@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2540_HUMAN: (2015-12-09 )
MDPETRGQEIIKVTPLQQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKLWYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKLGENETCIPIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIKIAPACAIMISTYEFGKAFFQKQNVRRQQY
Atome Classification :
(20 SA)
------.........10----.........20.--.-----......30....---....40-........50...---------.....60........70.......----.80........90-........---100.------.......110.....-..120.-----------.....----.-130.....---------..----140....-----...150.......-160---------------.------........-----170----....--------.....180..---...----..190-----.......--.200.....--..210-----..--......-220..---.....---230....-...240.......250...-....260-...------.--...270.......---280.......290-.-------------------......300....-----...310.......----320------.......---------330.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MDPETRG
Q
E
I
-----
I
K
VT
P
L
Q
Q
M
L
A
S
--
C
-----
T
G
A
I
L
T
S
V
I
VTP---
L
D
V
V
K
I
-
R
L
Q
AQNNPLPKG
K
---------
C
F
V
Y
SNGL
M
D
H
L
C
V
CEEGGNK
L
W
Y
----KKPGNFQ
G
T
L
D
A
F
-
F
K
I
I
R
NE
G
---
I
K
-
S
------
L
WSGLPP
T
L
V
M
AVP
A
-
T
V
I
Y
F
T
-----------
C
Y
D
Q
L
----
S
-
A
L
L
R
S
KLG---------EN----ET
C
I
P
I
V
-----
A
G
I
V
A
RFG
A
V
T
V
I-
S
-----------------
P
------
L
E
L
I
R
T
K
M
-----Q------SKK
F
--------
S
Y
V
E
L
H
R
F
V
S
---
K
K
V----SEDG------
W
I
S
L
W
RG--WA
P
T
V
L
RDV--PF
S
A
------
M
Y
--
W
Y
N
Y
E
I
-
L
K
K
W
L
---
C
EKSG---LYE
P
T
F
M
-
I
N
FTSGALSGS
F
A
A
V
A
TL
P
-
F
D
V
VKTQ-KQ
T
------
Q
--
L
W
T
YES
H
K
I
SM
P
L
---H
M
S
T
W
I
I
M
K
N
I
V
A-K-------------------NG
F
S
G
L
F
S
G
L
I
P
R
-----
L
I
K
IAP
A
C
A
I
M
I
S
----
T
Y
E
------
F
G
K
A
F
F
Q
---------
K
Q-NVRRQQY-
36
Fugue
82.28
21%
-90
- C6 -
4MUO
-
YBIB_ECOLI
A:
[1-320]
------
M
D
Y
R
K
I
I
K
E
I
-----
G
R
G
K
N
H
A
R
D
L
D
R
--
D
-----
T
A
R
G
L
Y
A
H
M
L
-----------------
N
G
E
V
P
-------------------------
D
L
E
L
G
G
V
L
I
A
L
----
R
I
K
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-
Y
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A
M
Q
N
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---
I
K
L
T
------
P
P
A
G
K
P
M
P
I
V
I
P
S
Y
N
-
G
A
R
K
Q
A
-----------
N
L
T
P
L
----
L
-
A
I
L
L
H
K
L
G
FP
V
V
V
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V
S
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----
P
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V
-
L
T
-----
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G
-
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T
P
T
-
L
-----------------
H
------
G
G
Q
A
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A
K
L
-----
D
------
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H
Q
P
--------
V
F
M
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V
G
A
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C
P
P
L
-
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Q
----
L
A
M
R
------
W
R
M
G
V
R
N
--
S
A
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T
L
A
K
L
A
T-
P
F
A
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GE
A
L
R
L
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--
V
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Y
-
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V
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---
K
F
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---
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G
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A
L
L
-
M
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T
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---
Y
A
N
P
Q
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C
P
Q
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N
L
I
D
R
E
-
G
M
R
------
V
--
L
Y
E
K
Q
A
K
D
---
P
E
---
T
T
A
Q
W
I
E
R
C
---------------------------
L
A
G
--
S
E
P
I
P
E
-----
S
L
K
I
Q
M
A
C
C
L
V
A
T
GEAA
T
I
S
------
D
G
L
A
R
V
N
---------
Q
A
-
F
-------
35
Fugue
81.66
19%
-101
- C8 -
4Q9T
-
?
