@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTCP4_HUMAN: (2015-12-08 )
MDGNDNVTLLFAPLLRDNYTLAPNASSLGPGTDLALAPASSAGPGPGLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAASHGPSPFPRPWAPHALPFWDTPLNHGLNVFVGAALCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAVAVLLCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSWAWINTPIVQLLPLGTVTLTLCSTLIPIGLGVFIRYKYSRVADYIVKVSLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGSEMLHKRDPLDEDEDTDISYKKLKEEEMADTSYGTVKAENIIMMETAQTSL
Atome Classification :
(20 SA)
.........10........20........30........40........50.-.......60....---------....70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250....----..-.----260.......270.....-..280.......290........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDGND
N
V
T
L
L
F
A
P
LLRDNYTLAPNASSLGPGT
D
L
A
LAPASSAGPGPGLSLGP-GPSFGFSPGPTPT---------PEPTTSGLAGGAASHGPSPFPRPWAPHALPFWD
T
P
L
NHG
L
N
V
F
V
G
A
A
L
C
I
T
M
LGLG
C
T
V
D
V
N
H
F
G
A
H
V
R
R
P
V
G
A
L
L
A
A
L
C
Q
F
G
L
L
P
L
L
A
F
L
L
A
L
A
F
K
L
D
E
V
A
A
V
A
V
L
L
CGCCPGG
N
L
S
N
L
M
S
L
L
VDGDM
N
L
S
I
I
M
T
I
S
S
T
L
L
A
L
V
L
M
P
L
C
L
W
I
Y
S
W
A
WINT
P
I
V
Q
L
LPL
G
T
V
T
L
T
L
C
S
T
L
I
P
IG
L
G
V
F
I
R
Y
----
K
Y
-
S
----
R
V
A
D
Y
I
V
K
V
S
L
W
S
L
L
V
T
L
-
V
V
L
F
I
M
TGTML
G
P
E
-
L
L
A
S
I
P
A
A
V
Y
V
I
A
I
F
M
P
L
A
GYASGY
G
L
A
T
L
FHLPPNC
K
R
T
V
C
LETGSQ
N
V
Q
L
C
T
A
I
L
K
LAF
P
P
Q
F
I
G
S
M
Y
M
F
P
L
L
Y
A
L
F
Q
SAEA
G
I
F
V
L
I
Y
K
MY
G
S
E
M
LHKRDPLDEDEDTD
I
S
Y
K
K
L
K
E
E
E
MADTSYG
T
V
K
AE
N
I
I
M
M
ETAQTSL
1
PsiBlast_PDB
93.97
27%
-155
- C1 -
4N7W
2
?
A:
[29-273]
-----------------------------------------------------------------------------------------------------------------
G
I
G
P
Y
V
G
P
L
L
M
L
I
M
F
A
M
G
V
T
L
R
L
D
D
F
K
R
V
L
S
R
P
A
P
V
A
A
A
T
F
L
H
Y
L
I
M
P
L
T
A
W
I
L
A
M
L
F
R
M
P
P
D
L
S
A
G
M
V
L
V
G
S
V
A
S
G
T
A
S
N
V
M
I
Y
L
A
K
G
D
V
A
L
S
V
T
I
S
A
V
S
T
L
V
G
V
F
A
T
P
L
L
T
R
L
Y
V
D
A
T
I
S
V
D
V
V
-----
G
M
L
K
S
I
L
Q
I
V
V
I
P
I
T
A
G
L
V
I
H
H
----
T
F
-
T
K
T
V
K
R
I
E
P
Y
L
P
A
M
S
M
------
V
-
C
I
L
A
I
I
S
A
V
V
A
G
S
Q
S
H
I
A
S
V
G
F
V
V
I
I
A
V
I
L
H
N
G
I
G
L
L
S
G
Y
W
G
G
K
L
F
G
F
D
E
S
T
C
R
T
L
A
I
E
V
G
M
Q
N
S
G
L
A
A
T
L
G
K
I
Y
F
S
P
L
A
A
L
P
G
A
L
F
S
V
W
H
N
L
S
G
S
L
L
A
G
Y
W
S
G
K
P
V
K
K
D
Q
E
-------------------------------------------------
29
Fugue
93.24
22%
-139
- C1 -
3ZUY
8
?
