@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S43A3_HUMAN: (2015-12-11 )
MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSAGSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYGLCPGNGTTKEEKETAEHENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAVALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHPFLVYRECRTWKESPSAIA
Atome Classification :
(20 SA)
-.........10.......-.20........30........40........50........60........70........80........90........100..---.....110....----...--120.........130....-..-.----140.......150.-......160........170..-..-..-..180-------------------------.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300-....-...---.310.......320.......330.......340.......350.......360.......370....-...-380-...---.----...390.......400.......410.....---..420.......-430......-.440.......450-........460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MAGQGL
P
L
H
V
A
T
L
L
T
G
L
L
-
E
C
L
G
F
A
G
V
L
FGWP
S
L
V
F
V
FKN
E
D
Y
F
K
D
LCGPDAGPIGNATGQADCKAQDE
R
F
S
L
I
F
T
L
G
S
F
M
N
N
F
MTFP
T
G
Y
I
F
D
R
F
K
T
T
V
A
R
L
I
A
---
I
F
F
Y
T
T
A
T
L
I
I
A
----FTS--A--G
S
A
V
L
L
F
L
A
M
P
M
L
T
I
G
-
G
I
-
L
----
F
L
ITNL
Q
I
G
N
L
FGQ-HR
S
T
I
I
T
L
-YNGAFDSS
S
A
-
V
F
-
L
I
-
I
K
-
L
L
Y
EK-------------------------GI
S
L
R
A
S
F
I
F
I
S
VCS
T
W
H
V
A
R
T
F
L
LMPRGHIPYPLPPNYSYGLCPGNGT
T
K
E
E
K
E
TAEHENR
E
L
Q
S
K
E
F
L
SAKEETPGA
G
Q
K
Q
E
L
R
S
F
W
S
Y
A
F
S
R
R
F
A
W
H
L
V
W
L
S
V
I
Q
L
W
H
Y
L
F
I
G
T
L
N
--
S
L
L
T
-
N
MA---GGD
M
A
R
V
S
T
Y
T
N
A
F
A
F
T
QF
G
V
L
CAPW
N
G
L
L
M
D
R
L
K
Q
K
Y
Q
K
E
A
R
KTGSS
T
L
A
V
A
L
C
ST
V
P
S
L
A
L
T
S
L
L
C
-
L
G
F
-
A
L
C
-ASV---P----I
L
P
L
Q
Y
L
T
F
I
L
Q
V
I
S
R
S
FLYGSN
A
A
F
L
T
L
AF---
P
S
E
H
F
G
K
L
F
G
L
V
-
M
A
L
S
A
V
V
S
L
-
L
Q
F
P
I
F
T
L
I
K
G
SL--QND
P
F
Y
V
N
V
M
F
M
L
A
I
L
L
T
F
F
H
P
F
L
V
Y
R
E
C
R
T
WKESPSAIA-
34
Fugue
86.75
13%
-106
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
-
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
-
A
L
A
M
P
Y
L
V
E
Q
G
F
S
R
G
D
---------
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
--
S
--
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
-
M
G
-
W
----
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
-
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
-
L
L
-
F
L
-
L
G
M
A
W
-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
-----
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
-----------------------
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
---------------------
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
------------------------
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
LA
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
--
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
21
HHSearch
82.43
12%
-133
- C1 -
1PW4
-
GLPT_ECOLI
A:
[21-428]
---
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
-
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
---------
Y
L
V
-
E
--------
Q
G
F
S
-----
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
----
F
V
P
--
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
-
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
-
I
P
-
P
L
-
L
F
L
L
G
M
A
W
-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
--------
Y
-
K
N
D
----------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
--
T
Y
L
K
-
E
V
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
--
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
