@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR9_HUMAN: (2015-12-08 )
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
Atome Classification :
(20 SA)
......-...10........20........30........40...--.....50....--....60........70........80........90..--......100.......110.......120.......130.......140.....----..150.--......160-------------..--....---------------------...170.......180.......190.......---200--.......-----.210.......220---....------------.-..230----.........-----240.....-..250.......260......-------.270.......280..-----.....290.......300.......310.......320.....--.-.330.......340.-----------------..-...----------------.350.....-----..360......------.370.......380--..-....-..390--......------.400.......410......----------------.420.....-..----430.......440-.......450.......460.-...---...470...-------.-------..-------.480-..-------.....490.......500-----------------.........510.........520......--------.530.......540---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARKQN-RNSKELG
L
V
PLTDDTSHAGPPGPG
R
A
L
L
E
C
D
H
L
RSGVP--GGRRRKDW
S
C
S
--
L
L
V
A
S
L
A
G
A
F
GS
S
F
L
Y
G
Y
N
L
S
VVNAP
T
P
Y
I
K
A
F
Y
N
E
S
W
--
E
RRHGRPIDPD
T
L
T
L
L
W
S
V
T
V
S
I
F
A
I
G
G
L
V
G
T
L
I
V
K
M
I
G
K
V
LGRK
H
T
L
LANNG
F
----
A
I
S
A
A
L
--
L
M
A
C
SLQ---------------AG--A
F
E
M
---------------------
L
I
V
G
R
F
I
MGIDG
G
V
A
L
S
V
L
P
M
Y
L
S
EI
S
P
K
E
I
R
G---SL---G
Q
V
T
A
I
F
-----
I
C
I
G
V
F
T
G
Q
L
LG
L
P
---
E
L
LG------------K-EST------W
P
Y
L
F
G
V
I
V
-----
V
P
A
V
V
Q
L
L-SLPFLPDSP
R
Y
L
L
L
EKHNE
A
R
-------
A
V
K
A
F
Q
T
F
LGKA
D
V
S
Q
-----
E
V
E
E
V
L
A
E
S
R
V
Q
R
S
I
R
L
V
S
V
L
E
L
L
RAPY
V
R
W
Q
V
V
T
V
I
V
T
M
A
C
Y
--
Q
-
L
CGL
N
A
I
W
F
YTNSIF-----------------GK-AGI----------------PPAK
I
P
Y
V
T
-----LSTG
G
I
E
T
L
A
A
------
V
F
S
G
L
V
I
E
HLGRR---
P
L
-
L
I
G
G
-
F
G
L
M
G
--
L
F
FG
T
L
------
T
I
T
L
T
LQDHAP
W
V
P
Y
L
S
I
V
G
----------------
I
L
A
I
I
A
S
FC-SG----PGG
I
P
F
I
L
T
G
E
F
F
-
Q
QSQR
P
A
A
F
I
I
A
G
T
V
N
W
L
S
N
F
-
A
V
G
---
L
L
F
P
F
I
Q
K
S
-------
L
-------
D
T
-------
Y
C
F
L
-
V
F
-------
A
T
I
C
I
TG
A
I
Y
L
Y
F
VLP-------------------ETKN
R
T
Y
A
E
I
--
S
Q
A
F
S
KRNKAYP
P
E
E
K
I
D
--------
S
AVTDGKINGRP-----------------------
1
PsiBlast_PDB
100.00
38%
-127
- C3 -
4PYP
1
GTR1_HUMAN
A:
[12-455]
-------------------------------------------------------------
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
T
Q
T
W
--
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
----
A
F
V
S
A
V
--
L
M
G
F
S
K
L
---------------
G
K
--
S
F
E
M
---------------------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
---
A
L
---
G
T
L
H
Q
L
G
-----
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
---
S
I
M
G
------------
N
-
K
D
L
------
W
P
L
L
L
S
I
I
F
-----
I
P
A
L
L
Q
C
I
-
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
-------
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
-----
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
-----------------
E
K
-
A
G
V
------------------
Q
Q
P
V
Y
A
T
-----
I
G
S
G
I
V
N
T
A
F
T
------
V
V
S
L
F
V
V
Q
R
A
G
R
R
---
T
L
H
L
I
G
L
-
A
G
M
A
G
--
C
A
I
-
L
M
------
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
----------------
I
F
G
F
V
A
F
F
E
-
V
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
-
I
V
G
---
M
C
F
Q
Y
V
E
Q
L
-------
C
-------
G
P
-------
Y
V
F
I
-
I
F
-------
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
-------------------
E
T
-----------------------------------------------------------------------
5
PsiBlast_PDB
93.30
36%
-116
- C3 -
5C65
8
?
