@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2551_HUMAN: (2015-12-09 )
MMDSEAHEKRPPILTSSKQDISPHITNVGEMKHYLCGCCAAFNNVAITFPIQKVLFRQQLYGIKTRDAILQLRRDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSCLLHKHVSAPEFATSGVAAVLAGTTEAIFTPLERVQTLLQDHKHHDKFTNTYQAFKALKCHGIGEYYRGLVPILFRNGLSNVLFFGLRGPIKEHLPTATTHSAHLVNDFICGGLLGAMLGFLFFPINVVKTRIQSQIGGEFQSFPKVFQKIWLERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKVI
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10....--....20........30........40..--.....--.50...----..---.-..60.-----.-.--------------....----------.70.-..-...-..80-----........90-------.........100.----...-...---110------.-----......120...--...-.130-.-----...-.--..--------.-140.-......---150--------.---.------.-....-.-----160.------------.--------.-....170.......180......---.190.-------......-200....----..-.---210..--------------------------.....220--.......230....--------...240..------.-----....250......--.260..------.....270.......280.....-..290.....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMDSEAHEKRPPILT--SSKQDISPHIT
N
V
G
E
M
K
H
Y
L
C
G
C
C
A
A
FN--
N
V
A
I
T
--
F
P
I
Q
K
V
----
L
F
---
R
-
Q
Q
LYG-----I-
K
--------------
T
R
D
A
----------
I
L
Q
L
-
R
R
-
D
G
F
-
R
N
L
Y
-----
R
G
IL
P
P
L
M
Q
--------
K
T
T
T
L
A
L
M
F
G
L
Y
E
----
D
L
S
-
C
L
L
---
H
KH------V-----SA
P
E
F
A
T
S
G
V
A
A
--
V
L
A-G
T
T
--
E
-----
A
I
F
-
T
--
P
L
--------
E
-
R
V
Q
T
-
L
L
Q
DHK---
H
H
---------
D
---
K
------
F
-
T
N
T
Y
-
Q
-----
A
F
K
A
------------
L
--------
K
-CH
G
I
G
E
Y
Y
R
G
L
V
P
I
L
F
RNG
L
S
N
V
---
L
F
FGL-------RG
P
I
K
E
-HLPTATT----H
S
-
A
---
H
L
V
N
D
--------------------------
F
I
C
G
G
L
L
G
--
A
M
L
G
F
L
F
F
P
I
N
V
V
K
--------
T
R
I
Q
S
Q
IG------
G
-----
E
F
Q
S
F
P
K
V
F
Q
K
I
W
--
L
E
R
D
R
K
------
L
I
N
L
F
R
GAH
L
N
Y
H
R
S
L
I
S
W
G
I
I
N
-
A
T
Y
E
F
L
L
KVI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
84.64
22%
-64
* C4 *
1OKC
10
ADT1_BOVIN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
--
S
K
T
A
V
--
A
P
I
E
R
V
----
K
L
---
L
-
L
Q
V
Q
H
-----
A
-
S
KQISAEKQYKG---
I
I
D
C
----------
V
V
R
I
P
K
E
-
Q
G
F
-
L
S
F
W
-----
R
G
N
L
A
N
V
I
R
--------
Y
F
P
T
Q
A
L
N
F
A
F
K
D
----
K
Y
K
-
Q
I
F
---
L
G
G
------
V
DRHKQ
F
W
R
Y
F
A
G
N
L
A
S
G
--
G
A
A
-
G
A
T
--
S
-----
L
C
F
V
Y
--
P
L
--------
D
-
F
A
R
T
-
R
L
A
A
D
V
---
G
K
GAAQ-----
R
---
E
------
F
-
T
G
L
G
-
N
-----
C
I
T
K
------------
I
F
-------
K
-
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
---
A
Y
F
G
V
-------
Y
D
T
A
K
G
-
M
L
P
D
P
K
------
N
-
V
---
H
I
I
V
S
--------------------------
W
M
I
A
Q
T
V
T
--
A
V
A
G
L
V
S
Y
P
F
D
T
V
R
--------
R
R
M
M
M
Q
S
G
------
R
KGADI
M
Y
T
G
T
V
D
C
W
R
K
I
A
