
Q
L
V
--------------------------
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
--
P
A
G
Y
K
----
G
T
A
M
G
V
Y
S
T
S
Q
----
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
--
L
I
A
E
E
E
H
-
S
A
Y
V
-----
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
--
A
L
---------------------------------------------------------------------------------------
23
HHSearch
48.87
11%
-115
- C3 -
1PW4
-
GLPT_ECOLI
A:
[253-419]
----------------------
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
D
K
S
---
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
----
M
N
--
P
A
----
G
N
P
T
V
--
D
---
M
I
C
M
I
V
I
G
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
------
L
E
--
L
A
-----
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
-
F
G
W
-------
D
G
G
F
M
V
------
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
-
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
44.30
12%
-101
- C3 -
2GFP
-
EMRD_ECOLI
A:
[14-167]
----------------------------
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
L
-
N
V
-
R
E
G
A
V
---
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
S
I
F
M
L
A
T
L
V
A
V
T
-------
T
--
S
------
S
L
T
V
--
L
---
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
------
R
D
--
L
Y
-----
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
-
W
N
W
-------
R
A
C
Y
L
F
------
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
-
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
-
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
-
F
G
A
----
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
-
I
C
C
L
L
A
G
L
L
M
W
I
P
D
-
W
F
-
G
V
M
N
V
W
T
L
L
--------------------------
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
--
P
F
L
A
G
----
T
A
G
A
L
V
G
G
L
Q
N
----
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.05
24%
-131
- C3 -
2YDO
1
?
A:
[6-99]
--------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
T
A
S
S
----
I
F
S
L
L
A
I
A
I
D
R
Y
I
------
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
-
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
G
W
N
N
C
G
Q
-
P
K
E
-------
G
K
A
H
S
Q
------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
-
F
C
P
----
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
-
R
E
-
F
R
Q
T
F
R
K
I
I
--------------------------
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.97
24%
-132
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[6-99]
--------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
T
A
S
S
----
I
F
S
L
L
A
I
A
I
D
R
Y
I
------
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
-
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
G
W
N
N
C
G
Q
-
P
K
E
-------
G
K
A
G
C
G
------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
-
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
-
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
-
I
I
N
----
C
F
T
F
F
C
P
D
C
H
A
P
L
W
L
M
Y
L
-
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
-
A
Y
R
I
R
E
F
R
Q
--------------------------
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
41.92
25%
15
- C3 -
2F9Y
-
ACCA_ECOLI
A:
[190-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
A
E
E
R
G
Q
S
E
A
I
A
R
N
-
L
R
E
M
S
R
L
G
V
-
P
V
V
C
T
V
I
G
E
G
G
S
G
-
G
A
L
-------
A
I
G
V
G
D
K
V
N
M
L
Q
Y
S
T
Y
S
V
I
S
P
E
G
C
A
S
I
L
W
K
-
S
A
D
K
A
P
L
A
A
E
A
M
G
I
I
-
R
--
P
R
L
K
E
L
K
L
I
D
S
I
I
P
E
P
L
G
G
A
H
R
N
P
E
A
M
A
A
S
L
K
A
Q
L
L
A
D
L
A
D
L
D
V
L
S
T
E
D
L
K
N
R
R
-
Y
Q
R
----
L
M
S
Y
G
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
41.89
24%
-126
- C3 -
2YDV
3
?
