@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR8_HUMAN: (2015-12-08 )
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
Atome Classification :
(20 SA)
-----.........10.......-----.20........30........40........50.....----------.-..60----------....-....70.....---.---..80.......-.90...-.....100.---..-....----------110-....------------------..----..----.-120--......--------...130...----.----...140.......150.......160--.........170..------...-----...------------180----------........--.190......-.200.......210......-..220......----.------230.-......-240...---------.....250....---...260.......270......-.280.--..--.-.-.--.--290.........300.......310.......320.......330.......340.......350.......360.......370.......380.....-..390.......400..-.....410.-......420-......------.430----.------........440.......450.......460.......-470..-...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MTPEDPEETQPLLGPPGG-----SAPRGR
R
V
F
L
A
A
F
A
A
A
L
G
P
L
S
F
G
F
ALGYSSPAIP
S
L
Q
R----------A-APPA----------PRL
D
-
D
A
A
A
S
W
F
G
A
V
V
---
T
---
L
GAAA
G
G
V
L
G
G
-
W
L
V
DRA-G
R
K
L
S
L
L
L
C---S
V
-
P
F
V
A
----------
G
---
F
A
V
I
------------------
T
A
----
A
Q
----
D
-
V
----
W
M
L
L
G
G
--------
R
L
L
T
G
L
A
C
G
----
V
----
A
S
L
V
A
P
V
Y
I
S
E
I
A
Y
P
A
V
R
G
L
L
G
S
C
----
V
Q
L
M
V
V
V
G
I
L
L
-
A
Y
------
L
A
G
-----
W
V
L
------------
E
------------
W
R
W
L
A
V
LG--CV
P
P
S
L
M
L
L
L
-
M
C
FMPET
P
R
F
L
L
-
T
Q
H
R
R
Q
E
-
A
M
A
A
L
R
F
L
WGS----E------QGWE-DPPIGA-EQ-
S
F
H
---------
L
A
L
LRQPGIY
K
P
---
F
I
I
G
V
S
L
M
A
F
Q
Q
LSG
V
N
A
V
M
F
Y
-
A
E
T
I
F
--
E
E
--A-K-F--K--D--
S
S
L
A
S
V
V
V
G
V
I
Q
V
L
F
T
A
V
A
A
L
I
M
D
RAG
R
R
L
L
L
V
L
S
G
V
V
M
V
F
STSAF
G
A
Y
F
K
L
TQGGPGNS
S
H
V
A
I
SAPVSAQPV
D
A
S
V
G
L
A
W
L
A
V
G
S
M
C
L
F
I
A
G
F
AV-GWG
P
I
P
W
L
L
M
S
E
IF
P
L
H
-
V
K
G
V
A
T
G
I
C
-
V
L
T
N
W
L
M
A
F
-
L
V
T
K
E
F
------
S
S
------
L
------
M
E
V
L
R
P
Y
G
A
F
W
L
A
S
A
F
C
I
F
S
V
L
F
T
L
FCVPETKG
K
T
L
E
Q
-
I
T
A
HF-EGR
1
PsiBlast_PDB
92.32
31%
-128
- C1 -
4ZW9
4
?
A:
[39-490]
------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
-
A
P
P
S
----------
E
V
L
L
-
T
S
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
---
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
V
----
A
K
----
S
-
V
----
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
----
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
----
N
Q
L
G
I
V
V
G
I
L
V
-
A
Q
------
I
F
G
LE---
F
I
L
GS----------
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
----
Q
------
D
V
S
Q
-
D
I
Q
E
M
K
-
D
E
-
S
A
R
M
S
Q
E
KQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
---
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
G
I
F
--
K
D
--
A
-
G
-
V
--
Q
--
E
--
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
------
P
S
------
A
------
A
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
-
I
T
R
A
F
-
E
G
Q
2
PsiBlast_PDB
91.36
31%
-127
- C1 -
4ZWB
1
?
A:
[39-490]
------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
-
A
P
P
S
----------
E
V
L
L
-
T
S
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
---
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
V
----
A
K
----
S
-
V
----
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
----
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
----
N
Q
L
G
I
V
V
G
I
L
V
-
A
Q
------
I
F
G
LE---
F
I
L
GS----------
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
----
Q
------
D
V
S
Q
-
D
I
Q
E
M
K
-
D
E
-
S
A
R
M
S
Q
E
KQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
---
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
G
I
F
--
K
D
--
A
-
G
-
V
--
Q
--
E
--
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
------
P
S
------
A
------
A
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
-
I
T
R
A
F
-
E
G
Q
3
PsiBlast_PDB
90.41
31%
-127
- C1 -
4ZWC
3
?
