@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5A5_HUMAN: (2015-12-11 )
MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL
Atome Classification :
(19 SA)
----.........10........20........30........40........--50........60...------.....70........80.-...---..--..90.........100......---.110-.-......120...-.-------...-130.....------.-.140.-....----..150---.......160-----.--..----.--..--.170....-...180...-....190...--....200.......210..-..-------...220...-----....230....-...-240........-250.......-260.---......270-------........----280.......290.......300.......310-----...---.---------.--...320------.........330...------..-..340..----.....350...-....360.......370..-..-...-380-....---.....390.......400.......--410.......420-.........430.......440----------------..----.....450.......460.......470.....--..480.......490...---------------....500....-...510.......520.......530...---....540.......550.......560.......570.......580.......590.......600.......610......------.620.......630.......640.----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MEAVETGERPTFG
A
W
D
Y
G
V
F
A
L
M
L
L
V
STGI
G
L
W
V
G
LARGGQR
S
A
E
D
F
FT--GG
R
R
L
A
A
LPVG
L
S
L
S
------
A
S
F
M
S
A
V
Q
V
LGV
P
S
E
A
Y
R
-
Y
G
L
---
K
F
--
L
W
M
-
C
L
G
Q
L
L
N
S
V
L
T
A
L
L
F
M
P
V
---
F
Y
R
L-G-L
T
S
T
Y
E
Y
L
E
M
R
F
-
S
-------
R
A
V
-
R
L
C
G
T
L
Q
Y
------
I
-
V
A
T
M
L
-YT
G
I
----
V
I
Y
A
P
---
A
L
I
L
N
QVT
G
L
-----
D
--
I
W
----
A
--
S
L
--
L
ST
G
I
I
C
T
-
F
Y
T
AVGG
M
K
-
A
V
V
W
T
D
V
F
Q
V
--
V
V
M
LS
G
F
W
V
V
L
AR
G
V
M
LVG-G
P
-------
R
Q
V
L
T
L
AQN-----H
S
R
I
N
L
M
DFNP-DPR-S-
R
Y
T
F
W
T
F
VV-G
G
T
L
V
W
L
S
MY-GV
N
Q
---
A
Q
V
Q
R
Y
V
A
--------CRTE
K
Q
A
K
----
L
A
L
L
I
N
QV
G
L
F
L
I
VSSA
A
C
C
G
I
V
M
F
V
F
YTDC
D
------
P
L
L
---
L
---------G--RISA--------PDQY
M
P
L
L
V
L
D
I
F
E
D------LP-GV
P
G
L
F
L
----
A
C
AYSGTLSTA-STSI
N
A
M
A
A
V
T
V
E
D
L
I
K
P
R
-
L
R
-SLA-P---
R
K
L
V
---
I
ISKG
L
S
L
I
YG
S
A
C
L
T
V
A
A
L
S
S
L
LG--GGVLQG
S
F
T
V
M
---
G
VIS
G
P
L
L
G
A
F
I
L
G
M
F
LPACNT----------------
P
G
----
V
L
A
G
L
G
A
G
L
A
L
S
L
W
V
A
LGATLYPP
S
E
Q
T
M
R
VLP--SSA
A
R
C
V
A
L
S
VNASGLLD---------------PALLPANDSSR-APSSGMDASR
P
A
L
A
D
S
F
Y
A
I
S
Y
L
Y
YG
A
L
G
---
T
L
T
T
V
L
C
G
A
L
I
S
C
LTGPTKRSTLA
P
G
L
L
W
W
D
L
A
R
Q
TASVAPKE
E
V
A
ILDDNLVKG
P
E
ELPTGNKKPPGFLPTNE
D
R
L
F
F
L
G
Q
K
------ELEGAGSWTPCVGHDGGRD
Q
Q
ETNL----------------
1
PsiBlast_PDB
92.81
25%
-136
- C5 -
2XQ2
3
SGLT_VIBPH
A:
[12-487]
-------------------
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
--------------------
L
P
W
W
A
V
G
A
S
L
I
------
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
G
L
AIA
S
Y
--
E
W
M
-
S
A
I
T
L
---
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
-
I
Y
T
I
P
E
F
V
E
K
R
F
-
N
-------
K
K
L
-
K
---
T
I
L
A
------
V
-
F
W
I
S
L
-
Y
I
F
V
N
L
T
S
V
L
Y
L
G
---
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
----
Y
--
S
I
--
L
G
L
A
L
F
A
L
-
V
Y
S
I
Y
G
G
----
V
V
W
T
D
V
I
Q
V
--
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
-
G
T
DG
W
F
A
G
V
S
K
M
V
D
A
A
P
G
-----
H
F
E
M
I
L
D
Q
S
N
P
-
Q
Y
M
-
N
-
L
P
G
I
A
V
L
I
G
-
G
L
W
V
A
N
L
Y
Y
W
-
G
F
N
Q
---
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
----
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
