@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S19A2_HUMAN: (2015-12-09 )
MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS
Atome Classification :
(20 SA)
---------.........10---........20........30.........40.----------.......50......---..60........70....-----------------------------....80........90........100..---..-..---.110...---------..--.----.120.-.......130.....-----.------.140......----..150....---...160........-170.......180.......190.......200..-.---..--.-.210...---------....220-----......----...230..-.....240.------......-250.---------------------------------......260..-.-....270.......280....-...290...-----------....300..---....------------..310.-----......320.......330.......-340.......350..-------.....360....-...370.......380--.---......390.-......400.----------......410.......420.......430--.....-...440...-..------------..450.......-----460.......470........480..-..---------...490...-..--------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MDVPGP
V
S
R
R
A
---
A
A
A
A
A
T
V
L
L
R
T
A
R
V
R
R
E
C
W-FL
P
T
A
L
L
C
A
Y
G
F
----------
F
ASLRPSEPFLT
P
Y
L---LGPDKN
L
T
E
R
E
V
F
N
E
IY
P
-----------------------------
V
W
T
Y
S
Y
L
V
L
L
F
P
V
F
L
AT
D
Y
LRYK
P
V
V
L
L
Q
---
G
L
-
S
L
---
I
V
T
W
F
M
L
---------
L
Y
--A----
Q
G
-
L
L
-
A
I
Q
F
L
E
F
F
Y
G
I
A
T
A
T
-----
E
------
I
A
Y
-
Y
S
Y
I
Y
S
----
V
V
D
L
G
M
Y
Q
K
---
V
T
S
Y
-
C
RSAT
L
V
G
F
-
T
V
G
S
V
L
G
Q
I
L
V
S
VAG
W
S
L
F
S
L
N
V
I
S
L
T
C
V
S
V
A
F
A
V
-
A
---
W
F--L-PMPQ
K
S
L
---------
F
F
HHI-------
P
S
T
C
Q
R----VN
G
I
K
VQN-G
G
I
V
TDTPA------SNHLP
G
-
W
E
D
I
---------------------------------
E
SKIPLNMEEP-P-VEEPEPKPD
R
L
L
V
L
K
V
L
W
N
D
F
-
L
M
C
YSSR
P
L
-----------
L
C
W
S
V
-
W
W
A
---
L
STC------------G
Y
F
Q
V
V
-----
N
Y
T
Q
G
L
W
E
K
V
M
P
S
R
Y
A
A
I
YNG
G
V
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A
V
-
S
T
L
L
G
A
V
A
V
F
A
V
G
Y
I
-------
K
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WST
W
G
E
M
T
L
-
S
L
F
S
L
L
I
A
A
A
V
Y
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M
DT--V---G
N
I
W
V
C
Y
A
S
Y
-
V
V
F
R
I
I
Y
M
L
L
----------
I
T
I
A
T
F
Q
I
AANLS
M
E
R
Y
A
L
V
FG
V
N
T
F
I
A
---
L
A
L
Q
T
-
L
L
T
L
I
V
VDA-SG------------L
G
L
E
I
T
T
Q
F
L
I
Y
-----
A
S
Y
F
A
L
I
A
V
V
F
-LAS
G
A
V
S
V
M
K
K
C
R
K-LE---------DPQSSSQVT-TS--------------------------------------------------
20
Fugue
81.15
15%
-121
- C4 -
4IKW
13
?
