@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35F4_HUMAN: (2015-12-10 )
MDELLLDLFHKLTSGRQLAAGNGLCGISHKEQEVWKPGHNILVKMRKEDKSLVWLIHSTLARYTQVTNFLGTSRSSVTRCKPGANCPSSHSGISRQLSPLSVTEDSSAPILELQNQGSSGVCGHRVERQNRSADDGTQTHSENSSQENRIKARCLSCTSMVLKGIWGLLIILSVSSSWVGTTQIVKITYKNFYCPFFMTWFSTNWNIMFFPVYYSGHLATAQEKQSPMKKFRECSRIFGEDGLTLKLFLKRTAPFSILWTLTNYLYLLALKKLTATDVSALFCCNKAFVFLLSWIVLKDRFMGVRIVAAIMAITGIVMMAYADNFHADSIIGVAFAVGSASTSALYKVLFKMFLGSANFGEAAHFVSTLGFFNLIFISFTPVILYFTKVEHWSSFAALPWGCLCGMAGLWLAFNILVNVGVVLTYPILISIGTVLSVPGNAAVDLLKQEVIFNVVRLAATIIICIGFLLMLLPEEWDEITLRFINSLKEKKSEEHVDDVTDPSIHLRGRGRANGTVSIPLA
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-----.........130.......140....-...150.......160.......170.......180.......190.......200.......210...-....220.......230.......240.......250.......260.......270.......-280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.....-------..420.....-..------430-........440.......450.......460.......--------470....---..-.480........490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
E
L
L
L
D
L
F
H
K
LTSG
R
Q
LAAGNGLCGISH
K
E
Q
E
V
WKPGH
N
I
L
V
K
M
RKEDK
S
L
V
W
L
I
H
S
T
L
A
R
Y
T
Q
V
T
N
F
LGTSRSSVTRCKPGANCPSSHSG
I
S
RQLSPLSVTEDSSA
P
I
L
E
L
QNQGSSG-------VCGH
R
V
ERQNRSADDGTQTHSENSS
Q
-
E
N
R
I
K
A
R
C
L
S
C
T
S
M
V
L
K
G
I
W
G
L
L
I
I
L
SVSSSWVG
T
T
Q
I
V
K
I
T
YKNFY
C
P
F
F
M
T
W
FSTNW
N
I
M
F
F
P
V
Y
YS-GHLA
T
A
Q
E
K
Q
S
P
M
K
K
F
R
E
C
S
R
I
FGEDG
L
T
L
K
L
F
L
KRTAP
F
S
I
L
W
T
L
T
N
Y
L
Y
L
L
A
L
K
K
L
T
A
T
D
V
S
-
A
L
F
C
C
N
K
A
F
V
F
L
L
S
W
I
V
L
K
DRF
M
G
V
R
I
V
A
A
I
M
A
I
T
G
I
V
M
M
A
YADNFHAD
S
I
I
G
V
A
F
AVGSA
S
T
S
A
L
Y
K
V
L
F
K
M
F
LGSANF
G
E
A
A
H
F
V
S
T
L
G
F
F
N
L
I
F
I
SFT
P
V
I
L
Y
F
T
K
V
E
H
W
S
SFAAL
P
W
G
C
L
C
G
M
A
G
L
W
L
A
F
N
I
L
V
-------
N
V
G
V
V
L
T
Y
P
I
-
L
I
------S-I-G
T
V
LSVP
G
N
A
A
V
D
L
L
K
Q
E
V
I
F
N
V
V
R
L
A
A
T
I
I
I
C
I
G
F
L
L
--------
M
LLPE
E
W
---
D
E
-
I
T
-
L
R
F
I
N
S
L
K
E
KKSEEHVDDVTDP
S
I
H
L
R
GRGRAN
G
T
V
SIPLA
16
Fugue
83.07
16%
-78
* C7 *
4B3X
3
IF2_THET8
A:
[1-363]
M
A
K
---------
V
R
I
Y
Q
L
A
K
E
L
G
M
-----
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
A
Y
K
S
H
A
S
T
L
------
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
E
K
L
A
E
E
E
R
R
K
S
L
---------------
P
R
R
P
P
V
V
V
I
M
-----
G
-------
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
G
G
G
I
-
T
Q
H
V
G
A
F
E
V
K
T
P
Q
-------
G
T
V
V
F
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
--------------
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
-------------------------------
A
G
A
K
L
I
F
A
I
N
K
I
D
L
P
Q
A
D
-------------------------
P
E
K
V
K
R
Q
L
M
E
R
G
F
V
----
P
E
E
Y
G
G
D
A
I
V
I
P
I
----
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
L
L
A
E
L
E
D
---
Y
R
A
D
P
N
-------
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
----------------
I
I
A
N
M
L
V
-------
Q
E
G
T
F
R
V
G
D
Y
-
V
V
A
GE
A
Y
G
R
-
I
-
R
A
M
M
D
A
D
G
N
Q
-----
R
K
E
A
G
P
G
------
S
A
V
Q
V
L
G
F
----------
Q
E
L
P
H
A
G
---
D
---
V
-
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
K
A
R
R
P
R
T
M
A
E
L
L
R
3
HHSearch
62.74
14%
-153
- C- -
3B5D
1
EMRE_ECOLI
A:
[33-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
T
I
I
C
Y
C
A
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
53.66
17%
89
- C6 -
1I8N
-
LAPP_HAEOF
A:
[37-125]
----------------------------------------------------------------------------
E
T
I
T
A
G
N
E
D
C
W
S
K
R
P
G
W
K
L
P
D
N
L
L
T
K
T
E
F
T
S
V
D
E
C
R
K
M
C
E
E
S
A
V
EPSCY
I
L
Q
I
N
T
E
T
N
E
C
Y
R
N
N
E
G
D
V
T
W
S
S
L
Q
Y
D
Q
-
P
N
V
V
Q
W
H
L
H
A
C
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
51.20
30%
58
- C6 -
1WMI
-
?