--
I
T
S
D
------
P
Q
L
M
A
S
L
---------
G
------NLPSAAN-
A
D
K
A
Y
P
W
L
T
----
Q
F
------
L
P
V
G
V
K
G
V
V
F
----
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
-
D
---
H
K
L
V
---
N
V
G
R
T
A
A
V
---
V
A
L
I
I
A
A
L
I
A
P
M
L
G
GI
G
Q
C
F
Q
Y
I
Q
E
Y
T
---
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
--
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
---------------
D
P
K
G
I
S
V
T
S
S
M
-
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
---
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
-------------------------------------------------------------------------------------------------------
4
HHSearch
89.06
23%
-134
- C5 -
2XQ2
3
SGLT_VIBPH
A:
[9-471]
----------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
--------------------
L
P
W
W
A
V
G
A
S
L
I
------
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
G
L
---
A
I
--
A
S
Y
-
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
-
I
Y
T
I
P
E
F
V
E
K
R
F
-
N
-------
K
K
L
-
K
T
I
L
A
V
F
W
------
I
S
L
Y
I
F
V
-
N
L
T
S
----
V
L
Y
L
G
---
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
----
Y
--
S
I
--
L
G
L
A
L
F
A
L
-
V
Y
S
I
Y
G
G
----
V
V
W
T
D
V
I
Q
V
--
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
-
G
T
-------
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
-
D
Q
S
N
P
Q
-
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
-
G
F
N
Q
---
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
----
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G--
N
---
L
---------
P
--
S
A
A
N
--------
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
--------
V
-
G
V
K
G
V
V
F
----
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
-
D
S
G
-
D
---
H
K
L
V
---
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
L
G
G
I
G
---
Q
C
F
Q
Y
I
Q
E
Y
T
---
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
--
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
---------------
D
P
K
G
I
S
V
T
S
S
M
-
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
---
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
-------------------------------------------------------------------------------------------------------
20
Fugue
77.80
18%
-80
- C5 -
4RKN
10
MCCA_WOLSU
A:
[43-702]
MQMT
K
E
A
R
E
I
I
A
H
P
K
G
T
K
E
S
R
G
V
I
S
L
Q
D
Y
I
V
E
E
Q
A
M
Y
D
W
L
F
K
N
-----
H
P
I
F
T
KY
G
G
K
T
V
G
K
L
V
V
K
-
D
R
G
------
E
E
W
I
E
E
G
R
G
N
D
F
S
K
A
S
K
R
-
S
G
--------------
G
E
G
F
S
S
M
M
------------
Y
R
V
-
A
-
R
N
S
T
L
Q
Y
P
N
K
F
I
G
P
-------
E
K
C
-
G
E
C
H
P
A
Q
Y
------
E
-
T
W
S
R
S
-
R
H
A
T
----
T
I
R
F
P
GEH
P
E
V
N
N
K
L
N
D
------
P
--
V
F
DKDT
A
--
S
I
--
L
P
Q
G
I
T
P
D
V
V
Y
C
T
V
G
H
I
R
T
K
F
G
F
F
D
A
W
L
L
RG
T
Y
H
V
E
G
G
L
L
K
N
G
T
G
Q
I
V
A
G
-
G
N
-------
Q
W
Q
R
T
W
A
L
N
-------------
L
S
P
-
E
V
A
-
K
-
K
I
K
K
W
V
P
D
F
-
P
V
T
---
L
E
E
Y
-
G
D
N
G
---
G
Y
V
R
G
L
A
S
---------------
Y
----
A
A
K
Y
K
K
S
M
S
F
Q
A
S
T
S
Y
C
E
V
C
H
P
W
K
F
D
F
K
N
E
S
E
------
F
Y
A
A
--
L
---------
G
--
N
A
K
E
--------
L
Q
K
H
T
I
S
K
G
V
S
C
E
E
C
H
GAGGH
L
E
-
G
G
S
G
L
L
I
S
NCE
R
C
H
Q
R
F
S
Y
S
P
D
-
L
M
R
N
N
P
L
N
A
G
K
P
D
L
A
L
S
S
K
-
F
K
-
S
M
G
-
P
G
C
G
S
E
G
S
---
Q
T
Y
F
T
A
H
Y
E
K
G
M
R
C
A
T
C
H
D
P
H
D
V
T
G
--
