@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S26A4_HUMAN: (2015-12-10 )
MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
Atome Classification :
(20 SA)
--------.........10........20........30........40........50........60........70...----.....80--....---..---...90--..------.----.....100.......110...--....120-.-......130---.......-.140.......150.....-..160......-----.170.......180......----.190......-.200..-..----...210...---....220.......230.-------.----.....240.......250-.........260....------...270.......280.......290.......300...----....310.......320....-...330-.......340.......350......----.360.......370----......----...380.......390.......400.......410.......420.......430-----------------.....--..440.----......450...--------------....460.......470.......480.....------..490----------.-.......500.......510.......520.......530.......540---.........550-....-----------------...560...-.-----...570...---------.-..---.580--.......590....----------...600.......610.......620.......630.-.....-----.640....--.-..650.......660.......670.-......680.---..-....690.......700...--....710...-----....720.......730.......740.......750.......760--------....---....--770.......780----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MAAPGGRSEPPQLPEYS
C
S
Y
MVSR
P
V
Y
S
E
L
A
F
Q
Q
Q
H
E
R
R
L
Q
E
R
K
T
L
R
E
S
L
A
K
C
CSC
S
R
K
R
A
F
G
V
L
K
T
L
V
P
I
L
E
W
----
L
P
K
Y
R
V
---
K
E
W
L
---
L
S
---
D
V
I
S
G
--
V
S
------
T
----
G
L
V
A
T
L
Q
G
M
A
Y
A
L
L
A
A
V
P
V
G
Y
--
G
L
Y
S
A
F
F
-
P
-
I
L
T
Y
F
I
F-G---TSRHISV-G
P
F
P
V
V
S
L
M
V
G
S
V
V
L
SMAP-D
E
H
F
L
V
SSSN
G
-----
T
V
L
N
T
T
M
IDTAA
R
D
T
A
R
V
L
I
----
A
S
A
L
T
L
L
V
G
I
-
I
Q
L
I
FG-G
L
----
Q
I
G
F
I
V
R
Y
L
---
A
D
P
LVGG
F
T
T
A
A
A
F
Q
V
L
V
-------
S
----
Q
L
K
I
V
L
N
VSTKNY
N
G
V
---
L
S
I
I
Y
T
L
V
E
I
F
Q
N
IGD------T
N
L
A
D
F
T
A
G
L
L
T
I
V
V
C
M
A
V
K
E
L
N
D
R
F
RHKIPVP
I
P
I
E
V
I
----
V
T
I
I
A
T
A
I
SYGANLEKNYNA
G
-
I
V
K
SIP-RGFLPPEL
P
P
V
S
L
F
S
E
M
L
A
A
S
F
S
I
A
V
----
V
A
Y
A
I
A
V
S
VG
K
V
------
Y
A
T
K
Y
D
----
Y
T
IDGN
Q
E
F
I
A
F
G
I
S
N
I
F
S
G
F
F
S
C
F
V
A
T
T
A
L
S
R
T
A
VQESTGG
K
T
Q
V
A
G
I
I
S
A
A
I
V
M
-----------------
I
A
I
L
A
--
L
G
K
L
L
E
----
P
L
Q
K
S
V
L
A
A
V
V
I
--------------
A
N
L
K
G
M
F
M
Q
LCD
I
P
R
L
W
R
QNKI
D
A
V
I
W
V
F
T
C
I
------
V
S
I
I
-----------
L
-
G
L
D
L
G
L
L
A
G
L
I
F
G
L
L
T
V
V
L
R
V
QFPSWNGLGSIP
S
T
D
I
Y
K
STKNYKNIE-----EPQG
V
K
I
L
R