A:
[3-494]
-----SID
K
Q
Q
I
A
A
S
V
P
Q
R
G
FFG
H
P
K
G
L
F
T
L
F
F
T
E
F
W
E
R
F
S
Y
-
Y
G
M
R
A
I
L
V
Y
Y
M
Y
----------
Y
E
V
S
K
G
G
---------------
L
G
L
D
E
H
L
A
L
A
I
M
S
I
-----------------------------
Y
G
A
L
V
Y
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I
I
G
G
W
L
A
D
R
V
F
G
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Y
G
---
G
L
-
L
I
---
M
A
G
H
I
A
L
---------
A
I
--
P
----
G
G
-
V
A
-
A
L
F
V
S
M
A
L
I
V
L
G
T
G
L
-----
L
------
K
P
N
-
V
S
S
I
V
G
--------
D
M
Y
K
P
GDD
R
R
D
A
-
G
F
S
I
F
Y
M
G
I
-
N
L
G
A
F
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
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F
G
L
A
A
V
G
M
F
L
G
L
-
V
---
V
F
--
V
-
A
T
R
K
K
N
L
---------
G
L
A
G
T
YVP
N
P
L
T
P
A
E
K
K
K
----
A
A
A
I
M
A
V
G
-
A
V
V
I
A
V
L
L
A
------
I
L
I
P
N
G
-
W
F
T
V
---------------------------------
E
T
F
I
S
L
V
G
I
L
G
-
I
-
I
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R
S
P
K
T
T
A
E
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R
-
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V
I
A
Y
I
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L
-----------
F
V
A
S
A
M
F
W
A
---
I
Q
E
Q
------------
G
S
T
I
L
A
-----
N
Y
A
D
K
----
R
T
Q
L
D
V
A
G
I
H
L
S
P
A
W
-
F
-
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
-------
A
W
M
W
V
K
L
G
K
R
Q
P
-
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
--
F
---
I
V
I
L
V
P
G
H
L
S
-
G
G
G
L
V
H
P
I
W
L
----------
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
---
A
F
S
A
Q
-
T
M
S
L
W
F
L
S
N
-
A
A
------------
A
Q
A
I
N
A
Q
L
V
R
F
Y
TPENE
T
A
Y
F
G
T
I
G
G
A
A
-
L
V
L
G
L
I
-
L
L
A
I
A
P
R
-
I
G
---------
R
L
M
K
G
---------------------------------------------------------
25
Fugue
73.96
20%
-117
* C3 *
4O5P
-
?
A:
[5-815]
NFGFHIAPT
H
P
V
A
G
R
L
T
Y
D
S
---
K
K
L
S
E
N
I
L
K
Q
Q
S
D
E
R
V
F
S
R
A
Q
C
C
K
A
I
H
I
T
L
G
F
D
G
TNNN
D
K
A
D
G
S
S
V
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P
S
C
S
N
V
A
R
L
I
H
A
S
I
G
S
G
D
D
I
N
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R
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I
F
K
Y
Y
C
P
G
VGTVFPDIKEFTPSNMGLIG
A
E
G
G
E
N
R
I
N
W
G
L
V
Q
L
V
D
A
L
F
Y
T
L
L
K
S
R
L
K
L
N
D
V
Q
G
L
V
---
E
E
M
S
T
---
N
W
T
V
S
T
L
T
G
G
L
L
E
N
G
E
K
K
--
R
----
R
A
-
A
L
-
E
P
K
L
K
E
L
E
E
K
L
R
Q
R
Q
-----
N
S
GQKPH
I
L
A
M
R
L
Y
I
Y
G
F
S
R
G
A
A
E
A
R
A
F
A
N
---
W
L
Q
E
-
L
T
R
V
S
D
A
D
G
-
R
V
E
Y
R
F
A
G
L
P
I
S
I
E
F
L
G
L
F
D
----
T
V
A
A
V
G
L
P
F
A
A
-
G
H
MD
W
A
DD
T
M
R
L
P
D
E
A
L
PEDCSFLK
R
C
V
H
L
V
-------
S
C
H
E
Q
R
AS
F
P
L
D
S
I
R
R
R
D
M
N
G
R
R
T
G
P
S
C
Y
R
K
W
T
V
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Y
A
Y
P
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H
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D
V
GGGYGVGNQGKAVGGSEFLLS
Q
I
A
L
Q
H
M
Y
A
E
A
F
E
A
G
A
P
L
Q
V
P
E
W
R
V
M
V
P
K
I
E
A
E
F
S
V
S
E
E
L
A
T
R
F
N
A
W
-
Q
A
Q
A
K
A
G
P
L
E
E
V
I
R
R
E
T
A
L
I
T
A
W
R
I
-
D
R
Y
AGG
L
R
N
K
------------
A
F
F
A
N
V
PPDMP
E
A
Q
Q
K
A
W
E
A
L
H
K
R
R
S
R
E
Y
A
A
A
Q
Q
L
P
P
M
S
A
A
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Q
A
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W
D
R
N
V
A
L
I
GGEDQLR
D
L
R
V
E
K
Q
F
D
P
P
L
-
D
Q
R
Q
L
L
G
A
A
A
E