N
--
V
T
G
E
K
G
I
K
---
G
V
S
Y
N
S
E
Q
G
-
Y
L
S
S
L
Y
----
S
K
----------------
P
K
----
L
K
K
E
C
T
D
C
H
K
E
Q
A
Y
I
Q
S
K
A
D
T
H
S
K
N
S
C
A
S
C
H
M
P
FM
M
S
C
E
N
F
Y
A
I
Q
F
Q
D
Q
A
G
F
D
TQRRAHIW
K
I
D
V
D
PA
R
K
S
L
V
A
G
S
T
S
K
-
D
P
R
D
G
K
D
W
H
F
E
R
N
E
E
G
R
N
F
V
D
L
M
W
A
C
A
R
T
---
T
W
A
D
K
D
Q
A
E
A
K
G
C
H
S
P
V
V
--
S
E
L
K
E
T
L
H
F
K
D
Q
K
Q
V
Y
N
E
V
M
G
W
Q
T
P
V
K
D
K
F
T
Q
V
K
V
G
I
Q
G
L
Y
S
L
L
E
V
K
K
L
A
P
S
D
K
T
R
V
Y
E
L
I
E
K
A
Q
D
T
V
D
L
I
E
K
D
G
S
W
G
M
---
H
G
F
K
Y
T
K
Q
R
L
D
A
A
V
E
Y
I
N
E
A
Q
R
I
M
K
K
S
L
14
Fugue
75.99
20%
-88
- C5 -
3DH4
1
?
A:
[52-518]
-------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
------
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
G
L
---
A
I
--
A
S
Y
-
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
-
I
Y
T
I
P
E
F
V
E
K
R
F
-
N
-------
K
K
L
-
K
T
I
L
A
V
F
W
------
I
-
S
L
Y
I
F
V
N
L
T
S
----
V
L
Y
L
G
---
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
----
Y
--
S
I
--
L
G
L
A
L
F
A
L
-
V
Y
S
I
V
-------
V
W
T
D
V
I
Q
V
--
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
-
G
T
DG
W
F
A
G
-
V
S
K
M
V
D
A
A
P
-----
G
H
F
E
M
I
L
D
Q
S
N
-
P
Q
Y
-
M
-
N
L
P
G
I
A
V
L
I
-
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
---
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
----
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
------
L
M
A
---
S
L
GDIAATNL
P
--
S
A
A
N
--------
A
D
K
A
Y
P
W
L
T
Q
F
L
---------
P
V
-
G
V
K
G
V
V
F
----
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
-
P
D
S
G
D
---
H
K
L
V
---
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
I
G
--
Q
-
A
F
Q
Y
I
Q
E
Y
T
---
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
--
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
---------------
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.56
25%
-88
- C5 -
3DH4
1
?
A:
[53-458]
--------------------------------------------------------
G
K
S
L
P
W
W
A
V
G
A
S
L
I
------
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
G
L
AIA
S
Y
--
E
W
M
-
S
A
I
T
L
---
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
-
G
-
I
Y
T
I
P
E
F
V
E
K
R
F
-
N
-------
K
K
L
-
K
---
T
I
L
A
------
V
-
F
W
I
S
L
-
Y
I
F
V
N
L
T
S
V
L
Y
L
G
---
G
L
A
L
E
T
I
L
G
I
-----
P
--
L
M
----
Y
--
S
I
--
L
G
L
A
L
F
A
L
-
V
Y
S
I
-------
V
V
W
T
D
V
I
Q
V
--
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
-
G
T
DG
W
F
A
G
V
S
K
M
V
D
A
A
P
G
-----
H
F
E
M
I
L
D
Q
S
N
P
-
Q
Y
M
-
N
-
L
P
G
I
A
V
L
I
G
-
G
L
W
V
A
N
L
Y
Y
W
-
G
F
N
Q
---
Y
I
I
Q
R
T
L
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
----
L
P
G
I
A
A
Y
V
--
I
T
S
D
------
P
Q
L
M
A
S
L
---------
G
--
D
I
A
A
TNLPSAAN
A
D
K
A
Y
P
W
L
T
----
Q
F
------
L
P
V
G
V
K
G
V
V
F
----
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
-
D
---
H
K
L
V
---
N
V
G
R
T
A
A
V
V
----
A
L
I
I
A
C
L
I
A
P
M
L
--
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
--
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
---------------
D
P
K
G
I
S
V
T
S
S
M
-
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
---
K
---------------------------------------------------------------------------------------------------------------------------------
17
Fugue
64.18
15%
-81
- C3 -
4IA6
12
?
