@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SCMC3_HUMAN: (2015-12-12 )
MRGSPGDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGGGNPDPGAQQGISSEGDADPDGGLDLEEFSRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALGVTSR
Atome Classification :
(20 SA)
.........10........20..-......30........40--.---....------...50........60........70----......----------.------.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210...-..------.--.-----220----....-----.....230.......240.......250.......260.......270-----..-----....---.280-........-----.290.......300.....-----..-----310.-----......320.......330.......340.......350.......360.......370.......380.......390.---......400..---.....410-.....--...420.......430.......440.......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGSPG
D
A
E
R
R
Q
R
W
G
R
L
F
E
E
LDS-NKDG
R
V
D
V
H
E
L
R
Q
G
L
A
R
L--G---GGNP------DPGAQQGISSEGDADPDGGL
D
L
E
E
F
----
S
R
Y
L
Q
E
----------
R
------
E
Q
R
L
L
L
M
F
H
SLDRNQDGHI
D
V
S
E
I
Q
Q
S
F
R
ALG
I
S
I
S
L
E
Q
A
E
K
I
L
H
SMDRDG
T
M
T
I
D
W
Q
E
W
R
D
H
F
L
L
H
S
L
E
N
V
E
D
V
L
Y
F
WKH
S
T
V
LD
I
G
E
CLTV
P
D
E
F
S
K
Q
E
K
L
T
G
M
W
W
K
Q
L
V
A
G
A
V
A
G
AVSRTGTA
P
L
D
R
L
K
V
F
M
Q
V
-HA------S--K-----T------
N
R
L
N
-----
I
L
G
G
L
R
S
M
V
L
E
G
G
I
R
S
L
WRGNG
I
N
V
L
K
IAP
E
S
A
I
K
F
M
A
Y
E
Q
I
K
R
A
ILG-----QQ-----
E
T
L
H
---
V
Q
---
E
R
F
VAGSL-----AGATA
Q
T
I
I
Y
P
M
E
V
L
K
T
R
L
-----
T
L-----RRTG-----QYK
G
L
L
D
C
A
R
R
I
L
EREG
P
R
A
F
Y
R
GYL
P
N
V
L
GIIPYAG
I
D
L
A
V
Y
E
T
L
K
N
W
W
L
Q
Q
YSHDSADP
G
I
L
V
L
L
ACGT
I
S
S
T
C
G
Q
I
A
---SY
P
L
A
L
V
R
T
R
M
---
Q
A
QASIE--GGP
Q
L
--
S
M
L
G
L
L
R
H
I
L
S
Q
E
G
M
R
G
L
Y
R
GIA
P
N
F
M
K
V
IPAVS
I
S
Y
V
V
Y
E
N
M
K
Q
A
LGVTSR
1
PsiBlast_PDB
83.29
50%
-74
- C2 -
4N5X
1
SCMC1_HUMAN
A:
[22-176]
-----------
T
R
Y
E
T
L
F
Q
A
L
D
R
-
N
G
D
G
V
V
D
I
G
E
L
Q
E
G
L
R
N
L
--
G
IPL
G
Q
D
----------
A
E
E
K
I
F
T
T
G
D
V
N
K
D
G
K
L
D
F
E
E
F
----
M
K
Y
L
K
D
----------
H
------
E
K
K
M
K
L
A
F
K
S
L
D
K
N
N
D
G
K
I
E
A
S
E
I
V
Q
S
L
Q
T
L
G
L
T
I
S
E
Q
Q
A
E
L
I
L
Q
S
I
D
V
D
G
T
M
T
V
D
W
N
E
W
R
D
Y
F
L
F
N
P
V
T
D
I
E
E
I
I
R
F
W
K
H
S
T
G
I
D
I
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.32
50%
-79
- C2 -
4ZCU
2
?
B:
[13-165]
-----------
T
R
Y
E
T
L
F
Q
A
L
D
R
-
N
G
D
G
V
V
D
I
G
E
L
Q
E
G
L
R
N
L
--
G
I
P
L
G
Q
D
----------
A
E
E
K
I
F
T
T
G
D
V
N
K
D
G
K
L
D
F
E
E
F
----
M
K
Y
L
K
D
----------
H
------
E
K
K
M
K
L
A
F
K
S
L
D
K
N
N
D
G
K
I
E
A
S
E
I
V
Q
S
L
Q
T
L
G
L
T
I
S
E
Q
Q
A
E
L
I
L
Q
S
I
D
V
D
-
T
M
T
V
D
W
N
E
W
R
D
Y
F
L
F
N
P
V
T
D
I
E
E
I
I
R
F
W
K
H
S
T
G
I
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.06
50%
-74
- C2 -
4ZCU
2
?