-----------------
A
T
G
V
F
F
M
T
L
V
T
-
I
A
T
-
I
V
Y
-
W
M
N
---
P
AG--
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
---
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
--
G
W
D
G
G
F
M
--
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
-
22
HHSearch
66.82
12%
-132
* C1 *
3O7Q
1
FUCP_ECOLI
A:
[22-410]
--------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
---------
Q
F
Q
Q
A
--------
F
T
L
T
-----
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
----
P
A
A
E
I
M
--
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
-
L
----
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
I
-
I
A
-
V
V
F
G
Q
-
S
L
I
L
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
-
M
L
T
-
K
F
P
A
L
Q
S
D
N
--
H
S
-----------
D
A
--------------------------
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
--
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
--
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
---------------------
L
A
A
Y
A
L
I
A
-
M
A
L
-
C
L
I
S
A
F
A
---
G
----
G
H
V
-
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
---
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
--
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
--------------
36
Fugue
58.53
7%
-108
- C1 -
1PV6
-
LACY_ECOLI
A:
[1-417]
-
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
-
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
H
-------------------------
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
----
I
F
I
--
F
--
G
P
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
----------
I
Y
L
G
F
C
F
N
A
G
A
P
A
-
V
E
A
F
I
E
K
V
-
S
R
R
S
N
F
E
F
G
R
-
A
R
-
M
F
-
G
C
-
V
G
W
A
L
-------------------------
G
A
S
I
V
G
I
M
F
T
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
----------------------------
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
--
N
F
F
T
-
S
F
F
---
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
----------
F
F
A
P
L
I
I
N
R
I
G
---------
G
K
N
A
L
L
L
A
G
T
I
M
S
-
V
R
I
-
I
G
S
-
S
F
A
---
T
----
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
IG
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-
25
HHSearch
50.93
10%
-109
- C1 -
2CFQ
-
LACY_ECOLI
A:
[38-383]
-----------------------------------------------------------
N
H
I
S
-----
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
----
F
G
P
--
L
---
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
-
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
A
-
L
G
-
A
S
I
V
G
-
I
M
F
-
T
--------------------------
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
-
L
F
F
A
K
T
D
---
A
P
S
S
A
T
V
A
N
---------
A
V
G
-
A
-----------------------
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
--
N
F
F
T
-
S
F
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
--
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
---------------------
L
L
L
A
G
T
I
M
S
V
R
I
-
I
G
S
-
S
F
A
---
T
----
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
--
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
-
23
HHSearch
46.49
14%
-147
- C1 -
3WDO
-
?
A:
[41-186]
-----------------------------------------------------------
Q
G
A
S
-----
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
----
L
S
D
--
S
----
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
-
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
A
-
I
A
-
M
V
-
L
G
-
P
I
I
T
H
-------------------------