A:
[3-99]
----------------------------------------------------
I
-
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
T
A
S
S
----
I
F
S
L
L
A
I
A
I
D
R
Y
I
------
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
-
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
G
W
N
N
C
G
Q
-
P
K
E
-------
G
K
A
H
S
Q
------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
-
T
F
F
----
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
-
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
-
R
I
-
R
E
F
R
Q
T
F
R
K
--------------------------
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
41.50
11%
-102
- C3 -
1PW4
-
GLPT_ECOLI
A:
[46-320]
---------------------------------------
K
N
F
A
L
A
M
P
Y
L
-
V
E
Q
-
G
-
F
S
R
G
D
L
---
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
-----
W
A
--
T
----
S
S
I
A
V
--
M
---
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
------
V
H
--
W
W
-----
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
-------
H
A
A
L
Y
M
------
P
A
F
C
A
I
L
V
A
---
L
F
A
F
A
M
-
M
R
-
D
T
P
Q
S
C
G
L
P
P
I
E
-
E
Y
K
N
D
------------------------------------------------
T
A
K
Q
I
F
M
Q
----
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
-
K
E
V
K
H
F
A
L
D
K
S
S
--------------------------
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
--
R
G
N
R
G
----
A
T
G
V
F
F
M
T
L
V
T
----
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
--
F
G
W
D
G
G
F
-
M
V
M
I
-----
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
--
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------
21
HHSearch
40.76
10%
-123
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[33-177]
-----------------------------
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
F
-
T
L
-
T
N
F
Q
A
---
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
---------
E
I
---
M
N
Y
T
L
--
F
---
L
V
G
L
F
I
I
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
------
T
V
--
L
G
-----
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
-
N
V
P
-------
H
Q
S
Q
D
V
------
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
-
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
-
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
-
S
Y
L
----
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
F
A
A
N
-
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
-
T
G
-
T
W
L
I
S
R
F
A
P
--------------------------
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
--
G
L
I
A
L
----
T
L
C
S
A
F
M
S
I
Q
Y
----
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
---------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
38.82
15%
-67
- C3 -
3WDO
-
?
A:
[33-159]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
--------------------------
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
--
R
K
P
L
I
----
V
G
G
L
A
V
F
A
A
G
S
----
V
I
A
----
A
L
S
D
S
----------------------------------------------------------
I
W
G
I
I
L
G
--
R
A
L
Q
G
S
G
---
A
I
-----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
--
K
A
M
A
F
I
G
V
S
F
G
I
T
--
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
-----
S
S
T
-
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
22
HHSearch
38.53
13%
-104
- C3 -
2CFQ
-
LACY_ECOLI
A:
[4-172]
-------------------
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
-
N
H
I
S
K
S
D
T
---
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
----
F
G
--
P
L
-----
L
Q
Y
N
--
I
---
L
V
G
S
I
V
G
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
------
E
K
--
V
S
-------
R
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
--
I
N
N
-------
Q
F
V
F
W
L
------
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
-
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
-
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
-
Y
V
T
----
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
-
N
R
I
G
G
K
N
A
L
L
L
A
G
T
-
I
M
-
S
V
R
I
I
G
S
S
F
--------------------------
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
--
F
K
Y
I
T
----
S
Q
F
E
V
R
F
S
A
T
I
----
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
37.94
24%
-128
- C3 -
4UG2
1
?
A:
[6-99]
--------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