FSS-
P
I
F
Y-----------------G
N
V
D
G
F
K
K
C
-
I
-----
K
S
TV
G
F
D
A
I
---------
R
-
V
Y
---
N
K
R
L
--
K
A
L
R
K
I
Q
K
L
I
KSGQ----------
L
R
ATKNG
I
I
SDAVSTNNAFEPD
E
D
I
E
D
L
E
E
LDIP
T
K
E
-
I
E
I
Q
V
-----DWNSEL
P
V
--
K
-
V
NVPKV
P
I
H
S
L
V
L
D
CG
A
I
S
F
L
D
V
V
G
V
-
R
S
L
R
V
I
V
K
E
F
---
Q
R-I
D
V
N
V
Y
F
A
S
L
Q
D
Y
V
I
E
K
L
E
Q--CGFFDDNIRK-----
D
T
F
F
L
T
V
H
D
A
I
L
Y
L
Q
N
Q
V
KSQEGQ
G
S
I
L
E
T
I
T
L
I
Q
D
C
K
D
T
L
E
L
I
E
T
---------EL
T
E
---
E
ELD--
V
Q
D
E
A
M
R
T
LAS------
25
Fugue
78.87
15%
-77
- C4 -
4HNY
4
NAT1_YEAST
A:
[54-862]
----------------------------------
V
D
S
L
A
L
K
G
L
D
L
Y
S
V
G
E
K
D
D
A
A
S
Y
V
A
N
A
I
R
A
S
P
I
C
C
H
V
L
G
I
Y
M
R
N
T
K
E
-------
Y
K
E
S
---
I
K
W
F
---
T
A
---
A
L
N
N
G
--
S
T
------
N
KQ
I
Y
R
D
L
A
T
L
Q
S
Q
I
G
D
F
K
N
A
L
V
S
R
K
--
K
Y
W
E
A
F
L
-
G
Y
R
A
N
W
T
S
L
-
A
---
V
A
Q
D
V
N
G
-
E
R
Q
Q
A
I
N
T
L
S
Q
F
E
K
L
A
E
G
K
I
S
D
S
E
K
Y
E
H
S
E
C
-----
L
M
Y
K
N
D
I
M
Y
K
A
A
S
D
N
-
Q
D
K
L
----
Q
N
V
L
K
H
L
N
D
I
-
E
P
C
V
F
D
-
K
F
----
G
L
L
E
R
K
A
T
I
---
Y
M
K
L
G
Q
L
K
D
A
S
I
V
Y
R
T
L
I
-------
K
----
R
------------
N
P
D
---
N
F
K
Y
Y
K
L
L
E
V
S
L
G
I
Q
G
------
D
--------------
N
K
L
K
K
A
L
Y
G
K
L
E
Q
F
Y
P
---
R
C
E
P
P
----
K
F
I
P
L
T
F
L
Q
D
K
E
E
L
S
K
K
L
R
E
Y
-
V
L
P
Q
L
E
-
R
G
-
V
P
A
T
F
S
N
V
K
P
L
Y
Q
R
R
K
S
K
V
S
P
L
L
----
E
K
I
V
L
D
Y
L
S
G
--------------------
L
D
P
T
Q
D
P
I
P
F
I
W
T
N
Y
Y
L
S
Q
H
F
L
F
L
K
D
F
P
K
A
Q
E
Y
I
D
A
A
L
D
H
T
P
T
---
L
V
E
F
Y
I
L
K
-----------------
A
R
I
L
K
--
H
L
G
L
M
D
----
T
A
A
G
I
L
E
E
G
R
Q
L
---------------
D
L
Q
D
R
F
I
N
C
K
T
V
K
Y
F
L
R
A
N
N
I
D
K
A
V
E
V
A
S
L
F
TKNDDS
V
N
G
I
-----------
K
-
D
L
H
L
V
E
A
S
W
F
I
V
E
Q
A
E
A
Y
Y
R
L
Y
L
D
R
K
K
K
L
D
D
L
A
S
Q
I
A
N
D
I
K
E
N
Q
W
L
V
R
-----
K
Y
K
G
L
A
L
K
R
F
N
A
I
P
K
F
Y
K
Q
F
E
D
D
Q
LDFH
S
Y
C
M
R
K
G
T
P
R
A
Y
L
E
M
-
L
-----
E
W
G
K
A
L
Y
T
K
---------
P
-
M
Y
---
V
R
A
M
--
K
E
A
S
K
L
Y
F
Q
M
H
D
D
R
----------
L
K
R
K
S
D
S
L
D
E
N
D
V
F
G
E
K
L
I
E
T
S
T
P
M
E
D
F
A
T
E
--
F
Y
N
N
-
Y
S
M
Q
V
REDER
D
Y
I
L
D
F
E
F
--
N
-
Y
R
I
G
K
L
A
L
C
F
A
S
L
N
K
F
A
K
R
F
G
T
T
S
G
L
F
G
S
M
A
I
V
L
L
H
A
---
T
R
-
P
----
F
D
P
I
L
K
K
V
V
T
K
S
L
E
K
EY
S
E
F
D
W
L
N
F
Y
Q
-----
E
K
F
G
K
N
D
I
N
G
L
L
F
L
Y
R
Y
R
D
D
V
P
-----
I
G
S
S
N
L
K
E
M
I
I
S
S
L
S
P
L
E
P
---------
H
S
Q
N
---
E
I
L
Q
--
Y
Y
L
Y
P
Y
D
V
P
D
Y
------
23
Fugue
78.66
20%
-120
- C4 -
5DA0
2
?
