@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MFTC_HUMAN: (2015-12-08 )
MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLLDLREKRK
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------.........10......-------..20........30......-----..40-....-....50---.---....----.------.---.60.-...-----...------.70....--------.....80........90...-------....-.100----........----110.----..----.-...120..----......-----130-----....---------...140.......150.....------.-------.160.-......170......------.-180..-------.....190-.--------..-.....200..---...---..210......-.220......-.230-----.......240--------------------..-..-..---..250---.------..------.-.------..260.-......270.......280...--....290------------..-----------.-...-----..300.......310...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------MTGQGQSASG
S
S
A
W
S
T
V
-------
F
R
H
V
R
Y
E
N
L
I
A
GVSG
G
V
L
S
N-----LALH-P
L
D
L
-
V
K
I
R
F
A
---V---SDG
L
----
E
------L---RPKY-
N
G
I
-----
L
H
C
------
L
T
-
T
I
W
K
--------
L
D
G
L
R
G
L
Y
QGVTPNIWG
A
G
L
-------
S
W
G
L
-
Y
F
F
-----
F
Y
N
A
I
K
S
Y----KTEG----
R
A
----
E
-
R
L
E
A
-
T
E
Y
----
L
V
S
A
AE-----AG
A
-----
M
T
L
C
---------ITNP
L
W
V
T
K
T
R
L
M
L
Q
Y
D
A
VVN------S-------
P
H
R
Q
Y
-
K
G
M
F
D
T
L
V
K
I
Y
KYE
G
------
V
-
R
G
L
Y
K
-------
G
FVPGLF--G--------TS-
H
G
A
L
Q
F
M
A
Y
E
---
L
L
K
---
L
K
Y
N
Q
H
I
N
RLP-EAQL
S
T
V
E
Y
I
-
S
V
A
A
-----
L
S
K
I
F
A
V
AA---------------------TY-
P
Y
-
Q
V
---
V
R
A
R
L
---Q------DQ------
H
-
M
------
F
Y
S
G
V
I
-
D
V
I
T
K
T
W
R
KEGVG
G
F
Y
KGIAP
N
--
L
I
R
V
T
P
-------------
A
C
-----------
C
-
I
T
F
-----
V
V
Y
E
N
V
S
H
F
L
L
D
L
R
E
KRK---
16
HHSearch
86.61
26%
-72
- C3 -
1OKC
10
ADT1_BOVIN
A:
[3-293]
------------------------------------------------------------------------------------------------------------
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
-----
T
A
V
A
-
P
I
E
R
-
V
K
L
L
L
Q
---
V
---
Q
H
A
S
----
K
------
Q
ISA
E
K
Q
Y
-
K
G
I
-----
I
D
C
------
V
V
-
R
I
P
K
--------
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
Y
K
Q
I
----
F
L
G
G
----
V
D
RHKQ
F
-
W
R
Y
F
-
A
G
N
----
L
A
S
G
G
A
-----
A
G
A
-----
T
S
L
C
---------
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
A
---------------
A
Q
R
E
F
-
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
------
L
-
R
G
L
Y
Q
-------
G
F
N
V
S
V
Q
--
G
I
-------
I
I
-
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
---
G
M
L
P
D
P
K
-------
N
V
H
I
I
V
S
W
-
M
I
A
Q
-----
T
V
T
A
V
A
G
L
V
---------------------
S
Y
-
P
F
-
D
T
---
V
R
R
R
M
---
M
------
M
Q
------
S
-
G
RKGADI
M
Y
T
G
T
V
-
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
--
V
L
R
G
M
G
--------------
G
-----------
A
-
F
V
L
-----
V
L
Y
D
E
I
---------------
25
Fugue
85.91
25%
-75
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
----------------------------------------------------------------------------------------------------
