@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S26A3_HUMAN: (2015-12-10 )
MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINTNGGLRNRVYEVPVETKF
Atome Classification :
(20 SA)
-.........10.....----....20........30........40........50-........60........70..---..---....80.------.......90........100.......110.......-120.......130.......140.......150...--....160.......170.......180...----....190....----...200.......210.......--220.......230.......240-........250.......260.......270.......280.......290.......300...------....310.......320.------.......330........340.......350.......360....----..-.370.......380.......390.......400.......410....--...420------.....--..430.......440...-------.-----...450.......460.-......470.......480----------....----....490.......500---------.-.......510-........520.......530.......540.-----.------.....550.......560..----------------.....570.......580.---.......590..--....-.600.......610-----........--.620.......630.......640.......650.......660.......670-....-...680.......690..------------.....700.......710...--....720.......730.......740.......750.......----760..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MIEPFGN
Q
Y
I
-
V
ARPV----YSTNA
F
E
E
N
H
K
KTGR
H
H
K
T
F
L
D
H
L
K
V
C
CSC
S
P
Q
K
A
K
-
R
I
V
L
S
L
F
P
I
A
S
W
L
P
A
Y
R
L
K
E
W
L
---
L
S
---
D
I
V
S
G
I
S
------
T
G
I
V
A
V
L
Q
G
L
A
F
A
L
LVDIP
P
V
Y
G
L
Y
A
S
F
F
P
A
I
I
Y
L
FF-GTSRHISVG
P
F
P
I
L
S
M
M
V
G
L
A
VS
G
A
V
SKAVPDRN
A
T
--
T
LGLPNNSNNSSLLDDE
R
V
R
V
A
A
A
A
S
V
T
V
L
----
S
G
I
I
Q
L
A
F
G
I
L
----
R
I
G
F
V
V
I
Y
L
S
E
S
L
ISG
F
T
T
A
A
A
V
--
H
V
L
V
S
Q
L
K
F
I
F
Q
LTVPSHT
D
P
V
--
S
I
F
K
V
L
Y
S
V
F
S
Q
I
EKT
N
I
A
D
L
V
T
A
L
I
V
L
L
V
V
S
I
V
K
E
I
N
Q
R
F
K
DKLPVPI
P
I
E
F
I
M
T
V
I
A
A
GVSY------GCDFK
N
R
F
K
V
A
V
V
GD-MN------PGFQPPITP-
D
V
E
T
F
Q
N
T
V
G
D
C
F
G
I
A
M
V
A
F
A
V
A
F
S
V
A
S
V
Y
S
L
K
YD----YP-LDGN
Q
E
L
I
A
L
G
L
G
N
I
V
C
G
V
F
R
GFAGS
T
A
L
S
R
S
A
V
QESTGG
K
T
Q
I
A
G
L
I
--
G
A
I
I
V
L
------
I
V
V
L
A
--
I
G
F
L
L
A
P
L
Q
K
S
V
L
A
A
L
A
L
-------
G
-----
N
L
K
G
M
L
M
Q
F
A
E
I
G
R
L
W
R-KDKY
D
C
L
I
W
I
M
T
F
I
F
T
I
V
-----------
L
G
L
G
----
L
G
L
A
A
S
V
A
F
Q
L
L
T
I
V
F
----------R-TQFPK
C
S
T
L
--
A
NIGRTNIYKNK
K
D
YYDMYEPEG
V
K
I
F
RCPS
P
-----
I
------
Y
F
A
N
I
G
F
F
R
R
K
L
I
D
AVG
F
S
P
----------------
L
R
I
L
R
K
R
N
K
A
L
R
K
I
R
K
-
L
Q
---KQG
L
L
Q
VTPK
G
F
--
I
C
T
V-DTIKDSDEELDN-------N
Q
I
E
V
LDQ--PINTTD
L
P
F
H
I
DWNDDL
P
L
N
I
EVP
K
I
S
L
H
S
L
I
L
D
F
S
A
V
S
F
L
D
V
S
S
V
R
G
L
K
S
I
L
Q
-
E
F
I
R
-
I
K
V
D
V
Y
I
VGT
D
D
D
F
I
E
K
L
------------
N
RYEFFDGEVK
S
S
I
F
F
L
T
I
H
D
--
A
V
L
H
I
L
M
KKDYSTSKFNPSQEKD
G
K
I
D
F
T
I
NTNGGLRN
R
V
Y
EVP----VETKF
28
Fugue
83.67
21%
-108
- C2 -
5DA0
2
?