A:
[14-484]
-------------------------------------------------------------------------------------------
Q
---
R
E
W
F
AN
P
R
K
---
D
V
L
A
G
--
I
V
------
V
----
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
--
G
L
Y
A
S
F
I
-
I
-
A
L
I
T
A
F
L
-
G
---
G
R
P
G
M
I
S
-
A
A
T
G
A
M
A
L
L
M
T
G
L
V
-----------------------------------
K
D
H
G
I
Q
Y
----
L
F
A
A
T
V
L
T
G
V
-
L
Q
V
V
F
G
-
W
A
----
K
L
A
R
Y
L
K
F
V
---
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
-------
A
----
Q
L
P
Q
F
V
G
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
M
----------------------------------------
P
S
A
L
V
A
I
----
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
M
G
T
L
P
T
A
L
P
-
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
P
V
A
L
T
L
S
L
----
V
G
L
L
E
S
L
L
T
A
Q
L
------
I
D
E
R
T
D
----
T
T
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
A
F
L
M
-----------------
V
L
I
L
A
--
L
Q
P
L
L
V
----
Q
----
I
P
M
A
A
L
V
--------------
A
V
M
M
V
V
A
I
S
T
F
D
W
G
S
L
R
F
P
K
G
E
T
V
V
M
L
A
T
V
A
V
------
T
V
F
T
-----------
H
-
D
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
-----------------
Q
L
S
Q
V
T
P
V
D
-----
E
V
D
G
T
R
T
Y
R
V
R
G
-
Q
L
F
F
-----------------
V
S
T
H
D
F
L
H
Q
-
F
DFTHP
A
R
R
V
V
I
D
L
S
---------
D
-
A
H
F
WD
G
S
A
V
--
G
A
L
D
K
V
M
L
K
F
M
R
Q
G
----------
T
S
V
E
L
R
G
L
N
A
A
S
A
T
L
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.40
22%
-122
- C4 -
5DA0
2
?
A:
[14-410]
------------------------------------------------------------------------------------------
Q
----
R
E
W
F
---
A
N
P
R
K
D
V
L
A
G
--
I
V
------
V
----
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
--
G
L
Y
A
S
F
I
I
A
-
L
I
T
A
F
L
G
-
G
---
R
P
G
M
I
S
A
-
A
T
G
A
M
A
L
L
M
T
G
L
V
-------
K
D
H
G
I
---------------------------
Q
Y
L
F
----
A
A
--
T
V
L
T
G
V
-
L
Q
V
V
F
G
-
W
A
----
K
L
A
R
Y
L
K
F
V
---
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
-------
A
----
Q
L
P
Q
F
V
G
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
M
----------------------------------------
P
S
A
L
V
A
I
----
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
---
T
V
G
-
D
M
G
T
L
P
-
T
A
L
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
------
I
D
E
R
T
D
----
T
T
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
A
F
L
M
-----------------
V
L
I
L
A
--
L
Q
P
L
L
V
----
Q
I
P
M
A
A
L
V
A
V
M
M
--------------
V
V
A
I
S
T
F
-
D
W
G
S
L
R
----
F
P
K
G
E
T
V
V
M
L
A
T
V
A
------
V
T
V
F
-----------
T
H
D
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
-----
S
Q
L
S
Q
V
T
P
V
D
E
V
D
G
T
R
T
Y
R
V
R
G
-----
Q
L
F
F
V
S
T
H
D
F
L
H
-
Q
F
D
F
-----------------
T
H
