@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPT3_HUMAN: (2015-12-08 )
MDGKPATRKGPDFCSLRYGLALIMHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVADAFNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGIISSTATGFLISQVGPVY
Atome Classification :
(20 SA)
------.........10........20........30........40.......-.50........60........70........80........90........100.......110.......---..120.....---....130-.....-------------....140..--.......150.......160---........170.......180.......190.-......200...--------------------------.--------...-210.-----......220.......230.......240...--.---------------------...250.......260..-.....270.......280.......290.---------......300.-.---.....310.---..-------....320.......330.......340.........350......------.360.......-370........380.......390.......400.-.......410.-.....-.420-.......430.......---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MDGKPATRKGP
D
F
C
S
L
R
Y
G
L
A
L
I
M
HFSNF
T
M
I
T
Q
R
V
S
L
S
I
A
I
I
A
M
VN
T
-
T
Q
QQGLSNASTEGPVADAFNNS
S
I
S
I
K
EFDTKA
S
V
Y
QWSPETQ
G
I
I
F
SSINY
G
I
I
L
T
LIPS
G
--
Y
L
A
G
I
F
G
---
A
K
K
--
M
L
G
A
G
---
L
L
I
S
S
---
L
L
T
L
F
-------------
T
P
L
A
A
--
D
F
--
G
V
I
L
V
I
M
V
R
T
V
Q
G
M
A
QGMA----WT
G
Q
F
T
I
W
AKWAPPLERS
K
L
T
T
IAGSG
S
A
F
G
S
-
F
I
I
L
C
V
G
G
L
I
S
Q
--------------------------A--------LSW-
P
F
I
F
-----
Y
I
FGS
T
G
C
V
C
C
L
L
W
F
T
V
IYDDPMHHP
C
I
S
V
R
E
--
K
---------------------
E
H
I
L
S
S
L
A
QQPSSPG
R
A
V
-
P
I
K
A
M
V
T
C
L
P
L
W
A
I
F
L
G
F
F
S
H
F
W
L
C
T
I
I
L
---------
T
Y
L
P
T
Y
I
S
T
L
-
L
---
H
V
N
IRDSGV---LS-------SL
P
F
I
A
AA
S
C
TIL
G
G
Q
L
A
D
F
L
L
S
R
N
--
L
L
R
L
I
T
V
R
K
L
F
S
S
L
G
L
L
L
------
P
S
I
C
A
V
A
L
P
F
V
-
A
-
S
S
Y
V
I
T
I
I
L
L
I
L
IPGTSNLCDSG
F
I
I
N
TLDI-
A
-
P
R
Y
A
S
F
L
M
G
I
S
-
R
G
F
G
L
-
I
A
G
I
-
I
S
STAT
G
F
L
I
SQVGPVY---------------------------
21
Fugue
95.87
15%
-136
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
FKPAPH
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
E
Q
-------------------------------------
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
--
S
V
S
D
R
S
N
---
P
R
V
--
F
L
P
A
G
---
L
I
L
A
A
---
A
V
M
L
F
-------------
M
G
F
V
P
--
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
--------------------------
F
--------
N
D
W
-
H
A
A
L
-----
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
---------------------------------
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
-
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
---------
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
---
A
Y
-------
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
--
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
NPA
G
N
P
T
V
D
M
I
C
M
I
-
V
-
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
-
A
A
G
T
A
A
G
-
F
-
T
G
L
F
G
Y
L
G
G
S
V
-
A
A
S
A
I
-
V
G
Y
T
-
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
LLQELVP
10
HHSearch
95.02
18%
-128
- C1 -
1PW4
-
GLPT_ECOLI
A:
[13-413]
--------
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
------------------------------------
V
-
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
--
S
V
S
D
R
S
N
---
P
R
V
--
F
L
P
A
G
---
L
I
L
A
A
---
A
V
M
L
F
-------------
M
G
F
V
P
W
A
T
S
--
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
--------
N
D
W
-
H
A
A
L
-----
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
YK
N
---------------------
D
-------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
---------
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
---
A
Y
-------
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
--
R
G
A
-------
T
G
V
F
F
M
T
L
------
V
T
I
A
T
I
V
Y
W
M
N
-
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
-
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
-
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
---------------------------
22
Fugue
85.13
17%
-136
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
--------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
----------------------------
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
--
Y
C
S
N
R
F
G
R
R
D
S
L
K
--
I
A
A
V
L
---
F
F
I
S
G
---
V
G
S
A
W
PELGFTSINPDNT
V
P
V
Y
L
--
A
G
--
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
-
L
L
V
Y
C
V
N
Y
F
I
A
R
--------------------------
S
--------
G
D
A
-
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
-
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
T
L
A
--
T
---------------------
Q
A
V
Q
E
I
K
H
S
L
D
R
L
L
M
F
G
V
-
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
GAS
T
D
I
A
L
L
Q
T
I
I
V
G
V
-
I
---
N
L
T
F
T
V
L
A
I
---
M
T
V
DKFGRK
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
------
G
P
V
C
W
V
L
L
S
E
I
-
F
-
P
N
A
I
R
G
K
A
L
A
I
A
V
A
--
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
-
M
-
D
K
N
S
W
L
V
A
H
F
H
-
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
GKTL-----------------------
13
HHSearch
70.69
14%
-128
- C1 -
3WDO
-
?