--
K
D
E
G
--------
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
-
G
A
F
V
L
-
V
L
Y
D
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.99
22%
-77
- C4 -
4C9J
4
ADT3_YEAST
A:
[83-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
-
E
G
L
-
I
S
F
W
-----
R
G
N
T
A
N
V
I
R
--------
Y
F
P
T
Q
A
L
N
F
A
F
K
D
----
K
I
K
-
L
M
F
GFK
K
E
E
------
G
-----
Y
G
K
W
F
A
G
N
L
A
S
G
--
G
A
A
-
G
A
L
--
S
-----
L
L
F
-
V
Y
-
S
L
--------
D
-
F
A
R
T
R
L
A
A
D
A
K
---
S
---------------ARQFNG
L
-
T
D
V
Y
-
K
-------
K
T
------------
L
--------
K
-
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
---
L
Y
F
G
M
-------
F
D
S
L
K
---------------------------------------------------
F
L
L
G
W
V
V
T
--
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
--------
R
R
M
M
M
T
S
G
------
Q
AV---
K
Y
N
G
A
I
D
C
L
K
K
I
V
--
A
S
E
G
--------
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
I
S
-
M
Y
D
Q
L
Q
M
I
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.86
22%
-77
- C4 -
4C9Q
5
ADT3_YEAST
A:
[83-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
-
E
G
L
-
I
S
F
W
-----
R
G
N
T
A
N
V
I
R
--------
Y
F
P
T
Q
A
L
N
F
A
F
K
D
----
K
I
K
-
L
M
F
GFK
K
E
-------
G
-----
Y
G
K
W
F
A
G
N
L
A
S
G
--
G
A
A
-
G
A
L
--
S
-----
L
L
F
-
V
Y
-
S
L
--------
D
-
F
A
R
T
R
L
A
A
D
A
K
---
S
---------------ARQFNG
L
-
T
D
V
Y
-
K
-------
K
T
------------
L
--------
K
-
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
---
L
Y
F
G
M
-------
F
D
S
L
K
P
-
L
-----------------
F
L
A
S
---------------------------
F
L
L
G
W
V
V
T
--
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
--------
R
R
M
M
M
T
S
G
------
Q
AV---
K
Y
N
G
A
I
D
C
L
K
K
I
V
--
A
S
E
G
--------
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
I
S
-
M
Y
D
Q
L
Q
M
I
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.03
21%
-63
- C4 -
4C9H
5
ADT2_YEAST
A:
[80-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
E
G
V
-
I
S
F
W
-----
R
G
N
T
A
N
V
I
R
--------
Y
F
P
T
Q
A
L
N
F
A
F
K
D
----
K
I
K
-
A
M
F
G
F
K
K
E
E
------
G
-----
Y
A
K
W
F
A
G
N
L
A
S
G
--
G
A
A
-
G
A
L
--
S
-----
L
L
F
-
V
Y
-
S
L
--------
D
-
Y
A
R
T
R
L
A
A
D
S
--------------------ARQFNG
L
-
I
D
V
Y
-
K
-------
K
T
------------
L
--------
K
-
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
R
G
---
L
Y
F
G
M
-------
Y
D
S
L
K
---------------------
L
A
S
---------------------------
F
L
L
G
W
V
V
T
--
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
--------
R
R
M
M
M
T
S
G
QAVKYD
G
-----
A
F
D
C
L
R
K
I
V
A
A
--------
E
G
------
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
I
S
-
M
Y
D
Q
L
Q
M
I
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
71.98
21%
-73
- C2 -
4FDW
-
?