A:
[1-591]
-----
M
Y
Y
S
N
G
N
Y
E
A
F
A
D
P
K
--------------------
K
P
A
G
V
D
K
K
S
A
Y
I
I
--
G
S
G
-
L
A
G
L
S
T
A
V
F
L
V
R
DAQMK
G
E
N
I
H
I
L
E
E
L
P
V
A
G
F
V
V
R
-
G
G
R
---
E
M
E
N
H
F
E
-
C
L
W
D
M
Y
R
S
I
-------
P
S
---
L
E
V
P
-
G
-
A
S
Y
L
D
E
Y
Y
W
L
D
K
-
E
D
P
N
S
S
NC
R
L
I
-
Y
N
R
G
D
R
L
P
SDGQYG
L
-
G
K
C
A
N
-
E
I
V
K
----
L
I
M
T
P
---
E
K
E
I
E
G
Q
T
I
E
-----
E
--
F
F
----
S
--
D
E
--
F
F
K
T
N
F
W
T
-
Y
W
S
T
M
F
A
F
E
-
K
--
W
H
S
L
A
E
M
--
R
R
Y
A
M
R
F
I
H
H
I
D
G
-----------------------------------
L
P
D
F
T
A
-
L
K
F
-
N
-
K
Y
N
Q
Y
E
S
M
V
-
K
P
L
L
A
Y
L
K
D
H
-
G
V
Q
F
E
Y
D
C
H
V
K
N
V
E
V
--------
D
H
E
G
D
S
K
I
----
A
K
K
I
V
M
T
Q
N
G
K
D
K
E
I
D
L
T
H
N
D
I
V
F
V
T
N
G
S
I
T
E
------
S
S
T
---
Y
---------
G
D
Q
N
T
P
A
--------
P
I
T
N
A
K
G
D
S
W
K
L
W
E
N
------
L
A
-
K
Q
D
P
A
F
G
----
H
P
D
V
F
C
E
N
L
P
E
-
R
S
W
F
V
S
A
T
A
T
L
E
N
K
K
L
A
P
Y
-
F
E
-
R
L
T
-
K
---
R
S
L
Y
DGK
V
N
T
G
G
I
I
T
I
V
D
S
N
W
E
L
S
F
T
I
H
R
---------
Q
P
H
F
K
S
Q
------
N
P
D
Q
I
V
V
W
I
Y
A
L
Y
---
S
D
T
----------------
E
G
----
N
Y
I
K
K
R
---------
I
V
D
C
T
G
K
E
I
A
E
E
L
L
Y
H
L
G
--
V
P
E
S
Q
I
S
E
L
A
S
E
E
N
M
N
T
V
---------------
P
V
Y
M
P
Y
I
T
S
Y
F
-
M
P
R
R
D
G
D
--
R
P
D
V
V
-
P
E
G
S
I
N
L
A
F
I
G
N
F
A
ESP
T
R
D
T
V
F
T
-------
T
E
Y
S
V
R
T
A
M
E
A
V
Y
T
L
L
N
V
D
R
---
G
V
P
E
V
F
D
S
I
Y
D
I
R
Q
L
L
R
A
M
Y
Y
M
S
D
K
K
K
L
A
D
Q
D
M
P
L
P
E
K
L
A
V
K
T
G
M
R
------
K
I
K
K
---------
T
W
V
E
E
L
L
K
E
A
N
L
V---------------
6
HHSearch
61.81
16%
-124
- C5 -
2JLN
-
?