D
-------
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
-----
T
A
V
A
-
P
I
E
R
-
V
K
L
L
L
Q
---
V
---
Q
H
A
S
----
K
QIS---
A
---
E
K
Q
Y
-
K
G
I
-----
I
D
C
------
V
V
-
R
I
P
K
--------
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
Y
K
Q
I
----
F
L
G
G
VDRH
K
Q
----
F
-
W
R
Y
F
-
A
G
N
----
L
A
S
G
G
A
-----
A
G
A
-----
T
S
L
C
---------
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
--
G
------
A
-------
A
Q
R
E
F
-
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
------
L
-
R
G
L
Y
Q
-------
G
F
N
V
S
V
Q
--
G
I
-------
I
I
-
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
---
G
M
L
P
D
P
-------
K
N
V
H
I
I
V
S
W
-
M
I
A
Q
-----
T
V
T
A
V
A
G
L
V
---------------------
S
Y
-
P
F
-
D
T
---
V
R
R
R
M
---
M
M
Q
SGRK
G
A
------
D
-
I
------
M
Y
T
G
T
V
-
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
--
V
L
R
G
M
G
-------------
G
A
-------------
F
V
L
-----
V
L
Y
D
E
I
---------------
4
PsiBlast_PDB
85.75
26%
-76
- C3 -
2C3E
4
ADT1_BOVIN
A:
[9-293]
------------------------------------------------------------------------------------------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
-----
T
A
V
A
-
P
I
E
R
-
V
K
L
L
L
Q
---
V
QHA
S
K
Q
I
----
S
------
A
---
E
K
Q
Y
-
K
G
I
-----
I
D
C
------
V
V
-
R
I
P
K
--------
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
Y
K
Q
I
----
F
L
G
G
----
V
D
----
R
-
H
K
Q
F
-
W
R
Y
F
A
G
N
L
A
S
G
G
A
-----
A
G
A
-----
T
S
L
C
---------
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
--
D
V
G
K
G
------
A
-------
A
Q
R
E
F
-
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
------
L
-
R
G
L
Y
Q
-------
G
F
N
V
S
V
Q
--
G
--------
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
----------
G
M
L
P
-
D
P
K
N
V
H
I
-
I
V
-
S
W
M
I
-----
A
Q
T
V
T
A
V
A
G
L
V
-------------------
S
Y
-
P
F
-
D
T
---
V
R
R
R
M
---
M
------
M
Q
SGRKGA
D
-
I
------
M
Y
T
G
T
V
-
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
--
V
L
R
G
M
G
-------------
G
A
-----------
F
-
V
-
L
-----
V
L
Y
D
E
I
---------------
3
PsiBlast_PDB
85.06
26%
-76
- C3 -
1OKC
10
ADT1_BOVIN
A:
[9-293]
------------------------------------------------------------------------------------------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
-----
T
A
V
A
-
P
I
E
R
-
V
K
L
L
L
Q
---
V
QHA
S
K
Q
I
----
S
------
A
---
E
K
Q
Y
-
K
G
I
-----
I
D
C
------
V
V
-
R
I
P
K
--------
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
Y
K
Q
I
----
F
L
G
G
----
V
D
----
R
-
H
K
Q
F
-
W
R
Y
F
A
G
N
L
A
S
G
G
A
-----
A
G
A
-----
T
S
L
C
---------
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
--
D
V
G
K
G
------
A
-------
A
Q
R
E
F
-
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
------
L
-
R
G
L
Y
Q
-------
G
F
N
V
S
V
Q
--
G
--------
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
----------
G
M
L
P
-
D
P
K