A:
[21-401]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASLEDFSIEQLPAKTIYALGENIDLTG
L
N
V
T
G
K
Y
DDG
K
Q
R
P
V
K
V
T
SEQISG
F
S
S
S
V
P
V
D
K
Q
E
V
T
I
T
I
E
G
K
Q
K
S
F
S
V
H
I
S
P
V
R
V
E
N
G
V
L
T
E
I
L
K
G
Y
N
--
E
I
I
L
P
--
N
S
V
K
S
I
PKDA
F
R
---
N
-
S
Q
I
A
K
-----
V
-
V
--------------
L
N
E
G
----------
L
K
S
I
-
G
D
M
A
F
F
-
N
S
T
V
-----
Q
E
I
V
F
P
S
T
L
--------
E
Q
L
K
E
D
I
F
Y
Y
C
Y
N
LKKA
D
L
S
-
K
T
K
---
I
T
K
------
L
-----
P
A
S
T
F
V
Y
A
G
I
E
E
--
V
L
L
-
P
V
T
LK
E
-----
I
G
S
-
Q
--
A
F
--------
L
-
K
T
S
Q
-
L
K
T
I
E
I
---
P
E
---------
N
---
V
------
S
-
T
I
G
Q
-
E
-----
A
F
R
E
-------------------------------
S
G
I
T
T
V
K
L
P
N
G
V
T
N
I
ASR
A
F
Y
Y
C
-------
P
------
E
L
A
E
V
T
T
----
Y
G
-
S
---
T
F
N
D
D
PEAMIHPYCLEGCPKLA
R
F
E
I
P
ESIR
I
L
G
Q
G
L
L
G
GN
R
K
V
T
Q
L
T
I
P
A
N
V
T
Q
INFSAFNN
T
G
I
K
-
E
V
K
------
V
-----
E
G
T
T
P
P
Q
V
F
E
K
V
W
YG
F
P
D
D
I
T
------
V
I
R
V
P
A
E
S
V
E
K
Y
K
N
A
-------
N
-
G
W
R
D
F
T
N
K
I
T
TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.48
23%
-60
- C4 -
2LCK
-
UCP2_MOUSE
A:
[30-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
--
F
P
L
D
T
A
----
K
V
---
R
-
L
Q
I
Q
G
ESQG
L
V
-
R
--------------
T
A
A
S
AQYRG
V
L
G
T
I
L
T
M
V
-
R
T
-
E
G
P
-
R
S
L
Y
-----
N
G
L
V
A
G
L
Q
R
--------
Q
M
S
F
A
S
V
R
I
G
L
Y
D
----
S
V
K
-
Q
F
Y
---
T
K
--------------
G
S
E
H
A
G
I
G
-
S
R
--
L
L
A
-
G
S
T
--
T
G
A
L
A
V
A
V
A
-
Q
--
P
T
--------
D
-
V
V
K
V
-
R
F
Q
A
Q
A
---
R
A
---------
G
GGR
R
------
Y
-
Q
S
T
V
-
E
-----
A
Y
K
T
------------
I
A-------
R
-
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
---
A
E
L
V
T
-------
Y
D
L
I
K
D
-
T
L
L
K
A
N
L
----
M
T
-
D
---
D
L
P
C
H
--------------------------
F
T
S
A
F
G
A
G
--
F
C
T
T
V
I
A
S
P
V
D
V
V
K
--------
T
R
Y
M
N
S
A
L
------
G
-----
Q
Y
H
S
A
G
H
C
--
A
L
T
--
M
L
R
K
E
G
------
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
-
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
69.80
22%
-62
- C4 -
2LCK
-
UCP2_MOUSE
A:
[14-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
--
A
D
L
I
T
--
F
P
L
D
T
A
----
K
V
---
R
-
L
Q
I
Q
G
-----
E
-
S
QG
L
V
R
T
A
ASAQYRG
V
L
G
T
----------
I
L
T
M
V
R
T
-
E
G
P
-
R
S
L
Y
-----
N
G
L
V
A
G
L
Q
R
--------
Q
M
S
F
A
S
V
R
I
G
L
Y
D
----
S
V
K
-
Q
F
Y
---
T
K
G
------
S
-----