A:
[21-469]
------------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
L
--
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
----
A
V
T
G
G
C
--
F
M
G
L
C
K
V
---------------
A
K
--
S
V
E
M
---------------------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
---
A
F
---
G
T
L
N
Q
L
G
-----
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
---
F
I
L
G
------------
S
-
E
E
L
------
W
P
L
L
L
G
F
T
I
-----
L
P
A
I
L
Q
S
A
-
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
-------
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
-----
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
-----------------
K
D
-
A
--------------------
P
I
--
Y
A
T
-----
I
G
A
G
V
V
N
T
I
F
T
------
V
V
S
L
F
L
V
E
R
A
G
R
R
---
T
L
-
H
M
I
G
-
L
G
G
M
A
--
F
C
S
T
L
M
------
T
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
----------------
I
L
V
F
V
A
F
F
E
-
I
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
---
L
L
F
P
S
A
A
H
Y
-------
L
-------
G
A
-------
Y
V
F
I
-
I
F
-------
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
-------------------
E
T
R
G
R
T
F
E
D
I
--
T
R
A
F
E
G
Q
A
-----------------------------------------------------
13
PsiBlast_CBE
93.22
37%
-121
- C3 -
4ZWC
2
?
B:
[43-490]
------------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
--
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
----
A
V
T
G
G
C
--
F
M
G
L
C
K
V
---------------
A
K
--
S
V
E
M
---------------------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
---
A
F
---
G
T
L
N
Q
L
G
-----
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
---
F
I
L
G
------------
S
-
E
E
L
------
W
P
L
L
L
G
F
T
I
-----
L
P
A
I
L
Q
S
A
-
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
-------
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
-----
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
-----------------
K
D
-
A
G
V
----------------
Q
E
P
I
--
Y
A
T
-----
I
G
A
G
V
V
N
T
I
F
T
------
V
V
S
L
F
L
V
E
R
A
G
R
R
---
T
L
-
H
M
I
G
-
L
G
G
M
A
--
F
C
S
T
L
M
------
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
----------------
I
L
V
F
V
A
F
F
E
-
I
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
---
L
L
F
P
S
A
A
H
Y
-------
L
-------
G
A
-------
Y
V
F
I
-
I
F
-------
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
-------------------
E
T
R
G
R
T
F
E
D
I
--
T
R
A
F
E
G
Q
A
H
----------------------------------------------------
2
PsiBlast_PDB
93.00
37%
-121
- C3 -
4ZW9
4
?
A:
[43-490]
------------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
--
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
----
A
V
T
G
G
C
--
F
M
G
L
C
K
V
---------------
A
K
--
S
V
E
M
---------------------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
---
A
F
---
G
T
L
N
Q
L
G
-----
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
---
F
I
L
G
------------
S
-
E
E
L
------
W
P
L
L
L
G
F
T
I
-----
L
P
A
I
L
Q
S
A
-
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
-------
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
-----
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
-----------------
K
D
-
A
G
V
----------------
Q
E
P
I
--
Y
A
T
-----
I
G
A
G
V
V
N
T
I
F
T
------
V
V
S
L
F
L
V
E
R
A
G
R
R
---
T
L
-
H
M
I
G
-
L
G
G
M
A
--
F
C
S
T
L
M
------
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
----------------
I
L
V
F
V
A
F
F
E
-
I
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
---
L
L
F
P
S
A
A
H
Y
-------
L
-------
G
A
-------
Y
V
F
I
-
I
F
-------
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
-------------------
E
T
R
G
R
T
F
E
D
I
--
T
R
A
F
E
G
Q
A
H
----------------------------------------------------
3
PsiBlast_PDB
92.74
37%
-120
- C3 -
4ZWB
1
?