P
A
R
R
V
V
I
-
D
-----
L
S
D
A
H
F
W
D
G
---------
S
-
A
V
---
G
A
L
D
--
K
V
M
L
K
F
M
R
Q
G
T
S
V
E
----------
L
R
G
L
N
A
A
S
A
T
L
V
E
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
69.40
14%
-82
- C4 -
4BSM
-
XPO1_HUMAN
A:
[3-1017]
A
I
M
T
M
L
A
D
H
A
A
R
Q
L
L
D
F
S
Q
K
L
D
I
N
L
L
D
N
V
V
N
C
L
Y
H
G
E
G
A
Q
Q
R
M
A
Q
E
V
L
T
H
L
K
E
H
P
D
A
W
T
R
V
D
T
Q
N
M
N
T
K
Y
Y
G
L
Q
I
L
E
N
V
I
K
T
RWKI
L
P
R
N
Q
C
E
G
I
K
K
Y
V
---
V
G
---
L
I
I
K
T
--
S
S
------
D
----
P
T
C
V
E
K
E
K
V
Y
I
G
K
L
N
M
I
L
V
Q
I
L
K
Q
E
W
P
K
H
W
-
P
-
T
F
I
S
D
I
V
-
G
A
S
R
T
S
E
S
L
C
Q
-
N
N
M
V
I
L
K
L
L
S
E
E
V
I
-
T
Q
V
K
-
S
K
H
L
K
D
S
M
C
N
E
F
S
Q
I
F
Q
L
C
Q
F
V
M
E
N
S
Q
N
A
P
L
V
H
A
T
L
----
E
T
L
L
R
F
L
N
W
I
P
L
G
Y
I
F
E
T
K
L
----
I
S
T
L
I
Y
K
F
L
---
N
V
P
M
F
R
N
V
S
L
K
C
L
T
E
I
A
G
VSVSQYE
E
----
Q
F
V
T
L
F
T
L
T
M
M
Q
L
K
Q
M
---
L
P
L
N
T
N
I
R
L
A
Y
S
N
G
K
D
D
E
Q
N
F
I
Q
N
L
S
L
F
L
C
T
F
L
K
E
H
D
Q
L
I
E
K
R
L
N
L
R
E
T
L
M
E
A
L
H
Y
M
L
L
V
S
E
VEE
T
E
I
F
K
I
C
L
E
Y
W
N
H
L
A
A
E
L
Y
R
E
-
S
P
F
S
T
S
-
A
S
P
H
F
D
V
P
P
R
R
Q
L
Y
L
P
M
L
F
K
V
R
L
L
M
V
----
S
R
M
A
K
P
E
E
V
L
V
V
E
N
DQG
E
V
V
R
E
F
M
----
K
D
T
D
S
I
N
L
Y
K
N
M
R
E
T
L
V
Y
L
T
H
L
D
Y
V
D
T
E
R
I
M
T
E
K
L
H
N
Q
V
N
G
T
E
W
S
W
K
N
L
N
T
L
C
W
A
I
G
S
I
SGAMH
E
E
D
E
K
R
F
L
V
T
V
I
K
D
--
L
L
G
L
C
E
Q
KRG
K
D
N
K
A
I
I
A
S
N
I
M
Y
I
V
G
Q
Y
P
R
F
L
R
A
H
W
K
F
L
K
T
V
V
N
K
L
F
E
F
M
H
E
T
H
D
G
V
Q
D
M
A
C
D
T
F
I
K
I
------
A
Q
K
C
-----------
R
-
R
H
F
V
Q
V
Q
V
G
E
V
M
P
F
I
D
E
I
L
N
N
I
N
T
I
I
C
D
L
Q
P
Q
Q
V
H
T
F
Y
E
A
V
G
Y
M
I
G
A
Q
-----
T
D
Q
T
V
Q
E
H
L
I
E
K
-
Y
M
L
L
-----------------
P
N
Q
V
W
D
S
I
L
-
K
-----
T
N
V
R
A
C
K
A
V
GHPF
V
I
Q
L
G
R
-
I
Y
---
L
D
M
L
--
N
V
Y
K
C
L
S
E
N
I
S
A
A
I
Q
A
NMVTKQ
P
L
I
R
S
M
R
T
V
K
R
E
T
L
K
L
I
S
G
W
V
S
R
S
N
D
P
Q
M
V
A
E
N
F
V
P
P
L
L
-
D
A
V
L
I
-----
D
Y
Q
R
N
V
P
A
AE
V
-
L
S
T
M
A
I
I
V
N
K
L
H
I
T
A
E
I
P
Q
I
F
D
A
V
F
E
-
C
T
L
N
M
I
N
K
D
E
Y
P
E
H
R
-
T
N
F
F
L
L
L
Q
A
V
N
S
H
C
F
P
P
T
Q
F
--
K
L
V
L
D
S
I
I
W
A
F
K
HTM
R
N
V
A
D
T
G
L
Q
I
L
F
T
L
L
Q
N
V
A
Q
E
E
A
A
A
Q
S
F
Y
Q
T
Y
F
C
D
I
L
Q
H
I
F
S
V
V
T
N
---------
L
V
E
E
GKL
Q
E
Y
V
--
A
N
P
A
F
K
E
H
L
R
D
------
26
Fugue
65.33
18%
-58
- C4 -
4RKN
10
MCCA_WOLSU
A:
[43-702]
--------
M
Q
M
T
K
E
A
R
E
I
I
A
H
P
K
G
T
K
E
S
R
G
V
I
S
L
Q
D
Y
I
V
E
E
Q
A
M
Y
D
W
L
F
K
N
H
P
I
F
T
K
Y
-------
G
G
K
T
V
G
K
L
V
V
K
D
R
G
E
E
W
----
I
E
E
G
R
G
---
N
D
F
S
---
K
A
---
S
K
R
S
G
GE
G
F
------
S
----
S
M
M
Y
R
V
A
R
N
S
T
L
Q
Y
P
N
K
F
I
G
P
--
E
K
C
G
E
C
H
-
P
--
A
Q
Y
E
T
W
-
S
---
R
S
R
H
A
T
T
-
I
R
F
P
----------------
G
E
H
P
E
V
N
N
K
---------
L
N
D
P
V
F
D
---
K
D
T
A
S
I
L