E
H
A
G
I
G
S
R
L
L
A
G
--
S
T
T
-
G
A
L
--
A
-----
V
A
V
A
Q
--
P
T
--------
D
-
V
V
K
V
-
R
F
Q
A
Q
A
---
R
A
GGG------
R
---
R
------
Y
-
Q
S
T
V
-
E
-----
A
Y
K
T
------------
I
A-------
R
-
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
---
A
E
L
V
T
-------
Y
D
L
I
K
D
-
T
L
L
K
A
N
L
----
M
T
-
D
---
D
L
P
C
H
--------------------------
F
T
S
A
F
G
A
G
--
F
C
T
T
V
I
A
S
P
V
D
V
V
K
--------
T
R
Y
M
N
S
A
L
------
G
-----
Q
Y
H
S
A
G
H
C
A
L
T
M
L
--
R
K
E
G
--------
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
M
F
-
V
T
Y
E
Q
L
K
R
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
69.49
17%
-34
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
--
G
V
A
A
A
I
S
K
T
A
V
-------------
A
P
I
E
--
R
V
K
L
L
--
L
Q
V
Q
H
A
----
S
K
QIS
A
-
E
K
Q
Y
K
-----
G
-
I
--------------
I
D
C
V
----------
V
R
I
P
-
K
E
-
Q
G
F
-
L
S
F
W
-----
R
G
N
L
A
N
V
I
R
--------
Y
F
P
T
Q
A
L
N
F
A
F
K
D
----
K
Y
K
-
Q
I
F
---
L
G
G
VDRHKQ
F
-----
W
R
Y
F
A
G
N
L
A
S
G
G
--
A
A
G
-
A
T
S
--
L
-----
C
F
V
-
Y
--
P
L
--------
D
-
F
A
R
T
-
R
L
A
A
D
V
---
G
K
---------
G
---
A
------
A
-
Q
R
E
F
-
T
G
L
G
N
C
I
T
K
I
------------
F
--------
K
-
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
---
A
Y
F
G
V
-------
Y
D
T
A
K
G
-
M
L
P
D
--
P
----
K
N
-
V
---
H
I
I
V
S
--------------------------
W
M
I
A
Q
T
V
T
--
A
V
A
G
L
V
S
Y
P
F
D
T
V
R
--------
R
R
M
M
M
Q
S
G
RKG---
A
-----
D
I
M
Y
T
G
T
V
D
C
W
R
K
--
I
A
K
D
E
G
------
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
L
V
-
L
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
66.86
20%
-73
- C4 -
1OKC
8
ADT1_BOVIN
A:
[5-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
L
K
D
F
L
A
G
--
G
V
A
-
A
A
I
--
S
-----
K
T
A
V
A
--
P
I
--------
E
-
R
V
K
L
-
L
L
Q
V
Q
H
---
A
S
KQISAE---
K
---
Q
------
Y
-
K
G
I
I
-
D
-----
C
V
V
R
------------
I
P-------
K
-
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
D
K
Y
K
Q
-
I
F
L
G
G
V
D
RHKQ
F
W
-
R
---
Y
F
A
G
N
--------------------------
L
A
S
G
G
A
A
G
--
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
--------
T
R
L
A
A
D
V
G
------
K
GAAQR
E
F
T
G
L
G
N
C
I
T
K
I
F
--
K
S
D
G
--------
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
-
G
V
Y
D
T
A
K
G
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
64.11
13%
-71
- C3 -
1N81
-
?
