@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LAT2_HUMAN: (2015-12-08 )
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.-.......80..-----......90----........100........110....--..-.120-----..--.......130.......140.--......150.......160.-......170........180.......-190-.......200.......210...-------...--.220---.....-..--230-.....--.-..-.240.......250.......-----260.......270.......280......---.290...---------------..--..-300.......310----...---..-...-.320......---.330.......340.......350..-------....----.360..----.....370.......----380.---.-------.......390......-..400.......--------410.......420------.........430.......440.--------......450.......460......---------------.470.......480.......490......-.500.......510.......520.......530...------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEEGARHRNNTEKKHPGGGESDASPEAGSGGG
G
V
A
L
K
KEIG
L
V
S
A
C
G
I
I
V
G
N
I
IGS
G
I
F
VS
P
K
G
V
LENAGS
V
-
G
L
A
L
I
V
W
I
V
T
G
-----
F
I
T
V
V
G
A
L
----
C
Y
A
E
LG
V
T
IP-KSGG
D
Y
S
Y
V
K
D
I
F
G
G
--
L
A
-
G
F
-------
L
R
--
L
W
I
A
V
L
V
I
YPTN
Q
A
V
I
A
L
T
FS--N
Y
V
L
QPLFPTCFP
P
E
S
G
L
R
L
-
L
A
A
I
C
L
L
-
L
L
T
WVNCSSV
R
W
A
T
R
V
Q
D
I
-
F
T
A
-
G
K
L
L
A
L
A
L
I
I
I
M
G
I
V
Q
ICKG
E
Y
F
-------
W
LE--
P
K
N
A
---FENFQ-EP--
D
---
I
G
L
V
A
--
L
-
A
F
-
L
QGSFAYG
G
W
N
F
L
N
Y
V
T
E
E
L
V
-----
D
P
Y
KNLP
R
A
I
F
I
S
I
P
L
V
T
F
V
Y
V
F
A
N
V
A
Y
V
---TAM
S
P
Q
E
---------------
L
L
--AS-N
A
V
A
V
T
F
G
E
K
L
------
L
G
V
---
M
A
-
W
I
M
-
P
I
S
V
A
L
S
TFG---GVNG
S
L
F
TSS
R
L
F
F
AGAREG
H
L
P
S
V
L
-------
A
M
I
H
----VKRCTP----
I
P
A
L
L
F
T
C
I
S
T
L
L
M
L
----
V
--
T
---
S
-------
D
M
Y
T
L
I
N
Y
-
V
G
F
I
N
Y
L
-
F
Y
G
V
T
V
A
G
Q
I
V
L
--------
R
WKKPDIPR
P
I
--------
K
I
N
L
L
F
P
I
I
Y
L
L
F
W
A
F
L
L
V
F
S
LW--------SEP
V
V
C
G
I
G
L
A
I
M
LTGVP
V
Y
F
L
G
V
Y---------------WQHK
P
K
C
F
S
D
F
I
E
L
L
T
L
V
SQK
M
C
V
V
V
Y
PEV-ERGSGT
E
E
A
N
E
D
M
E
E
Q
QQPMYQPTPTKDKDVAGQPQP------------------------------------------------------------
16
Fugue
83.33
19%
-131
- C2 -
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
---
R
N
L
P
E
T
F
I
L
S
G
-----
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
--
N
I
-
I
T
-------
G
A
--
L
S
I
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
--
G
Y
F
L
P
L
I
N
A
P
--
I
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
-
I
V
L
-
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
S
Y
V
--------------
I
P
D
---
L
A
P
S
A
-
V
S
--
G
---
M
I
F
A
S
--
A
-
I
F
-
F
---
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
L
P
I
D
E
---------------
L
I
K
A
S
E
-
N
A
L
A
V
A
A
K
P
F
L
------
G
N
L
---
G
F
-
L
L
I
-
S
I
G
A
L
F
S
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
-------
E
R
K
V
----
W
F
K
S
T
E
----
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
----
F
--
N
---
M
-------
E
G
V
A
S
I
T
S
-
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
Y
I
L
-------------
I
D
E
V
G
G
R
K
--------
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
--------
T
----------------------------------------------
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
-
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------
18
Fugue
80.23
14%
-120
- C2 -
4DJK
-
GADC_ECOLI
A:
[12-501]
---------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
V
Y
E
Y
P
T
F
A
T
S
G
----------------
F
-
S
L
V
F
F
L
L
L
G
G
I
-----
L
W
F
I
P
V
G
L
----
C
A
A
E
M
A
T
--
V
-
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
--
R
W
-
G
F
-------
A
A
--
I
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
--
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
T
K
T
I
-
A
A
L
I
I
L
W
-
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
-
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
T
F
F
P
D
-------
F
S
K
--
V
G
T
L
------------------------
V
-
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
-----