A:
[14-484]
---------------------------------------------------------------------------
Q
R
E
W
F
AN
P
R
K
---
D
V
L
A
G
I
V
------
V
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
----
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
D
H
----------------------------
G
I
Q
Y
L
F
A
A
T
V
L
----
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
--
L
I
F
M
A
Q
L
P
Q
F
----------------------
V
G
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
--------
P
L
V
F
K
---
A
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
------
G
A
D
V
K
T
V
G
D
M
G
T
L
P
T
-
A
L
------
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
----
T
T
-
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
--
A
G
A
F
L
M
------
V
L
I
L
A
------
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
-------
A
-----
V
M
M
V
V
A
I
S
T
F
D
W
G
S
L
R
F
-
P
K
G
E
T
V
V
M
L
A
T
V
A
V
T
V
F
T
-----------
H
D
L
S
----
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
----------
K
V
S
Q
L
S
Q
V
T
P
V
--
D
E
V
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
F
T
H
P
AR
R
V
V
I
------
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
V
M
----------------
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
L
N
-
A
A
---
S
A
T
L
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
71.62
15%
-83
- C2 -
2GMH
14
ETFD_PIG
A:
[4-584]
------------
C
K
V
P
R
----
I
T
T
H
Y
T
I
Y
P
R
D
Q
D
K
R
W
E
G
V
N
M
E
R
F
A
E
E
A
D
---------
V
V
I
V
G
A
G
P
A
G
L
S
A
A
T
R
L
K
Q
L
A
---
A
Q
---
H
------------------
E
K
D
L
R
V
C
L
V
E
K
A
A
H
I
G
A
-------------------
H
T
L
S
G
---------
A
C
L
D
P
R
A
F
E
E
L
F
P
D
W
K
E
K
GA
P
L
N
T
P
V
T
E
D
R
F
G
I
L
T
E
K
Y
R
I
P
V
P
I
L
P
G
L
P
M
NNHG
N
Y
V
V
R
L
G
H
L
V
S
----
W
M
G
E
Q
A
E
A
L
G
V
E
V
Y
P
G
Y
A
A
A
E
I
L
--
F
H
E
D
G
S
V
K
G
I
A
T
N
D
V
G
I
Q
K
D
G
-------------
A
P
K
T
T
F
E
R
G
L
E
L
H
A
K
V
T
I
F
A
E
G
C
H
G
H
L
A
K
Q
L
Y
K
K
F
D
L
R
A
N
C
E
P
Q
T
Y
G
I
G
L
K
E
L
W
------
V
I
D
E
K
K
W
K
P
G
R
V
D
H
T
-
V
--------
G
W
--
P
L
D
R
-------
H
T
Y
G
G
S
F
L
Y
H
L
N
E
G
E
P
L
L
A
L
G
F
V
V
G
L
D
Y
Q
----
N
P
Y
L
S
P
F
R
E
F
Q
R
W
K
H
H
P
S
I
K
P
T
L
E
G
---
G
K
R
I
A
Y
G
A
R
A
L
N
E
G
G
F
Q
S
I
P
K
L
T
FP
G
G
L
L
I
G
------
C
---
S
--
P
G
F
M
N
V
P
K
I
K
-----------------------------------------------------------------------
G
----
T
H
T
A
M
K
S
G
T
L
A
A
E
S
I
F
----------
N
-
Q
L
T
S
E
N
L
Q
S
--
K
T
I
G
-
L
H
V
T
E
Y
E
D
N
L
K
N
S
W
V
W
K
E
L
Y
S
V
R
N
I
R
P
-----
S
------
C
H
G
I
L
G
V
Y
G
G
M
I
Y
T
G
I
F
Y
W
I
----------------
F
R
G
M
E
P
W
T
L
K
H
K
G
S
D
S
-
D
Q
---
L
K
P
A
K
D
C
T
P
I
E
Y
----------
P
K
P
D
G
Q
I
S
F
-------
D
L
L
S
S
V
A
L
S
G
T
N
H
E
H
D
Q
P
A
H
L
T
L
K
D
D
----------------------
S
V
P
V
N
R
N
L
S
I
Y
D
G
P
E
Q
-
R
F
C
P
-
A
G
V
-----------------------------
Y
E
F
V
P
L
E
Q
G
D
G
F
R
L
Q
I
N
A
Q
--
N
C
V
H
C
-----
K
T
C
D
I
K
D
P
S
Q
N
----
I
N
W
V
V
P
E
G
G
G
G
-------
P
----
A
Y
N
G
M
1
PsiBlast_PDB
71.14
23%
-114
- C2 -
5DA0
2
?