A:
[21-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
Y
E
H
--
E
T
H
A
P
L
S
P
R
I
R
K
V
G
D
I
E
F
H
A
C
S
D
Y
I
Y
L
L
--
M
T
L
S
K
--
D
P
-------------
E
-
K
F
N
Y
A
-----
L
-
K
--------------
D
R
V
S
----------
I
R
R
Y
-
V
R
-
K
N
Q
-
N
R
Y
N
YFLIE
E
R
V
Q
D
N
I
V
N
--------
R
I
S
D
R
L
I
S
Y
C
T
D
K
----
E
V
T
-
E
D
Y
---
I
K
K
------
I
-----
D
D
Y
L
W
V
E
Q
R
V
I
E
--
E
V
S
-
I
N
V
--
D
-----
H
-
A
-
R
--
E
V
--------
K
-
E
K
K
R
-
I
M
N
D
K
K
---
L
I
---------
R
---
M
------
L
-
F
D
T
Y
-
E
-----
Y
V
K
D
------------
V
--------
K
----
F
T
D
D
Q
Y
K
D
A
A
A
R
I
S
Q
F
L
I
D
V
---
V
D
S
Y
I
-------
I
K
P
I
P
A
-
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
60.58
11%
-68
* C3 *
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
APKLFKDM
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
AEGCA
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
T
S
E
C
T
S
R
V
Q
--
T
H
A
A
A
A
L
V
N
F
S
E
F
A
S
K
D
I
L
E
P
Y
L
D
S
L
L
T
--
N
L
L
V
L
--
L
Q
S
N
K
L
----
Y
V
---
Q
-
E
Q
A
-------
L
-
T
--------------
T
I
A
F
----------
I
A
E
A
-
A
K
-
N
K
F
-
I
K
Y
Y
-----
D
T
L
M
P
L
L
L
N
--------
V
L
K
V
N
S
V
L
K
G
K
C
M
----
E
C
A
-
T
L
I
---
G
F
A
------
V
-----
G
K
E
K
F
--------------------------
H
-
E
--
H
S
--------
Q
-
E
L
I
S
-
I
L
V
A
L
Q
---
N
S
---------
D
---
A
------
L
-
R
S
Y
L
-
E
-----
Q
S
W
S
------------
R
--------
I
-
C
R
I
L
G
D
D
F
V
P
L
L
P
I
V
I
P
P
L
L
I
T
A
---
K
A
T
Q
D
-------
V
G
L
I
E
E
-
E
E
A
A
N
F
Q
----
Q
Y
-
P
---
D
W
D
V
V
--------------------------
Q
V
Q
G
K
-----------
H
I
A
I
H
T
S
V
--------
L
D
D
K
V
S
A
M
------
E
-----
L
L
Q
S
Y
A
T
L
L
R
G
Q
F
--
A
V
Y
V
K
E
------
V
M
E
E
I
A
L
P
S
L
D
F
Y
---
L
H
D
G
V
R
A
-
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
AE
E
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
EPM
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GDNCLS
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GHY
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
LE
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
YEQTASMKNAF
I
P
K
V
T
E
C
L
ISPD
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
47
HHSearch
57.08
22%
-50
- C4 -
2LCK
-
UCP2_MOUSE
A:
[15-203]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
L
G
A
--
G
T
A
-
A
C
I
--
A
-----
D
L
I
T
F
--
P
L
--------
D
-
T
A
K
V
-
R
L
Q
I
Q
G
---
E
S
QG
L
V
R
T
A
AS
A
---
Q
------
Y
-
R
G
V
L
-
G
-----
T
I
L
T
------------
M
V
-------
R
-
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
A
S
---
V
R
I
G
L
-------
Y
D
S
V
K
Q
-
F
Y
T
K
G
S
-----
E
H
-
A
---
G
I
G
S
R
--------------------------
L
L
A
G
S
T
T
G
--
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
--------
V
R
F
Q
A
Q
A
R
------
A
GGGR-
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
--
R
E
E
G
--------
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
-
V
T
Y
D
L
I
K
D
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.41
25%
-65
- C4 -
2C3E
4
ADT1_BOVIN
A:
[10-145]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
A
G
G
V
A
A
--
A
I
S
-
K
T
A
--
V
-----
A
------
P
I
--------
E
-
R
V
K
L
-
L
L
Q
-
V
Q
---
H
A
---------
S
---
K
------
Q
-
I
S
A
E
-
K
-----
Q
Y
K
G
------------
I
I
D