A:
[43-490]
------------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
--
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
----
A
V
T
G
G
C
--
F
M
G
L
C
K
V
---------------
A
K
--
S
V
E
M
---------------------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
---
A
F
---
G
T
L
N
Q
L
G
-----
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
---
F
I
L
G
------------
S
-
E
E
L
------
W
P
L
L
L
G
F
T
I
-----
L
P
A
I
L
Q
S
A
-
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
-------
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
-----
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
-----------------
K
D
-
A
G
V
----------------
Q
E
P
I
--
Y
A
T
-----
I
G
A
G
V
V
N
T
I
F
T
------
V
V
S
L
F
L
V
E
R
A
G
R
R
---
T
L
-
H
M
I
G
-
L
G
G
M
A
--
F
C
S
T
L
M
------
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
----------------
I
L
V
F
V
A
F
F
E
-
I
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
---
L
L
F
P
S
A
A
H
Y
-------
L
-------
G
A
-------
Y
V
F
I
-
I
F
-------
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
-------------------
E
T
R
G
R
T
F
E
D
I
--
T
R
A
F
E
G
Q
A
H
----------------------------------------------------
4
PsiBlast_PDB
91.82
37%
-121
- C3 -
4ZWC
3
?
A:
[43-490]
------------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
--
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
----
A
V
T
G
G
C
--
F
M
G
L
C
K
V
---------------
A
K
--
S
V
E
M
---------------------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
---
A
F
---
G
T
L
N
Q
L
G
-----
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
---
F
I
L
G
------------
S
-
E
E
L
------
W
P
L
L
L
G
F
T
I
-----
L
P
A
I
L
Q
S
A
-
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
-------
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
-----
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
-----------------
K
D
-
A
G
V
----------------
Q
E
P
I
--
Y
A
T
-----
I
G
A
G
V
V
N
T
I
F
T
------
V
V
S
L
F
L
V
E
R
A
G
R
R
---
T
L
-
H
M
I
G
-
L
G
G
M
A
--
F
C
S
T
L
M
------
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
----------------
I
L
V
F
V
A
F
F
E
-
I
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
---
L
L
F
P
S
A
A
H
Y
-------
L
-------
G
A
-------
Y
V
F
I
-
I
F
-------
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
-------------------
E
T
R
G
R
T
F
E
D
I
--
T
R
A
F
E
G
Q
A
H
----------------------------------------------------
14
PsiBlast_CBE
90.34
36%
-116
- C3 -
5C65
7
?
B:
[21-469]
------------------------------------------------------------------------
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
L
--
T
D
K
--
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
----
A
V
T
G
G
C
--
F
M
G
L
C
K
V
---------------
A
K
--
S
V
E
M
---------------------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
---
A
F
---
G
T
L
N
Q
L
G
-----
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
---
F
I
L
G
------------
S
-
E
E
L
------
W
P
L
L
L
G
F
T
I
-----
L
P
A
I
L
Q
S
A
-
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
-------
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
-----
D
I
Q
E
M
K
D
E
S
A
R
M
S
---
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
--
Q
-
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
-----------------
K
D
-
A
-------------------
E
P
I
--
Y
A
T
-----
I
G
A
G
V
V
N
T
I
F
T
------
V
V
S
L
F
L
V
E
R
A
G
R
R
---
T
L
-
H
M
I
G
-
L
G
G
M
A
--
F
C
S
T
L
M
------
T
V
S
L
L
L
K
D
N
Y
----
F
V
C
I
G
A
----------------
I
L
V
F
V
A
F
F
E
-
I
G
----
P
G
P
I
P
W
F
I
V
A
E
L
F
-
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
---
L
L
F
P
S
A
A
H
Y
-------
L
-------
G
A
-------
Y
V
F
I
-
I
F
-------
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
-------------------
E
T
R
G
R
T
F
E
D
I
--
T
R
A
F
E
G
Q
A
-----------------------------------------------------
26
Fugue
78.20
21%
-109
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
------------------------------------------------------
Y
N
S
S
--
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