N
V
H
I
-
I
V
-
S
W
M
I
-----
A
Q
T
V
T
A
V
A
G
L
V
-------------------
S
Y
-
P
F
-
D
T
---
V
R
R
R
M
---
M
------
M
Q
SGRKGA
D
-
I
------
M
Y
T
G
T
V
-
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
--
V
L
R
G
M
G
-------------
G
A
-----------
F
-
V
-
L
-----
V
L
Y
D
E
I
---------------
27
Fugue
83.69
18%
-100
- C2 -
4QIK
2
RC3H1_HUMAN
A:
[4-313]
--------------------------------------------------------------------------------------
G
V
E
D
T
K
H
Y
E
E
A
K
K
C
V
-------
E
E
L
A
L
Y
L
K
P
L
S
S
A
R
G
V
G
L
N
S
TTQSV
L
S
R
P
M
Q
R
K
L
-
V
T
L
V
H
C
---
Q
---
L
V
E
E
----
E
------
G
---
R
I
R
A
M
R
A
A
-----
R
S
L
------
G
E
R
T
V
T
E
--------
L
I
L
Q
H
Q
N
P
Q
Q
L
S
S
N
L
W
A
A
V
R
-------
A
R
G
C
-
Q
F
L
-------------------------
G
P
----
A
M
Q
E
E
A
-
L
K
L
----
V
L
L
A
L
E
-----
D
G
S
-----
A
------------------
L
S
R
K
V
L
V
L
F
V
V
Q
R
L
E
------
P
-------
R
F
P
Q
A
S
K
T
S
I
G
H
V
V
Q
L
L
Y
R
-------------------------
A
S
C
F
--
K
--------
S
L
M
Q
L
K
E
E
F
R
T
Y
E
---
A
L
R
---
R
E
H
D
S
Q
I
V
Q
I
A
M
E
A
G
L
R
----
I
-
A
P
D
Q
-----
W
S
S
L
L
Y
G
D
Q
---------------------
S
H
K
S
H
M
Q
S
---
I
I
D
K
L
---
Q
------
T
P
------
A
--------
S
F
A
Q
S
V
-
Q
E
L
T
I
A
L
Q
R
T
G
D
P
A
N
L
N
R
L
R
P
H
--
L
E
L
L
A
N
IDPSPDAPPPT
W
E
Q
L
-----------
E
-
N
G
L
-----
V
A
V
R
T
V
V
H
G
L
V
D
Y
I
Q
N
H
----
5
PsiBlast_PDB
82.86
29%
-72
- C3 -
4C9G
5
ADT2_YEAST
A:
[28-294]
--------------------------------------------------------------------------------------------------------------------
L
M
G
G
V
S
A
A
V
-
A
K
-----
T
A
A
S
-
P
I
E
R
-
V
K
L
L
I
Q
---
N
---
Q
D
E
M
L
K
Q
G
T
------
L
---
D
R
K
Y
-
A
G
I
-----
L
D
C
------
F
K
-
R
T
A
T
--------
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
I
K
A
M
F
GFK
K
E
E
G
----
Y
A
----
K
-
W
F
A
G
-
N
------
L
A
S
G
G
A
-----
A
G
A
-----
L
S
L
L
---------
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
D
S
---------------------
R
Q
F
-
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
------
V
-
A
G
L
Y
R
-------
G
F
L
P
S
V
V
--
G
I
-------
V
V
-
Y
R
G
L
Y
F
G
M
Y
D
---
S
L
----------------------------
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
---------------------
S
Y
-
P
L
-
D
T
---
V
R
R
R
M
M
M
T
S
------
G
Q
------
A
-
V
------
K
Y
D
G
A
F
-
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
--
I
L
R
G
V
A
-------------
G
A
-----------
G
-
V
I
S
-----
M
Y
D
Q
L
Q
---------------
1
PsiBlast_PDB
81.74
28%
-68
- C3 -
4C9J
4
ADT3_YEAST
A:
[32-298]
--------------------------------------------------------------------------------------------------------------------
L
M
G
G
V
S
A
A
I
-
A
K
-----
T
A
A
S
-
P
I
E
R
-
V
K
I
L
I
Q
---
N
---
Q
D
E
M
I
K
Q
G
T
------
L
---
D
K
K
Y
-
S
G
I
-----
V
D
C
------
F
K
-
R
T
A
K
--------
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
I
K
L
M
FGFK
K
E
E
G
----
Y
G
----
K
-
W
F
A
G
-
N
------
L
A
S
G
G
A
-----
A
G