P
QGIT
P
D
V
V
Y
C
T
V
G
H
-
I
R
T
----------
K
F
G
F
F
D
A
W
L
LRG
T
Y
H
V
E
G
G
L
L
K
N
G
T
G
Q
I
V
A
-------
G
GNQW
Q
R
T
W
A
L
N
L
S
P
E
V
A
K
K
I
---
K
K
W
V
P
D
F
P
V
T
L
E
E
Y
G
D
------
N
--
G
G
Y
V
R
G
L
A
----------------------------------------
S
Y
A
A
K
Y
K
K
S
M
S
F
Q
-
A
S
T
S
Y
C
-
E
V
C
H
P
W
K
F
D
F
K
N
E
S
E
F
Y
A
A
L
G
N
A
K
E
L
----
Q
K
H
T
I
S
K
G
V
S
C
E
------
E
C
H
G
A
G
----
G
H
L
E
G
G
S
G
L
L
---
I
S
N
C
E
R
C
H
Q
R
F
S
Y
S
P
D
L
M
R
N
N
P
L
N
A
---
G
K
P
D
L
A
--
L
S
S
K
F
K
S
-----------------
M
G
P
-----
G
C
G
S
E
----
G
S
Q
T
Y
F
T
A
H
Y
E
------------------
K
G
M
R
C
A
T
C
H
D
P
-----
H
D
V
T
G
N
V
T
G
E
K
G
I
------
K
G
V
S
-----------
Y
-
N
S
E
Q
G
Y
L
S
S
L
Y
----------
S
K
P
K
L
K
K
----
E
C
T
D
C
H
K
E
Q
A
Y
I
Q
S
K
A
-----
D
T
H
S
K
N
S
C
A
S
C
H
-
M
P
F
M
-----------------
M
S
C
E
N
F
Y
A
I
Q
F
-----
Q
D
Q
A
G
F
D
T
Q
---------
R
R
A
H
---
I
W
K
I
--
D
V
D
P
A
R
K
S
L
V
A
G
S
T
----------
S
K
D
P
R
D
G
-------
K
D
W
H
F
E
R
N
E
E
G
R
N
F
--------------
V
-----
D
---------------------
L
M
W
A
C
A
R
T
T
W
A
D
K
D
Q
A
-
E
A
K
G
C
H
S
P
V
V
---
S
E
-
L
K
E
T
L
H
F
K
D
-
Q
K
Q
V
Y
N
E
V
M
G
-----
W
Q
T
P
V
K
D
-----
K
F
T
Q
V
K
V
G
I
Q
G
L
Y
S
L
L
E
V
K
K
L
A
-
P
S
D
K
T
R
V
Y
E
L
I
E
K
A
Q
D
T
V
D
L
I
E
K
D
GSWGMHG
F
K
Y
T
K
---
Q
R
L
D
--
A
A
V
E
Y
I
N
E
A
Q
R
I
M
K
K
S
L
30
Fugue
55.14
16%
-53
- C1 -
3CUZ
-
MASY_ECOLI
A:
[4-532]
--------------
A
T
T
T
D
E
L
A
F
T
R
P
Y
G
E
Q
E
K
Q
I
L
T
A
E
A
V
E
F
L
T
E
L
V
T
H
F
T
P
Q
R
N
K
L
L
A
A
R
I
Q
Q
Q
Q
D
I
D
N
G
T
L
P
D
F
I
S
E
T
-------
A
S
I
R
D
---
A
D
W
K
---
I
R
---
G
I
P
A
D
--
L
---------------------------------------------------------
E
D
R
R
V
E
I
T
G
P
------------------------------------
V
E
R
K
M
V
I
N
A
L
N
A
N
V
K
V
F
M
----
A
D
------------------------------
F
---
E
D
S
L
A
P
D
W
N
K
V
I
D
G
Q
I
N
L
-------
R
----
D
A
-
V
N
G
T
I
S
Y
T
N
E
A
G
------------------
K
I
------
Y
Q
L
K
P
N
P
A
V
L
I
C
R
V
R
G
L
H
L
P
E
K
H
V
T
W
R
G
---------------
E
A
I
P
G
S
L
F
D
F
A
L
Y
F
F
H
N
Y
Q
A
L
-
L
A
K
G
S
G
-
P
Y
F
Y
L
P
K
T
Q
S
---
W
Q
E
A
A
W
W
S
E
V
F
S
Y
----
A
E
D
R
F
N
L
P
R
G
T
I
------
K
A
T
L
L
I
----
E
T
L
P
A
V
-----
F
Q
M
D
E
I
L
H
A
L
---------------------
R
D
H
I
V
G
L
N
C
G
R
--
W
-----------------
D
Y
I
F
S
--
Y
I
K
T
L
K
----
N
Y
P
D
R
V
L
P
D
R
Q
A
--------------
V
T
M
D
K
P
F
L
N
A
Y
S
R
L
L
I
K
T
C
H
K
R
G
A
----------------------------------------
F
A
M
G
G
M
A
-------------
A
F
I
P
S
K
D
E
E
H
N
N
Q
V
L
N
K
V
K
-----
A
D
K
S
L
E
A
N
N
---------------------------------------------
G
H
D
G
T
---------
W
-
I
A
---
H
P
G
L
A
D
T
A
M
A
V
F
N
D
I
L
G
S
R
K
----------
N
Q
L
E
V
M
R
E
Q
D
A
P
I
T
A
D
Q
L
L
A