--------
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
----
F
F
I
S
G
V
--
G
S
A
W
P
E
L
GFTSINPDNTVPVYL
A
G
--
Y
V
P
E
---------------------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
---
K
L
---
V
S
F
N
Q
F
A
-----
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
---
I
A
R
S
------------
G
-
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
-----
I
P
A
L
L
F
L
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
-
R
G
K
Q
E
Q
-------
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
-----
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
--
Q
-
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------------
K
T
-
L
G
A
----------------
S
T
D
I
A
L
L
Q
T
-----
I
I
V
G
V
I
N
L
T
F
T
------
V
L
A
I
M
T
V
D
K
F
G
R
K
---
P
L
-
Q
I
I
G
-
A
L
G
M
A
--
I
G
M
F
S
L
------
G
T
A
F
Y
T
Q
A
P
----
G
I
V
A
L
L
S
----------------
M
L
F
Y
V
A
A
F
A
-
M
S
----
W
G
P
V
C
W
V
L
L
S
E
I
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
M
D
K
N
-------
S
-------
W
L
V
A
H
FHNG
F
S
Y
W
-
I
Y
-------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
-------------------
E
T
K
G
K
T
L
E
E
L
--
E
A
L
W
E
--------------------------------------------------------
27
Fugue
75.71
23%
-113
- C3 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
---------------------------------------------------------
S
--
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
--------
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
------
R
D
S
L
----
K
I
A
A
V
L
--
F
F
I
S
G
V
G
---------------
S
A
--
W
P
E
L
GFTSINPDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
---
K
L
V
S
F
N
Q
F
A
I
I
F
-----
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
SGD
A
S
W
L
------------
N
-
T
D
G
------
W
R
Y
M
F
A
S
E
C
-----
I
P
A
L
L
F
L
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
T
L
A
T
Q
A
V
Q
-------
E
I
K
H
S
L
D
R
L
L
M
F
G
V
G
V
-----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
-----------------------------------
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------------
K
T
-
L
G
A
----------------
S
T
D
I
A
L
L
Q
T
-----
I
I
V
G
V
I
N
L
T
F
T
------
V
L
A
I
M
T
V
D
K
F
G
R
K
---
P
L
-
Q
I
---
I
G
A
L
G
--
M
A
I
G
M
F
------
S
L
G
T
A
F
Y
T
Q
A
P
--
G
I
V
A
L
L
S
----------------
M
L
F
Y
V
A
A
F
A
-
M
S
----
W
G
P
V
C
W
V
L
L
S
E
I
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
M
D
K
N
-------
S
W
L
V
A
H
FH
N
G
-------
F
S
Y
W
-
I
Y
-------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
-------------------
E
T
K
G
K
T
L
------------------------------------------------------------------
6
PsiBlast_PDB
71.26
29%
-120
- C3 -
4LDS
-
?
A:
[46-427]
----------------------------------------------------------------------------------------------------------------------
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
----
F
I
I
G
A
L
--
I
L
A
A
S
T
N
--------------------
L
A
L
---------------------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
---
S
L
---
G
S
L
N
Q
L
M
-----
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
-----
F
A
------------
D
-
I
E
G
------
W
R
W
M
L
G
L
A
V
-----
V
P
S
V
I
L
L
V
-
G
I
Y
F
M
P
E
S
P
R
W
-
L
L
E
N
R
N
E
E
A
-------
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
-----
E
L
K
E
M
K
E
I
N
A
I
S
E
S
T
W
T
V
-----
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
--
Q
-
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
-----------------
A
K
-
A
G
L
----------------
G
E
A
A
S
I
L
G
S
-----
V
G
I
G
T
I
N
V
L
V
T
------
I
V
A
I
F
V
V
D
K
I
D
R
K
---
K
L
-
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
------
I
W
T
I
G
I
A
S
S
A
----
W
I
I
I
V
C
----------------
L
S
L
F
I
V
F
F
G
-
I
S
----
W
G
P
V
L
W
V
M
L
P
E
L
F
-
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
-
I
V
S
---
L
F
F
P
I
L
S
D
A
-------
L
-------
S
T
E------
W
V
F
L
-
I
F
-------
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
-------------------
E
T
R
G
---------------------------------------------------------------------
11
PsiBlast_PDB
67.03
21%
-110
* C3 *
4J05
-
?