F
A
H
D
Y
--
K
---
G
D
-
W
G
V
L
D
D
G
M
T
V
G
G
V
I
D
L
L
L
G
G
T
V
F
L
I
N
E
E
D
E
A
E
E
Y
S
Q
I
H
R
D
G
S
A
R
Y
H
Q
L
F
S
A
P
D
R
V
A
PGQ
E
K
L
V
A
-
L
F
D
E
Q
V
H
D
S
-
R
A
PFTDYFRYRLVH
F
D
N
E
S
N
K
R
L
S
V
L
-----
A
T
A
G
R
V
V
G
V
G
V
M
L
A
S
V
G
L
S
V
K
R
R
D
P
R
M
L
L
GG
L
P
E
I
S
A
F
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P
L
T
G
I
A
L
P
M
V
G
G
A
A
L
D
N
L
R
AFTRE
P
G
D
K
V
E
Q
I
G
Q
LPPPPP
L
A
V
A
A
V
QS
P
A
L
Q
Q
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L
L
A
Q
Q
T
V
19
Fugue
73.27
12%
-122
- C4 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----------
F
K
P
A
P
H
K
A
R
L
---
P
A
A
E
-----
I
D
P
T
Y
R
R
L
R
W
-
Q
I
F
L
G
I
F
F
G
Y
A
A
----------
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
---
V
E
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
-----------------------------
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
-
L
A
---
A
A
V
M
L
F
M
---------
G
F
--
V
----
P
W
-
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
-----
Q
------
G
M
G
-
W
P
P
C
G
R
----
T
M
V
H
W
W
S
Q
K
---
E
R
G
G
-
I
V
S
V
W
N
C
A
H
-
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
-
A
---
L
F
--
A
-
F
A
M
M
R
D
T
-------------------------------------------------------------------------------------------------------
P
Q
S
C
G
L
P
-
P
-
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
------------------------
K
L
L
-
W
Y
I
---
A
I
A
N
------------
V
F
V
Y
L
L
-----
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
-
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
-------
G
W
M
S
D
K
V
F
R
G
N
R
-
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
--
V
---
Y
W
M
N
P
A
G
N
P
T
-
V
D
M
I
C
M
I
V
I
G
----------
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
---
F
T
G
L
F
-
G
Y
L
G
G
S
V
A
A
-
S
A
------------
I
V
G
Y
T
V
D
F
F
G
W
D
-----
G
G
F
M
V
M
I
G
G
S
I
-
L
A
V
I
L
L
I
V
V
M
I
G
E
K
-
R
R
---------
H
E
Q
L
L
Q
E
L
V
-
P
---------------------------------------------------
9
HHSearch
68.31
11%
-131
- C4 -
1PW4
-
GLPT_ECOLI
A:
[20-448]
---------------------------------
D
P
T
Y
R
R
L
R
W
-
Q
I
F
L
G
I
F
F
G
Y
A
A
----------
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
---
V
E
--
Q
G
F
S
R
G
D
L
-
G
F
A
L
S
-----------------------------
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
-
L
A
---
A
A
V
M
L
F
M
---------
G
F
--
V
P
W
A
T
S
S
-
I
A
-
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
-----
G
W-----
P
P
C
-
G
R
T
M
V
H
----
W
W
S
Q
K
E
R
G
G
---
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
-
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
---
A
M
--
M
-
R
D
T
P
Q
S
C
---------
G
L
P
P
--------
I
E
E
Y
K
--------------
N
-------------------
D
----------------------------------------------------------------
T
A
---
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
-----------
W
Y
I
A
I
-
A
N
V
---
F
V
Y
L
------------
L
R
Y
G
I
L
-----
D
W
S
P
T
Y
L
K
E
V
K
H
-
F
-
A
L
D
K
S
S
W
A
Y
F
L
-
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
-------
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
NP
A
---
G
N
P
T
V
D
M
I
C
M
-
I
V
I
G
F
L
I
Y
G
P
----------
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
---
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
------------