A
-----
L
S
L
L
---------
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
D
A
K
S
------------------
A
R
Q
F
-
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
------
I
-
A
G
L
Y
R
-------
G
F
M
P
S
V
V
--
G
I
-------
V
V
-
Y
R
G
L
Y
F
G
M
F
D
---
S
L
K
------------------------------F
L
L
G
W
V
V
T
T
G
A
S
T
C
---------------------
S
Y
-
P
L
-
D
T
---
V
R
R
R
M
M
M
T
S
------
G
Q
------
A
-
V
------
K
Y
N
G
A
I
-
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
--
I
L
R
S
V
A
-------------
G
A
-----------
G
-
V
I
S
-----
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
-------
6
PsiBlast_PDB
81.30
29%
-70
- C3 -
4C9H
5
ADT2_YEAST
A:
[28-294]
--------------------------------------------------------------------------------------------------------------------
L
M
G
G
V
S
A
A
V
-
A
K
-----
T
A
A
S
-
P
I
E
R
-
V
K
L
L
I
Q
---
N
---
Q
D
E
M
L
K
Q
G
T
------
L
---
D
R
K
Y
-
A
G
I
-----
L
D
C
------
F
K
-
R
T
A
T
--------
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
I
K
A
M
F
G
F
K
K
E
E
G
----
Y
A
----
K
-
W
F
A
G
-
N
------
L
A
S
G
G
A
-----
A
G
A
-----
L
S
L
L
---------
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
D
S
--------------------
A
R
Q
F
-
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
------
V
-
A
G
L
Y
R
-------
G
F
L
P
S
V
V
--
G
I
-------
V
V
-
Y
R
G
L
Y
F
G
M
Y
D
---
S
L
K
---------------------------
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
---------------------
S
Y
-
P
L
-
D
T
---
V
R
R
R
M
M
M
T
S
------
G
Q
------
A
-
V
------
K
Y
D
G
A
F
-
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
--
I
L
R
G
V
A
-------------
G
A
-----------
G
-
V
I
S
-----
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
------
2
PsiBlast_PDB
81.00
28%
-68
- C3 -
4C9Q
5
ADT3_YEAST
A:
[32-298]
--------------------------------------------------------------------------------------------------------------------
L
M
G
G
V
S
A
A
I
-
A
K
-----
T
A
A
S
-
P
I
E
R
-
V
K
I
L
I
Q
---
N
---
Q
D
E
M
I
K
Q
G
T
------
L
---
D
K
K
Y
-
S
G
I
-----
V
D
C
------
F
K
-
R
T
A
K
--------
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
-------
T
Q
A
L
-
N
F
A
-----
F
K
D
K
I
K
L
M
FGFK
K
E
-
G
----
Y
G
----
K
-
W
F
A
G
-
N
------
L
A
S
G
G
A
-----
A
G
A
-----
L
S
L
L
---------
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
D
A
K
S
------------------
A
R
Q
F
-
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
------
I
-
A
G
L
Y
R
-------
G
F
M
P
S
V
V
--
G
I
-------
V
V
-
Y
R
G
L
Y
F
G
M
F
D
---
S
L
K
-------------
P
-
L
----------
F
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
---------------------
S
Y
-
P
L
-
D
T
---
V
R
R
R
M
M
M
T
S
------
G
Q
------
A
-
V
------
K
Y
N
G
A
I
-
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
--
I
L
R
S
V
A
-------------
G
A
-----------
G
-
V
I
S
-----
M
Y
D
Q
L
Q
M
I
L
F
G
K
---------
32
Fugue
71.85
18%
-104
- C2 -
4QTZ
-
?