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
--
V
F
V
F
-
C
V
G
---
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
-
G
S
L
-
G
G
W
-
I
D
G
---
M
----
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
---
S
L
R
I
E
I
P
A
D
I
A
A
-
N
E
A
L
K
V
R
L
L
-
E
T
E
G
V
K
E
V
L
I
A
E
E
--
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
---------------
24
HHSearch
42.39
19%
-109
- C1 -
2GFP
-
EMRD_ECOLI
A:
[38-172]
-----------------------------------------------------------
L
N
V
R
-----
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
----
T
T
S
--
S
----
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
-
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
L
-
L
A
-
P
L
-
I
G
-
G
L
L
D
T
-------------------------
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
--
S
V
I
C
-
C
L
L
---
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
-
S
L
S
-
A
M
L
-
P
Q
T
---
G
----
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
-------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.17
24%
3
- C1 -
2IZS
2
KC1G3_HUMAN
A:
[129-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
K
P
E
N
F
L
I
G
R
---
P
G
-
N
K
T
Q
Q
V
I
H
I
I
D
F
A
L
A
K
E
Y
I
D
P
E
T
K
K
H
I
P
Y
R
E
H
K
S
L
T
G
T
A
R
YM
S
I
N
T
-
H
L
G
---
K
E
Q
S
R
R
D
D
L
E
A
L
G
H
M
F
M
Y
F
L
R
G
S
L
P
W
Q
G
L
K
A
D
T
L
K
E
R
Y
Q
K
I
G
-
D
T
K
R
A
T
P
I
E
V
L
C
E
N
F
P
E
M
A
T
Y
L
R
Y
V
-
R
R
L
-
D
F
F
-
E
K
P
---
D
----
Y
D
Y
L
R
K
L
F
T
D
L
F
D
R
K
G
Y
M
F
D
Y
E
Y
D
W
I
G
K
Q
L
P
---
T
P
-----------------------------------------------------------------------------
3
PsiBlast_PDB
41.82
24%
6
- C1 -
2IZT
1
KC1G3_HUMAN
A:
[129-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
K
P
E
N
F
L
I
G
R
---
P
G
-
N
K
T
Q
Q
V
I
H
I
I
D
F
A
L
A
K
E
Y
I
D
P
E
T
K
K
H
I
P
Y
R
E
H
K
S
L
T
G
T
A
R
YM
S
I
N
T
-
H
L
G
---
K
E
Q
S
R
R
D
D
L
E
A
L
G
H
M
F
M
Y
F
L
R
G
S
L
P
W
Q
G
L
K
A
D
T
L
K
E
R
Y
Q
K
I
G
-
D
T
K
R
A
T
P
I
E
V
L
C
E
N
F
P
E
M
A
T
Y
L
R
Y
V
-
R
R
L
-
D
F
F
-
E
K
P
---
D
----
Y
D
Y
L
R
K
L
F
T
D
L
F
D
R
K
G
Y
M
F
D
Y
E
Y
D
W
I
G
K
Q
L
P
---
T
P
V
----------------------------------------------------------------------------
5
PsiBlast_PDB
41.71
24%
6
- C1 -
2CHL
1
KC1G3_HUMAN
A:
[150-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
K
P
E
N
F
L
I
G
R
---
P
G
-
N
K
T
Q
Q
V
I
H
I
I
D
F
A
L
A
K
E
Y
I
D
P
E
T
K
K
H
I
P
Y
R
E
H
K
S
L
T
G
T
A
R
YM
S
I
N
T
-
H
L
G
---
K
E
Q
S
R
R
D
D
L
E
A
L
G
H
M
F
M
Y
F
L
R
G
S
L
P
W
Q
G
L
K
A
D
T
L
K
E
R
Y
Q
K
I
G
-
D
T
K
R
A
T
P
I
E
V
L
C
E
N
F
P
E
M
A
T
Y
L
R
Y
V
-
R
R
L
-
D
F
F
-
E
K
P
---
D
----
Y
D
Y
L
R
K
L
F
T
D
L
F
D
R
K
G
Y
M
F
D
Y
E
Y
D
W
I
G
K
Q
L
P
---
T
P
-----------------------------------------------------------------------------
1
PsiBlast_PDB
41.46
24%
7
- C1 -
2IZR
2
KC1G3_HUMAN
A:
[129-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
K
P
E
N
F
L
I
G
R
---
P
G
-
N
K
T
Q
Q
V
I
H
I
I
D
F
A
L
A
K
E
Y
I
D
P
E
T
K
K
H
I
P
Y
R
E
H
K
S
L
T
G
T
A
R
YM
S
I
N
T
-
H
L
G
---
K
E
Q
S
R
R
D
D
L
E
A
L
G
H
M
F
M
Y
F
L
R
G
S
L
P
W
Q
G
L
K
A
D
T
L
K
E
R
Y
Q
K
I
G
-
D
T
K
R
A
T
P
I
E
V
L
C
E
N
F
P
E
M
A
T
Y
L
R
Y
V
-
R
R
L
-
D
F
F
-
E
K
P
---
D
----
Y
D
Y
L
R
K
L
F
T
D
L
F
D
R
K
G
Y
M
F
D
Y
E
Y
D
W
I
G
K
Q
L
P
---
T
P
V
----------------------------------------------------------------------------
29
HHSearch
41.22
15%
-128
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[57-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
--