--
F
I
A
C
F
V
L
V
L
T
A
S
S
----
I
F
S
L
L
A
I
A
I
D
R
Y
I
------
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
-
I
C
W
V
L
S
F
A
I
-
G
L
T
P
M
L
G
W
N
N
C
G
Q
-
P
K
E
-------
G
K
A
H
S
Q
------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
-
P
D
C
----
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-
F
R
-
Q
T
F
R
K
I
I
R
S
--------------------------
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
37.54
9%
-81
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[48-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
Q
F
Q
-
Q
A
-
F
T
L
T
N
F
Q
A
G
--------------------------
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
--
Y
K
A
G
I
----
I
T
G
L
F
L
Y
A
L
G
A
----
A
L
F
W
---
P
A
A
E
I
-----------------------------------------------------
M
---
N
Y
T
L
F
L
V
G
--
L
F
I
I
A
A
G
-
L
G
C
L
-----
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
--
F
R
L
N
L
A
Q
T
F
N
S
F
G
--
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
-----
S
V
Q
-
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
24
HHSearch
37.40
9%
-89
- C3 -
2CFQ
-
LACY_ECOLI
A:
[257-384]
---------------------------------------------------------
G
T
R
V
F
---
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
-------
F
A
--
T
------
S
A
L
E
--
V
---
V
I
L
K
T
L
H
M
F
----
E
V
P
F
L
L
V
G
C
F
K
Y
I
------
T
S
--
Q
F
-----
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
-
I
G
F
-------
Q
G
A
Y
L
V
------
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
-
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
33.84
13%
-77
- C3 -
2GFP
-
EMRD_ECOLI
A:
[31-157]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
M
A
-
R
D
-
L
N
V
R
E
G
A
V
Q
--------------------------
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
--
R
R
P
V
I
----
L
V
G
M
S
I
F
M
L
A
T
----
L
V
A
----
V
T
T
S
----------------------------------------------------------
S
L
T
V
L
I
A
A
--
S
A
M
Q
G
M
G
-
T
G
V
G
-----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
--
H
A
N
S
L
L
N
M
G
I
L
V
S
--
P
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
-----
T
R
P
-
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
30
Fugue
32.76
12%
190
- C3 -
1JTH
-
SNP25_RAT
A:
[11-72]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
M
Q
R
R
A
D
Q
L
-
A
D
E
S
L
E
S
T
R
R
M
L
Q
L
V
E
E
S
K
D
A
G
I
R
T
L
V
M
L
D
E
Q
G
E
Q
L
E
R
I
E
E
G
M
D
Q
I
N
K
D
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
31.79
43%
201
- C4 -
4DEP
-
IL1R1_HUMAN
B:
[133-164]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
-
N
E
N
N
E
L
P
K
L
Q
W
Y
K
D
C
K
P
L
L
L
D
N
I
H
F
S
G
V
K
D
R
L
I
V
M
N
V
A
E
K
H
R
G
N
Y
T
C
H
A
S
Y
T
Y
L
G
K
Q
-
Y
P
I
----
T
R
V
I
E
F
I
T
L
E
E
N
K
P
T
R
P
V
-
I
V
S
P
A
N
E
T
M
E
V
D
L
Q
-
I
Q
-
L
I
C
N
V
T
G
Q
L
--------------------------
S
D
I
A
Y
W
K
W
N
G
S
V
I
D
E
D
D
P
V
L
G
E
D
Y
Y
--
S
V
E
N
P
----
A
N
K
R
R
S
T
L
I
T
V
----
L
N
I
S
E
I
E
S
R
F
Y
K
H
P
F
T
C
F
A
K
N
T
H
G
I
D
A
A
Y
I
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
30.30
43%
232
- C4 -
1G0Y
1
IL1R1_HUMAN
R:
[128-159]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
-
N
E
N
N
E
L
P
K
L
Q
W
Y
K
D
C
K
P
L
L
L
D
N
I
H
F
S
G
V
K
D
R
L
I
V
M
N
V
A
E
K
H
R
G
N
Y
T
C
H
A
S
Y
T
Y
L
G
K
Q
-
Y
P
I
----
T
R
V
I
E
F
I
T
L
E
E
N
K
P
T
R
P
V
-
I
V
S
P
A
N
E
T
M
E
V
D
L
G
-
S
Q
-
I
Q
L
I
C
N
V
T
G
--------------------------
Q
L
S
D
I
A
Y
W
K
W
N
G
S
V
I
D
E
D
D
P
V
L
G
E
D
--
Y
Y
S
V
E
----
N
P
A
N
K
R
R
S
T
L
I
----
T
V
L
N
I
S
E
I
E
S
R
F
Y
K
H
P
F
T
C
F
A
K
N
T
H
G
I
D
A
A
Y
I
Q
L
I
Y
P
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
30.06
30%
-44
- C2 -
2WYA
2
HMCS2_HUMAN
A:
[330-418]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
N
M
-
Y
T
-
S
S
L
Y
G
C
L
A
S
--------------------------
L
L
S
H
H
S
A
Q
E
-
L
A
G
S
--------
R
I
G
--
A
F
S
Y
G
------
S
G
L
A
-
A
S
F
F
----
S
F
R
V
S
Q
D
A
A
P
G
S
P
L
D
K
L
V
S
S
T
S
D
L
P
K
R
L
A
S
R
K
C
V
S
P
E
E
F
T
E
I
M
N
Q
R
E
Q
F
Y
H
K
V
N
F
S
P
P
G
D
T
N
S
L
F
P
G
T
W
Y
L
E
R
V
D
E
Q
--
H
R
R
K
Y
A
R
-
R
P
V
-------------------------------------------------------------------------------------------------------------------