A:
[12-446]
-------
T
K
I
L
T
E
T
E
K
-----
Y
S
V
T
K
L
S
T
D
L
S
F
--
L
PF
E
G
L
V
D
T
A
L
Q
K
A
L
V
N
D
---
L
D
H
I
Y
I
W
N
Y
N
S
I
Q
K
D
T
P
I
C
K
I
S
LHS
S
P
P
I
C
L
F
T
S
S
--
I
N
G
I
C
I
I
N
K
K
N
S
Q
F
L
Y
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EDI
S
T
I
N
N
L
A
H
V
L
D
---
L
K
L
K
D
N
E
N
---
I
T
-
S
------
T
I
N
C
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G
I
I
I
A
T
S
L
G
R
V
L
F
I
T
IKDSTGK
P
K
L
E
L
K
Q
Q
L
IKPQ
N
-
S
F
F
F
R
N
L
D
---------
S
S
----
K
E
I
I
S
L
K
-----
K
G
P
I
V
G
K
G
E
R
L
L
Y
-
I
-----------------
T
T
RGG
S
-
L
Q
I
W
Q
L
S
I
-----
N
------
S
K
S
F
--------
K
R
L
E
I
N
--------------
I
Y
E
H
------
V
L
D
S
L
Q
D
--
L
Y
P
F
A
H
G
T
L
--
A
F
L
D
------
S
H
PI
Y
S
D
T
S
S
-
A
H
L
T
L
---
A
S
I
S
N
---
G
N
E
I
Y
Y
L
M
I
T
V
I
L
D
E
K
T
N
S
F
Q
I
F
S
I
Y
K
-
L
N
T
Y
F
T
K
-
S
T
V
DLNH
K
P
Q
--
L
F
I
P
N
A
L
D
S
I
V
S
P
---
T
L
S
V
Y
V
L
F
N
N
A
V
V
M
T
-------------------
Q
I
S
S
K
L
D
S
S
F
P
L
R
RK
W
E
D
I
I
R
F
N
K
D
V
E
I
I
G
S
----
G
Y
S
------
T
D
S
I
Y
V
I
C
--------
K
D
M
G
V
L
K
I
A
S
H
2
PsiBlast_PDB
81.08
23%
-54
- C5 -
4C9H
5
ADT2_YEAST
A:
[24-317]
--------------------------
L
I
D
F
L
M
G
--
G
-----
V
S
A
A
V
A
K
T
A
A
S
P
---
I
E
R
V
K
L
-
L
I
Q
N
Q
D
E
M
L
K
Q
G
T
-----------------
L
D
R
---------------------
K
Y
A
G
I
L
D
C
F
-
K
R
T
A
T
Q
E
G
---
V
I
-
S
------
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
-
Q
A
L
N
F
A
-----------
F
K
D
K
I
----
K
-
A
M
F
G
F
K
-----------
K
E
----
E
G
Y
A
K
W
F
-----
A
G
N
L
A
S
G
G
A
A
G
A
L
-
S
L
L
FV
Y
------------
S
------
L
D
Y
A
R
T
R
L
A
A
DS---------------------
A
R
Q
F
N
G
L
I
D
V
Y
K
K
T
L
----
K
S
D
G
------
V
A
G
L
Y
R
G
--
F
L
P
S
V
V
G
I
V
--
V
Y
R
G
------
L
Y
--
F
G
M
Y
D
S
-
L
K
--------------------
L
-
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
-
L
D
T
V
R
---
R
R
M
------
M
--
M
T
S
G
Q
A
V
K
--------
Y
D
G
A
F
D
C
L
R
K
I
V
A
-
A
-------------------
E
G
V
G
S
L
F
K
G
C
G
A
N
-----
I
L
R
-
G
V
A
G
A
G
V
I
S
----
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
---------------------
3
PsiBlast_PDB
76.32
22%
-51
- C5 -
4C9J
4
ADT3_YEAST
A:
[38-321]
-------------------------------------------
A
A
I
A
K
T
A
A
S
P
---
I
E
R
V
K
I
-
L
I
Q
N
Q
D
E
M
I
K
Q
G
T
-----------------
L
D
K
---------------------
K
Y
S
G
I
V
D
C
F
-
K
R
T
A
K
Q
E
G
---
L
I
-
S
------
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
-
Q
A
L
N
F
A
-----------
F
K
D
K
I
----
K
-
L
M
F
G
F
K
-----------