F
G
W
--
D
G
G
F
M
V
M
-----
I
-
G
G
S
I
L
A
V
I
L
-
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
-
L
L
---------
Q
E
L
V
P
---------------------------------------------------------
11
HHSearch
62.45
13%
-96
- C4 -
2GFP
-
EMRD_ECOLI
A:
[25-355]
---------------------------------------------------------------------
T
I
Y
I
P
A
I
A
D
M
A
---
R
-
D
-
L
N
V
R
E
G
A
V
-
Q
S
V
M
G
-----------------------------
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
-
I
F
---
M
L
A
T
L
V
A
---------
V
T
--
T
----
S
S
-
L
T
-
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
----
G
------
V
M
A
-
R
T
L
P
R
D
----
L
Y
E
R
T
Q
L
R
H
---
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
-
M
A--
R
W
--
M
-
P
E
T
R
P
V
D
------------
A
P
-------
R
T
R
L
-----------------------------------------------------------------------------------------------------
L
T
----
S
Y
-
K
T
L
F
G
N
S
G
F
-----------
N
C
Y
L
L
-
M
L
I
---
G
G
L
A
------------
G
I
A
A
F
E
-----
A
C
S
G
V
L
M
G
A
V
L
G
-
L
-
S
S
M
T
V
S
I
L
F
I
L
-
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
-------
N
K
R
F
S
T
L
-
M
W
Q
S
-
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
---
M
N
V
W
T
L
L
V
P
A
-
A
L
F
F
F
G
A
G
M
L
----------
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
---
N
I
G
S
G
-
V
L
A
S
L
S
A
M
L
-
P
Q
------------
T
G
Q
G
S
L
G
L
L
M
T
L
-----
M
G
L
L
I
V
L
C
W
L
P
-
L
---------------------------------------------------------------------------------------
10
HHSearch
46.54
15%
-121
- C4 -
3WDO
-
?
A:
[25-189]
-------------------------------------------------------------------
G
M
F
M
V
L
P
V
L
T
T
Y
G
---
M
A
L
-
Q
G
A
S
E
A
L
I
-
G
I
A
I
G
-----------------------------
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
-
V
F
---
A
A
G
S
V
I
A
---------
A
L
--
S
----
D
S
-
I
W
-
G
I
I
L
G
R
A
L
Q
G
S
G
A
-
I
-----
A
------
A
A
V
-
M
A
L
L
S
D
----
L
T
R
E
Q
N
R
T
K
---
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
--
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
---
W
V
--
V
-
P
N
S
S
T
H
V
---------
L
N
R
E
S
-------
G
M
V
K
G
S
----
F
S
K
V
L
A
E
P
-
R
L
L
K
L
N
F
G
I
------
M
C
L
H
M
L
-
L
M
S
T
---------------------------------
F
V
A
L
P
G
Q
L
A
D
A
-
G
-
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
-
V
P
F
I
I
Y
A
E
V
-----------
K
R
K
M
K
-
Q
V
F
---
V
F
C
V
------------
G
L
I
V
V
A
-----
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
-
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
-------
A
G
Y
K
G
T
A
M
G
V
Y
S
-
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
--
I
---
D
G
M
F
D
G
Q
G
V
F
-
L
A
G
A
M
L
A
A
V
W
----------
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
---
A
L
K
V
R
-
L
L
E
T
E
G
V
K
E
-
V
L
------------
I
A
E
E
E
H
S
A
Y
V
K
I
-----
D
S
K
V
T
N
R
F
E
V
E
-
Q
A
I
R
Q
A
L
---------------------------------------------------------------------------------
2
PsiBlast_PDB
43.65
26%
-92
- C2 -
1XSF
-
A:
[24-98]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
-----------
I
D
G
S
I
-
W
D
A
---
I
A
G
C
E
AGGNWAINTGN
G
Y
Y
G
G
V
-----
Q
F
D
Q
G
T
W
E
A
N
G
G
L
R
Y
A
P
R
A
D
-----
L
-
A
T
R
E
E
Q
I
A
V
A
E
V
T
R
L
-------
R
Q
G
W
G
A
W
P
V
C
A
A
-
R
A
G
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
42.14
12%
-136
- C4 -
3WDO
-
?