A:
[13-165]
-----------
T
R
Y
E
T
L
F
Q
A
L
D
R
-
N
G
D
G
V
V
D
I
G
E
L
Q
E
G
L
R
N
L
--
G
I
P
L
G
Q
D
----------
A
E
E
K
I
F
T
T
G
D
V
N
K
D
G
K
L
D
F
E
E
F
----
M
K
Y
L
K
D
----------
H
------
E
K
K
M
K
L
A
F
K
S
L
D
K
N
N
D
G
K
I
E
A
S
E
I
V
Q
S
L
Q
T
L
G
L
T
I
S
E
Q
Q
A
E
L
I
L
Q
S
I
D
V
D
G
T
-
T
V
D
W
N
E
W
R
D
Y
F
L
F
N
P
V
T
D
I
E
E
I
I
R
F
W
K
H
S
T
G
I
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.74
50%
-67
- C2 -
4ZCV
1
?
A:
[12-165]
----------
P
T
R
Y
E
T
L
F
Q
A
L
D
R
-
N
G
D
G
V
V
D
I
G
E
L
Q
E
G
L
R
N
L
--
G
I
P
L
G
Q
D
----------
A
E
E
K
I
F
T
T
G
D
V
N
K
D
G
K
L
D
F
E
E
F
----
M
K
Y
L
K
D
----------
H
------
E
K
K
M
K
L
A
F
K
S
L
D
K
N
N
D
G
K
I
E
A
S
E
I
V
Q
S
L
Q
T
L
G
L
T
I
S
E
Q
Q
A
E
L
I
L
Q
S
I
D
V
D
G
T
M
T
V
D
W
N
E
W
R
D
Y
F
L
F
N
P
V
T
D
I
E
E
I
I
R
F
W
K
H
S
T
G
I
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.08
50%
-65
- C2 -
4ZCV
1
?
C:
[14-164]
------------
R
Y
E
T
L
F
Q
A
L
D
R
-
N
G
D
G
V
V
D
I
G
E
L
Q
E
G
L
R
N
L
--
G
I
P
L
G
Q
D
----------
A
E
E
K
I
F
T
T
G
D
V
N
K
D
G
K
L
D
F
E
E
F
----
M
K
Y
L
K
D
----------
H
------
E
K
K
M
K
L
A
F
K
S
L
D
K
N
N
D
G
K
I
E
A
S
E
I
V
Q
S
L
Q
T
L
G
L
T
I
S
E
Q
Q
A
E
L
I
L
Q
S
I
D
V
D
G
T
M
T
V
D
W
N
E
W
R
D
Y
F
L
F
N
P
V
T
D
I
E
E
I
I
R
F
W
K
H
S
T
G
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
77.87
50%
-66
- C2 -
4ZCV
1
?
B:
[13-164]
-----------
T
R
Y
E
T
L
F
Q
A
L
D
R
-
N
G
D
G
V
V
D
I
G
E
L
Q
E
G
L
R
N
L
--
G
IPL
G
Q
D
----------
A
E
E
K
I
F
T
T
G
D
V
N
K
D
G
K
L
D
F
E
E
F
----
M
K
Y
L
K
D
----------
H
------
E
K
K
M
K
L
A
F
K
S
L
D
K
N
N
D
G
K
I
E
A
S
E
I
V
Q
S
L
Q
T
L
G
L
T
I
S
E
Q
Q
A
E
L
I
L
Q
S
I
D
V
D
G
T
M
T
V
D
W
N
E
W
R
D
Y
F
L
F
N
P
V
T
D
I
E
E
I
I
R
F
W
K
H
S
T
G
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
77.71
28%
-69
* C3 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
-
Q
H
ASKQIS
A
--
E
-----
K
------
Q
Y
K
G
-----
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
GVDRH
K
Q
-----
F
W
R
Y
---
F
A
---
G
N
L
A
S
G
G
A
-----
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
A
DVGKG
A
A
Q
R
-----
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
-----
P
D
P
K
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
---
S
Y
P
F
D
T
V
R
R
R
M
---
M
M
Q
S
G
R
K
--
G
A
D
I
M
YT
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
-
A
F
V
L
V
L
Y
D
E
I
---------
27
HHSearch
75.38
27%
-61
- C3 -
1OKC
10
ADT1_BOVIN
A:
[3-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
-
Q
H
------
A
--
S
-----
K
QISAEK
Q
Y
K
G
-----
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
-----
G
V
DRHKQ
F
W
R
Y
---
F
A
---
G
N
L
A
S
G
G
A
-----
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
A
-----
D
V
G
K
GAAQR
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
P
D
P
K
-----
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
---
S
Y
P
F
D
T
V
R
R
R
M
---
M
M
Q
S
G
R
K
GA
D
I
M
Y
T
--
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
---------
4
PsiBlast_PDB
72.99
29%
-68
- C3 -
1OKC
10
ADT1_BOVIN
A:
[9-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
A
------
S
--
K
QISAE
K
------
Q
Y
K
G
-----
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
-----
G
V
-----
D
R
H
K
---
Q
F
---
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
A
DVGKG
A
A
Q
R
-----
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
--------
P
D
P
K
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
---
M
M
Q
S
G
R
K
--
G
A
D
I
M
YT
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
-
L
V
L
Y
D
E
I
---------
5
PsiBlast_PDB
72.87
29%
-67
- C3 -
2C3E
4
ADT1_BOVIN
A:
[9-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
A
------
S
--
K
QISAE
K
------
Q
Y
K
G
-----
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
-----
G
V
-----
D
R
H
K
---
Q
F
---
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
A
DVGKG
A
A
Q
R
-----
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
--------
P
D
P
K
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
---
M
M
Q
S
G
R
K
--
G
A
D
I
M
YT
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
-
L
V
L
Y
D
E
I
---------
8
PsiBlast_PDB
71.54
26%
-68
- C3 -
4C9Q
5
ADT3_YEAST
A:
[30-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
Q
N
-
Q
D
------
E
M
I
K
-----
Q
------
G
T
L
D
KKYSG
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
G
F
-----
K
K
-----
E
-
G
Y
G
K
W
F
A
---
G
N
L
A
S
G
G
A
-----
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
DAK
S
----------AR---
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
F
D
S
L
K
P
L
-------------
F
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
---
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
S
G
Q
A
V
K
Y
--
N
G
A
------
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
---
7
PsiBlast_PDB
69.48
26%
-60
- C3 -
4C9J
4
ADT3_YEAST
A:
[30-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
Q
N
-
Q
D
------
E
M
I
K
-----
Q
------
G
T
L
D
KKYSG
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
G
F
-----
K
K
-----
E
E
G
Y
G
K
W
F
A
---
G
N
L
A
S
G
G
A
-----
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
DAK
S
----------AR---
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
F
D
S
L
K
-------------------
F
L
L
G
W
V
V
T
T
G
A
S
T
C
---
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
S
G
Q
A
V
K
Y
--
N
G
A
------
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
-
6
PsiBlast_PDB
62.90
28%
-68
- C3 -
4C9H
5
ADT2_YEAST
A:
[27-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
L
L
I
Q
N
-
Q
D
------
E
M
L
K
-----
Q
------
G
T
L
D
RKYAG
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
A
M
F
G
F
-----
K
K
-----
E
E
G
Y
---
A
K
W
F
A
G
N
L
A
S
G
G
A
-----
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
DS------------AR---
Q
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
Y
D
S
L
K
------------
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
-------
S
Y
P
L
D
T
V
R
R
R
M
---
M
-
M
T
S
G
Q
--
A
V
K
Y
D
--
G
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
35
HHSearch
57.84
22%
-50
- C2 -
3NYV
-
?