B:
[7-67]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
K
E
L
E
R
L
K
V
E
I
Q
---
R
L
E
A
--------
M
L
M
P
E
E
R
---
D
E
D
I
T
-
E
E
E
I
A
E
L
L
E
L
A
R
D
E
D
P
E
N
W
I
D
A
E
E
L
P
E
P
E
D
-----------
15
Fugue
45.53
22%
362
- C6 -
2AKF
-
COR1A_MOUSE
A:
[1-32]
---------------------------------------------------------------------------------------------------------------------------------
V
S
R
L
E
E
D
V
R
N
L
N
A
I
V
Q
K
L
Q
E
R
L
D
R
L
E
E
T
V
Q
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
43.16
18%
318
- C6 -
5CMZ
-
?
B:
[2-33]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
W
E
E
W
---
D
K
-
K
I
-
E
E
L
I
K
K
S
E
E
L
I
K
K
I
E
E
Q
I
K
K
Q
E
-------------------
10
Fugue
40.56
22%
539
- C6 -
3VU5
-
?
B:
[4-23]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
E
W
---
D
K
-
K
I
-
E
E
Y
T
K
K
I
E
E
L
I
K
K
S
---------------------------
17
Fugue
40.16
14%
-67
- C7 -
2Q82
-
?
A:
[14-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
N
R
L
A
Q
Y
E
T
S
L
M
V
M
S
H
N
G
D
V
P
V
I
T
G
F
N
V
M
R
V
------
T
-
T
M
L
D
A
L
K
V
P
A
V
A
V
L
G
D
D
A
Q
D
L
A
Y
V
F
G
A
R
P
L
A
V
G
V
N
I
I
R
V
V
DVPG
Q
Q
P
S
A
L
V
D
A
E
L
GAL
H
E
-
V
S
M
V
R
V
L
N
D
I
A
D
E
Q
L
V
K
A
N
M
------------------------
4
HHSearch
38.61
12%
-200
- C- -
3B5D
1
EMRE_ECOLI
A:
[40-105]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
A
S
F
W
L
L
-------
A
Q
T
L
A
Y
I
P
T
G
-
I
A
------
Y
A
I
-
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
G
V
L
I
--------
I
N
L
L
S
----------------------------------------------------
7
HHSearch
37.43
44%
719
- C5 -
1X5V
-
A:
[2-17]
------------------------
C
G
I
L
H
D
N
C
-
V
Y
V
P
A
Q
N
P
C
C
R
G
L
Q
C
R
Y
G
K
C
L
V
Q
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
37.05
17%
188
- C6 -
1KZU
5
LHB5_RHOAC
B:
[1-41]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
T
A
E
Q
S
E
E
L
H
K
Y
V
I
D
G
T
R
V
F
L
G
L
A
L
V
A
H
F
L
A
F
S
A
T
P
W
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
HHSearch
35.03
10%
3
- C6 -
2I68
-
EMRE_ECOLI
A:
[38-104]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Y
C
A
S
F
W
L
L
-------
A
Q
T
L
A
------
I
A
------
Y
-
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
------
A
I
I
G
M
M
L
I
C
A
G
V
L
I
--------
I
N
L
L
-----------------------------------------------------
9
HHSearch
32.69
35%
600
- C4 -
2LL1
-
A:
[2-18]
------------------------
C
G
H
L
H
D
P
C
P
N
D
R
P
G
H
R
T
C
C
I
G
L
Q
C
R
Y
G
K
C
L
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
28.73
19%
376
* C6 *
3J47
2
R:
[1-26]
---------------------------
N
A
Q
Y
H
L
L
V
K
Q
G
D
G
L
L
T
K
L
Q
K
Y
G
A
A
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
26.22
25%
782
- C3 -
1H9I
-
ITR2_ECBEL
I:
[18-30]
---------------
G
C
V
C
T
N
N
K
F
C
G
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
26.03
38%
1353
- C1 -
1H9H
-
ITR2_ECBEL
I:
[21-30]
------------------
C
G
P
N
G
F
C
G
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
25.11
45%
419
- C6 -
2AP7
-
BMNH5_BOMVA
A:
[1-20]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
I
-
G
P
V
L
G
L
V
G
S
A
L
G
G
L
L
K
K
I
-------------------------------------------------------------------------------------
5
HHSearch
15.59
56%
3474
- C2 -
2HGO
1
CASSI_CORCC
A:
[11-17]
-------------------
F
G
N
G
F
C
G
D
N
C
G
N
S
W
A
C
S
G
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------