A:
[25-189]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
F
M
V
L
-----
P
V
L
T
T
Y
G
M
A
L
Q
G
-
A
-
S
E
A
L
I
G
I
A
I
G
I
-
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
-------
S
D
R
I
G
R
K
--
P
L
I
-
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
--
S
---
D
S
I
W
G
I
I
L
G
R
-
A
L
Q
G
S
G
--
A
I
----------
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
---
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
------------
L
G
L
--
H
A
L
F
W
M
I
-----
A
-
I
L
A
T
T
G
I
A
L
-
T
I
W
V
V
P
N
S
S
T
H
V
L
N
-
R
E
---------
S
G
M
V
K
G
S
F
S
-
K
V
--------------------------------------------------
14
HHSearch
40.51
13%
-104
- C4 -
2CFQ
-
LACY_ECOLI
A:
[256-391]
-----------------------------------------------------------------------------------------
Q
G
T
R
V
F
-
G
Y
V
T
T
-----------------------------
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
-
I
M
---
S
V
R
I
I
G
S
---------
S
F
--
A
----
T
S
-
A
L
-
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
-----
L
L-----
V
G
C
-
F
K
Y
I
T
S
----
Q
F
E
V
R
F
S
A
T
---
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
--
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
-
S
---
V
F
--
T
-
L
S
G
P
G
P
L
---------
S
L
L
R
R
-------
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
40.23
23%
-119
- C4 -
4ZP0
1
?
A:
[68-176]
--------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
-
W
F
---
I
V
T
C
L
A
I
---------
L
L
--
A
----
Q
N
-
I
E
-
Q
F
T
L
L
R
F
L
Q
G
I
S
L
C
F
-----
I
------
G
A
V
G
Y
A
A
I
R
E
----
S
F
E
E
A
V
C
I
K
---
I
T
A
L
-
M
A
N
V
A
L
I
A
P
-
L
L
G
P
L
V
G
A
A
W
I
H
V
L
P
W
E
G
M
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
-
R
---
A
M
--
P
-
E
T
A
T
R
I
G
---------
E
K
L
S
L
-------
K
E
L
G
R
D
----
Y
K
L
V
L
K
N
G
-
R
F
V
A
G
A
L
A
L
------
G
F
V
S
L
P
-
L
L
A
W
---------------------------------
I
A
Q
S
P
I
I
I
I
T
G
-
E
-
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
-
N
L
L
L
A
R
L
T
S
-----------
R
R
T
V
R
-
S
L
I
---
I
M
G
G
------------
W
P
I
M
I
G
-----
L
L
V
A
A
A
A
T
V
I
S
S
H
A
Y
L
W
M
T
A
G
L
S
I
Y
A
-
F
G
I
G
L
A
N
A
G
L
V
R
L
T
L
-------
F
A
S
D
M
S
K
G
T
V
S
A
-
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
--
S
---
K
H
A
W
L
N
G
G
N
G
-
L
F
N
L
F
N
L
V
N
G
----------
I
L
W
L
S
L
M
V
I
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
40.21
15%
-109
- C4 -
2CFQ
-
LACY_ECOLI
A:
[23-181]
--------------------------------------------------------------------
M
G
A
Y
F
P
F
F
P
I
W
L
---
H
D
I
-
N
H
I
S
K
S
D
T
-
G
I
I
F
A
-----------------------------
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
-
V
M
---
F
A
P
F
F
I
F
---------
I
F
--
G
----
P
L
L
Q
Y
-
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
CFNAG
A
------
P
A
V
-
E
A
F
I
E
K
----
V
S
R
--
R
S
N
F
---
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
---
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
-
L
---
F
F
--
A
-
K
T
D
A
P
S
S
---------
A
T
V
A
N
-------
A
V
G
A
N
H
----
S
A
F
S
L
K
L
A
-
L
E
L
F
R
Q
P
K
L
------
W
F
L
S
L
Y
-
V
I
G
V
---------------------------------
S
C
T
Y
D
V
F
D
Q
Q
F
-
A
-
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
-
T
M
G
E
L
L
N
A
S
-----------
I
M
F
F
A
-
P
L
I
---
I
N
R
I
------------
G
G
K
N
A
L
-----
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
-
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
-------
F
K
Y
I
T
S
Q
F
E
V
R
F
-
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
--
M
---
I
F
M
S
V
L
A
G
N
M
-
Y
E
S
I
G
F
Q
G
A
Y
----------
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
---
R
Q
V
N
E
-
V
A
-------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.99
23%
-116
- C4 -
4ZP2
-
?