A:
[22-423]
----------------------------------------------------
Y
--
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
------
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
--
M
T
-
S
S
F
---
Q
V
--
W
Q
V
-
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
-
G
--
I
N
F
T
V
A
A
R
M
P
F
-
G
-------
I
R
G
-
S
L
I
P
I
T
L
K
------
A
-
L
L
S
L
F
-
W
F
G
F
----
Q
T
W
L
G
---
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
--
L
P
----
L
--
W
I
--
V
I
F
G
A
I
Q
V
-
V
T
T
-
F
Y
G
I
T
-
F
I
R
W
M
N
V
F
A
S
--
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
-------
G
E
V
M
S
M
G
G
E
--------------
N
------
P
-
G
M
P
F
S
T
-
A
I
-
M
I
F
V
G
G
W
I
A
V
-
V
V
S
I
---
H
D
I
V
K
E
C
K
VDPNAS
R
E
G
Q
T
K
A
D
A
R
----
Y
A
T
A
-
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
-----------------------------
W
N
--------
P
V
I
A
I
T
E
V
V
G
G
-
V
S
--------
I
-
P
M
A
I
L
F
Q
----
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
R
V
-
F
T
-----------------
F
K
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
P
W
Q
--
F
A
---
G
V
L
N
T
F
L
N
L
L
---
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
R
IS
L
H
D
L
Y
RTKGIYTYW
R
G
VN
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
--
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
---------------
N
E
D
Y
L
R
P
I
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.71
21%
-71
- C5 -
1FFT
2
CYOB_ECOLI
A:
[380-524]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
M
L
--
W
T
I
G
F
I
V
T
-
F
--
S
V
G
G
M
T
-
G
V
L
L
A
V
P
G
A
D
--
F
V
L
H
N
S
L
F
L
I
A
H
F
H
N
V
I
I
G
-
G
V
-------
V
F
G
C
F
A
G
M
T
-----
Y
W
W
P
K
A
F
G
F
K
L
-
N
E
T
W
G
-
K
R
A
F
W
F
W
I
I
-
G
F
F
V
A
F
M
P
L
Y
-
A
L
G
F
---
M
G
M
T
R
R
L
S
--------
Q
Q
I
D
P
Q
F
H
----
T
M
L
M
I
A
A
S
G
A
V
L
I
A
L
G
I
L
C
L
V
I
Q
M
Y
V
S
I
R
D
R
D
------
Q
N
R
---
D
---------
L
--
T
G
D
P
--------
W
G
G
R
T
L
E
W
A
T
S
S
P
P
P
------
F
Y
-
N
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
37.20
20%
42
- C4 -
2W0C
-
P6_BPPM2
T:
[1-127]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
N
F
L
T
K
N
F
V
W
I
L
A
A
G
V
G
V
W
F
Y
Q
K
A
--
D
N
A
A
K
T
A
T
K
P
I
A
D
F
L
A
E
L
---------------
Q
F
L
V
N
G
S
N
Y
V
K
-
F
P
N
A
G
F
V
L
T
R
D
A
L
Q
D
D
F
I
A
Y
D
D
R
I
K
A
W
L
G
-----------------
T
H
D
R
H
K
D
F
L
A
E
I
L
---
D
H
E
R
R
V
K
P
V
Y
R
K
L
I
G
N
I
I
D
A
S
T
I
R
A
A
S
G
V
E
L
---------------------------------------------------------------------
16
Fugue
35.20
15%
203
- C5 -
2KHK
-
ATPF_ECOLI
A:
[1-53]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
A
I
E
K
R
Q
K
E
I
A
D
G
L
A
S
A
E
R
A
H
K
D
L
D
L
A
K
A
S
A
T
D
Q
L
K
K
A
K
A
E
A
Q
V
I
I
E
Q
A
N
K
R
-----------------------------------------------------------------
7
HHSearch
34.93
13%
-108
- C5 -
3L1L
2
ADIC_ECO57
A:
[8-169]
---------------------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
------
G
A
I
M
G
S
G
V
F
L
-
L
P
A
N
L
A
S
-
T
G
G
---
I
A
--
I
Y
G
W
L
V
T
I
I
G
A
-
L
G
L
S
M
V
Y
A
K
M
---
S
F
L
D
-
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
-
G
-------
P
F
L
-
G
Y
Q
T
N
V
L
Y
------
W
-
L
A
C
W
I
-
G
N
I
A
----
M
V
V
I
G
---
V
G
Y
L
S
Y
F
F
P
I
-----
L
KD
P
W
----
V
--
L
T
I
T
C
V
V
V
L
W
I
F
-
V
L
L
N
I
V
G
P
K
-
M
I
T
R
V
Q
A
V
A
T
--
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
-------
T
Y
M
A
A
I
Q
S
T
-----
L
N
V
T
L
W
S
F
I
G
V
-
E
S
A
-
S
-
V
A
A
G
V
V
K
N
P
-
K
R
N
V
P
I
A
T
I
G
-
G
V
L
I
---
A
A
V
C
Y
V
L
S
--------
T
T
A
I
M
G
M
I
----
P
N
A
A
L
R