K
E
----
E
G
Y
G
K
W
F
-----
A
G
N
L
A
S
G
G
A
A
G
A
L
-
S
L
L
FV
Y
------------
S
------
L
D
F
A
R
T
R
L
A
A
DAK
S
-------------------
A
R
Q
F
N
G
L
T
D
V
Y
K
K
T
L
----
K
S
D
G
------
I
A
G
L
Y
R
G
--
F
M
P
S
V
V
G
I
V
--
V
Y
R
G
------
L
Y
--
F
G
M
F
D
S
-
L
K
------------------------
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
-
L
D
T
V
R
---
R
R
M
------
M
--
M
T
S
G
Q
A
V
K
Y
N
G
A
I
---
D
-----
C
L
K
K
I
V
A
-
S
-------------------
E
G
V
G
S
L
F
K
G
C
G
A
N
-----
I
L
R
-
S
V
A
G
A
G
V
I
S
----
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
----------------------
31
Fugue
73.85
18%
-64
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
---------------
D
-----
Q
A
L
S
F
L
K
D
F
L
A
G
--
G
-----
V
A
A
A
I
S
K
T
A
V
A
P
---
I
E
R
V
K
L
-
L
L
Q
V
Q
H
A
S
K
Q
-----------------------------------
I
----
S
A
E
K
Q
Y
K
G
I
I
D
C
V
-
V
R
I
P
K
E
Q
G
---
F
L
-
S
------
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
-
Q
A
L
N
F
A
-----------
F
K
D
K
Y
----
K
-
Q
I
F
L
G
G
V
D
RHKQ
F
----
W
R
----
Y
F
A
G
N
L
A
-----
S
G
G
A
A
G
A
T
S
L
C
F
V
-
Y
-----------------
P
------
L
D
F
A
R
T
R
L
-----
A
A
DVGKG
A
A
Q
R
--------
E
F
T
G
L
G
N
C
I
T
---
K
I
F
----
K
S
D
G
------
L
R
G
L
Y
Q
G
--
F
N
V
S
V
Q
G
I
I
--
I
Y
R
A
------
A
Y
--
F
G
V
Y
D
T
-
A
K
G
M
L
---
P
D
P
K
------
N
V
H
I
I
-
V
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
-
F
D
T
V
R
R
R
-
M
M
M
------
Q
--
S
----
G
R
K
G
A
D
I
M
---
Y
T
G
T
V
D
C
W
R
K
I
A
K
-
D
-------------------
E
G
P
K
A
F
F
K
G
A
W
S
N
-----
V
L
R
G
M
G
G
A
F
V
L
V
L
----
Y
D
E
------
I
--------------------------
22
HHSearch
72.59
19%
-54
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
---------------
D
-----
Q
A
L
S
F
L
K
D
F
L
A
G
--
G
-----
V
A
A
A
I
S
K
T
A
V
A
P
---
I
E
R
V
K
L
-
L
L
Q
V
Q
H
A
S
K
Q
I
S
---------------------------------------
A
E
K
Q
Y
K
G
I
I
D
C
V
-
V
R
I
P
K
E
Q
G
---
F
L
-
S
------
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
-
Q
A
L
N
F
A
-----------
F
K
D
K
Y
----
K
-
Q
I
F
L
G
G
V
D
RHKQ
F
----
W
R
----
Y
F
A
G
N
L
A
-----
S
G
G
A
A
G
A
T
S
L
C
F
V
-
Y
-----------------
P
------
L
D
F
A
R
T
R
L
-----
A
------
A
D
V
G
KGAAQR--
E
F
T
G
L
G
N
C
I
T
---
K
I
F
----
K
S
D
G
------
L
R
G
L
Y
Q
G
--
F
N
V
S
V
Q
G
I
I
--
I
Y
R
A
------
A
Y
--
F
G
V
Y
D
T
-
A
K
G
M
L
---
P
D
P
------
K
N
V
H
I
I
-
V
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
-
F
D
T
V
R
R
R
-
M
M
M
------
Q
--
S
G
R
K
G
A
D
----
I
M
---
Y
T