A:
[38-365]
---------------------------------------------------------------------------------------
M
A
L
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
--
L
L
S
D
R
I
G
---
R
K
P
--
L
I
V
G
G
---
L
A
V
F
A
---
A
G
S
V
I
-------------
A
A
L
S
----
D
--
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
--------
L
G
L
-
H
A
L
F
-----
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
---
E
--
S
---------------------
G
-------------
M
V
K
G
-
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
---------
V
A
L
P
G
Q
L
A
D
A
-----
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
-------
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
------------
F
V
F
C
V
G
L
I
V
--------
V
A
E
I
V
L
W
N
A
-
Q
-
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
-
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
-
L
G
V
A
-
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
---------------------------
14
HHSearch
69.56
15%
-112
- C1 -
2CFQ
-
LACY_ECOLI
A:
[35-378]
---------------------------------------------------------------------------------------
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
--
L
L
S
D
K
L
G
---
L
R
K
--
Y
L
L
W
I
I
T
G
M
L
V
M
F
---
A
P
F
F
I
-------------
F
I
F
G
P
---
L
--
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
-----------------------------------
I
N
N
-
Q
F
V
F
-----
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
-
A
V
--
G
------------------------
A
----
N
H
--
S
A
F
S
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
---------
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
---
V
T
-------
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
--
A
L
----------
L
L
A
G
T
I
------
M
S
V
R
I
I
G
S
S
F
A
-
T
--
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
-
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
-
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
---------------------------
12
HHSearch
62.52
11%
-117
- C1 -
2GFP
-
EMRD_ECOLI
A:
[35-360]
---------------------------------------------------------------------------------------
A
R
D
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
--
P
I
S
D
R
V
G
---
R
R
P
--
V
I
L
V
G
---
M
S
I
F
M
---
L
A
T
L
V
-------------
A
V
T
T
----
S
--
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
--------
W
N
W
-
R
A
C
Y
-----
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
-----
P
--
R
---------------------
T
-------------
R
L
L
T
-
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
---------
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
I
---
L
F
-------
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
--
W
---------
Q
S
V
I
C
C
L
L
------
A
G
L
L
M
W
I
P
D
W
F
G
V
-
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
-
F
-
P
F
L
A
G
T
A
G
A
L
V
-
G
G
L
Q
N
-
I
G
S
G
-
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
---------------------------
11
HHSearch
58.84
14%
-99
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[29-326]
---------------------------
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
------------------------------------
Q
Q
A
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
--
I
L
M
K
K
L
S
---
Y
K
A
--
G
I
I
T
G
---
L
F
L
Y
A
---
L
G
A
A
L
-------------
F
W
P
A
A
E
-
I
M
--
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
--------
L
S
V
-
Q
T
P
Y
-----
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
--
L
T
K
F
P
A
L
Q
S
D
N
H
-
S
D
--
A
---------------------
K
-----------
Q
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
---------
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
---
Y
L
-------
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
--
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
------
A
G
G
H
V
G
L
I
A
L
T
-
L
-
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
-
V
-
M
T
I
I
G
G
G
I
V
T
P
-
V
M
G
F
V
-
S
D
A
A
-
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
---------------------------
17
HHSearch
53.27
17%
-135
- C1 -
3WDO
-
?