A:
[1-321]
--------------------------------------------------------------------------------------------
L
G
N
V
V
C
V
T
-------------------
G
A
S
G
Y
I
A
S
W
-----
L
V
R
L
-
L
L
H
R
G
Y
T
V
K
A
T
---
V
---
R
D
-----------------
P
N
D
P
-
K
K
V
-----
D
H
L
------
V
-----
K
--------
L
D
G
A
K
E
R
L
Q
L
F
K
A
N
L
L
E
E
G
A
FDSVVQG
C
H
G
V
-
F
H
T
A
S
P
--
F
Y
H
D
V
K
D
P
----
Q
A
E
L
----
I
D
----
P
-
A
L
K
G
-
T
L
N
----
V
L
N
S
C
A
-----
K
S
P
SLK--
R
V
V
L
---------
T
S
S
I
A
A
V
A
Y
N
G
K
P
R
T
P
D
V
V
V
D
ETWFTD
A
-------
D
F
C
A
K
-
S
N
L
W
Y
V
V
S
K
T
L
A
E
E
A
------
A
-
W
K
F
V
K
E
N
N
I
D
M
V
T
I
N
P
A
M
V
IG
P
--------
L
L
-
Q
P
V
L
N
T
S
A
A
A
---
I
L
N
---
L
-----
I
N
G
A
Q
-
T
F
P
N
A
S
F
G
W
V
-
N
V
K
D
-----
V
A
N
A
H
I
L
A
Y
---------------------
E
N
-
A
S
-
A
S
---
G
R
H
C
L
---
V
------
E
R
------
V
-
A
------
H
Y
S
E
V
V
-
R
I
L
R
E
L
Y
P
S
L
Q
L
P
E
K
C
A
D
D
K
P
Y
V
P
I
Y
Q
V
S
K
-------------
E
K
-----------
A
-
K
S
L
G
L
E
Y
T
P
L
E
V
S
I
K
E
T
V
E
S
L
K
E
K
K
F
ANL
28
Fugue
69.24
18%
-78
- C2 -
4TXA
-
RC3H1_MOUSE
A:
[6-399]
----------------------------------------------------------------------------------PQ
W
T
D
F
L
S
C
P
I
C
T
Q
T
F
D
E
T
-------
I
R
-----
K
P
I
S
L
G
C
G
H
T
V
C
K
-----
M
C
L
N
-
K
L
H
R
-
K
A
C
P
F
D
QTT
I
---
N
T
D
I
----
E
------
L
---
L
P
V
N
-
S
A
L
-----
L
Q
L
V
GLCSG
V
E
-
D
T
K
H
--------
Y
E
E
A
K
K
C
V
E
E
L
A
L
Y
L
-
K
P
V
L
-------
S
R
P
M
-
Q
R
K
-----
L
V
T
L
V
H
C
Q
----
L
V
E
-----
E
E
----
G
-
R
I
R
A
-
M
R
A
----
A
R
S
L
G
E
-----
R
T
V
-----
T
E
L
I
---------
L
Q
H
Q
---
N
P
Q
Q
L
S
S
N
L
W
A
A
V
R
------
A
R
GCQFLG
P
A
R
Q
E
-
E
A
L
K
L
V
L
L
A
L
E
D
G
S
A
------
L
S
R
K
V
L
V
-------
L
F
V
V
Q
R
L
--
E
PRFPQAS
K
T
S
-
I
G
H
V
V
Q
L
L
Y
R
A
SC
F
K
V
---
T
K
R
D
S
S
L
M
Q
L
K
-
E
E
F
-
R
T
Y
E
A
L
-
R
R
E
H
-----
D
S
Q
I
V
Q
I
A
M
E
A
G
L
R
I
A
P
D
Q
W
S
S
L
L
YGDQSH
K
S
-
H
M
-
Q
S
---
I
I
D
K
L
---
Q
------
T
P
------
A
-
S
------
F
A
Q
S
V
Q
-
E
-
L
T
I
A
L
Q
R
T
G
D
P
A
N
L
N
R
L
R
P
H
--
L
E
L
L
A
N
IDPSPDAPPPT
W
E
Q
L
-----------
E
-
N
G
L
-----
V
A
V
R
T
V
V
H
G
L
V
D
Y
I
Q
N
H
S
---
7
PsiBlast_PDB
64.77
26%
-57
- C3 -
2LCK
-
UCP2_MOUSE
A:
[22-306]
-------------------------------------------------------------------------------------------------------------------------
T
A
A
C
I
A
D
-----
L
I
T
F
-
P
L
D
T
-
A
K
V
R
L