C
V
V
R
I
P
K
-
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
D
K
Y
K
Q
I
F
L
G
G
V
D
R
----
H
K
-
Q
F
W
R
Y
F
A
G
N
--------------------------
L
A
S
G
G
A
A
G
--
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
--------
T
R
L
A
A
D
V
G
------
K
-----
G
A
A
Q
R
E
F
T
G
L
G
N
C
--
I
T
K
I
F
K
------
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
-
A
Y
F
G
V
Y
D
T
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
54.99
19%
-79
- C1 -
2G3V
1
CAGS_HELPY
A:
[22-182]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
I
E
S
L
Q
E
N
E
LL
N
T
D
E
K
--
K
K
I
I
D
Q
----
I
K
---
T
M
H
D
F
F
K
-----
Q
M
H
--------------
T
N
K
G
----------
A
L
D
K
-
V
L
-
R
N
Y
M
K
D
-
Y
-----
R
A
V
I
K
S
I
----------
G
V
D
K
F
K
K
V
Y
R
L
L
E
----
S
E
T
M
E
L
L
---
H
A
I
------
A
-----
E
N
P
N
F
L
F
S
K
F
D
R
--
S
I
L
-
G
I
F
--
L
-----
P
F
F
-
S
--
K
P
I
M
F
K
MS
I
R
E
M
D
S
Q
I
-
E
L
Y
G
T
K
L
P
L
L
K
---------
L
---
F
------
V
M
T
D
E
E
M
N
-----
F
Y
A
N
------------
L
--------
K
T
I
E
Q
Y
N
D
Y
V
R
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
51.15
25%
-59
- C4 -
1OKC
7
ADT1_BOVIN
A:
[10-145]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
A
G
G
V
A
A
--
A
I
S
-
K
T
A
--
V
-----
A
------
P
I
--------
E
-
R
V
K
L
-
L
L
Q
-
V
Q
---
H
A
---------
S
---
K
------
Q
-
I
S
A
E
-
K
-----
Q
Y
K
G
------------
I
I
D
C
V
V
R
IP
K
-
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
---
L
N
F
A
F
-------
K
D
K
Y
K
Q
I
F
L
G
G
V
D
R
----
H
K
-
Q
F
W
R
Y
F
A
G
N
--------------------------
L
A
S
G
G
A
A
G
--
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
--------
T
R
L
A
A
D
V
G
------
K
-----
G
A
A
Q
R
E
F
T
G
L
G
N
C
--
I
T
K
I
F
K
------
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
-
A
Y
F
G
V
Y
D
T
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
49.75
7%
-75
- C3 -
3GMI
-
Y951_METJA
A:
[1-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q
A
M
L
I
G
E
I
M
D
L
N
L
K
N
F
L
E
D
R
E
E
I
I
R
--
D
A
K
R
K
D
E
K
S
F
K
D
F
K
K
I
V
E
E
I
K
E
R
E
N
K
D
K
--
I
V
C
D
F
TE
Y
N
P
L
H
K
----
G
H
---
K
-
Y
A
L
E
K
-----
G
-
K
--------------
E
H
G
I
----------
F
I
S
V
-
L
P
-
G
P
L
-
E
R
S
G
-----
R
G
-
I
P
Y
F
L
N
--------
R
Y
I
R
A
E
M
A
I
R
A
G
A
----
D
I
V
-
V
E
G
P
P-
M
G
I
------
M
-----
G
S
G
Q
Y
M
R
C
L
I
K
M
--
F
Y
S
L
G
A
E
--
I
-----
I
P
R
-
G
Y
I
P
E
--------
K
-
T
M
E
K
-
V
I
D
C
I
N
---
K
G
---------
Y
---
H
------
I
-
Q
V
K
P
-
Y
-----
K
I
I
C
IETGEILGEKLN
I
--------
D
-
N
Y
V
I
A
S
M
S
Q
M
I
Y
K
L
N
R
E
G
L
K
F
N
P
---
K
F
V
F
V
K
R
LEGIS
G
T
K
I
R
E
-
A
I
F
S
G
K
F
----
E
D
I
K
---
N
M
L
P
K
--------------------------
T
T
L
S
I
L
K
E
--
L
Y
D
N
G
K
L
N
E
L
I
L
K
R
--------
F
E
D
R
I
L
E
T
------
A
-----
N
E
Y
D
L
Y
E
Y
L
P
S
N
V
--
A
E
I
L
E
K
K
RPFNN
I
E
E
I
K
N
S
L
P
Y
G
F
S
R
H
F
R
E
R
I
L
S
K
-
L
E
A
R
I
P
N
E
T
L
S
K
Y
I
N
N
YPA
K
I
K
I
LAVK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
48.94
33%
-60
- C4 -
3ZLJ
2
MUTS_ECOLI
B:
[490-564]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
R
R
-
Q
T
L
-
K
N
A
E
-----
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
----
E
L
F
-
D
L
L
---
L
P
H
------
L
-----
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