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
---
M
V
I
P
G
N
E
---------------
I
N
--
L
S
-
A
G
V
M
Q
T
F
T
V
L
M
SHVAPE
I
E
W
---
T
V
-
R
V
I
-
S
A
L
L
L
L
G
V
L
A
---
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
-------
A
K
M
N
KN
G
V
P
V
T
L
V
I
----
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
TGGG
N
--
N
---
M
-------
S
F
L
I
A
L
A
L
-
T
V
V
I
Y
L
C
-
A
Y
F
M
L
F
I
G
Y
I
V
L
--------
V
L
K
H
P
D
L
K
R
T
F
--------
N
I
P
-----------
G
G
K
G
V
K
L
V
V
--------
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
------------------
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
----------------------------
V
H
F
F
L
H
P
R
A
R
S
P
------------------------------------------------------------
10
HHSearch
77.87
20%
-114
- C2 -
3GIA
6
Y609_METJA
A:
[3-370]
----------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
---
N
L
P
E
T
F
I
L
S
G
-----
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
--
N
I
I
T
G
-------
A
L
--
S
I
L
L
W
M
S
-
Y
V
I
S
I
A
L
F
A
K
G
F
A
--
G
Y
F
L
P
L
I
N
A
P
I
--
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
-
I
V
L
-
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
-----------------
S
Y
V
---
I
P
D
L
A
-
P
S
--
A
---
V
S
G
M
I
--
F
-
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
L
P
I
D
E
---------------
L
I
--
K
A
S
E
N
A
L
A
V
A
A
K
P
F
------
L
G
N
L
--
G
F
-
L
L
I
-
S
I
G
A
L
F
S
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
-------
E
R
K
V
-----
W
F
K
S
T
-----
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
----
L
--
L
---
F
-------
N
M
E
G
V
A
S
I
-
T
S
A
V
F
M
V
-
I
Y
L
F
V
I
L
S
H
Y
I
L
--------
I
D
E
V
G
G
R
K
E
I
V
--------
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
--------
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
---------------
R
T
F
S
N
N
M
Y
V
K
S
---------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.91
24%
-125
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-332]
------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
-
G
I
A
I
Y
G
W
L
V
T
---------
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
-------
Q
T
--
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
----
Y
L
S
Y
F
F
P
I
L
K
D
P
W
V
-
L
T
I
-
T
C
V
V
V
L
W
-
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
-
A
T
------
V
L
A
L
I
P
I
V
G
I
A
V
F
---
G
W
F
-------
W
F
R
--
G
E
T
Y
---
M
A
----------------------
A
-
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
-
I
---
M
G
M
I
P
N
A
---------------
A
L
--
R
V
-
S
A
S
P
F
G
D
A
A
R
M
A
-----
L
G
D
---
T
A
G
A
I
V
-
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
-------
A
R
V
N
-----
K
A
G
T
P
----
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
----
L
--
S
---
S
-------
I
S
P
N
A
T
K
E
-
F
G
L
V
S
S
V
-
S
V
I
F
T
L
V
P
Y
L
Y
T
--------
C
A
A
L
L
L
L
G
H
G
H
--------
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
--------
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
---------------
Y
N
R
L
H
K
N
P
Y
P
L
D
A
-------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.78
24%
-127
- C2 -
3LRC
-
ADIC_ECO57
A:
[6-332]
-----------------------------------
D
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
-
G
I
A
I
Y
G
W
L
V
T
---------
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
-------
Q
T
--
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
----
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
-
L
T
I
-
T
C
V
V
V
L
W
-
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
-
A
T
------
V
L
A
L
I
P
I
V
G
I
A
V
F
---
G
W
F
-------
W
F
R
--
G
E
T
Y
---
M
A
A
W
N
-
V
S
--
G
---
L
G
--
T
--
F
-
G
A
-
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
-
I
---
M
G
M
I
P
N
----------------------------------------------
T
A
G
A
I
V
-
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
-------
A
R
V
N
-----
K
A
G
T
P
----
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