A:
[2-309]
-
N
I
L
S
K
I
S
S
F
I
G
K
T
F
S
L
W
A
A
L
F
A
A
A
A
F
F
A
P
D
T
-------------------------------------------------------------------------------
F
K
W
A
G
P
Y
I
P
W
L
L
G
I
I
M
F
G
M
G
L
T
L
K
P
S
D
F
D
I
L
F
K
H
P
K
V
V
I
I
G
V
I
A
Q
F
A
I
M
P
A
T
A
W
L
L
S
K
L
L
N
L
P
A
E
I
A
V
G
V
I
L
V
G
C
C
P
G
G
T
A
S
N
V
M
T
Y
L
A
R
G
N
V
A
L
S
V
A
V
T
S
V
S
T
L
I
S
P
L
L
T
P
A
I
F
L
M
L
A
G
E
M
L
E
I
Q
A
A
G
M
L
M
S
I
V
K
M
V
-----
L
L
P
I
V
L
G
L
I
V
H
K
----
V
L
G
S
----
K
T
E
K
L
T
D
A
L
P
L
V
S
V
A
A
I
V
-
L
I
I
G
A
V
V
G
A
--
S
K
G
-
K
I
M
E
S
G
L
L
I
F
A
V
V
V
L
H
N
G
I
G
Y
L
L
G
F
F
A
A
K
W
T
G
L
P
Y
D
A
Q
K
T
L
T
I
E
V
G
M
Q
N
S
G
L
A
A
A
L
A
A
A
H
F
A
A
A
-------------
P
V
V
A
V
P
G
A
L
F
S
V
W
H
N
I
S
G
S
L
L
A
T
Y
W
A
A
K
A
----------------------------------------
2
PsiBlast_PDB
92.31
26%
-165
- C1 -
4N7X
-
?
A:
[34-278]
-----------------------------------------------------------------------------------------------------------------
G
I
G
P
Y
V
G
P
L
L
M
L
I
M
F
A
M
G
V
T
L
R
L
D
D
F
K
R
V
L
S
R
P
A
P
V
A
A
A
T
F
L
H
Y
L
I
M
P
L
T
A
W
I
L
A
M
L
F
R
M
P
P
D
L
S
A
G
M
V
L
V
G
S
V
A
S
G
T
A
S
N
V
M
I
Y
L
A
K
G
D
V
A
L
S
V
T
I
S
A
V
S
T
L
V
G
V
F
A
T
P
L
L
T
R
L
Y
V
D
A
T
I
S
V
D
V
V
-----
G
M
L
K
S
I
L
Q
I
V
V
I
P
I
T
A
G
L
V
I
H
H
----
T
F
-
T
K
T
V
K
R
I
E
P
Y
L
P
A
M
S
M
------
V
-
C
I
L
A
I
I
S
A
V
V
A
G
S
Q
S
H
I
A
S
V
G
F
V
V
I
I
A
V
I
L
H
N
G
I
G
L
L
S
G
Y
W
G
G
K
L
F
G
F
D
E
S
T
C
R
T
L
A
I
A
V
G
M
Q
N
S
G
L
A
A
T
L
G
K
I
Y
F
S
P
L
A
A
L
P
G
A
L
F
S
V
W
H
N
L
S
G
S
L
L
A
G
Y
W
S
G
K
P
-------------------------------------------------------
3
PsiBlast_PDB
78.06
27%
-141
- C1 -
3ZUY
7
?