P
C
D
G
E
R
T
E
E
G
M
R
A
N
I
R
V
A
V
Q
Y
I
E
-----
A
W
I
S
G
N
G
C
---------
V
P
I
Y
G
L
M
E
D
--------
A
A
T
A
-
E
I
S
R
T
S
I
W
Q
W
---
I
H
------
H
Q
K
T
L
S
N
--------------
G
K
P
V
T
K
-----
A
L
F
R
Q
M
L
G
E
E
M
K
V
I
A
S
E
L
G
E
E
R
F
S
Q
G
---------
R
F
D
D
A
A
R
L
M
E
Q
---------
I
T
T
S
---
D
E
L
I
DF
L
T
L
P
G
Y
R
L
L
A
-------
2
PsiBlast_PDB
53.41
36%
-56
- C5 -
3LLO
1
A:
[64-136]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
T
V
I
L
D
F
T
Q
V
N
F
M
D
S
V
G
V
-
K
T
L
A
G
I
V
K
E
Y
---
G
D
-
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
T
S
--
N
R
F
F
E
N
P
A
L
K
-----
E
L
L
F
H
S
I
H
D
A
V
L
G
S
Q
V
R
E
A
------------------------------------------------------------------
14
HHSearch
53.09
18%
-83
- C5 -
1TH8
-
SP2AA_GEOSE
B:
[8-114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
K
Q
D
V
L
I
V
R
L
S
G
-
E
L
D
H
-----------------
H
T
A
E
E
L
R
E
Q
-
V
-----
T
D
V
L
E
------------------------------------------------------------------------------------------------------------------
N
R
A
I
R
H
I
V
L
N
L
G
Q
L
T
F
M
D
S
S
G
L
-
G
V
I
L
G
R
Y
K
Q
I
---
K
N
-
V
G
G
Q
M
V
V
C
A
V
S
P
A
V
K
R
L
F
D
M
--
S
G
L
F
K
I
---------
I
R
V
E
A
D
E
Q
F
A
L
Q
A
L
G
V
A
--------------------------------------------------------------------
9
HHSearch
51.67
14%
-118
- C4 -
3QE7
2
URAA_ECOLI
A:
[13-410]
-------------------------------------------------------------------------------------------------
P
L
---
L
Q
---
T
I
P
L
S
--
L
Q
H
L
F
A
M
F
G
----
A
T
V
L
V
P
V
L
F
H
------
I
N
P
A
T
--
V
L
L
F
N
G
I
-
G
-
T
L
L
Y
L
F
I
C
K
---
G
K
I
P
A
Y
L
-
G
S
S
F
A
F
I
S
P
V
L
L
L
L
-
P
-----------------------------------
L
G
Y
E
V
----
A
L
G
G
F
I
M
C
G
V
-
L
F
C
L
V
S
-
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
---
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
-------
V
----
A
A
G
M
A
G
L
L
P
A
---
E
G
------------------
Q
T
------
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
F
-----
L
A
I
I
P
I
L
I
----
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
---
T
T
-
P
I
I
N
A
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
--
W
F
A
I
L
T
I
L
P
A
A
L
----
V
V
I
A
E
H
V
G
H
L
V
V
------
T
A
N
I
V
K
KDLL
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
R
V
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
-----------------
L
L
S
C
V
G
K
L
A
A
A
I
Q
----
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
-------
A
S
G
I
R
V
L
I
E
--
S
K
V
D
Y
N
--
K
A
Q
N
L
I
L
T
S
V
I
L
I
------
I
G
V
S
GAKVNIGAAEL
K
-
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
50.66
22%
-60
- C5 -
1SBO
-
Y1442_THEMA
A:
[9-110]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
E