----
L
--
S
---
S
-------
I
S
P
N
A
T
K
E
-
F
G
L
V
S
S
V
-
S
V
I
F
T
L
V
P
Y
L
Y
T
--------
C
A
A
L
L
L
L
G
H
G
H
--------
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
--------
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
---------------
Y
N
R
L
H
K
N
P
------------------------------------------------------------------------------------------------------------------------
11
HHSearch
76.74
19%
-118
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-386]
------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
-
G
G
---
I
A
I
Y
G
W
L
V
T
I
-----
I
G
A
L
G
L
S
M
----
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
-------
Q
T
--
N
V
L
Y
W
L
A
-
C
W
I
G
N
I
A
M
V
V
I
G
V
--
G
Y
L
S
Y
F
F
P
I
L
K
--
D
P
W
V
L
T
I
-
T
C
V
V
V
L
W
-
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
-
A
T
V
-
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
--------------
Y
M
A
--------------------
A
I
Q
--
S
-
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
-----
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
---
G
M
I
P
N
A
A
---------------
L
R
--
V
S
-
A
S
P
F
G
D
A
A
R
M
A
------
L
G
D
T--
A
G
-
A
I
V
-
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
-------
A
R
V
N
-----
K
A
G
T
P
----
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
----
L
--
S
---
S
ISPNATK
E
F
G
L
V
S
S
V
-
S
V
I
F
T
L
V
-
P
Y
L
Y
T
C
A
A
L
L
L
L
--------
G
H
G
H
F
G
K
A
R
P
A
--------
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
--------
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
---------------
P
Y
P
L
D
A
--------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.38
24%
-124
- C2 -
3OB6
1
ADIC_ECOLI
A:
[5-332]
----------------------------------
A
D
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
-
G
I
A
I
Y
G
W
L
V
T
---------
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
--
C
W
I
G
A
I
A
M
-----
V
V
I
G
V
G
Y
L
--
S
Y
----
F
F
P
I
L
K
D
P
L
V
-
L
T
I
-
T
C
V
V
V
L
W
-
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
-
A
T
------
V
L
A
L
I
P
I
V
G
I
A
V
F
---
G
W
F
-------
W
F
R
--
G
E
T
Y
---
M
A
A
W
N
-
V
S
--
G
---
L
G
--
T
--
F
-
G
A
-
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
-
I
---
M
G
M
I
P
N
A
---------------
A
L
--
R
V
-
S
A
S
P
F
G
D
A
A
R
M
A
-----
L
G
D
---
T
A
G
A
I
V
-
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
-------
A
R
V
N
-----
K
A
G
T
P
----
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
----
L
--
S
---
S
-------
I
S
P
G
L
V
S
S
-
V
S
V
I
F
T
L
-
V
P
Y
L
Y
T
C
A
A
L
L
L
--------
L
G
H
G
H
F
G
K
A
R
P
--------
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
--------
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
---------------
N
P
Y
P
L
D
A
-------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.12
22%
-132
- C2 -
4DJI
-
GADC_ECOLI
A:
[39-405]
-------------------------------------------------------------------------
G
F
S
L
V
F
F
L
L
L
G
G
I
LW-
F
I
P
V
--
G
L
----
C
A
A
E
M
A
T
V
D
G
W
E
E
G
G
V
F
A
W
V
S
N
T
L
G
P
--
R
W
-
G
F
-------
A
A
--
I
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
--
W
P
A
L
N
E
D
P
I
T
K
T
I
-
A
A
L
I
I
L
W
-
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
-
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
S
G
----------
A
I
E
MD
S
K
T
F
---
F
P
D
F
S
-
K
V
--
G
---
T
L
V
V
F
--
V
-
A
F
-
I
---
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
-----
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
---
M
V
I
P
G
N
E
---------------
I
N
--
L
S
-
A
G
V
M
Q
T
F
T
V
L
M
------
S
H
V
APE
I
E
-
W
T
V
-
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
-------
A
K
M
N
-----
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
----
N
--
T
GGG
N
-------
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
--------
V
L
K
H
P
D
L
K
R
T
F
--------
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