A:
[15-333]
----------------------------------------------------------------------------
R
E
W
F
---
A
N
P
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
-------
G
R
P
G
M
I
S
-----
A
A
T
G
A
M
A
L
L
M
------------------
T
G
L
V
K
D
H
G
I
Q
Y
L
F
A
A
--
T
V
L
----
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
--
L
I
F
M
A
Q
L
--------
P
Q
----------------
F
V
G
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
------
F
K
---
A
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
------
G
A
D
V
K
T
------
V
G
D
-
M
G
TLPTAL
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
----
T
T
-
S
D
K
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
--
A
G
A
F
L
M
------
V
L
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
-----
V
A
I
S
T
F
D
W
G
S
L
R
F
P
K
G
E
-
T
V
V
M
L
A
T
V
A
V
T
V
F
T
H
D
L
S
-----------
L
G
V
L
----
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
----------
L
-
S
Q
V
T
P
V
D
E
V
--
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
F
T
H
P
A
R
R
-----
V
------
V
I
D
L
S
D
A
H
F
W
D
G
S
A
V
G
A
L
D
K
----------------
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
-
L
N
---
A
A
S
A
T
L
V
E
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
66.92
15%
-68
- C2 -
4XHJ
7
GH_VZVO
A:
[36-791]
A
L
L
R
E
Y
S
D
R
N
M
S
L
K
L
E
A
----
F
Y
P
T
G
F
D
E
E
L
I
K
S
L
H
W
G
N
D
R
K
H
V
F
L
V
I
V
K
V
N
P
T
T
H
E
G
D
V
G
L
V
I
F
P
------
K
Y
L
L
S
P
Y
R
---
F
G
---
F
L
S
H
P
V
T
------
P
D
V
-----------------------
S
F
F
D
S
S
F
A
P
Y
L
-
T
T
Q
H
L
V
A
F
T
T
F
P
P
N
P
L
V
W
H
L
E
R
A
E
T
A
A
T
A
E
R
P
F
G
V
S
--
L
L
P
A
R
P
T
V
P
K
N
T
I
L
E
H
K
----------------------------------------------
A
H
F
A
T
W
D
A
L
A
R
H
T
F
F
S
A
E
A
I
I
T
N
S
T
L
R
I
H
V
-
P
L
FG
S
V
W
P
I
R
Y
W
A
T
G
S
V
L
L
T
S
D
S
G
R
V
E
V
N
I
G
V
G
F
M
S
S
L
I
S
L
S
S
G
L
P
I
E
L
I
V
-
V
P
H
T
V
K
L
N
A
V
T
S
D
T
T
W
F
Q
L
N
P
P
G
P
D
P
G
P
S
Y
R
V
Y
L
L
G
R
G
L
D
------
M
N
F
S
K
H
A
T
V
-
D
I
C
A
Y
P
E
E
S
L
D
Y
R
Y
H
L
S
M
A
H
T
E
A
L
R
M
T
T
K
A
D
---------
Q
-
H
D
I
N
E
E
S
Y
Y
H
I
A
A
R
I
A
T
S
I
F
A
L
S
E
M
G
R
T
T
E
Y
F
L
L
D
E
I
V
D
V
Q
Y
Q
L
K
F
L
N
--
Y
I
L
M
R
I
GAGAHP
N
T
I
S
G
--
T
S
D
L
I
F
A
D
P
S
Q
L
H
D
E
L
S
L
-------
L
F
G
QFI
S
Y
D
E
A
R
D
Q
L
K
T
A
Y
A
L
S
R
G
Q
D
H
V
N
A
L
S
L
A
R
R
V
I
M
S
I
Y
-----------
K
G
L
L
V
K
QN
L
N
A
T
E
R
Q
A
L
F
F
A
S
M
I
L
L
NFS
S
R
V
L
D
G
R
-
T
T
L
L
L
M
T
S
M
--
C
T
A
A
H
A
T
Q
A
A
L
N
I
Q
E
G
L
A
Y
L
N
P
S
K
H
M
F
T
I
P
N
------
V
------
Y
S
P
C
M
G
S
L
R
T
D
L
T
E
E
I
H
V
M
N
----------------
L
L
S
A
I
P
T
R
P
G
L
N
E
V
L
H
-
T
Q
LD
E
S
E
I
F
D
A
A
F
K
T
M
M
--
I
F
T
T
-
W
T
A
K
D
-
L
H
I
L
H
T