A:
[32-504]
----------------------------------------------------------P
Q
I
K
L
V
L
L
A
G
V
--
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
A
Q
V
Y
F
P
------
K
T
G
L
P
A
Q
R
Q
D
L
M
------
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
G
R
K
F
V
Y
G
K
E
L
I
L
----
I
I
V
A
T
I
F
Q
M
S
A
P
S
H
W
---------------
D
G
N
R
V
L
T
W
---------------------
I
T
I
C
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
R
R
G
---
T
L
---
L
C
F
I
F
A
N
-----
Q
G
W
G
S
F
V
G
S
L
V
T
I
V
---
T
I
S
G
F
K
H
RLKSGHTHD
V
-
D
K
A
------
W
R
I
L
I
G
L
S
L
-----
I
P
A
F
G
T
L
Y
-
Q
R
-----------------------------------------------------------------------------
W
Q
E
F
V
A
Y
F
S
T
W
N
H
F
R
N
-
L
L
G
S
M
L
G
W
F
L
V
D
I
A
F
Y
G
I
N
L
N
QSVV
L
A
Q
I
G
FA
G
K
-
T
G
D
----------------
V
Y
D
K
L
--
F
Q
-----
L
A
T
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
V
G
R
K
---
K
L
-
Q
F
M
G
-
F
I
M
S
G
--
L
F
L
A
I
L
------
A
G
E
I
---
D
H
I
G
K
G
P
L
L
A
C
F
------------------
T
F
M
Q
F
F
F
N
-
F
G
----
A
N
T
T
T
F
I
V
A
A
E
L
F
-
P
T
R
I
R
A
S
A
H
G
I
S
A
A
A
G
K
C
G
A
I
-
L
S
S
---
L
V
F
N
Q
L
K
A
K
-------
I
-------
G
T
-------
S
A
V
L
W
I
F
-------
F
S
T
C
I
L
G
F
I
S
T
-
F
L
I
D
-------------------
E
T
M
G
V
D
P
D
E
K
--
D
L
E
E
R
R
A
R
-----------------------------------------------------
10
PsiBlast_PDB
63.62
24%
-104
- C3 -
4GC0
4
XYLE_ECOLI
A:
[123-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--
Y
V
P
E
---------------------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
---
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
-
G
D
A
---
S
W
L
N
------------
T
-
D
G
-------
W
R
Y
M
F
A
S
E
C
-----
I
P
A
L
L
F
L
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-------
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
-----
A
V
Q
E
I
--
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
M
F
G
V
-----
G
V
I
V
I
G
V
M
L
S
I
F
--
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------------
K
T
-
L
G
A
----------------
S
T
D
I
A
L
L
Q
T
-----
I
I
V
G
V
I
N
L
T
F
T
------
V
L
A
I
M
T
V
D
K
F
G
R
K
---
P
L
-
Q
I
---
I
G
A
L
G
--
M
A
I
G
M
F
------
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
----------------
M
L
F
Y
V
A
A
F
A
-
M
S
----
W
G
P
V
C
W
V
L
L
S
E
I
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
-------
N
G
-------
F
S
Y
W
-
I
Y
-------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
-------------------
E
T
K
G
K
T
L
E
E
L
--
E
A
L
W
E
--------------------------------------------------------
8
PsiBlast_PDB
63.57
24%
-107
- C3 -
4GBY
4
XYLE_ECOLI
A:
[123-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--
Y
V
P
E
---------------------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
---
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
-
G
D
A
---
S
W
L
N
------------
T
-
D
G
-------
W
R
Y
M
F
A
S
E
C
-----
I
P
A
L
L
F
L
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-------
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
-----
A
V
Q
E
I
--
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
M
F
G
V
-----
G
V
I
V
I
G
V
M
L
S
I
F
--
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------------
K
T
-
L
G
A
----------------
S
T
D
I
A
L
L
Q
T
-----
I
I
V
G
V
I
N
L
T
F
T
------
V
L
A
I
M
T
V
D
K
F
G
R
K
---
P
L
-
Q
I
---
I
G
A
L
G
--
M
A
I
G
M
F
------
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
----------------
M
L
F
Y
V
A
A
F
A
-
M
S
----
W
G
P
V
C
W
V
L
L
S
E
I