A:
[329-481]
-----
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R-----
D
A
S
MLD
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
----
V
T
V
A
M
D
R
K
T
L
L
-----
S
------
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
--
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
57.49
22%
-33
- C2 -
2OBH
2
CETN2_HUMAN
A:
[2-142]
-------
E
E
Q
K
Q
E
I
R
E
A
F
D
L
F
D
A
-
D
G
T
G
T
I
D
V
K
E
L
K
V
A
M
R
A
L
--
G
---
F
E
P
-------
K
K
E
E
I
K
K
M
I
S
E
I
D
K
E
G
T
G
K
M
N
F
G
D
F
----
L
T
V
M
T
Q
----------
K
M
S
E
K
D
T
K
E
E
I
L
K
A
F
K
L
F
D
D
D
E
T
G
K
I
S
F
K
N
L
K
R
V
A
K
E
L
G
E
N
L
T
D
E
E
L
Q
E
M
I
D
E
A
D
R
D
G
D
G
E
V
S
E
Q
E
F
L
R
I
M
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
55.24
26%
-26
- C2 -
1TOP
-
TNNC2_CHICK
A:
[11-160]
--
R
A
F
L
S
E
E
M
I
A
E
F
K
A
A
F
D
M
F
D
A
-
D
G
G
G
D
I
S
T
K
E
L
G
T
V
M
R
M
L
--
G
---
Q
N
P
-------
T
K
E
E
L
D
A
I
I
E
E
V
D
E
D
G
S
G
T
I
D
F
E
E
F
----
L
V
M
M
V
R
Q
M
K
E
D
A
K
G
K
-
S
------
E
E
E
L
A
N
C
F
R
I
F
D
K
N
A
D
G
F
I
D
I
E
E
L
G
E
I
L
R
A
T
G
E
H
V
T
E
E
D
I
E
D
L
M
K
D
S
D
K
N
N
D
G
R
I
D
F
D
E
F
L
K
M
M
E
G
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
55.24
23%
-25
- C2 -
3QRX
1
CATR_CHLRE
A:
[20-164]
---
V
G
L
T
E
E
Q
K
Q
E
I
R
E
A
F
D
L
F
D
T
-
D
G
S
G
T
I
D
A
K
E
L
K
V
A
M
R
A
L
--
G
---
F
E
P
-------
K
K
E
E
I
K
K
M
I
S
E
I
D
K
D
G
S
G
T
I
D
F
E
E
F
----
L
T
M
M
T
A
K
M
G
E
R
D
----
S
------
R
E
E
I
L
K
A
F
R
L
F
D
D
D
N
S
G
T
I
T
I
K
D
L
R
R
V
A
K
E
L
G
E
N
L
T
E
E
E
L
Q
E
M
I
A
E
A
D
R
N
D
D
N
E
I
D
E
D
E
F
I
R
I
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.09
31%
-20
- C2 -
2TN4
-
TNNC2_RABIT
A:
[23-151]
-----------------
F
D
M
F
D
A
-
D
G
G
G
D
I
S
V
K
E
L
G
T
-
V
M
R
M
--
L
---
G
Q
T
P
------
T
K
E
E
L
D
A
I
I
E
E
V
D
E
D
G
S
G
T
I
D
F
E
E
F
L
V
M
M
V
R
Q
M
K
E
D
A
K
G
K
-----
S
------
E
E
E
L
A
E
L
F
R
I
F
D
R
N
A
D
G
Y
I
D
A
E
E
L
A
E
I
F
R
A
S
G
E
H
V
T
D
E
E
I
E
S
L
M
K
D
G
D
K
N
N
D
G
R
I
D
F
D
E
F
L
K
M
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
54.07
20%
-25
- C2 -
2JNF
-
?
A:
[4-155]
--
V
S
K
L
S
S
N
Q
V
K
L
L
E
T
A
F
R
D
F
E
T
P
E
G
S
G
R
V
S
T
D
Q
I
G
I
I
L
E
V
L
--
G
---
I
Q
Q
-------
T
K
S
T
I
R
Q
L
I
D
E
F
D
P
F
G
N
G
D
I
D
F
D
S
F
----
K
I
I
G
A
R
FLGEEVNPEQ
M
------
Q
Q
E
L
R
E
A
F
R
L
Y
D
K
E
G
N
G
Y
I
S
T
D
V
M
R
E
I
L
A
E
L
D
E
T
L
S
S
E
D
L
D
A
M
I
D
E
I
D
A
D
G
S
G
T
V
D
F
E
E
F
M
G
V
M
T
G
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
54.06
31%
-31
- C2 -
1A2X
-
TNNC2_RABIT
A:
[23-151]
-----------------
F
D
M
F
D
A
-
D
G
G
G
D
I
S
V
K
E
L
G
T
-
V
M
R
M
--
L
---
G
Q
T
P
------
T
K
E
E
L
D
A
I
I
E
E
V
D
E
D
G
S
G
T
I
D
F
E
E
F
L
V
M
M
V
R
Q
M
K
E
D
AKGK-----
S
------
E
E
E
L
A
E
C
F
R
I
F
D
R
N
A
D
G
Y
I
D
A
E
E
L
A
E
I
F
R
A
S
G
E
H
V
T
D
E
E
I
E
S
L
M
K
D
G
D
K
N
N
D
G
R
I
D
F
D
E
F
L
K
M
M
E
G
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------