-------
H
V
P
E
V
F
------
T
C
Q
D
A
A
A
R
N
G
-----
E
Y
V
L
I
L
P
A
V
Q
G
H
S
Y
V
I
T
R
N
K
P
Q
R
G
L
V
Y
S
L
A
D
V
D
V
Y
N
P
I
S
V
V
Y
-
L
S
K
D
T
C
V
S
E
H
G
V
I
E
T
V
A
L
------------
P
H
P
D
N
L
K
E
C
L
Y
C
G
S
V
F
L
R
Y
L
T
TG
A
I
M
D
I
I
I
I
D
S
K
D
T
E
R
Q
L
A
A
M
G
N
S
T
I
P
P
F
N
P
D
M
H
G
D
D
S
K
A
V
L
L
F
P
NG
T
V
V
T
L
L
G
29
Fugue
65.92
24%
-66
- C2 -
3LLO
1
A:
[1-143]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
---
S
Y
T
V
L
G
Q
L
P
D
T
D
--
V
Y
I
D
-
I
D
A
Y
E
E
V
K
E
I
P
G
-------
I
K
I
F
Q
I
N
A
--
P
I
Y
Y
A
N
S
D
L
Y
S
S
A
N
-------------
I
H
T
V
I
L
D
F
T
Q
V
N
F
M
D
S
V
G
V
K
T
L
A
G
I
V
K
-
E
Y
G
D
-
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
------------
T
S
N
R
F
F
E
N
P
A
L
K
E
L
L
F
H
S
I
H
D
--
A
V
L
G
S
Q
V
R
E
A
-------------------------------------------
33
Fugue
59.73
14%
-93
- C2 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
----
Q
S
Q
L
K
L
L
-
V
T
R
G
K
EQGY
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
G
-
R
---
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
---
T
R
---
E
G
E
I
D
I
A
------
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
------------
Y
P
E
A
I
T
Y
L
L
-
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
T
G
F
V
D
D
P
E
L
A
R
E
K
F
A
E
L
R
A
--
Q
Y
V
V
T
R
D
T
I
K
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
----
P
K
Q
F
D
Y
L
V
N
S
M
----
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
---------------------
L
C
V
E
Q
C
K
M
P
K
--
K
N
F
---
I
T
L
F
T
G
N
E
T
S
D
----------------------------------
T
W
F
N
A
A
I
A
M
N
----------------------------------------
K
P
-
W
S
E
K
L
H
D
----------
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
--------------------------------------------
T
G
L
T
------
I
--
E
Q
V
K
D
I
------
N
R
R
M
S
--
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
-------
R
-----
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
-
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
-----------
Y
R
R
G
----
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
----------
R
-
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
----
R
E
P
T
P
-----
E
------
E
L
A
E
---------------------------------
R
M
L
M
P
E
D
K
-
I
R
K
V
L
K
-
I
A
---
K
E
P
I
S
M
E
T
P
I
G
-------------------
D
-------
D
E
D
S
H
L
G
D
--
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
-------------------
A
G
L
T
A
R
E
A
-
K
V
L
R
-
M
R
F
G
I
-------
D
M
N
T
D
Y
------------
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
--
K
A
L
R
K
L
R
---------
H
P
S
R
S
E
V
L
R
S
F
L
D
------------------------
18
HHSearch
58.13
16%
-90
- C2 -
3NY7
2
?