Q
D
D
K
A
I
V
R
V
Q
G
-
D
I
D
A
-----------------
Y
N
S
S
E
L
K
E
Q
-
L
-----
R
N
F
I
S
------------------------------------------------------------------------------------------------------------------
T
T
S
K
K
K
I
V
L
D
L
S
S
V
S
Y
M
D
S
A
G
L
-
G
T
L
V
V
I
L
K
D
A
---
K
I
-
N
G
K
E
F
I
L
S
S
L
K
E
S
I
S
R
I
L
K
L
--
T
H
L
D
K
----
I
-----
F
K
I
T
D
T
V
E
E
A
---------------------------------------------------------------------------
12
HHSearch
49.54
14%
-75
- C5 -
2KA5
-
Y1081_THEMA
A:
[5-125]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
H
H
H
H
H
H
M
F
P
Y
K
-----
I
V
D
D
V
V
I
L
M
P
N
K
-
E
L
N
I
-----------------
E
N
A
H
L
F
K
K
W
-
V
-----
F
D
E
F
L
------------------------------------------------------------------------------------------------------------------
N
K
G
Y
N
K
I
F
L
V
L
S
D
V
E
S
I
D
S
F
S
L
-
G
V
I
V
N
I
L
K
S
I
---
S
S
-
S
G
G
F
F
A
L
V
S
P
N
E
K
V
E
R
V
L
S
L
--
T
N
L
D
R
I
---------
V
K
I
Y
D
T
I
S
E
A
M
E
E
V
R
R
K
--------------------------------------------------------------------
13
HHSearch
49.53
19%
-78
- C5 -
3NY7
2
?
A:
[14-118]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
D
V
L
V
L
R
V
I
G
-
P
L
F
F
-----------------
A
A
A
E
G
L
F
T
D
-
L
-----
E
S
R
L
--------------------------------------------------------------------------------------------------------------------
E
G
K
R
I
V
I
L
K
W
D
A
V
P
V
L
D
A
G
G
L
-
D
A
F
Q
R
F
V
K
R
L
---
P
--
E
G
C
E
L
R
V
C
N
V
E
F
Q
P
L
R
T
M
A
R
--
A
G
I
Q
P
-
I
P
G
R
-----
L
A
F
F
P
N
R
R
A
A
M
A
D
L
-----------------------------------------------------------------------
15
HHSearch
48.09
12%
-61
- C5 -
1H4X
1
SP2AA_LYSSH
A:
[8-112]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
E
T
V
V
I
R
L
F
G
-
E
L
D
H
-----------------
H
A
V
E
Q
I
R
A
K
-
I
-----
S
T
A
I
F
------------------------------------------------------------------------------------------------------------------
Q
G
A
V
T
T
I
I
W
N
F
E
R
L
S
F
M
D
S
S
G
V
-
G
L
V
L
G
R
M
R
E
L
---
E
A
-
V
A
G
R
T
I
L
L
N
P
S
P
T
M
R
K
V
F
Q
F
--
S
G
L
G
P
W
---------
M
-
M
D
A
T
E
E
E
A
I
D
R
V
R
----------------------------------------------------------------------
22
Fugue
47.25
25%
-31
* C5 *
3LLO
1
A:
[1-143]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Y
T
V
L
G
Q
L
P
D
T
D
V
Y
I
D
I
D
A
Y
E
E
V
K
E
I
P
G
I
-
K
I
F
Q
I
-----
N
A
P
I
Y
Y
A
N
--
S
-
D
L
Y
S
S
A
N
I
H
T
V
I
L
D
F
T
Q
V
N
F
M
D
S
V
G
V
-
K
T
L
A
G
I
V
K
E
Y
---
G
D
-
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
T
S
--
N
R
F
F
E
N
P
A
L
K
-----
E
L
L
F
H
S
I
H
D
A
V
L
G
S
Q
V
R
E
A
------------------------------------------------------------------
17
HHSearch
46.08
15%
-35
- C5 -
3T6O
-
?