G
T
V
D
C
W
R
K
I
A
K
-
D
-------------------
E
G
P
K
A
F
F
K
G
A
W
S
N
-----
V
L
R
G
M
G
-
G
A
F
V
L
V
----
L
Y
D
------
E
I
-------------------------
34
Fugue
72.57
16%
-79
* C8 *
3LRV
-
PRP19_YEAST
A:
[11-343]
APKWPI
L
K
N
L
E
L
L
Q
A
Q
N
Y
S
RN
I
K
T
F
P
Y
K
E
L
N
K
S
--
M
-----
Y
Y
D
K
W
V
C
M
C
R
C
E
---
D
G
A
L
H
F
-
T
Q
L
K
D
S
K
T
I
T
T
I
T
---------
T
P
N
P
R
T
G
G
E
H
P
A
I
I
S
R
G
P
C
N
R
L
L
L
----
L
Y
P
G
N
Q
I
T
I
L
D
S
K
T
N
K
V
L
R
E
I
E
---
V
D
-
S
ANEII
Y
M
Y
G
H
N
T
E
Y
F
I
W
A
D
N
R
-
G
T
I
G
F
Q
-----------
S
Y
E
D
D
----
S
----
Q
Y
I
V
H
---------
S
A
----
K
S
D
V
E
Y
S
-----
S
G
V
L
H
K
D
S
L
L
L
A
L
Y
S
-----------------
P
D
G
I
L
D
V
Y
N
L
S
S
P
D
Q
-----
A
------
S
S
R
F
--------
P
V
D
E
E
A
K
I
K
E
---
V
K
F
----
A
D
N
G
------
Y
W
M
V
V
E
C
--
D
Q
T
V
V
C
F
D
L
RK
D
V
G
T
------
L
A
--
Y
P
T
Y
T
I
G
T
V
T
Y
D
---
I
D
D
S
G
-------
K
N
M
-
I
A
Y
S
N
E
----------
S
N
S
-
L
T
I
Y
K
F
D
-
K
K
T
------
K
--
N
W
T
K
D
E
E
S
A
---
L
---
C
L
A
D
F
T
D
M
D
V
V
C
G
-
D
-------------------
G
G
----------------------
I
A
A
I
L
K
T
----
N
D
S
------
F
N
I
V
A
L
T
---------
P
----------
21
HHSearch
71.28
23%
-67
- C5 -
2LCK
-
UCP2_MOUSE
A:
[14-304]
--------------------------
T
V
K
F
L
G
A
--
G
-----
T
A
A
C
I
A
D
L
I
T
F
P
---
L
D
T
A
K
V
-
R
L
Q
I
Q
G
E
S
Q
G
L
V
--------------------------------
R
T
----
A
A
S
A
Q
Y
R
G
V
L
G
T
I
-
L
T
M
V
R
T
E
G
---
P
R
-
S
------
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
-
A
S
V
R
I
G
-----------
L
Y
D
S
V
----
K
-
Q
F
Y
T
K
G
S
E
---------
H
A
----
G
I
G
S
R
L
L
-----
A
G
S
T
T
G
A
L
A
V
A
V
A
-
Q
-----------------
P
------
T
D
V
V
K
V
R
F
-----
Q
------
A
Q
A
R
AGGGR---
R
Y
Q
S
T
V
E
A
Y
K
---
T
I
A
----
R
E
E
G
------
I
R
G
L
W
K
G
--
T
S
P
N
V
A
R
N
A
--
I
V
N
C
------
A
E
--
L
V
T
Y
D
L
-
I
K
D
T
L
---
L
K
A
-
N
---
L
M
T
D
D
L
P
-
C
H
F
T
S
A
F
G
A
G
F
C
T
T
V
I
A
S
P
-
V
D
V
V
K
T
R
-
Y
M
N
------
S
--
A
L
G
Q
------------
Y
H
S
A
G
H
C
A
L
T
M
L
R
-
K
-------------------
E
G
P
R
A
F
Y
K
G
F
M
P
S
-----
F
L
R
L
G
S
W
N
V
V
M
F
V
----
T
Y
E
------
Q
L
K
R
A
L
M
---------
A
A
-
Y
Q
S
R
E
A
P
-
4
PsiBlast_PDB
70.06
22%
-54
- C5 -
4C9Q
5
ADT3_YEAST
A:
[38-319]
-------------------------------------------
A
A
I
A
K
T
A
A
S
P
---
I
E
R
V
K
I
-
L
I
Q
N
Q
D
E
M
I
K
Q
G
T
-----------------
L
D
K
---------------------
K
Y
S
G
I
V
D
C
F
-
K
R
T
A
K
Q
E
G
---
L
I
-
S
------
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
-
Q
A
L
N
F
A
-----------
F