A:
[39-490]
------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
-
A
P
P
S
----------
E
V
L
L
-
T
S
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
---
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
V
----
A
K
----
S
-
V
----
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
----
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
----
N
Q
L
G
I
V
V
G
I
L
V
-
A
Q
------
I
F
G
LE---
F
I
L
GS----------
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
----
Q
------
D
V
S
Q
-
D
I
Q
E
M
K
-
D
E
-
S
A
R
M
S
Q
EKQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
---
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
G
I
F
--
K
D
--
A
-
G
-
V
--
Q
--
E
--
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
------
P
S
------
A
------
A
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
-
I
T
R
A
F
-
E
G
Q
14
PsiBlast_CBE
89.98
31%
-130
- C1 -
4ZWC
2
?
B:
[39-490]
------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
FITKTLTDKG
N
-
A
P
P
S
----------
E
V
L
L
-
T
S
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
---
N
L
-
L
A
V
T
----------
G
GCF
M
G
L
C
------------------
K
V
----
A
K
----
S
-
V
----
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
----
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
----
N
Q
L
G
I
V
V
G
I
L
V
-
A
Q
------
I
F
G
LE---
F
I
L
GS----------
E
------------
E
L
W
P
L
L
L
G
FT
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
----
Q
------
D
V
S
Q
-
D
I
Q
E
M
K
-
D
E
-
S
A
R
MSQEKQVTV
L
E
L
F
R
V
S
S
Y
R
Q
P
---
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
G
I
F
--
K
D
--
A
-
G
-
V
--
Q
--
E
--
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
------
P
S
------
A
------
A
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
-
I
T
R
A
F
-
E
G
Q
4
PsiBlast_PDB
89.09
31%
-129
- C1 -
5C65
8
?
A:
[17-468]
------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
L
T
D
KG
N
-
A
P
P
S
----------
E
V
L
L
-
T
S
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
---
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
V
----
A
K
----
S
-
V
----
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
----
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
----
N
Q
L
G
I
V
V
G
I
L
V
-
A
Q
------
I
F
G
LE---
F
I
L
GS----------
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
----
Q
------
D
V
S
Q
-
D
I
Q
E
M
K
-
D
E
-
S
A
R
M
S
Q
E
KQVT
V
L
E
L
F
R
V
S
S
Y
R
Q
P
---
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
G
I
F
--
K
D
--
A
------------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
------
P
S
------
A
------
A
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
-
I
T
R
A
F
-
E
G
Q
15
PsiBlast_CBE
87.77
31%
-127
- C1 -
5C65
7
?
B:
[17-468]
------------------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
L
T
D
K---
A
P
P
S
----------
E
V
L
L
-
T
S
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
I
V
---
N
L
-
L
A
V
T
----------
G
G
C
F
M
G
L
C
------------------
K
V
----
A
K
----
S
-
V
----
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
----
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
----
N
Q
L
G
I
V
V
G
I
L
V
-
A
Q
------
I
F
G
LE---
F
I
L
GS----------
E
------------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
----
Q
------
D
V
S
Q
-
D
I
Q
E
M
K
-
D
E
-
S
A
R
M
SQVT
V
---
L
E
L
F
R
V
S
S
Y
R
Q
P
---
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
G
I
F
--
K
D
--
A
---------
E
--
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
---------------------
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
----
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
------
P
S
------
A
------
A
H
Y
L
G
A
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
-
I
T
R
A
F
-
E
G
Q
27
Fugue
87.24
30%
-133
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
------------------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
-
F
V
A
P
QNLS------
E
S
A
A
-
N
S
L
L
G
F
C
V
A
S
A
---
L
---
I
G
C
I
I
G
G
A
L
G
G
-
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
---
A
V
-
L
F
F
I
----------
S
---
G
V
G
S
A
WPELGFTSINPDNTVPV
Y
L
----
A
G
----
Y
-
V
----
P
E
F
V
I
Y
--------
R
I
I
G
G
I
G
V
G
----
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
-
V
Y
------
C
V
N
-----
Y
F
I
------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