-
N
L
A
--
E
-----
R
A
Y
-
T
--
L
N
--------
Y
-
T
C
P
T
-
F
I
D
K
P
G
---
I
R
---------
I
---
T
------
E
-
G
R
H
P
-
V
-----
V
E
Q
V
------------
L
--------
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
---
M
G
G
K
S
-------
T
Y
M
R
Q
T
-
A
L
I
A
L
M
A
----
Y
I
-
G
---
S
Y
V
P
A
--------------------------
Q
K
V
E
I
G
P
I
--
D
R
I
F
T
R
V
G
A
A
D
D
L
A
--------
S
G
R
S
T
F
M
V
------
E
-----
M
T
E
T
A
N
I
L
H
N
A
T
E
--
Y
S
L
V
L
M
------
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
-
A
N
K
I
K
A
L
T
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
47.02
33%
-62
- C4 -
1OH8
1
MUTS_ECOLI
B:
[490-564]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
R
R
-
Q
T
L
-
K
N
A
E
-----
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
----
E
L
F
-
D
L
L
---
L
P
H
------
L
-----
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
-
N
L
A
--
E
-----
R
A
Y
-
T
--
L
N
--------
Y
-
T
C
P
T
-
F
I
D
K
P
G
---
I
R
---------
I
---
T
------
E
-
G
R
H
P
-
V
-----
V
E
Q
V
------------
L
--------
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
---
M
G
G
K
S
-------
T
Y
M
R
Q
T
-
A
L
I
A
L
M
A
----
Y
I
-
G
---
S
Y
V
P
A
--------------------------
Q
K
V
E
I
G
P
I
--
D
R
I
F
T
R
V
G
T
F
M
V
E
M
--------
T
E
T
A
N
I
L
H
------
N
-----
A
T
E
Y
S
L
V
L
M
D
E
I
G
--
R
G
T
S
T
Y
------
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
-
A
T
H
Y
F
E
L
T
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
45.71
33%
-59
- C4 -
1WB9
2
MUTS_ECOLI
B:
[490-564]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
R
R
-
Q
T
L
-
K
N
A
E
-----
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
----
E
L
F
-
D
L
L
---
L
P
H
------
L
-----
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
-
N
L
A
--
E
-----
R
A
Y
-
T
--
L
N
--------
Y
-
T
C
P
T
-
F
I
D
K
P
G
---
I
R
---------
I
---
T
------
E
-
G
R
H
P
-
V
-----
V
E
Q
V
------------
L
--------
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
---
M
G
G
K
S
-------
T
Y
M
R
Q
T
-
A
L
I
A
L
M
A
----
Y
I
-
G
---
S
Y
V
P
A
--------------------------
Q
K
V
E
I
G
P
I
--
D
R
I
F
T
R
V
G
T
F
M
V
E
M
--------
T
E
T
A
N
I
L
H
------
N
-----
A
T
E
Y
S
L
V
L
M
D
E
I
G
--
R
G
T
S
T
Y
------
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
-
A
T
H
Y
F
E
L
T
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
45.53
33%
-59
- C4 -
1W7A
2
MUTS_ECOLI
B:
[490-564]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
R
R
-
Q
T
L
-
K
N
A
E
-----
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
----
E
L
F
-
D
L
L
---
L
P
H
------
L
-----
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
-
N
L
A
--
E
-----
R
A
Y
-
T
--
L
N
--------
Y
-
T
C
P
T
-
F
I
D
K
P
G
---
I
R
---------
I
---
T
------
E
-
G
R
H
P
-
V
-----
V
E
Q
V
------------
L
--------
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
---
M
G
G
K
S
-------
T
Y
M
R
Q
T
-
A
L
I
A
L
M
A
----
Y
I
-
G
---
S
Y
V
P
A
--------------------------
Q
K
V
E
I
G
P
I
--
D
R
I
F
T
R
V
G
A
A
D
D
S
G
--------
R
S
T
F
M
V
E
M
------
T
-----
E
T
A
N
I
L
H
N
A
T
E
Y
S
--
L
V
L
M
D
E
------
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
-
K
I
K
A
L
T
L
F
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------