K
D
K
I
----
K
-
L
M
F
G
F
K
-----------
K
E
-----
G
Y
G
K
W
F
-----
A
G
N
L
A
S
G
G
A
A
G
A
L
-
S
L
L
FV
Y
------------
S
------
L
D
F
A
R
T
R
L
A
A
DAK
S
-------------------
A
R
Q
F
N
G
L
T
D
V
Y
K
K
T
L
----
K
S
D
G
------
I
A
G
L
Y
R
G
--
F
M
P
S
V
V
G
I
V
--
V
Y
R
G
------
L
Y
--
F
G
M
F
D
S
-
L
K
P
L
-----------------
F
L
-
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
-
L
D
T
V
R
---
R
R
M
------
M
--
M
T
S
G
Q
A
V
K
Y
N
G
A
I
---
D
-----
C
L
K
K
I
V
A
-
S
-------------------
E
G
V
G
S
L
F
K
G
C
G
A
N
-----
I
L
R
-
S
V
A
G
A
G
V
I
S
----
M
Y
D
Q
L
Q
M
I
L
F
G
K
------------------------
40
Fugue
68.96
14%
-96
- C3 -
1DT9
-
ERF1_HUMAN
A:
[5-422]
------
P
S
A
A
D
R
N
V
E
I
-----
W
K
I
K
K
L
I
K
S
L
E
A
AR
G
-----
N
G
T
S
M
I
S
L
I
I
P
P
KDQ
I
S
R
V
A
K
-
M
L
A
D
E
F
G
T
A
S
N
I
K
-------------
S
R
V
N
R
L
S
V
L
G
A
I
T
S
V
Q
Q
R
L
K
----
L
Y
N
K
V
P
P
N
G
L
V
V
Y
-
C
G
T
I
V
T
E
E
G
K
E
K
K
-
V
------
N
I
D
F
E
P
F
K
-----
P
I
-
N
T
S
L
Y
L
-----------
C
D
N
K
F
----
H
T
E
A
L
T
A
L
L
S
---------
D
D
----
S
K
F
G
F
I
V
I
D
GS
G
A
L
F
G
T
L
Q
G
N
T
R
E
V
-
L
H
K
F
T
V
DLPKKHGRGGQS
A
------
L
R
F
A
R
L
R
M
-----
E
------
K
R
H
N
--------
Y
V
R
K
V
A
E
T
A
V
---
Q
L
F
----
I
S
G
D
KVNVA
G
L
V
L
A
G
S
A
--
D
F
K
T
E
L
S
Q
S
--
D
M
F
D
------
Q
R
--
L
Q
S
-
K
V
-
L
K
L
V
D
---
I
S
Y
G
G
---
E
N
G
F
N
Q
A
-
I
E
L
S
T
E
V
L
S
N
V
K
F
I
Q
E
K
K
L
-
I
G
R
Y
F
D
E
-
I
S
Q
------
D
TG
K
Y
C
F
G
V
E
D
T
L
K
A
L
E
M
G
A
V
E
I
L
I
V
Y
E
N
L
D
I
-
M
R
Y
V
LI
L
Y
L
T
PEQEKDKSHF
T
E
S
M
P
L
L
E
W
F
A
N
N
-----
Y
K
K
F
G
A
T
L
E
I
V
T
D
----
K
S
Q
------
E
G
S
Q
F
V
K
GFGGIGGIL
R
Y
-
R
V
D
F
Q
G
M
-
32
Fugue
68.42
12%
-94
* C6 *
1B0P
1
POR_DESAF
A:
[1-257]
-------------
G
K
K
-----
M
M
T
T
D
G
N
T
A
T
A
H
--
V
-----
A
Y
A
M
S
E
V
A
A
I
Y
P
---
I
T
P
S
S
T
-
M
G
E
E
A
D
D
W
A
A
Q
G
R
---------
K
N
I
F
--------------
G
Q
T
L
T
I
----
R
E
M
Q
S
E
A
G
A
A
G
A
V
-
H
G
A
L
A
---------------------
A
G
A
L
T
T
T
F
T
A
-
S
Q
G
L
L
L
-----------
M
I
P
N
M
----
Y
-
K
I
S
G
E
L
L
--------------------
P
G
V
-----
F
H
V
T
A
R
A
I
A
A
H
A
L
-
S
-----------------
I
------
F
G
D
H
Q
D
I
Y
-----
A
------
A
R
Q
T
--------
G
F
A
M
L
A
--------------------------------------------
S
S
S
V
------
Q
E
--
A
H
D
M
A
L
-
V
A
H
L
A
---
A
I
E
S
N
---
V
---
P
F
M
-
H
F
F
D
G
F
R
T
S
H
E
I
Q
K
I
E
V
L
D
-
Y
A
D
M
A
S
L
V
N
Q
K
------
A
--
L
A
E
F
R
A
K
S
M
N
P
E
H
---
P
H
V
R
-------------------------------
G
T
A
Q
N
P
D
I
Y
F
Q
G
-----
R
E
A
A
N