-
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
----
T
------
L
A
T
Q
-
A
V
Q
E
I
K
-
H
S
-
L
D
H
---------
G
R
K
T
G
G
R
L
L
M
F
G
VG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
-
A
P
E
V
F
--
K
T
--
L
-
G
-
A
S
T
D
--
I
--
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
-------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
------
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
-
L
E
A
L
W
-
E
--
9
PsiBlast_PDB
86.71
29%
-142
- C1 -
4GC0
5
XYLE_ECOLI
A:
[10-479]
-----------------------------------
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
Q
----------
N
L
S
E
-
S
A
A
N
S
L
L
G
F
C
V
---
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
-
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
---
A
V
-
L
F
F
I
S
G
V
G
S
A
WPEL
G
---
F
T
S
I
------------------
N
P
----
D
N
----
T
-
V
----
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
----
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
-
V
Y
------
C
V
N
-----
Y
F
I
------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
-
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
----
T
L
A
T
Q
A
V
Q
E
I
K
-
H
S
L
D
H
G
-
R
K
-
T
G
G
---------
R
L
L
M
F
G
V
G
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
-
A
P
E
V
F
--
K
T
L
G
A
-
S
-
T
--
D
--
I
--
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
------
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
-
L
E
A
L
W
-
E
--
8
PsiBlast_PDB
85.99
29%
-143
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[10-479]
-----------------------------------
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
Q
----------
N
L
S
E
-
S
A
A
N
S
L
L
G
F
C
V
---
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
-
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
---
A
V
-
L
F
F
I
S
G
V
G
S
A
W
PEL
G
---
F
T
S
I
------------------
N
P
----
D
N
----
T
-
V
----
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
----
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
-
V
Y
------
C
V
N
-----
Y
F
I
------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
-
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
----
T
L
A
T
Q
A
V
Q
E
I
K
-
H
S
L
D
H
G
-
R
K
-
T
G
G
---------
R
L
L
M
F
G
V
G
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
-
A
P
E
V
F
--
K
T
L
G
A
-
S
-
T
--
D
--
I
--
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
------
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
-
L
E
A
L
W
-
E
--
10
PsiBlast_PDB
85.91
28%
-132
- C1 -
4PYP
1
GTR1_HUMAN
A:
[11-455]
----------------------------------
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
----------
F
-
Y
T
Q
T
W
V
H
R
YG
E
S
I
L
P
T
T
L
-
T
T
L
W
S
L
S
V
A
I
F
---
S
---
V
G
G
M
I
G
S
F
S
V
G
-
L
F
V
N
R
F
-
G
R
R
N
S
M
L
M
M
---
N
L
L
A
F
V
S
A
V
L
M
------
G
---
F
S
K
L
------------------------
G
K
----
S
-
F
----
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
----
L
----
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
----
H
Q
L
G
I
V
V
G
I
L
I
-
A
Q
V
F
G
LDS
I
M
G
-----
N
K
D
------------
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
V
-
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
-
A
K
S
V
L
K
K
L
R
G
T
----
A
------
D
V
T
H
-
D
L
Q
E
M
K
-
E
E
-
S
R
Q
MMREKKVT
I
L
E
L
F
R
S
P
A
Y
R
Q
P
---
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
-
S
T
S
I
F
--
E
K
--
A
-
G
-
V
--
Q
--
Q
--
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
---------------------
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
-
P
R
P
A
A
I
A
V
A
-
G
F
S
N
W
T
S
N
F
-
I
V
G
M
C
F
------
Q
Y
------
V
------
E
Q
L
C
G
P
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-----------------
7
PsiBlast_PDB
85.75
29%
-143
- C1 -
4GBY
5
XYLE_ECOLI
A:
[10-479]
-----------------------------------
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
Q
----------
N
L
S
E
-
S
A
A
N
S
L
L
G
F
C
V
---
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
-
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
---
A
V
-
L
F
F
I
S
G
V
G
S
A
WPEL
G
---
F
T
S
I
------------------
N
P
----
D
N
----
T
-
V
----
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
----
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
-
V
Y
------
C
V
N
-----
Y
F
I
------------
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
-