--------
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
---------------
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
V
T
L
E
P
I
N
S
Q
-
N
A
P
K
G
H
F
F
L
H
P
R
A
R
S
P
H
Y
I
V
M
N
D
K
-------------------------------------------------------------------------
2
PsiBlast_PDB
75.50
24%
-124
- C2 -
3LRB
-
ADIC_ECO57
A:
[6-332]
-----------------------------------
D
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
-
G
I
A
I
Y
G
W
L
V
T
---------
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
-------
Q
T
--
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
----
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
-
L
T
I
-
T
C
V
V
V
L
W
-
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
-
A
T
------
V
L
A
L
I
P
I
V
G
I
A
V
F
---
G
W
F
-------
W
F
R
--
G
E
T
Y
---
M
A
A
W
N
-
V
S
--
G
---
L
G
--
T
--
F
-
G
A
-
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
-
I
---
M
G
M
I
P
N
----------------------------------------------
T
A
G
A
I
V
-
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
-------
A
R
V
N
-----
K
A
G
T
P
----
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
----
L
--
S
---
S
-------
I
S
P
N
A
T
K
E
-
F
G
L
V
S
S
V
-
S
V
I
F
T
L
V
P
Y
L
Y
T
--------
C
A
A
L
L
L
L
G
H
G
H
--------
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
--------
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
---------------
Y
N
R
L
H
K
N
P
------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.41
22%
-130
- C2 -
4DJK
-
GADC_ECOLI
A:
[39-405]
-------------------------------------------------------------------------
G
F
S
L
V
F
F
L
L
L
G
G
ILW-
F
I
P
V
--
G
L
----
C
A
A
E
M
A
T
V
D
G
W---
G
V
F
A
W
V
S
N
T
L
G
P
--
R
W
-
G
F
-------
A
A
--
I
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
--
W
P
A
L
N
E
D
P
I
T
K
T
I
-
A
A
L
I
I
L
W
-
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
-
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
-------------------
T
F
---
F
P
D
F
S
-
K
V
--
G
---
T
L
V
V
F
--
V
-
A
F
-
I
---
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
-----
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
---
M
V
I
P
G
N
E
---------------
I
N
--
L
S
-
A
G
V
M
Q
T
F
T
V
L
M
------
S
H
V
APE
I
E
-
W
T
V
-
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
-------
A
K
M
N
-----
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
----
N
--
T
GGG
N
-------
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
--------
V
L
K
H
P
D
L
K
R
T
F
--------
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
--------
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
---------------
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.70
25%
-108
- C2 -
3GIA
5
Y609_METJA
A:
[5-309]
------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
-
T
F
I
L
S
G
-----
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
-
G
A
-------
L
S
I
L
L
W
M
S
----
Y
V
I
S
I
A
L
F
A
K
G
F
A
--
G
Y
F
L
----
P
L
I
N
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
-
I
V
L
-
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
---------------
H
--
P
S
Y
V
---
I
P
D
L
A
-
P
S
--
A
---
V
S
G
M
I
--
F
-
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
L
P
I
D
E
---------------
L
I
K
A
S
E
-
N
A
L
A
V
A
-
A
K
P
F
------
L
G
N
---
L
G
-
F
L
L
I
S
I
G
A
L
F
S
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
-------
E
R
K
V
----
W
F
K
S
T
E
----
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
----
F
--
N
---
M
-------
E
G
V
A
S
I
T
S
-
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
Y
I
L
I
D
--------
E
V
G
G
R
K
E
I
V
I
F
--------
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
--------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
---------------
F
S
N
N
M
Y
V
K
S
-----------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.29
25%
-106
- C2 -
3GI9
-
Y609_METJA
C:
[5-309]