P
Y
Y
L
K
V
P
G
----
I
V
A
------
E
Y
M
Q
K
V
A
---------
S
L
-
T
--
G
R
S
Y
-
1
PsiBlast_PDB
67.59
23%
-67
- C5 -
2LCK
-
UCP2_MOUSE
A:
[16-292]
----------------------------
K
F
L
G
A
--
G
-----
T
A
A
C
I
A
D
L
I
T
F
P
---
L
D
T
A
K
V
-
R
L
Q
I
Q
G
E
-------------------
S
Q
G
L
V
R
T
A
A
S
A
Q
-----------------
Y
R
G
V
L
G
T
I
-
L
T
M
V
R
T
E
G
---
P
R
-
S
------
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
-
A
S
V
R
I
G
-----------
L
Y
D
S
V
----
K
-
Q
F
Y
T
K
G
S
E
---------
H
A
----
G
I
G
S
R
L
L
-----
A
G
S
T
T
G
A
L
A
V
A
V
A
-
Q
-----------------
P
------
T
D
V
V
K
V
R
F
-----
Q
------
A
Q
A
R
AGGGRRYQ
S
T
V
E
A
Y
K
T
I
A
---
R
-------
E
E
G
------
I
R
G
L
W
K
G
--
T
S
P
N
V
A
R
N
A
--
I
V
N
C
------
A
E
--
L
V
T
Y
D
L
-
I
K
D
T
L
---
L
-
K
A
N
---
L
M
T
D
D
L
P
-
C
H
F
T
S
A
F
G
A
G
F
C
T
T
V
I
A
S
P
-
V
D
V
V
K
T
R
Y
M
N
S
------
A
--
L
G
Q
Y
H
S
A
G
--------
H
C
A
L
T
M
L
R
------
K
-------------------
E
G
P
R
A
F
Y
K
G
F
M
P
S
-----
F
L
R
L
G
S
W
N
V
V
M
F
V
----
T
Y
E
------
Q
L
K
R
A
L
M
---------
A
A
-
Y
Q
S
R
E
A
P
-
33
Fugue
63.92
11%
-70
- C2 -
4XOH
-
?
A:
[5-324]
--------
P
L
P
L
G
R
F
Y
-----
I
H
L
N
S
I
L
N
I
S
I
S
--
E
-----
V
H
S
P
I
K
I
I
V
N
T
P
---
T
Q
N
M
Q
L
-
P
W
Q
A
V
N
---------------------------------
G
N
N
R
L
D
H
----
D
F
A
F
H
V
D
D
N
F
K
V
S
-
F
M
F
L
D
---------------------
I
P
I
E
D
I
K
K
V
S
-
G
T
A
T
L
N
-----------
L
G
N
V
K
----
D
-
S
C
F
G
K
A
------------
F
----
N
V
E
I
P
I
I
-----
S
R
T
L
G
N
L
T
L
T
C
L
Y
-
I
-----------------
P
------
E
L
S
V
P
E
Q
E
LP---
F
------
T
L
E
Q
--------
A
T
M
D
L
R
H
V
R
S
---
N
Y
L
----
Y
N
E
G
------
Y
L
Y
R
L
E
D
S
S
I
R
R
R
F
V
V
L
R
--
S
K
Q
L
------
N
F
--
Y
A
--------------
E
K
G
G
---
Q
Y
L
D
T
F
Q
-
L
S
K
T
V
V
S
I
P
------------
M
V
N
F
S
E
-
A
V
S
------
N
--
L
G
L
V
A
G
I
L
A
T
S
V
D
---
R
R
H
V
Q
L
F
A
D
S
K
K
V
-
C
-------------------
Q
K
W
L
Q
V
M
N
S
R
S
F
A
-----
L
D
R
G
--------
T
----
E
K
L
------
W
L
Q
E
Y
V
N
---------
F
M
---------
38
Fugue
59.45
15%
-54
- C7 -
3WUQ
-
A:
[3-265]
---T
V
D
Q
V
E
E
L
R
R
D
L
R
-----
I
K
S
Q
E
L
E
V
K
N
A
A
--
A
-----
N
D
K
L
K
K
M
V
K
D
Q
Q
---
E
A
E
K
K
K
-
V
M
S
Q
E
I
Q
E
Q
L
H
K
Q
---------
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
---------------------------------------------------
E
P
A
V
I
E
A
Q
N
-
A
V
K
S
I
K
-------------
K
Q
H
----
L
-
V
E
V
R
S
M
A
N
---------
P
P
----
A
A
V
K
L
A
L
-----
E
S
I
C
L
L
L
G
E
S
T
---
T
-----------------
D
------
W
K
Q
I
R
S
I