A:
[44-265]
--------------------------------------------------------------------------------------------------------------------------
L
G
I
I
M
F
G
M
G
L
T
L
K
P
S
D
F
D
I
L
F
K
H
P
K
V
V
I
I
G
V
I
A
Q
F
A
I
M
P
A
T
A
W
L
L
S
K
L
L
N
L
P
A
E
I
A
V
G
V
I
L
V
G
C
C
P
G
G
T
A
S
N
V
M
T
Y
L
A
R
G
N
V
A
L
S
V
A
V
T
S
V
S
T
L
I
S
P
L
L
T
P
A
I
F
L
M
L
A
-----
G
E
M
L
E
I
Q
A
A
G
M
L
M
S
I
V
K
M
V
L
L
P
I
V
L
G
L
I
V
H
K
V
L
GS
K
T
-
E
----
K
L
T
D
A
L
P
L
V
S
V
A
A
I
V
L
I
I
G
A
V
V
G
A
S
K
G
K
I
M
E
S
G
-
L
L
------
I
F
A
V
V
V
L
H
N
G
I
G
Y
L
L
G
F
F
A
A
K
W
T
G
L
P
Y
D
A
Q
K
T
L
T
I
E
V
G
M
Q
N
S
G
L
A
A
A
L
A
A
A
H
F
A
A
A
P
V
V
A
V
P
G
A
L
F
S
V
W
H
N
I
S
G
S
L
L
A
T
Y
W
A
A
K
A
-----------------------------------------------------
4
PsiBlast_PDB
77.82
26%
-143
- C1 -
3ZUX
7
?
A:
[49-270]
--------------------------------------------------------------------------------------------------------------------------
L
G
I
I
M
F
G
M
G
L
T
L
K
P
S
D
F
D
I
L
F
K
H
P
K
V
V
I
I
G
V
I
A
Q
F
A
I
M
P
A
T
A
W
C
L
S
K
L
L
N
L
P
A
E
I
A
V
G
V
I
L
V
G
C
C
P
G
G
T
A
S
N
V
M
T
Y
L
A
R
G
N
V
A
L
S
V
A
V
T
S
V
S
T
L
T
S
P
L
L
T
P
A
I
F
L
M
L
A
-----
G
E
M
L
E
I
Q
A
A
G
M
L
M
S
I
V
K
M
V
L
L
P
I
V
L
G
L
I
V
H
K
V
L
GS
K
T
-
E
----
K
L
T
D
A
L
P
L
V
S
V
A
A
I
V
L
I
I
G
A
V
V
G
A
S
K
G
K
I
M
E
S
G
-
L
L
------
I
F
A
V
V
V
L
H
N
G
I
G
Y
L
L
G
F
F
A
A
K
W
T
G
L
P
Y
D
A
Q
K
A
L
T
I
E
V
G
M
Q
N
S
G
L
A
A
A
L
A
A
A
H
F
A
A
A
P
V
V
A
V
P
G
A
L
F
S
V
W
H
N
I
S
G
S
L
L
A
T
Y
W
A
A
K
A
-----------------------------------------------------
18
PsiBlast_PDB
51.19
35%
97
- C2 -
4NHG
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
49.44
35%
123
- C2 -
1ZLS
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
------
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.35
35%
92
- C2 -
1OP3
-
IGHG1_HUMAN
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
48.90
35%
94
- C2 -
2OQJ
-
?
B:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
L
G
C
L
V
K
DYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.73
31%
97
- C2 -
4NHH
-
?
H:
[106-163]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
S
----------
V
F
P
L
A
P
S
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
48.45
35%
96
* C2 *
1OM3
-
?
H:
[104-175]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.39
35%
107
- C2 -
3OB0
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
----
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
48.14
35%
104
- C2 -
3OAY
-
?
M:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
------
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.04
35%
102
- C2 -
4RBP
1
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
----
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.00
35%
126
- C2 -
1ZLV
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
--------
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
46.89
35%
94
- C2 -
1OP5
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.92
35%
89
- C2 -
1ZLW
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
45.83
35%
102
- C2 -
1ZLU
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
--
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
45.79
35%
119
- C2 -
3OAU
-
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
------
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
43.87
35%
91
- C2 -
3OAZ
1
?
H:
[114-177]
----------------------------
G
P
G
T
V
V
T
V
S
P
A
S
T
K
G
P
----
S
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
A
LGCLVKDYF
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
H
K
P
S
N
T
K
V
D
K
K
V
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------