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
------
A
A
G
---
C
---------
L
--
G
S
L
G
--------
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
------
D
G
-
L
F
P
P
I
F
A
----
R
V
N
K
A
G
T
P
V
A
G
-
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
-
A
T
-
K
E
F
-
G
---
L
V
S
S
---
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
--
G
K
A
R
P
A
Y
L
A
V
T
---
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
----------------
F
V
----
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
34.76
9%
-89
- C5 -
3GIA
3
Y609_METJA
A:
[6-167]
---------------------------------------------------------
K
K
L
S
L
W
E
A
V
S
M
A
V
------
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
---
N
L
--
P
E
T
-
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
---
G
A
K
I
V
S
-
N
A
G
P
I
A
F
I
H
K
A
I
-
G
-------
D
N
I
I
T
G
A
L
S
I
L
L
------
W
-
M
S
Y
V
I
-
S
I
A
L
----
F
A
K
G
F
---
A
G
Y
F
L
P
L
I
N
A
-----
P
IN
T
F
----
N
I
A
I
T
--
E
I
G
I
V
A
F
F
-
T
A
L
N
F
F
G
S
K
-
A
V
G
R
A
E
F
F
I
V
--
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
-------
Y
V
I
P
D
L
A
P
S
-----
A
V
S
G
M
I
F
A
S
A
I
-
F
F
L
-
S
-
Y
M
G
F
G
V
I
T
N
-
A
S
E
H
I
E
N
P
K
K
-
N
V
P
R
---
A
I
F
I
S
I
L
I
--------
V
M
F
V
Y
V
G
V
----
A
I
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
------
G
F
L
---
L
---------
I
--
S
I
G
A
--------
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
------
A
N
-
V
A
Y
S
L
A
K
----
D
G
E
L
P
E
F
F
E
R
K
-
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
-
A
L
-
L
F
N
-
M
---
E
G
V
A
---
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
--
G
G
R
K
E
I
V
I
F
S
F
---
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
----------------
Y
G
----
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
31.55
15%
338
* C5 *
5CMZ
-
?
B:
[2-33]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
W
E
E
W
D
K
K
I
E
E
L
I
K
K
S
E
E
L
I
K
K
I
E
E
Q
I
K
K
Q
E
------------------------------------------------------------------------
15
Fugue
30.32
22%
535
- C5 -
2C5K
-
VPS51_YEAST
P:
[1-22]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
-
L
R
V
S
S
L
N
K
D
R
R
L
L
L
R
E
F
Y
N
L
----------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
29.28
21%
551
- C5 -
2C5I
-
VPS51_YEAST
P:
[7-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
S
-
L
R
V
S
S
L
N
K
D
R
R
L
L
L
R
E
F
Y
N
L
----------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
26.45
10%
193
- C5 -
2WSW
1
?
A:
[403-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
L
P
L
------
S
T
-
A
T
M
W
G
F
F
----
I
L
C
F
I
A
T
V
T
L
I
-
N
A
C
S
Y
T
L
A
M
S
T
C
R
S
M
K
E
G
A
-
D
P
-
P
L
L
-
V
---
R
I
G
W
---
S
V
L
V
G
I
I
G
I
I
L
L
A
L
G
G
L
K
P
I
Q
T
A
I
I
--
A
G
G
C
P
L
F
F
V
N
I
---
M
V
T
L
S
F
I
K
D
A
K
V
H
W
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
21.70
40%
1464
- C1 -
1XKM
3
?
A:
[2-11]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
V
P
P
G
F
T
A
L
I
K
T
L
R
K
C
K
I
I
------------------------------------------------
12
HHSearch
20.46
15%
227
- C5 -
2K21
-
KCNE1_HUMAN
A:
[49-81]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
G
---
F
F
G
F
F
T
L
G
I
M
L
S
Y
I
R
S
K
K
L
E
H
S
N
D
P
F
N
V
Y
I
E
S
D
A
W
Q
E
K
D
K
A
Y
V
Q
A
R
V
L
E
S
Y
K
S
C
Y
V
V
E
N
H
L
A
I
E
Q
P
N
T
H
L
P
E
T
K
P
S
P
-----------------------------------------------------
10
HHSearch
2.83
50%
1372
- C2 -
2JR3
-
PVAT_PELSI
A:
[8-17]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
S
G
G
W
G
P
C
L
P
I
V
D
L
L
C
I
V
H
V
T
V
----------------