I
-----
M
------
R
E
N
F
---------
I
P
T
I
V
N
F
S
A
---
E
E
I
----
S
D
A
I
------
R
E
K
M
K
K
N
--
Y
M
S
N
------------------
P
--
S
Y
N
Y
E
I
-
V
N
R
A
------------------------------
S
L
A
C
G
P
M
V
K
-
W
A
I
A
Q
L
N
-
Y
A
D
------
M
--
L
K
R
V
E
P
L
R
N
E
L
Q
K
---
L
E
D
D
A
--
K
D
N
Q
Q
K
-
A
-------------------
N
E
V
E
Q
M
I
R
D
L
E
A
S
-----
I
A
R
Y
K
E
E
Y
A
V
L
I
S
----
E
A
Q
------
A
I
K
A
D
L
A
---------
A
V
-
E
A
K
V
N
---
18
PsiBlast_PDB
57.75
25%
-92
- C5 -
2YKR
-
RS3_ECOLI
C:
[18-108]
--------------------------------------------------------------------------------------------------------
N
S
T
W
F
----
A
N
T
K
E
F
A
D
N
L
D
S
D
-
F
K
-
V
R
Q
Y
L
---
T
K
-
E
------
L
A
K
A
S
V
S
R
I
V
I
E
R
P
A
-
K
S
I
R
V
T
-----------
I
H
T
A
R
----
P
-
G
I
V
I
G
K
K
G
---------
E
D
VEKL
R
K
V
V
A
D
I
-----
A
G
V
P
A
Q
I
N
I
A
E
V
R
-
K
-----------------
P
------
E
L
D
A
K
L
V
A
-----
D
------
S
I
T
S
--------
Q
L
E
R
R
V
M
F
R
R
---
A
M
K
----
R
A
V
Q
------
N
A
M
R
L
G
A
--
K
G
I
K
V
E
V
S
G
--
R
L
G
G
------
A
E
--
I
A
R
T
E
W
-
Y
R
E
G
R
---
V
P
L
H
T
---
L
R
A
D
I
D
Y
-
N
T
S
E
A
H
T
T
Y
G
V
I
G
V
K
V
W
I
F
-
K
G
E
I
-----------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
57.63
20%
-43
* C5 *
1OKC
8
ADT1_BOVIN
A:
[5-204]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
S
F
L
K
D
F
L
-----
A
G
G
V
A
A
A
I
S
K
T
A
V
-
A
-----------------
P
------
I
E
R
V
K
L
L
L
-----
Q
------
V
Q
H
A
SKQISAEK
Q
Y
K
G
I
I
D
C
V
V
---
R
I
P
----
K
E
Q
G
------
F
L
S
F
W
R
G
--
N
L
A
N
V
I
R
Y
F
--
P
T
Q
A
------
L
N
--
F
A
F
K
D
K
-
Y
K
Q
I
F
---
L
G
G
V
D
RHK
Q
F
W
R
Y
F
A
-
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
-
L
D
F
A
R
T
R
-
L
A
A
------
D
--
V
G
K
G
A
A
Q
R
E
-------
F
T
G
L
G
N
C
I
T
K
I
F
K
-
S
-------------------
D
G
L
R
G
L
Y
Q
G
F
N
V
S
-----
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
----
V
Y
D
------
T
A
K
G
M
L
P
---------
D
P
-
K
N
V
H
I
I
V
-
6
PsiBlast_PDB
54.86
22%
-26
- C5 -
2C3E
4
ADT1_BOVIN
A:
[12-176]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
A
G
G
V
A
A
A
I
S
K
T
A
V
-
A
-----------------
P
------
I
E
R
V
K
L
L
L
-----
Q
VQHA--
S
K
Q
I
--------
S
A
E
K
Q
Y
K
G
I
I
---
D
C
V
V
R
I
P
K
E
Q
G
------
F
L
S
F
W
R
G
--
N
L
A
N
V
I
R
Y
F
--
P
T
Q
A
------
L
N
--
F
A
F
K
D
K
-
Y
K
Q
I
F
LGG
V
D
R
H
K
---
Q
F
W
R
Y
F
A
-
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
-
L
D
F
A
R
T
R
-
L
A
A
------
D
--
V
G
K
G
A
A
Q
R
E
F
T
G
L
---
G
N
C
I
T
K
I
F
K
S