A:
[68-176]
--------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
-
W
F
---
I
V
T
C
L
A
I
---------
L
L
--
A
----
Q
N
-
I
E
-
Q
F
T
L
L
R
F
L
Q
G
I
S
L
C
F
-----
I
------
G
A
V
G
Y
A
A
I
R
E
----
S
F
E
E
A
V
C
I
K
---
I
T
A
L
-
M
A
N
V
A
L
I
A
P
-
L
L
G
P
L
V
G
A
A
W
I
H
V
L
P
W
E
G
M
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
-
R
---
A
M
--
P
-
E
T
A
T
R
I
G
---------
E
K
L
S
L
-------
K
E
L
G
R
D
----
Y
K
L
V
L
K
N
G
-
R
F
V
A
G
A
L
A
L
------
G
F
V
S
L
P
-
L
L
A
W
---------------------------------
I
A
Q
S
P
I
I
I
I
T
G
-
E
-
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
-
N
L
L
L
A
R
L
T
S
-----------
R
R
T
V
R
-
S
L
I
---
I
M
G
G
------------
W
P
I
M
I
G
-----
L
L
V
A
A
A
A
T
V
I
S
S
H
A
Y
L
W
M
T
A
G
L
S
I
Y
A
-
F
G
I
G
L
A
N
A
G
L
V
R
L
T
L
-------
F
A
S
D
M
S
K
G
T
V
S
A
-
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
--
S
---
K
H
A
W
L
N
G
G
N
G
-
L
F
N
L
F
N
L
V
N
G
----------
I
L
W
L
S
L
M
V
I
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
39.18
23%
-113
- C4 -
4ZOW
1
?
A:
[67-175]
--------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
-
W
F
---
I
V
T
C
L
A
I
---------
L
L
--
A
----
Q
N
-
I
E
-
Q
F
T
L
L
R
F
L
Q
G
I
S
L
C
F
-----
I
------
G
A
V
G
Y
A
A
I
R
E
----
S
F
E
E
A
V
C
I
K
---
I
T
A
L
-
M
A
N
V
A
L
I
A
P
-
L
L
G
P
L
V
G
A
A
W
I
H
V
L
P
W
E
G
M
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
-
R
---
A
M
--
P
-
E
T
A
T
R
I
G
---------
E
K
L
S
L
-------
K
E
L
G
R
D
----
Y
K
L
V
L
K
N
G
-
R
F
V
A
G
A
L
A
L
------
G
F
V
S
L
P
-
L
L
A
W
---------------------------------
I
A
Q
S
P
I
I
I
I
T
G
-
E
-
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
-
N
L
L
L
A
R
L
T
S
-----------
R
R
T
V
R
-
S
L
I
---
I
M
G
G
------------
W
P
I
M
I
G
-----
L
L
V
A
A
A
A
T
V
I
S
S
H
A
Y
L
W
M
T
A
G
L
S
I
Y
A
-
F
G
I
G
L
A
N
A
G
L
V
R
L
T
L
-------
F
A
S
D
M
S
K
G
T
V
S
A
-
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
--
S
---
K
H
A
W
L
N
G
G
N
G
-
L
F
N
L
F
N
L
V
N
G
----------
I
L
W
L
S
L
M
V
I
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
38.92
31%
-20
- C2 -
4EMN
2
RPFB_MYCTU
A:
[16-71]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
---
I
N
T
G
N-----------
G
Y
Y
G
G
V
-----
Q
F
D
Q
G
T
W
E
A
N
G
G
L
R
Y
A
P
R
A
D
-----
L
-
A
T
R
E
E
Q
I
A
V
A
E
V
T
R
L
-------
R
Q
G
W
G
A
W
P
V
C
A
A
-
R
A
G
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
36.83
31%
-20
- C2 -
4KPM
2
RPFB_MYCTU
A:
[15-70]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
---
I
N
T
G
N-----------
G
Y
Y
G
G
V
-----
Q
F
D
Q
G
T
W
E
A
N
G
G
L
R
Y
A
P
R
A
D
-----
L
-
A
T
R
E
E
Q
I
A
V
A
E
V
T
R
L
-------
R
Q
G
W
G
A
W
P
V
C
A
A
-
R
A
G
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
35.48
31%
-21
- C2 -
4KL7
-
RPFB_MYCTU
A:
[15-70]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
---
I
N
T
G
N-----------
G
Y
Y
G
G
V
-----
Q
F
D
Q
G
T
W
E
A
N
G
G
L
R
Y
A
P
R
A
D
-----
L
-
A
T
R
E
E
Q
I
A
V
A
E
V
T
R
L
-------
R
Q
G
W
G
A
W
P
V
C
A
A
-
R
A
G
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
34.75
14%
-96
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[43-177]