A:
[48-120]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
V
L
I
D
L
E
G
V
E
F
F
G
S
S
F
I
-
E
L
L
V
R
G
W
K
R
I
---
K
E
D
Q
Q
G
V
F
A
L
C
S
V
S
P
Y
C
V
E
V
L
Q
V
--
T
H
I
D
E
----
V
-----
W
P
R
Y
S
T
K
Q
E
A
L
L
A
M
A
----------------------------------------------------------------------
11
HHSearch
43.19
18%
4
- C5 -
2KLN
-
?
A:
[1-124]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
-----
R
V
P
G
L
V
V
Y
R
Y
D
A
-
P
L
C
F
-----------------
A
N
A
E
D
F
R
R
R
-
A
-----
L
T
V
V
D
-------------------------------------
Q
---------------------------------------------------------------------------
D
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
-
D
A
L
D
Q
L
R
T
E
L
---
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
--
A
S
L
L
D
K
-
I
G
E
-----
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
--------------------------------------------------------------------
24
Fugue
38.14
13%
28
- C5 -
2KLN
-
?
A:
[1-124]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
G
L
V
V
Y
R
Y
D
A
P
L
-
C
F
A
N
A
-----
E
D
F
R
R
R
A
L
--
T
V
V
D
Q
D
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
-
D
A
L
D
Q
L
R
T
E
L
---
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
--
A
S
L
-
L
D
K
I
G
E
-----
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
--------------------------------------------------------------------
4
PsiBlast_PDB
33.91
26%
91
- C6 -
3E9F
1
EAF3_YEAST
A:
[27-109]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
I
W
D
P
S
S
K
M
Y
T
S
I
P
N
----------
K
E
I
K
P
Q
K
LG
E
D
E
S
I
P
E
E
I
I
N
G
-
K
C
F
F
-----------------
I
H
Y
Q
G
W
K
S
S
-
W
-----
D
E
W
V
G
Y
D
R
I
---------
R
-
A
Y
---
N
E
E
N
--
I
A
M
K
K
R
L
A
N
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
30.67
26%
105
- C6 -
2K3X
-
EAF3_YEAST
A:
[27-109]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
I
W
D
P
S
S
K
M
Y
T
S
I
P
N
D
K
P
G
G
S
S
Q
A
T
K
E
I
K
PQKLG
E
D
E
S
I
P
E
E
I
I
N
G
-
K
C
F
F
-----------------
I
H
Y
Q
G
W
K
S
S
-
W
-----
D
E
W
V
G
Y
D
R
I
---------
R
-
A
Y
---
N
E
E
N
--
I
A
M
K
K
R
L
A
N
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
30.55
26%
95
- C6 -
2K3Y
-
EAF3_YEAST
A:
[27-109]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
I
W
D
P
S
S
K
M
Y
T
S
I
P
N
D
K
P
G
G
S
S
Q
A
T
K
E
I
K
PQKLG
E
D
E
S
I
P
E
E
I
I
N
G
-
K
S
F
F
-----------------
I
H
Y
Q
G
W
K
S
S
-
W
-----
D
E
W
V
G
Y
D
R
I
---------
R
-
A
Y
---
N
E
E
N
--
I
A
M
K
K
R
L
A
N
E
A
G
S
T
----------
G
S
A
P
A
T
G
G
V
K
P
H
R
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------