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
----
T
L
A
T
Q
A
V
Q
E
I
K
-
H
S
L
D
H
G
-
R
K
-
T
G
G
---------
R
L
L
M
F
G
V
G
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
-
A
P
E
V
F
--
K
T
LG
A
-
S
-
T
--
D
--
I
--
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
------
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
-
L
E
A
L
W
-
E
--
6
PsiBlast_PDB
84.15
29%
-160
- C1 -
4JA4
-
XYLE_ECOLI
A:
[9-479]
----------------------------------
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
Q
----------
N
L
S
E
-
S
A
A
N
S
L
L
G
F
C
V
---
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
-
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
---
A
V
-
L
F
F
I
S
G
V
G
S
A
W
PEL
G
---
F
T
S
I
------------------
N
P
----
D
N
----
T
-
V
----
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
----
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
-
V
Y
------
C
V
N
-----
Y
F
I
------------
A
RSGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
-
L
Y
T
V
P
E
S
P
R
W
L
M
-----
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
----
T
L
A
T
Q
A
V
Q
E
I
K
-
H
S
L
D
H
G
-------------------
M
F
G
V
G
V
------
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
-
A
P
E
V
---------------------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
Q
-
A
P
G
-----------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
DKN
S
W
------------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
-
L
E
A
L
W
-
E
--
28
Fugue
80.71
34%
-152
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
---------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
----------
V
F
V
A
P
Q
----------
N
L
S
E
-
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
---
I
G
C
I
I
G
G
A
L
G
G
-
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
I
A
---
A
V
-
L
F
F
I
S
G
V
G
S
A
WPEL
G
---
F
T
S
I
------------------
N
P
----
D
N
----
T
-
V
----
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
----
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
----
N
Q
F
A
I
I
F
G
Q
L
L
-
V
Y
------
C
V
N
-----
Y
F
I
A
R
SGD
A
S
W
L
N
T
D
G
------------
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
L
-
L
Y
T
V
P
E
S
P
R
W
L
M
-
T
--
L
A
T
Q
-
A
V
Q
E
I
K
H
S
L
D
R
-----------------------------------------
L
L
M
F
G
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
-
A
P
E
V
F
--
K
T
L
G
A
-
S
-
T
--
D
--
I
--
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
-------------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
------
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
------------
5
PsiBlast_PDB
73.06
30%
-139
- C1 -
4LDS
-
?
A:
[53-427]
-------------------------------------------------------------------------------------------------------------------
I
G
A
I
V
G
A
G
S
S
G
-
P
L
A
D
K
L
-
G
R
R
R
L
V
M
L
I
---
A
I
-
V
F
I
I
----------
G
---
A
L
I
L
------------------
A
A
----
S
T
----
N
-
L
----
A
L
L
I
I
G
--------
R
L
I
I
G
L
A
V
G
----
G
----
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
----
N
Q
L
M
I
T
I
G
I
L
A
-
A
Y
------
L
V
N
-----
Y
A
F
------------
A
D
I
E
G
--------
W
R
W
M
L
G
L
A
--
V
V
P
S
V
I
L
L
V
G
-
I
Y
F
M
P
E
S
P
R
W
L
L
-
E
N
R
N
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
D
SE
I
D
K
------
E
L
K
E
-
M
K
E
I
N
A
-
I
S
-
E
S
T
---------
W
T
V
I
K
S
P
W
L
G
R
I
---
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
-
S
S
S
I
F
--
A
K
--
A
-
G
-
L
--
G
--
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
-------------------
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
---
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
-
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
-
A
R
G
A
A
T
G
I
S
-
A
L
V
L
N
I
G
T
L
-
I
V
S
L
F
F
------
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
---------------
30
Fugue
59.91
10%
-117
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-----
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
-----
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
E
-----------------------------
Q
G
F
S
-
R
G
D
L
G
F
A
L
S
G
I
---
S
---
I
A
Y
G
F
S
K
F
I
M
G
-
S
V
S
D
R
S
-
N
P
R
V
F
L
P
A
G
---
L
I
-
L
A
A
A
----------
V
---
M
L
F
M
------------------
G
F
----
V
P
----
W
-
A
T
S
SI
A
V
M
F
V
L
--------
L
F
L
C
G
W
F
Q
G
----
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