A:
[12-163]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
---------
P
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
---
A
I
-------
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
--
L
I
----------
V
G
G
L
A
V
------
F
A
A
G
S
V
I
A
A
L
S
-
D
--
S
I
W
G
I
I
L
G
R
A
L
Q
G
--
S
G
A
I
A
A
A
V
M
A
L
L
S
D
L
-
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
-
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
---------------------------
19
HHSearch
48.72
17%
-89
- C1 -
3O7Q
-
FUCP_ECOLI
A:
[290-420]
------------------------------------------------------------------------------------------
P
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
--
W
L
I
S
R
F
A
---
P
H
K
--
V
L
A
A
Y
---
A
L
I
A
M
---
A
L
C
L
I
-------------
S
A
F
A
----
G
--
G
H
V
G
L
-
I
A
L
T
L
C
S
A
F
M
S
I
Q
----
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
-
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
--------------------------
A
--------
A
G
N
I
P
T
A
E
-----
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.65
20%
-96
- C1 -
4GBY
3
XYLE_ECOLI
A:
[130-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
-
L
L
V
Y
C
V
N
Y
F
I
A
R
--------------------------
S
GD
A
S
W
L
N
T
D
G
W
-
R
Y
M
F
---------
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
--
K
Q
E
Q
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
-
M
F
G
V
G
V
I
V
I
---
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
---------
Y
Y
A
P
E
V
F
K
T
L
-
G
---
A
S
T
D
I
A
L
L
Q
---
T
I
-------
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
--
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
------
F
Y
T
Q
A
P
G
I
V
A
L
-
L
-
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
-
K
-
A
L
A
I
A
V
A
A
Q
W
L
-
A
N
Y
F
V
-
S
W
T
F
-
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
---------------------------
3
PsiBlast_PDB
48.18
20%
-106
- C1 -
4GBZ
3
XYLE_ECOLI
A:
[130-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
-
L
L
V
Y
C
V
N
Y
F
I
A
R
--------------------------
S
GD
A
S
W
L
N
T
D
G
W
-
R
Y
M
F
---------
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
--
K
Q
E
Q
A
E
G
I
L
R
K
I
MGNT
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
-
M
F
G
V
G
V
I
V
I
---
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
---------
Y
Y
A
P
E
V
F
K
T
L
-
G
---
A
S
T
D
I
A
L
L
Q
---
T
I
-------
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
--
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
------
F
Y
T
Q
A
P
G
I
V
A
L
-
L
-
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
-
K
-
A
L
A
I
A
V
A
A
Q
W
L
-
A
N
Y
F
V
-
S
W
T
F
-
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
---------------------------
4
PsiBlast_PDB
47.75
20%
-100
- C1 -
4GC0
3
XYLE_ECOLI
A:
[130-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
-
L
L
V
Y
C
V
N
Y
F
I
A
R
--------------------------
S
GD
A
S
W
L
N
T
D
G
W
-
R
Y
M
F
---------
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
--
K
Q
E
Q
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
-
M
F
G
V
G
V
I
V
I
---
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
---------
Y
Y
A
P
E
V
F
K
T
L
-
G
---
A
S
T
D
I
A
L
L
Q
---
T
I
-------
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
--
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
------
F
Y
T
Q
A
P
G
I
V
A
L
-
L
-
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
-
K
-
A
L
A
I
A
V
A
A
Q
W
L
-
A
N
Y
F
V
-
S
W
T
F
-
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
---------------------------
1
PsiBlast_PDB
46.37
33%
-115
* C2 *
2P3P
-
?
A:
[37-108]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
A
G
H
---
L
S
-------
G
F
T
H
T
A
S
L
E
S
S
-
L
G
G
T
V
T
-
F
L
L
N
R
N
--
F
I
R
I
Q
T
-----
S
T
V
G
E
V
F
------
M
R
I
----
L
P
F
S
-
D
-
S
S
S
V
I
C
V
V
T
T
V
L
H
P
V
A
D
S
R
I
D
F
Y
T
T
E
W
K
P
L
K
-
T
-
D
R
F
W
Q
Q
P
R
I
E
D
-
F
F
L
P
H
-
T
D
R
Q
-
S
Y
A
Y
Q
A
I
Y
A
S
L
T
P
S
Y
M
Q
---------------------------
5
PsiBlast_PDB
46.33
28%
-7
- C1 -
2BL2
5
NTPK_ENTHA
A:
[5-100]
------------------------------------
L
I
T
Q
N
G
G
M
V
F
A
V
L
A
M
A
T
A
-
T
I
F
S
G
I
G
S
A
K
G
V
G
M
T
G
E
A
A
A
A
L
T
T
S
Q
P
E
K
F
G
Q
A
L
I
L
Q
L
L
P
G
T
Q
G
L
Y
G
F
V
I
A
F
L
I
F
I
N
L
---
G
--
S
D
M
S
V
V
Q
---
G
L
N
--
F
L
G
A
S
---
L
P
I
A
F
---
T
G
L
F
S
-------------
G
I
A
Q
G
--
K
V
--
A
A
A
G
I
Q
I
L
A
K
K
P
E
H
A
T
K
G
I
----
I
F
A
A
M
V
E
T
Y
A
I
L
G
F
V
I
S
F
L
L
V
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
46.13
20%
-58
- C2 -
2KXG
-
?