------------------------
D
G
L
R
G
L
Y
Q
G
F
N
V
S
-----
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
----
V
Y
D
------
T
A
K
G
M
L
P
---------
D
P
-
K
N
V
H
I
I
V
-
23
HHSearch
54.06
24%
-45
- C5 -
2LCK
-
UCP2_MOUSE
A:
[113-301]
----------------------
H
A
G
I
G
S
R
L
L
A
G
--
S
-----
T
T
G
A
L
A
V
A
V
A
Q
P
---
T
D
V
V
K
V
-
R
F
Q
A
Q
A
R
A
G
------------------------------------------
G
G
R
R
Y
Q
S
T
V
E
A
Y
-
K
T
I
A
R
E
E
G
---
I
R
-
G
------
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
-
N
C
A
E
L
V
-----------
T
Y
D
L
I
----
K
-
D
T
L
L
K
A
N
L
M--------
T
D
----
D
L
P
C
H
F
T
-----
S
A
F
G
A
G
F
C
T
T
V
I
A
-
S
-----------------
P
------
V
D
V
V
K
T
R
Y
-----
M
------
N
S
A
L
G-------
Q
Y
H
S
A
G
H
C
A
L
---
T
M
L
----
R
K
E
G
------
P
R
A
F
Y
K
G
--
F
M
P
S
F
L
R
L
G
--
S
W
N
V
------
V
M
--
F
V
T
Y
E
Q
-
L
K
R
A
L
---
M
A
A
Y
Q
---
S
R
E
A
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.64
22%
-30
- C5 -
1OKC
7
ADT1_BOVIN
A:
[12-176]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
A
G
G
V
A
A
A
I
S
K
T
A
V
-
A
-----------------
P
------
I
E
R
V
K
L
L
L
-----
Q
VQHA--
S
K
Q
I
--------
S
A
E
K
Q
Y
K
G
I
I
---
D
C
V
V
R
IP
K
E
Q
G
------
F
L
S
F
W
R
G
--
N
L
A
N
V
I
R
Y
F
--
P
T
Q
A
------
L
N
--
F
A
F
K
D
K
-
Y
K
Q
I
F
L
GG
V
D
R
H
K
---
Q
F
W
R
Y
F
A
-
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
-
L
D
F
A
R
T
R
-
L
A
A
------
D
--
V
G
K
G
A
A
Q
R
E
F
T
G
L
---
G
N
C
I
T
K
I
F
K
S
------------------------
D
G
L
R
G
L
Y
Q
G
F
N
V
S
-----
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
----
V
Y
D
------
T
A
K
G
M
L
P
---------
D
P
-
K
N
V
H
I
I
V
-
17
PsiBlast_PDB
53.02
25%
-102
- C5 -
4ADV
-
RS3_ECOLI
C:
[18-108]
--------------------------------------------------------------------------------------------------------
N
S
T
W
F
----
A
N
T
K
E
F
A
D
N
L
D
S
D
-
F
K
-
V
R
Q
Y
L
---
T
K
-
E
------
L
A
K
A
S
V
S
R
I
V
I
E
R
P
A
-
K
S
I
R
V
T
-----------
I
H
T
A
R
----
P
-
G
I
V
I
G
K
K
G
---------
E
D
VEKL
R
K
V
V
A
D
I
-----
A
G
V
P
A
Q
I
N
I
A
E
V
R
-
K
-----------------
P
------
E
L
D
A
K
L
V
A
-----
D
------
S
I
T
S
--------
Q
L
E
R
R
V
M
F
R
R
---
A
M
K
----
R
A
V
Q
------
N
A
M
R
L
G
A
--
K
G
I
K
V
E
V
S
G
--
R
L
G
G
------
A
E
--
I
A
R
T
E
W
-
Y
R
E
G
R
---
V
P
L
H
T
---
L
R
A
D
I
D
Y
-
N
T
S
E
A
H
T
T
Y
G
V
I
G
V
K
V
W
I
F
-
K
G
E
I
-----------------------------------------------------------------------------------------------------------------------------------------