Q
---
I
QGE
S
Q
G
L
V
R
T
-
A
------
A
---
S
A
Q
Y
-
R
G
V
-----
L
G
T
------
I
L
-
T
M
V
R
--------
T
E
G
P
R
S
L
Y
N
G
L
V
-----
A
G
L
-------
Q
R
Q
M
-
S
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
----
Y
T
K
G
-----
S
----
E
-
H
A
G
I
-
G
S
R
----
L
L
A
G
S
T
-----
T
G
A
-----
L
A
V
A
---------
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
---------
G
-------
G
G
R
R
Y
-
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
------
I
-
R
G
L
W
K
-------
G
T
S
P
N
V
A
--
R
--------
N
A
I
V
N
C
A
E
L
V
T
Y
D
---
L
I
K
D
T
L
L
K
A
N
L
M
T
D
D
L
P
-------
C
H
F
T
-
S
A
F
G
-----
A
G
F
C
T
T
V
I
A
---------------------
S
--
P
V
-
D
V
---
V
K
T
R
Y
---
M
------
N
S
------
A
-
L
G-----
Q
Y
H
S
A
G
-
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
--
F
L
R
L
G
S
-------------
W
N
-----------
V
-
V
M
F
-----
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
---
15
HHSearch
61.66
23%
-56
- C3 -
2LCK
-
UCP2_MOUSE
A:
[14-302]
-----------------------------------------------------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
A
D
-----
L
I
T
F
-
P
L
D
T
-
A
K
V
R
L
Q
---
I
---
Q
G
E
S
----
Q
G
L
V
R
T
A
A
---
S
A
Q
Y
-
R
G
V
-----
L
G
T
------
I
L
-
T
M
V
R
--------
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
-------
F
A
S
V
-
R
I
G
-----
L
Y
D
S
V
K
Q
F
----
Y
T
K
G
----
S
-----
E
-
H
A
G
I
-
G
S
R
----
L
L
A
G
S
T
-----
T
G
A
-----
L
A
V
A
---------
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
G
----------------
G
G
R
R
Y
-
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
------
I
-
R
G
L
W
K
-------
G
T
S
P
N
V
A
--
R
N
-------
A
I
-
V
N
C
A
E
L
V
T
Y
D
---
L
I
K
---
D
T
L
L
K
A
N
L
M
-----
T
D
D
L
P
C
H
F
-
T
S
A
F
-----
G
A
G
F
C
T
T
V
I
---------------------
A
S
-
P
V
-
D
V
---
V
K
T
R
Y
---
M
------
N
S
------
A
L
G
------
Q
Y
H
S
A
G
-
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
--
F
L
R
L
G
S
-------------
W
N
-----------
V
-
V
M
F
-----
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
---
31
Fugue
59.77
15%
-41
- C1 -
4UX8
-
GFRA1_RAT
C:
[25-343]
-------------------------------------------------------------------------------------
D
R
L
D
C
V
K
A
S
D
Q
C
L
K
E
Q
-------
S
C
S
T
K
Y
R
T
L
R
Q
C
V
A
G
K
--------------------
E
T
N
F
S
---
L
---
T
S
G
L
----
E
------
A
---
K
D
E
C
-
R
S
A
-----
M
E
A
------
L
K
-
Q