------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
-
T
F
I
L
S
G
-----
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
-
G
A
-------
L
S
I
L
L
W
M
S
----
Y
V
I
S
I
A
L
F
A
K
G
F
A
--
G
Y
F
L
----
P
L
I
-
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
-
I
V
L
-
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
---------------
H
--
P
S
Y
V
---
I
P
D
L
A
-
P
S
--
A
---
V
S
G
M
I
--
F
-
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
L
P
I
D
E
---------------
L
I
K
A
S
E
-
N
A
L
A
V
A
-
A
K
P
F
------
L
G
N
---
L
G
-
F
L
L
I
S
I
G
A
L
F
S
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
-------
E
R
K
V
----
W
F
K
S
T
E
----
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
----
F
--
N
---
M
-------
E
G
V
A
S
I
T
S
-
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
Y
I
L
I
D
--------
E
V
G
G
R
K
E
I
V
I
F
--------
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
--------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
---------------
F
S
N
N
M
Y
V
K
S
L
E
S
--------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.38
25%
-105
- C2 -
3GI8
-
Y609_METJA
C:
[5-309]
------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
-
T
F
I
L
S
G
-----
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
NI
I
T
-
G
A
-------
L
S
IL
L
W
M
S
----
Y
V
I
S
I
A
L
F
A
K
G
F
A
--
G
Y
F
L
----
P
L
I
N
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
-
I
V
L
-
V
A
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
---------------
H
--
P
S
Y
V
---
I
P
D
L
A
-
P
S
--
A
---
V
S
G
M
I
--
F
-
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
---
G
N
L
P
I
D
E
---------------
L
I
KA
S
E
-
N
A
L
A
V
A
-
A
K
P
F
------
L
G
N
---
L
G
-
F
L
L
I
S
I
G
A
L
F
S
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
-------
E
R
K
V
----
W
F
K
S
T
E
----
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
----
F
--
N
---
M
-------
E
G
V
A
S
I
T
S
-
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
Y
I
L
I
D
--------
E
V
G
G
R
K
E
I
V
I
F
--------
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
--------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
---------------
F
S
N
N
M
Y
V
K
S
-----------------------------------------------------------------------------------------------------------------------
23
Fugue
55.33
12%
-118
- C2 -
3RKO
4
?
B:
[1-612]
-----
M
N
M
L
A
L
T
I
I
L
P
L
I
G
F
V
L
L
A
F
S
R
G
R
W
S
E
N
V
S
A
I
V
G
V
G
S
V
G
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
-------
N
G
E
Q
T
Y
-
S
Q
P
L
W
T
W
M
S
V
G
D
F
N
I
G
F
N
L
V
L
D
G
L
----
S
L
T
M
L
S
V
V
T
G
-
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
--
E
E
-
G
Y
-------
S
R
--
F
F
A
Y
T
N
L
F
I
---
A
S
M
V
V
L
V
L
A
--
D
N
L
L
L
M
Y
L
--------
G
W
E
G
-
V
G
L
C
S
Y
L
-
L
I
G
F
Y
Y
-
T
D
P
K
N
G
A
A
A
M
K
A
-
F
V
V
-
T
R
V
G
D
V
F
L
A
F
A
L
F
I
L
Y
N
E
L
G
T
L
N
-------
F
R
E
--
M
V
E
L
---
A
P
A
H
F
-
A
D
--
G
NN
M
L
M
W
A
T
--
L
-
M
L
-
L
G
G
A
V
G
K
S
A
Q
L
P
L
Q
T
---------------
W
L
A
D
A
M
A
G
P
T
P
V
S
A
L
I
H
A
-----
A
T
---
M
V
T
A
G
V
Y
---------------
L
I
--
A
R
-
T
H
G
L
F
L
M
T
P
E
V
------
L
H
L
---
V
G
-
I
V
G
-
A
V
T
L
L
L
A
G
F
A
---
A
L
V
Q
T
D
I
K
R
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
QA
W
D
A
A
I
F
H
----
L
M
T
H
A
F
----
F
K
A
L
L
F
L
A
S
G
S
V
I
L
A
----
C
H
H
E
---
Q
-------
N
I
F
K
M
G
G
L
-
R
K
S
I
P
L
V
-
Y
L
C
F
L
V
G
G
A
A
L
S
ALPLVT
A
G
F
F
S
K
D
E
I
L
A
G
A
M
A
N
GH
I
N
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
HGKEQIH
A
H
A
V
K
G
V
T
H
S
L
P
L
I
V
L
L
I
L
S
T
F
V
G
A
L
IVPPLQGVLPQTTEL
A
H
G
S
M
L
T
L
E
I
T
S
G
V
V
A
V
V
G
I
L
L
A
A
W
L
W
L
G
K
-
R
T
L
V
T
S
I
A
N
S
A
P
G
R
L
L
S
T
W
W
Y
N
A
W
G
F
D
W
L
Y
D
K
V
F
V
K
P
F
L
G
I
A
W
L
L
KRD
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
L
L
LSENGY
L
R
W
Y
V
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
12
HHSearch
34.89
9%
-89
- C2 -
3DH4
1
?