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
-------
N
G
-------
F
S
Y
W
-
I
Y
-------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
-------------------
E
T
K
G
K
T
L
E
E
L
--
E
A
L
W
E
--------------------------------------------------------
9
PsiBlast_PDB
62.97
24%
-105
- C3 -
4GBZ
4
XYLE_ECOLI
A:
[123-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--
Y
V
P
E
---------------------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
---
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
-
G
D
A
---
S
W
L
N
------------
T
-
D
G
-------
W
R
Y
M
F
A
S
E
C
-----
I
P
A
L
L
F
L
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
-------
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
-----
A
V
Q
E
I
--
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
M
F
G
V
-----
G
V
I
V
I
G
V
M
L
S
I
F
--
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------------
K
T
-
L
G
A
----------------
S
T
D
I
A
L
L
Q
T
-----
I
I
V
G
V
I
N
L
T
F
T
------
V
L
A
I
M
T
V
D
K
F
G
R
K
---
P
L
-
Q
I
---
I
G
A
L
G
--
M
A
I
G
M
F
------
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
----------------
M
L
F
Y
V
A
A
F
A
-
M
S
----
W
G
P
V
C
W
V
L
L
S
E
I
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
-------
N
G
-------
F
S
Y
W
-
I
Y
-------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
-------------------
E
T
K
G
K
T
L
E
E
L
--
E
A
L
W
E
--------------------------------------------------------
7
PsiBlast_PDB
60.39
24%
-127
- C3 -
4JA4
-
XYLE_ECOLI
A:
[123-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--
Y
V
P
E
---------------------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
---
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
-
G
D
A
---
S
W
L
N
------------
T
-
D
G
-------
W
R
Y
M
F
A
S
E
C
-----
I
P
A
L
L
F
L
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
-----
Q
E
Q
-------
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
-----
A
V
Q
E
I
--
K
H
S
L
D
H
G
--------
M
F
G
V
-----
G
V
I
V
I
G
V
M
L
S
I
F
--
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
---------------------------------------------
L
L
Q
T
-----
I
I
V
G
V
I
N
L
T
F
T
------
V
L
A
I
M
T
V
D
K
F
G
R
K
---
P
L
-
Q
I
---
I
G
A
L
G
--
M
A
I
G
M
F
------
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
----------------
M
L
F
Y
V
A
A
F
A
-
M
S
----
W
G
P
V
C
W
V
L
L
S
E
I
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
M
D
K
N
SW-------------
N
G
-------
F
S
Y
W
-
I
Y
-------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
-------------------
E
T
K
G
K
T
L
E
E
L
--
E
A
L
W
E
--------------------------------------------------------
33
Fugue
56.64
17%
-93
- C1 -
4XVK
3
DPOLN_HUMAN
A:
[1-666]
K
K
H
F
C
D
I
R
H
L
D
D
W
A
K
S
Q
L
I
E
M
L
K
Q
A
A
------
A
L
V
I
T
V
M
Y
T
D
G
S
T
QL
G
A
D
Q
T
P
V
S
S
V
R
--
G
I
V
V
L
V
K
R
Q
A
C
G
P
V
L
E
G
F
---
V
S
D
D
P
C
I
Y
I
Q
I
E
H
S
A
I
W
D
Q
E
Q
E
A
H
Q
Q
F
A
R
N
V
L
F
Q
T
M
K
C
K
C
P
V
I
C
F
N
---
A
K
D
F
V
R
I
V
L
Q
F
F
G
N
D
G
S
W
K
H
V
A
D
F
I
G
L
D
P
R
I
A
A
W
--
L
I
D
P
S
D
A
---------------
T
P
--
S
F
E
D
---------------------
L
V
E
K
Y
C
E
K
S
I
T
V
K
V
N
-
S
T
Y
G
N
S
S
R
N
I
V
N
Q
N
V
R
E
---
N
L
---
K
T
L
Y
R
L
T
-----
M
D
L
C
S
K
L
K
D
Y
-
G
L
W
---
Q
L
F
R
------------
T
L
E
L
P
------
L
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
K
E
E
M
E
K
-
T
S
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
G
ERFLITS
N
N
Q
L
R
E
I
L
F
G
K
L
K
L
H
L
LSYPS
T
S
E
A
V
L
N
A
L
R
D
L
H
P
L
P
K
I
-
I
L
E
Y
R
Q
V
H
K