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
---------------------
I
I
T
G
L
F
L
Y
-
A
L
G
A
A
L
F
-
W
P
A
A
E
I
M
----
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
---
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
--
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
-
4
PsiBlast_PDB
41.15
24%
5
- C1 -
2IZU
1
KC1G3_HUMAN
A:
[129-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
K
P
E
N
F
L
I
G
R
---
P
G
-
N
K
T
Q
Q
V
I
H
I
I
D
F
A
L
A
K
E
Y
I
D
P
E
T
K
K
H
I
P
Y
R
E
H
K
S
L
T
G
T
A
R
YM
S
I
N
T
-
H
L
G
---
K
E
Q
S
R
R
D
D
L
E
A
L
G
H
M
F
M
Y
F
L
R
G
S
L
P
W
Q
G
L
K
A
D
T
L
K
E
R
Y
Q
K
I
G
-
D
T
K
R
A
T
P
I
E
V
L
C
E
N
F
P
E
M
A
T
Y
L
R
Y
V
-
R
R
L
-
D
F
F
-
E
K
P
---
D
----
Y
D
Y
L
R
K
L
F
T
D
L
F
D
R
K
G
Y
M
F
D
Y
E
Y
D
W
I
G
K
Q
L
P
---
T
P
V
----------------------------------------------------------------------------
30
HHSearch
41.06
15%
-127
- C1 -
2CFQ
-
LACY_ECOLI
A:
[258-390]
--------------------------------------------------------------------
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
----
F
A
T
--
S
---
A
L
-
E
V
V
I
L
K
T
L
H
M
F
E
-
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
-
A
G
-
N
M
Y
E
S
--------------------------
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
40.25
14%
-109
- C1 -
3WDO
-
?
A:
[42-167]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
--
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
---------------------
I
V
G
G
L
A
V
F
-
A
A
G
S
V
I
A
-
A
L
S
---
D
----
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
--
G
A
I
A
A
A
V
M
A
L
L
S
D
L
T
---
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
--
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
-
28
HHSearch
35.69
11%
-83
- C1 -
1PW4
-
GLPT_ECOLI
A:
[59-181]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
--
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
---------------------
L
P
A
G
L
I
L
A
-
A
A
V
M
L
F
M
-
G
F
V
---
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
---
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
H
N
V
G
G
G
-
I
P
P
L
L
F
L
L
G
M
A
W
F
--
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
-
33
Fugue
33.19
18%
298
- C1 -
1R48
-
PROP_ECOLI
A:
[1-33]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
G
D
N
I
E
Q
K
I
D
D
I
D
H
E
I
A
D
L
Q
A
K
R
T
R
L
V
Q
Q
H
P
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
32.76
31%
87
- C1 -
4KBK
-
KC1D_HUMAN
A:
[214-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
V
L
M
Y
F
N
L
G
S
L
P
W
Q
G
L
K
A
A
T
K
R
Q
K
Y
E
R
I
S
E
K
K
M
S
T
P
I
E
V
-
L
C
K
G
Y
P
S
E
F
A
T
Y
L
N
F
-
C
R
S
-
L
R
F
-
D
D
K
---
P
----
D
Y
S
Y
L
R
Q
L
F
R
N
L
F
H
R
Q
G
F
S
Y
D
Y
V
F
D
W
N
M
L
------------------------------------------------------------------------------------
41
Fugue
31.55
11%
272
- C1 -
1Y03
-
ANP3_MYOSC
A:
[1-35]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
N
A
P
A
R
A
A
A
K
T
A
A
D
A
L
A
A
A
K
K
T
A
A
D
A
A
A
A
A
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
31.45
10%
-79
- C1 -
2GFP
-
EMRD_ECOLI
A:
[39-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
--
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
---------------------
I
L
V
G
M
S
I
F
-
M
L
A
T
L
V
A
-
V
T
T
---
S
----
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
---
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
I
L
V
S
P
L
-
L
A
P
L
I
G
G
L
L
D
T
M
W
--
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
-