A:
[53-355]
------------------------------------
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
---
I
A
S
Y
E
W
M
S
A
-----
I
T
L
I
I
V
G
K
----
Y
F
L
P
I
F
I
E
K
--
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
--
K
L
-
K
T
-------
I
L
--
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
--
L
A
L
E
T
I
L
G
-
I
-----
P
L
M
Y
S
-
I
L
G
L
A
L
F
-
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
-
Q
V
F
-
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
--
A
P
G
H
FEM
I
L
D
Q
S
N
P
Q
YM
N
---
L
P
G
I
A
VL
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
-----
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLPS
A
A
--
N
A
-
D
K
A
Y
P
W
L
T
-
Q
F
------
L
P
V
G--
V
K
-
G
V
V
-
F
A
A
L
A
A
A
I
V
S
---
S
L
A
S
M
L
N
S
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
-------
P
D
S
G
----
D
H
K
L
V
N
----
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
----
I
--
A
---
P
-------
M
L
G
G
I
G
Q
A
-
F
Q
Y
I
Q
E
Y
-
T
G
L
V
S
P
G
I
L
A
V
F
--------
L
L
G
L
F
W
K
K
T
T
S
--------
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
--------
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
---------------
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
-
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
---------------------------------------------------------------------------------
25
Fugue
32.33
19%
229
- C2 -
2K6I
-
Y223_METJA
A:
[1-47]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
V
S
V
M
E
A
I
K
E
V
K
L
A
E
E
Q
A
V
K
E
I
E
E
A
K
N
R
A
E
Q
I
K
A
E
A
I
E
E
A
K
K
L
I
A
C
------------------------------------------------------------
21
Fugue
30.63
14%
327
- C2 -
1Y03
-
ANP3_MYOSC
A:
[1-35]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
N
A
P
A
R
A
A
A
K
T
A
A
D
A
L
A
A
A
K
K
T
A
A
D
A
A
A
A
A
A
A
A
------------------------------------------------------------
19
Fugue
27.68
26%
429
- C2 -
4MQV
-
SMAL1_HUMAN
B:
[1-26]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
K
K
I
E
E
N
R
Q
K
A
L
A
R
R
A
E
K
L
L
A
-------------------------------------------------------------------
22
Fugue
26.66
17%
243
- C2 -
3G43
-
F:
[4-48]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
T
L
F
A
L
V
R
T
A
L
R
I
-
K
T
E
G
N
L
E
Q
A
N
E
E
L
R
A
I
I
K
K
I
W
K
R
T
S
M
K
L
L
D
Q
------------------------------------------------------------------
14
HHSearch
26.01
9%
-96
- C2 -
2JLN
-
?
A:
[21-180]
---------------------------------
R
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
M
-
T
-
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
-----
T
I
A
V
I
L
L
F
----
F
T
Q
S
A
A
I
R
W
G
---
I
N
F
T
V
A
A
R
M
P
F
G
I
--
R
G
-
S
L
-------
I
P
--
I
T
L
K
A
L
-
L
S
L
F
W
F
G
F
Q
T
W
L
G
A
--
L
A
L
D
E
I
T
R
L
L
--
T
G
F
T
N
L
P
L
-
W
I
V
I
F
G
A
-
I
Q
V
V
T
T
F
Y
G
I
T
F
I
R
W
M
N
V
F
-
A
S
P
-
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
-------
V
M
S
--
M
G
G
E
---
N
P
G
M
P
-
F
S
--
T
---
A
I
M
I
F
--
V
-
G
G
-
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
V
D
P
N
A
-----
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
---
I
G
A
A
S
M
V
---------------
L
V
--
G
E
-
W
N
P
V
I
A
I
T
E
V
V
------
G
G
V
---
S
I
-
P
M
A
-
I
L
F
Q
V
F
V
L
L
A
---
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
-------
F
K
T
G
----
V
I
V
S
A
V
----
V
G
L
L
M
M
P
W
Q
F
A
G
V
L
N
----
T
--
F
---
L
-------
N
L
L
A
S
A
L
G
-
P
L
A
G
I
M
I
-
S
D
Y
F
L
V
R
R
R
R
I
S
--------
L
H
D
L
Y
R
T
K
G
I
Y
--------
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
--------
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
---------------
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
----------------------------------------------------------------------------------------------------------