I
K
S
T
F
V
D
G
L
L
--
A
C
M
--
K
-
K
G
S
I
S
S
T
W
N
Q
T
G
T
V
T
-----------------
G
R
-
L
S
A
K
HPNIQGISK
H
P
I
Q
I
T
T
P
K
K
I
L
T
I
S
PRAM
F
V
S
S
K
G
H
T
F
L
A
A
------
D
F
S
Q
I
E
L
R
I
L
T
H
L
S
GD
P
E
-
L
L
K
L
-
D
D
V
F
S
--
T
L
T
S
Q
W
K
DVPVE
Q
V
T
H
A
D
R
E
Q
T
K
K
V
V
Y
A
V
V
Y
G
AG
K
E
R
L
A
A
C
L
GVP
I
Q
E
A
A
Q
F
L
E
S
F
L
-
Q
K
----
Y
K
K
I
K
D
F
A
R
A
A
I
A
-
Q
C
H
Q
T
G
C
V
V
S
I
M
G
R
R
R
P
L
P
R
I
-
H
A
H
D
Q
Q
L
R
A
Q
A
E
R
Q
A
-------
V
-------
N
F
-------
V
V
Q
G
-
S
A
-------
A
D
L
C
K
L
A
M
I
H
V
F
T
A
V
A
A
SHTLTARLVAQIHD
E
L
L
F
E
V
E
D
P
Q
I
P
E
C
--
A
A
L
V
R
R
T
M
E
S
L
E
Q
V
Q
A
L
E
LQLQ
V
P
L
K
V
S
L
S
A
G
R
S
W
G
H
L
VPLQ-------------------
28
Fugue
56.34
11%
-104
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-------------------------
F
K
P
A
P
H
K
A
-------
R
L
P
A
A
--
E
I
D
P
T
Y
R
R
L
R
W
--
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
----------------
V
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
---
P
R
V
F
L
P
A
G
L
I
L
A
----
A
A
V
M
L
F
--
M
G
F
V
P
W
A
---------------
T
S
--
S
I
A
V
---------------------
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
---
G
I
---
V
S
V
W
N
C
A
-----
H
N
V
G
G
G
I
-
P
P
L
L
F
L
---
L
G
M
A
------------
W
-
F
N
D
------
W
H
A
A
L
Y
M
P
A
-----
F
C
A
I
L
V
A
L
-
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
-------
K
--------
N
D
T
A
K
Q
I
-----
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
-------------------------
L
K
-----------------
E
V
-
K
H
F
----------------
A
L
D
K
S
S
W
A
Y
-----
F
L
Y
E
Y
A
G
I
P
G
T
------
L
L
C
G
W
M
S
D
K
V
F
R
G
--------
N
R
-
G
A
T
G
V
--
F
F
M
T
L
V
------
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
----------------
C
M
I
V
I
G
F
L
I
-
Y
G
----
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
-
A
A
S
---
A
I
V
G
Y
T
V
D
F
-------
F
-------
G
W
-------
D
G
G
F
-
M
V
-------
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
-------------------
I
G
E
K
R
R
H
E
Q
L
--
L
Q
E
L
V
P
-------------------------------------------------------
30
Fugue
54.58
11%
-98
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
Y
Y
L
K
N
-------------------------------------------
T
N
F
W
M
F
G
L
F
--
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
H
I
-----------------------
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
---
R
K
Y
L
L
W
I
I
T
G
M
----
L
V
M
F
A
P
--
F
F
I
F
I
F
G
---------------
P
L
--
L
Q
Y
N
---------------------
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
---
S
N
---
F
E
F
G
R
A
R
-----
M
F
G
C
V
G
W
A
L
G
A
S
I
V
---
G
I
M
F
------------
T
-
I
N
N
------
Q
F
V
F
W
L
G
S
G
-----
C
A
L
I
L
A
V
L
-
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
----------------------
H
-----
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
----------------
T
S
F
F
-----------------
A
T
-
G
E
Q
----------------
G
T
R
V
F
G
Y
V
T
-----
T
M
G
E
L
L
N
A
S
I
M
------
F
F
A
P
L
I
I
N
R
I
G
G
K
---
N
A
-
L
L
L
A
-
G
T
I
M
S
--
V
R
I
I
G
S
------
S
F
A
T
S
--------
A
L
E
V
V
I
L
----------------
K
T
L
H
M
F
E
V
P
-
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
E
-
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
---
V
L
A
G
N
M
Y
E
S
-------
I
G------
F
Q
-------
G
A
Y
L
-
V
L
-------
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
-------------------
G
P
G
P
L
S
L
L
R
R
--
Q
V
N
E
V
A
-------------------------------------------------------
34
Fugue
53.26
10%
-106
- C2 -
4GMO
-
?