A:
[1-95]
-----------------------------------------------------------------
G
P
G
P
A
I
G
E
V
I
G
I
S
V
N
D
P
R
V
K
E
I
A
E
F
A
L
K
Q
H
A
E
Q
N
L
I
L
A
G
V
D
A
G
Q
I
I
K
G
I
P
H
W
D
N
Y
Y
N
L
I
L
S
---
A
K
H
--
S
P
H
E
F
---
S
K
F
Y
N
---
V
V
V
L
E
-------------
K
A
--
S
--
D
N
--
S
L
K
L
V
A
F
V
P
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
45.90
30%
-89
- C1 -
4LDS
-
?
A:
[43-135]
------------------------------------------------------------------------------------------------
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
--
P
L
A
D
K
L
G
---
R
R
R
L
V
M
L
I
A
I
---
V
F
I
I
G
---
A
L
I
L
-----------------
A
A
--
S
T
--
N
L
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
----
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
-
L
A
A
Y
L
V
N
Y
A
F
A
D
--------------------------
I
--------
E
G
W
-
R
W
M
L
-----
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
L
E
N
R
N
E
E
A
--
A
---------------------
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
-
E
M
K
E
I
N
A
I
S
E
S
T
W
T
V
I
K
S
P
W
L
G
R
I
L
I
V
G
C
---------
I
F
A
I
F
Q
Q
F
I
G
-
I
---
N
A
V
I
F
Y
S
S
S
---
I
F
-------
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
--
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
------
G
N
I
G
M
I
A
S
L
L
I
-
M
-
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
-
G
-
P
V
L
W
V
M
L
P
E
L
F
-
P
M
R
A
R
-
G
A
A
T
-
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
---------------------------
6
PsiBlast_PDB
45.88
28%
-9
- C1 -
2CYD
2
NTPK_ENTHA
A:
[5-100]
------------------------------------
L
I
T
Q
N
G
G
M
V
F
A
V
L
A
M
A
T
A
-
T
I
F
S
G
I
G
S
A
K
G
V
G
M
T
G
E
A
A
A
A
L
T
T
S
Q
P
E
K
F
G
Q
A
L
I
L
Q
L
L
P
G
T
Q
G
L
Y
G
F
V
I
A
F
L
I
F
I
N
L
---
G
--
S
D
M
S
V
V
Q
---
G
L
N
--
F
L
G
A
S
---
L
P
I
A
F
---
T
G
L
F
S
-------------
G
I
A
Q
G
--
K
V
--
A
A
A
G
I
Q
I
L
A
K
K
P
E
H
A
T
K
G
I
----
I
F
A
A
M
V
E
T
Y
A
I
L
G
F
V
I
S
F
L
L
V
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
45.63
10%
-75
- C1 -
1PW4
-
GLPT_ECOLI
A:
[282-428]
----------------------------------------------------------------------------------------
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
--
W
M
S
D
K
V
F
---
R
G
N
--
R
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
-------------
Y
W
M
N
P
--
A
G
--
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
----
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
--------------------------
F
--------
F
G
W
-
D
G
G
F
-----
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
--
V
---------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
45.59
28%
-13
- C1 -
2DB4
6
NTPK_ENTHA
A:
[5-100]
------------------------------------
L
I
T
Q
N
G
G
M
V
F
A
V
L
A
M
A
T
A
-
T
I
F
S
G
I
G
S
A
K
G
V
G
M
T
G
E
A
A
A
A
L
T
T
S
Q
P
E
K
F
G
Q
A
L
I
L
Q
L
L
P
G
T
Q
G
L
Y
G
F
V
I
A
F
L
I
F
I
N
L
---
G
--
S
D
M
S
V
V
Q
---
G
L
N
--
F
L
G
A
S
---
L
P
I
A
F
---
T
G
L
F
S
-------------
G
I
A
Q
G
--
K
V
--
A
A
A
G
I
Q
I
L
A
K
K
P
E
H
A
T
K
G
I
----
I
F
A
A
M
V
E
T
Y
A
I
L
G
F
V
I
S
F
L
L
V
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
44.91
28%
-9
- C1 -
3AOU
-
NTPK_ENTHA
A:
[5-98]
------------------------------------
L
I
T
Q
N
G
G
M
V
F
A
V
L
A
M
A
T
A
-
T
I
F
S
G
I
G
S
A
K
G
V
G
M
T
G
E
A
A
A
A
L
T
T
S
Q
P
E
K
F
G
Q
A
L
I
L
Q
L
L
P
G
T
Q
G
L
Y
G
F
V
I
A
F
L
I
F
I
N
L
---
G
--
S
D
M
S
V
V
Q
---
G
L
N
--
F
L
G
A
S
---
L
P
I
A
F
---
T
G
L
F
S
-------------
G
I
A
Q
G
--
K
V
--
A
A
A
G
I
Q
I
L
A
K
K
P
E
H
A
T
K
G
I
----
I
F
A
A
M
V
G
L
H
T
Y
A
I
L
G
F
V
I
S
F
L
L
V
L
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------