---------------
K
S
L
Y
N
C
R
C
K
R
--
G
M
K
K
-------
E
K
N
C
-
L
R
I
-----
Y
W
S
M
Y
Q
S
K
----
G
N
N
C
----
L
D
----
A
-
A
K
A
C
N
L
D
D
----
T
C
K
K
Y
R
-----
S
A
Y
-----
I
T
P
C
---------
T
T
S
------------
M
S
N
E
V
C
------
N
-------
R
R
K
C
H
-
K
A
L
R
Q
F
F
D
K
V
P
A
K
H
S
------
Y
-
G
M
L
F
C
-------
S
C
R
D
-----
I
--------
A
C
-
T
E
R
R
R
Q
T
I
V
P
---
V
C
S
---
Y
E
E
R
E
R
P
N
C
L
S
-
L
Q
D
S
C
K
T
N
Y
I
-
C
R
S
R
-----
L
A
D
F
F
T
N
C
Q
---------------------
P
E
-
S
R
-
S
V
SNC
L
K
E
N
Y
---
A
------
D
C
------
L
-
L
------
A
Y
S
G
L
I
G
T
V
M
T
P
N
Y
V
D
-----------
S
S
--
S
L
S
V
A
P
-------------
W
C
DCSNSGNDLED
C
-
L
K
F
-----
L
N
F
F
K
D
N
T
C
L
K
N
A
I
Q
A
F
G
NG-
18
HHSearch
56.41
21%
-61
- C3 -
1OKC
8
ADT1_BOVIN
A:
[5-204]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
-
L
K
D
----
F
L
A
G
G
V
-----
A
A
A
-----
I
S
K
T
---------
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
Q
I
------
S
-------
A
E
K
Q
Y
-
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
------
F
-
L
S
F
W
R
-------
G
N
L
A
N
V
I
--
R
Y
-------
F
P
-
T
Q
A
L
N
F
A
F
K
D
---
K
Y
K
---
Q
I
F
L
G
G
V
D
R
H
K
-
Q
F
W
R
Y
F
A
G
N
L
-
A
S
G
G
-----
A
A
G
A
T
S
L
C
F
---------------------
V
Y
-
P
L
-
D
F
---
A
R
T
R
L
---
A
------
A
D
------
V
-
G
KGAAQR
E
F
T
G
L
G
-
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
--
V
Q
G
I
I
I
-------------
Y
R
-----------
A
-
A
Y
F
-----
G
V
Y
D
T
A
K
G
M
L
P
D
P
K
N
V
H
I
---
17
HHSearch
54.85
28%
-45
- C3 -
2LCK
-
UCP2_MOUSE
A:
[114-302]
--------------------------------------------------------------------------------------------------------------
A
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
-----
A
V
A
Q
-
P
T
D
V
-
V
K
V
R
F
Q
---
A
---
Q
A
R
A
----
G
------
G
---
G
R
R
Y
-
Q
S
T
-----
V
E
A
------
Y
K
-
T
I
A
R
--------
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
-------
V
N
C
A
-
E
L
V
-----
T
Y
D
L
I
K
D
T
----
L
L
K
A
----
N
L
----
M
-
T
D
D
L
-
P
C
H
----
F
T
S
A
F
G
-----
A
G
F
-----
C
T
T
V
---------
I
A
S
P
V
D
V
V
K
T
R
Y
M
N
S
A
L
--------------------
G
Q
Y
-
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
------
P
-
R
A
F
Y
K
-------
G
F
M
P
S
F
L
--
R
L
-------
G
S
-
W
N
V
V
M
F
V
T
Y
E
---
Q
L
K
---
R
A
L
M
A
A
Y
Q
S
R
E
-
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.19
29%
-34
- C3 -
4P6H
-
?