----
W
N
C
A
H
N
V
G
G
G
I
-------------------------------------------------------
P
P
L
L
F
L
L
G
M
A
-
W
F
N
D
W
H
A
A
L
Y
M
P
-
A
F
C
A
I
L
V
-
A
L
F
A
F
A
M
M
R
D
T
----
P
------
Q
S
C
G
-
L
P
P
I
E
E
-
Y
K
-
N
D
T
---------
A
K
Q
I
F
M
Q
Y
V
L
P
N
---
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
-
W
S
P
T
Y
--
L
K
--
E
-
V
-
K
--
H
--
F
--
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
---------------------
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
-
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
-
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
------
V
G
------
Y
------
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
-
L
L
Q
E
L
-
V
P
-
16
HHSearch
57.02
15%
-127
* C1 *
1PW4
-
GLPT_ECOLI
A:
[47-450]
-------------------------------------------------------
N
F
A
L
A
M
P
Y
L
V
E
--------------------------
Q
G
F
S
-
R
G
D
L
G
F
A
L
S
G
I
---
S
---
I
A
Y
G
F
S
K
F
I
M
G
-
S
V
S
D
R
S
-
N
P
R
V
F
L
P
A
G
---
L
I
-
L
A
A
A
----------
V
---
M
L
F
M
------------------
G
F
----
V
P
W
A
T
S
S
-
I
----
A
V
M
F
V
L
--------
L
F
L
C
G
W
F
Q
G
----
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
----
W
N
C
A
H
N
V
G
G
G
I
-
P
P
------
L
L
F
L
L
G
M
A
W
F
N
------------
D
------------
W
H
A
A
L
Y
M
P
--
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
-
L
P
P
I
E
E
Y
-
K
N
D
----------------------------
T
A
-
K
Q
-
I
F
M
---------
Q
Y
V
L
P
N
K
L
L
W
Y
I
---
A
I
-----
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
-
S
P
T
Y
L
--
K
E
--
V
K
H
-
F
--
A
L
D
K
--
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
-
M
N
P
A
--------------------
G
N
---
P
T
V
D
M
I
C
M
--
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
-
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
------
G
Y
------
T
------
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
-
L
Q
E
L
V
-
P
--
29
Fugue
55.56
13%
-122
- C1 -
1PV6
-
LACY_ECOLI
A:
[1-417]
-----
M
Y
Y
L
K
N
--------------------------
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
----------
D
-
I
N
-------------
H
I
S
-
K
S
D
T
G
I
I
F
A
A
I
---
S
---
L
F
S
L
L
F
Q
P
L
F
G
-
L
L
S
D
K
L
-
G
L
R
K
Y
L
L
W
I
---
I
T
-
G
M
L
V
----------
M
---
F
A
P
F
------------------
F
I
F
I
F
G
P
L
----
L
-
Q
----
Y
N
I
L
V
G
--------
S
I
V
G
G
I
Y
L
G
FCF
N
A
----
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
-
F
G
R
A
----
R
M
F
G
C
V
G
W
A
L
G
-
A
S
------
I
V
G
-----
I
M
F
------------
T
------------
I
N
N
Q
F
V
F
W
--
L
G
S
G
C
A
L
I
L
A
-
V
L
L
F
F
A
K
T
D
A
P
S
-
S
A
T
V
A
N
A
--------------------------
V
-
G
A
N
H
S
A
-
F
S
-
L
K
L
---------
A
L
E
L
F
R
Q
P
K
L
W
F
---
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
-
F
T
S
F
F
AT
G
E
--
Q
-
G
-
T
--
R
--
V
--
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
-----------------------------
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
-
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
-
S
A
T
I
Y
L
V
C
F
-
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
------
G
N
------
M
------
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
-
R
Q
V
N
E
-
V
A
-
31
Fugue
54.99
16%
-105
- C1 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
----------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
----
P
A
I
A
D
M
A
R
----------
D
-
L
N
V
--------------
R
-
E
G
A
V
Q
S
V
M
G
A
Y
---
L
---
L
T
Y
G
V
S
Q
L
F
Y
G
-
P
I
S
D
R
V
-
G
R
R
P
V
I
L
V
G
---
M
S
-
I
F
M
L
----------
A
---
T
L
V
A
------------------
V
T
----
T
S
----
S
-
L
----
T
V
L
I
A
A
--------
S
A
M
Q
G
M
G
T
G
----
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
----
L
N
M
G
I
L
V
S
P
L
L
-
A
P
------
L
I
G
-----
G
L
L
DT----------
M
------------
W
N
W
R
A
C
Y
L
--
F
L
L
V
L
C
A
G
V
T
-
F
S
M
A
R
W
M
P
E
T
R
P
-
V
D
A
P
R
T
R
-
L
L
T
S
Y
K
T
L
F
G
N
----
S
------
G
F
N
C
Y
L
L
M
L
I
G
-
G
L
-
A
G
I
---------
A
A
F
E
A
C
S
G
V
L
M
G
---
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
-
F
G
A
W
F
--
A
G
--
R
-
P
-
N
--
K
--
R
--
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
---------------
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
---------------------------------
V
L
A
S
L
S
A
M
-
L
P
Q
T
G
Q
------
G
S
------
L
------
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------
32
Fugue
50.52
16%
-103
- C1 -
4DNH
2
?