---------------------------------------------------------------------
N
L
N
D
I
L
L
P
Q
F
Q
---
Q
-
A
-
F
T
L
T
N
F
Q
A
-
G
L
I
Q
S
-----------------------------
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
-
L
Y
---
A
L
G
A
A
L
F
---------
W
P
--
A
A
E
I
-
M
N
-
Y
T
-
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
----
E
------
T
A
A
-
N
P
F
V
T
V
----
L
G
P
E
S
S
G
H
F
---
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
-
H
---
S
L
--
V
-
L
S
V
Q
T
P
Y
---------
M
I
I
V
A
-------
I
V
L
L
V
A
----
L
L
I
M
L
T
K
F
-
P
A
L
Q
S
D
N
H
S
------
D
A
K
Q
G
S
-
F
S
A
S
---------------------------------
L
S
R
L
A
R
I
R
H
W
R
-
W
-
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
-
Y
A
V
E
E
I
P
G
M
-----------
T
A
G
F
A
-
A
N
Y
---
L
T
G
T
------------
M
V
C
F
F
I
-----
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
-
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
-------
I
A
L
T
L
C
S
A
F
M
S
I
-
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
--
T
---
K
Y
G
S
S
F
I
V
M
T
-
I
I
G
G
G
I
V
T
P
V
----------
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
---
A
R
F
R
S
-
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
34.31
8%
-158
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[60-172]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
A
G
L
I
Q
S
A
-
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
-------
M
K
K
L
S
Y
K
--
A
G
I
-
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
--
A
A
E
I
M
N
Y
T
L
F
L
V
G
L
-
F
I
I
A
A
G
L
G
C
L
----------
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
---
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
-
I
L
------------
S
N
V
P
H
Q
S
Q
D
V
L
D
-----
K
M
S
P
E
Q
L
S
A
Y
K
-
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
-
V
A
---------
I
V
L
L
V
A
L
L
I
-
M
L
--------------------------------------------------
15
HHSearch
33.71
8%
-98
- C4 -
1PW4
-
GLPT_ECOLI
A:
[272-428]
-----------------------------------------------------------------------
I
L
D
W
S
P
T
Y
L
---
K
E
V
-
K
H
F
A
L
D
K
S
-
S
W
A
Y
F
-----------------------------
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
---
V
F
-
F
M
T
L
V
T
I
A
T
I
V
Y
---------
W
M
NP
A
----
G
N
-
P
T
-
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
----
V
------
M
L
I
-
G
L
H
A
L
E
----
L
A
P
K
K
A
A
G
T
---
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
--
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
-
L
---
I
V
--
V
-
M
I
G
E
K
R
R
---------
H
E
Q
L
L
-------
Q
E
L
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
32.18
11%
-127
- C4 -
2GFP
-
EMRD_ECOLI
A:
[42-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
A
V
Q
S
V
M
G
A
-
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
-------
S
D
R
V
G
R
R
--
P
V
I
-
L
V
G
M
S
I
F
M
L
A
T
L
V
A
V
T
--
T
---
S
S
L
T
V
L
I
A
A
S
-
A
M
Q
G
M
G
T
G
V
G
----------
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
---
L
V
S
P
L
-
L
A
P
L
I
G
G
L
L
D
T
M
------------
W
N
W
--
R
A
C
Y
L
F
L
-----
L
-
V
L
C
A
G
V
T
F
S
-
M
A
R
W
M
P
E
T
R
P
V
D
A
P
-
R
T
---------
R
L
L
T
S
Y
K
T
L
-
F
G
--------------------------------------------------