A:
[306-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
T
I
N
M
D
G
T
A
L
-------
Y
Q
G
V
A
T
F
F
-----
I
A
N
A
L
G
S
H
----
L
T
V
G
----
Q
Q
----
L
-
T
I
V
L
-
T
A
V
----
L
A
S
I
G
T
AGVPG
A
G
A
-----
I
M
L
C
M
V
L
H
S
V
GLP
L
T
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
------
M
-------
G
R
T
M
V
-
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
46.04
13%
-70
- C2 -
4XR7
-
PAN3_YEAST
B:
[1-456]
MH
S
L
L
Q
YRSADQLFIPNN
I
R
E
D
L
T
K
K
N
L
S
I
L
QVFPSSGKVIPSIVQDYFNLVPLNFNNKT
T
L
F
K
V
F
S
NYDGK
A
Y
V
L
K
R
LPNIDK
S
M
N
P
N
K
I
S
K
I
Y
Q
I
W
S
K
I
NCTN
L
I
K
F
R
D
I
F
Q
T
T
K
F
G
D
L
S
I
C
L
V
F
D
-----
Y
Y
P
N
-
S
L
S
L
-
Y
D
Y
H
F
V
---
N
---
F
P
K
F
----
P
------
I
---
T
N
N
Y
-
L
W
I
Y
L
V
Q
L
T
N
V
------
I
N
-
S
I
H
S
Q
NLSIGNT
L
N
W
R
K
V
L
I
T
G
D
P
G
R
I
K
L
S
H
C
-------
N
F
M
D
-
L
L
F
-----
N
D
D
T
D
T
V
V
----
S
S
T
I
----
E
G
----
Q
-
Q
Q
L
D
-
Y
K
Y
----
L
G
E
L
L
F
-----
N
L
S
-----
I
N
I
E
---------
N
S
N
N
N
T
A
P
K
E
Y
R
L
E
E
I
T
P
Q
S
I
------
D
-------
D
M
R
Q
I
-
D
D
K
F
K
D
V
L
K
Y
L
I
S
D
N
G
DSKKS
I
-
H
D
L
T
S
-------
H
F
Y
D
K
M
F
--
M
--------
V
L
-
E
S
S
Q
T
Y
T
E
Y
M
---
E
S
V
---
L
S
R
E
L
E
N
G
R
L
F
-
R
L
V
N
K
L
N
C
I
F
G
R
I
E
S
-----
R
I
D
I
N
W
S
E
S
---------------------
G
T
-
K
F
-
P
I
---
I
L
F
Y
D
---
Y
------
V
F
------
H
-
Q
------
V
D
S
N
G
K
-
P
I
M
D
L
T
H
V
L
R
C
L
N
K
L
D
A
G
I
Q
E
K
--
L
M
L
V
T
P
-------------
D
E
-----------
L
N
C
I
I
-----
I
S
Y
K
E
L
K
D
L
I
E
S
T
F
R
S
I
T
Q
H-
14
PsiBlast_PDB
43.63
27%
-48
- C4 -
2WE8
2
?
A:
[198-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
S
Y
----
A
P
R
P
----
R
M
----
L
-
V
F
G
A
-
I
D
F
----
A
A
A
V
A
Q
-----
Q
G
A
F
L
GYR
V
T
V
C
---------
D
A
R
P
V
F
A
T
T
A
R
F
P
T
A
D
E
V
V
V
D
------
W
-------
P
H
R
Y
L
-
A
A
Q
A
E
A
G
A
I
D
A
R
T
V
V
------
C
-
V
L
T
H
D
-------
P
K
F
D
V
P
L
--
L
--------
E
V
-
A
L
R
L
P
D
I
A
Y
I
---
G
A
M
---
G
S
R
R
T
H
E
D
R
L
A
-
R
L
R
E
A
G
L
T
E
E
-
E
L
A
R
-----
L
S
S
P
I
G
L
D
L
---------------------
G
G
-
R
T
-
P
E
---
E
T
A
V
S
---
I
------
A
A
------
E
-
I
------
I
A
K
R
W
G
----------------------------------------------------------------------------------------
29
Fugue
43.32
8%
-65
- C3 -
1EY1
-
NUSB_ECOLI
A:
[1-139]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---------
K
P
A
A
R
R
R
A
R
E
C
A
V
Q
A
L
Y
S
W
Q
L
------
S
-------
Q
N
D
I
A
-
D
V
E
Y
Q
F
L
A
E
Q
----
D
------
V
-
K
D
V
D
V
-------
L
Y
F
R
E
L
L
--
A
--------
G
V
-
A
T
N
T
A
Y
L
D
G
L
---
M
K
P
---
Y
L
S
R
-
L
L
E
E
L
G
-
Q
V
E
K
A
V
L
R
I
A
-
L
Y
E
L
-----
S
K
R
S
D
V
P
Y
K
---------------------
V
A
-
I
N
-
E
A
---
I
E
L
A
K
---
S
FGAE--
D
S
------
H
-
K
------
F
V
N
G
V
L
-
D
K
A
A
P
V
I
R
P
N
K
K
---------------------------------------------------------------------------