A:
[14-118]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
D
V
L
V
L
R
V
I
G
P
-----
L
------
F
F
A
A
A
E
G
L
F
T
D
L
E
S
R
L
-------------------------------------------------------------------------------------------------------------------
E
G
K
R
I
V
I
L
K
W
D
A
V
P
V
L
D
A
G
G
L
D
A
F
Q
R
F
V
K
-
R
L
P
--
E
G
C
E
L
R
V
C
N
V
E
F
Q
P
L
R
T
M
------------
A
R
A
G
I
Q
P
I
P
-
G
R
L
A
F
F
P
N
R
R
A
--
A
M
A
D
L
------------------------------------------------
14
HHSearch
57.50
13%
-116
- C2 -
3QE7
2
URAA_ECOLI
A:
[12-410]
-----------------------------------------------------------------------------
P
P
L
---
L
Q
---
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
P
V
L
F
H
------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
---------------------------------
L
G
Y
E
V
A
L
G
G
F
I
M
----
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
--
E
L
A
G
V
A
A
G
M
A
G
L
L
P
--
A
-
E
G
-----------------
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-----
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
------
A
M
G
I
V
---
D
T
T
P
I
I
N
-
A
H
W-----
F
A
L
P
T
L
Y
T
P
-
R
F
E
--
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
KDLL
R
D
-
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
R
V
Y
S
T
W
V
I
G
G
--
A
A
I
F
A
I
------
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
-----
S
G
I
R
V
L
I
E
S
--
K
V
D
Y
N
---
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
GAKVNIGAAEL
K
G
M
A
----
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
----------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
56.23
33%
-64
- C2 -
3LLO
1
A:
[63-136]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
H
T
V
I
L
D
F
T
Q
V
N
F
M
D
S
V
G
V
K
T
L
A
G
I
V
K
-
E
Y
G
D
-
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
------------
T
S
N
R
F
F
E
N
P
A
L
K
E
L
L
F
H
S
I
H
D
--
A
V
L
G
S
Q
V
R
E
A
-------------------------------------------
21
HHSearch
54.94
19%
-82
- C2 -
1SBO
-
Y1442_THEMA
A:
[10-110]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
D
D
K
A
I
V
R
V
Q
G
D
-----
I
------
D
A
Y
N
S
S
E
L
K
E
Q
L
R
N
F
I
S
-----------------------------------------------------------------------------------------------------------------
T
T
S
K
K
K
I
V
L
D
L
S
S
V
S
Y
M
D
S
A
G
L
G
T
L
V
V
I
L
K
-
D
A
K
I
-
N
G
K
E
F
I
L
S
S
L
K
E
S
I
S
R
I
L
------------
K
L
T
H
L
D
K
I
----
F
K
I
T
D
T
V
E
E
--
A
----------------------------------------------------
20
HHSearch
52.73
10%
-98
- C2 -
1TH8
-
SP2AA_GEOSE
B:
[8-114]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
Q
D
V
L
I
V
R
L
S
G
E
-----
L
------
D
H
H
T
A
E
E
L
R
E
Q
V
T
D
V
L
E
-----------------------------------------------------------------------------------------------------------------
N
R
A
I
R
H
I
V
L
N
L
G
Q
L
T
F
M
D
S
S
G
L
G
V
I
L
G
R
Y
K
-
Q
I
K
N
-
V
G
G
Q
M
V
V
C
A
V
S
P
A
V
K
R
L
F
------------
D
M
S
G
L
F
K
I
----
I
R
V
E
A
D
E
Q
F
--
A
L
Q
A
L
G
V
A
---------------------------------------------
16
HHSearch
52.12
20%
-23
- C2 -
2KLN
-
?
A:
[1-124]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
G
L
V
V
Y
R
Y
D
A
P
-----
L
------
C
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
D
Q
---------------------------------------------------------------------------------------------------------------
D
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
D
A
L
D
Q
L
R
T
-
E
L
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
------------
R
A
A
S
L
L
D
K
I
-
G
E
D
H
I
F
M
T
L
P
T
--
A
V
Q
A
F
R
R
R
---------------------------------------------
8
PsiBlast_PDB
51.71
25%
-14
- C2 -
3MGL
-
?
A:
[47-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
P
Q
I
----
L
I
L
R
L
K
W
V
P
F
M
D
I
T
G
I
Q
T
L
E
E
M
I
Q
-
S
F
H
K
-
R
G
I
K
V
L
I
S
G
A
N
S
R
V
S
Q
K
L
V
K
A
G
I
V
K
L
V
GEQ
N
V
Y
P
V
F
E
G
A
L
S
A
A
L
T
E
I
E
A
Q
--------------------------------------------------------
9
PsiBlast_PDB
51.53
25%
-13
- C2 -
4DGH
1
?
A:
[47-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
P
Q
I
----
L
I
L
R
L
K
W
V
P
F
M
D
I
T
G
I
Q
T
L
E
E
M
I
Q
-
S
F
H
K
-
R
G
I
K
V
L
I
S
G
A
N
S
R
V
S
Q
K
L
V
K
A
G
I
V
K
L
V
GEQ
N
V
Y
P
V
F
E
G
A
L
S
A
A
L
T
E
I
E
A
Q
--------------------------------------------------------
23
HHSearch
51.11
14%
-62
- C2 -
3T6O
-
?