A:
[2-387]
L
V
S
I
D
L
P
I
E
G
R
L
A
R
Y
D
L
T
G
R
P
V
P
F
N
S
R
D
A
K
A
F
S
R
V
A
F
A
A
A
H
V
V
A
D
----------------
P
L
A
D
N
----------
D
-
P
W
L
A
----------
P
A
I
D
W
E
R
T
L
A
F
R
H
R
L
W
---
D
---
L
G
L
---
G
V
A
E
S
M
D
T
A
Q
R
G
M
G
L
G
W
P
E
A
R
E
---
L
I
-
R
R
S
L
----------
A
---
E
A
R
G
------------------
R
P
----
D
A
----
L
-
I
----
A
C
G
A
G
T
--------
D
H
L
A
P
G
P
D
V
----
S
----
I
D
D
I
L
A
A
Y
E
S
Q
I
E
A
I
E
A
E
G
---------------
G
R
I
I
L
M
A
S
-------------------------------------------
R
A
L
A
A
A
A
--
K
G
P
E
D
Y
I
R
V
Y
-
D
R
V
L
S
Q
V
K
E
-
P
V
-
I
I
H
W
L
G
E
M
F
D
P
A
L
E
G
Y
W
G
N
----
A
------
D
---------
H
M
A
A
M
K
T
C
---------
L
D
V
L
E
A
---
H
A
A
---
K
V
D
G
I
K
I
S
L
L
S
-----
K
E
K
E
I
V
M
R
R
Q
L
P
--
K
G
--
V
-
R
M
Y
--
T
GD
D
--
F
N
Y
A
E
L
I
A
G
----------------
D
E
E
G
H
S
D
A
L
L
G
I
F
D
A
I
A
P
V
A
S
A
A
L
E
A
L
G
S
G
R
N
G
E
F
F
E
L
L
E
P
T
V
P
L
S
R
H
I
F
K
A
P
T
R
F
Y
K
T
G
V
V
F
L
A
Y
L
N
G
L
Q
D
-
H
F
--------------
V
M
I
G
G
Q
Q
S
A
----------------
R
S
L
------
V
H
------
L
------
A
E
L
F
R
L
A
D
K
A
G
A
----------------
L
A
D
P
E
L
A
T
A
R
M
R
R
V
L
A
M
H
G
V
20
HHSearch
50.30
14%
-123
- C1 -
2CFQ
-
LACY_ECOLI
A:
[21-391]
---------------------------------------------------
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
----------
D
-
I
-------------
N
H
I
S
-
K
S
D
T
G
I
I
F
A
A
I
---
S
---
L
F
S
L
L
F
Q
P
L
F
G
-
L
L
S
D
K
L
-
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
-
V
M
F
A
----------
P
---
F
F
I
F
------------------
I
F
----
G
P
----
L
L
Q
----
Y
N
I
L
V
G
--------
S
I
V
G
G
I
Y
L
G
----
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
-
V
G
------
I
M
F
-----
T
-
I
------------
N
------------
N
Q
F
V
F
W
L
G
--
S
G
C
A
L
I
L
A
V
L
-
L
F
F
A
K
T
D
A
P
S
S
---
A
T
V
A
N
A
-
V
G
---------------------
A
-
N
-
H
S
--
A
F
-
S
L
-
K
L
A
---------
L
E
L
F
R
Q
P
K
L
W
F
L
---
S
L
Y
V
I
-
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
-
F
T
S
F
F
--
A
T
--
G
-
E
-
Q
--
G
T
R
V
--
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
-----------------------
S
---
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
--
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
-
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
------
G
N
------
M
------
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
-
R
Q
V
N
E
-
V
A
-