A:
[25-675]
--
D
P
E
L
-
A
K
L
R
E
D
K
I
L
P
V
L
K
D
L
K
S
P
D
A
K
S
R
T
T
A
A
G
A
I
A
N
I
---
V
Q
--
D
A
K
C
R
K
L
L
L
R
E
--
Q
V
V
H
I
V
L
T
----
E
T
L
T
D
N
N
I
D
S
R
A
A
G
W
E
I
L
K
V
L
A
Q
E
E
-----------
E
A
D
F
C
V
H
L
Y
R
L
D
V
-
L
T
A
I
E
H
A
A
K
A
V
L
E
T
L
T
T
S
E
P
P
F
S
K
L
L
K
A
Q
Q
R
L
----
V
W
D
I
T
G
--
S
L
L
V
L
I
G
---------------
L
L
--
A
L
A
R
---------------------
D
E
I
H
E
A
V
A
T
K
Q
T
I
L
R
L
L
F
R
L
I
S
A
D
I
A
P
Q
D
I
Y
E
E
---
A
I
---
S
C
L
T
T
L
S
EDN
L
K
V
G
Q
A
I
T
D
D
Q
E
T
H
V
Y
---
D
V
L
L
------------
K
-
L
A
T
------
G
T
D
P
R
A
V
M
A
-----
C
G
V
L
H
N
V
F
-
T
S
L
Q
W
M
D
H
S
P
--
G
K
D
G
A
C
D
A
I
-------
L
I
P
T
L
T
R
A
L
E
H
V
V
P
G
G
-----
A
K
F
N
G
D
A
R
Y
A
N
I
T
L
L
A
L
V
T
L
A
S
I
G
T
D
F
Q
E
T
L
V
K
L
E
D
L
P
T
L
R
E
L
--
I
-
Q
T
A
V
P
Q
L
I
R
L
S
N
L
----------------------
P
I
D
----------------
S
D
E
S
L
T
I
Q
S
-----
H
A
L
S
A
L
N
N
I
S
W
------
T
I
S
C
L
E
F
A
N
G
E
N
A
---
N
I
-
H
N
A
W
-
Y
P
T
A
K
--
K
I
W
R
K
T
------
I
L
P
I
L
E
A
D
S
A
D
L
K
L
A
T
Q
V
T
S
----------------
L
A
W
A
V
A
R
V
L
-
H
G
ETPT
D
G
N
P
H
R
K
F
I
S
L
Y
H
-
S
S
K
Q
Q
P
F
Q
G
L
G
V
K
C
I
G
V
V
G
S
L
-
A
H
D
---
P
A
P
I
E
V
N
R
E
-------
V
-------
G
V
-------
F
L
V
T
-
L
L
R
Q
SNNVP
P
A
E
I
V
E
A
L
N
Q
L
F
D
I
Y
G
-------------------
D
E
E
L
A
C
D
K
E
V
FW
K
D
G
F
L
K
H
L
E
E
F
L
P
K
M
R
T
L
--------
T
K
G
I
D
K
R
T
Q
P
E
L
R
T
R
A
D
E
A
L
L
N
L
G
R
F
V
Q
Y
K
K
K
H
AP
15
HHSearch
50.39
14%
-118
- C3 -
1PW4
-
GLPT_ECOLI
A:
[65-448]
--------------------------------------------------------------------------------------------------------------------
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
----
A
A
A
V
M
L
--
F
M
G
F
V
P
W
A
--------------
T
S
--
S
I
A
V
---------------------
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
---
G
I
---
V
S
V
W
N
C
A
-----
H
N
V
G
G
G
I
P
P
L
L
F
L
L
---
G
-
M
A
------------
W
-
F
N
D
------
W
H
A
A
L
Y
M
P
A
-----
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
--
P
P
I
E
E
-------
Y
K
N
---------
D
---------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
----
Y
I
A
I
A
N
V
F
V
--
Y
-
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
-----------------
K
E
V
K
H
F
----------------
A
L
D
K
S
S
W
A
Y
-----
F
L
Y
E
Y
A
G
I
P
G
T
------
L
L
C
G
W
M
S
D
K
V
F
R
G
---
N
R
-
G
A
T
G
-
V
F
F
M
T
--
L
V
T
I
A
T
------
I
V
Y
W
M
N
P
A
G
N
P
T
---
V
D
M
I
C
------------------
M
I
V
I
G
F
L
I
Y
G
----
P
V
M
L
I
G
L
H
A
L
E
L
A
-
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
---
A
I
V
G
Y
T
V
D
F
-------
F
-------
G
W
D
------
G
G
F
M
-
V
M
-------
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
-------------------
G
E
K
R
R
H
E
Q
L
L
--
Q
E
L
V
P
--------------------------------------------------------