A:
[48-120]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
V
L
I
D
L
E
G
V
E
F
F
G
S
S
F
I
E
L
L
V
R
G
W
K
-
R
I
K
E
D
Q
Q
G
V
F
A
L
C
S
V
S
P
Y
C
V
E
V
L
------------
Q
V
T
H
I
D
E
V
----
W
P
R
Y
S
T
K
Q
E
--
A
L
L
A
M
A
-----------------------------------------------
17
HHSearch
50.98
15%
-100
- C2 -
2KA5
-
Y1081_THEMA
A:
[5-124]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
H
H
H
H
H
H
M
F
P
Y
K
I
V
D
D
V
V
I
L
M
P
N
K
E
-----
L
------
N
I
E
N
A
H
L
F
K
K
W
V
F
D
E
F
L
-----------------------------------------------------------------------------------------------------------------
N
K
G
Y
N
K
I
F
L
V
L
S
D
V
E
S
I
D
S
F
S
L
G
V
I
V
N
I
L
K
-
S
I
S
S
-
S
G
G
F
F
A
L
V
S
P
N
E
K
V
E
R
V
L
------------
S
L
T
N
L
D
R
I
----
V
K
I
Y
D
T
I
S
E
--
A
M
E
E
V
R
R
K
---------------------------------------------
19
HHSearch
50.20
13%
-89
- C2 -
1H4X
1
SP2AA_LYSSH
A:
[8-112]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
E
T
V
V
I
R
L
F
G
E
-----
L
------
D
H
H
A
V
E
Q
I
R
A
K
I
S
T
A
I
F
-----------------------------------------------------------------------------------------------------------------
Q
G
A
V
T
T
I
I
W
N
F
E
R
L
S
F
M
D
S
S
G
V
G
L
V
L
G
R
M
R
-
E
L
E
A
-
V
A
G
R
T
I
L
L
N
P
S
P
T
M
R
K
V
F
------------
Q
F
S
G
L
G
P
W
----
M
-
M
D
A
T
E
E
E
--
A
I
D
R
V
R
-----------------------------------------------
30
Fugue
44.22
11%
20
- C2 -
2KLN
-
?
A:
[1-124]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
-
I
D
D
Y
P
Q
A
K
R
V
P
G
-------
L
V
V
Y
R
Y
D
A
--
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
D
Q
---
D
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
D
L
T
A
L
D
A
L
D
Q
L
R
T
-
E
L
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
------------
R
A
A
S
L
-
L
D
K
I
G
E
D
H
I
F
M
T
L
P
T
--
A
V
Q
A
F
R
R
R
---------------------------------------------
32
Fugue
43.62
22%
31
- C2 -
4PQL
9
?
A:
[1-131]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
Q
Y
F
T
V
Q
E
N
Y
K
E
R
F
Y
Q
I
P
K
V
F
F
T
S
E
N
-----
Y
KNLT
N
D
M
K
I
A
Y
A
I
L
R
D
R
L
N
L
S
I
K
N
S
W
VDEDG
N
I
Y
F
VYS
N
E
K
L
M
E
I
L
N
C
K
K
E
K
L
T
K
I
K
K
G
L
E
---
N
D
G
L
L
I
Q
K
R
R
G
L
NK
P
N
I
L
-
Y
L
M
K
P
I
V
T
E
R
D
I
-------
Y
K
I
E
K
E
E
N
--
D
V
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
41.21
25%
39
- C2 -
3V47
-
FLIC_SALDU
C:
[41-163]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
E
I
N
N
N
L
Q
R
V
R
E
-
L
S
---
V
Q
A
T
N
G
T
N
S
D
S
D
--
L
K
S
I
Q
D
E
I
Q
Q
R
L
E
E
I
D
R
V
S
N
QTQF
N
G
V
K
V
L
S
Q
--
D
---
N
Q
M
K
I
Q
V
G
A
N
D
G
E
T
I
T
I
D
L
Q
K
I
D
V
K
S
L
G
L
D
G
F
N
V
N
G
P
K
E
A
T
V
G
D
L
K
S
S
F
K
-
N
V
---
T
G
Y
D
T
Y
A
A
G
A
D
K
Y
R
V
D
I
N
------------
S
G
A
V
V
T
D
A
V
A
P
D
K
V
Y
V
N
A
A
N
G
--
Q
L
T
T
D
D
A
E
N
N
T
K
T
K
N
E
S
A
K
L
S
D
L
E
A
N
N
A
V
K
G
E
S
K
I
T
V
N
G
A
E
Y
T
A
----
N
A
T
G
D