@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT14_HUMAN: (2015-12-08 )
MYTSHEDIGYDFEDGPKDKKTLKPHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSPGKNPNDPGEKDVRGLPAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKNMCALRILKTVSWLTMRVRKGFEDWYSGYFGTASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQPCIRIIEQSRRKYMDGAHV
Atome Classification :
(20 SA)
-.........10.......---.20........30.......----------.40.........50........60.--..-.....--70........80........90........100...---....110.......---120-.----..---......130.......140.......150.-.---.....160..-.....--.170-.......180..--------------------------...-..-190.......200.......210....-----...220........230.......240.......250.....--..260.--------......270.......280....----------...290.......300.......310.......320.......330...----....340.--.....--------.350---.......360.......370.....----.-.380.....-..390.......-400----.......410.......420-..-.....430.......440...-.-...450.-......460.......470-----------------------------------.........480.......---490....---------...500.......510--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MYTSHEDIGYDFEDGPKD---KKTLKPHPNID
G
G
W
A
W
M
M
V
L
----------
S
S
-
F
F
V
H
I
L
IMGSQ
M
A
L
G
V
L
N
V
E
W
L
--
E
E
-
F
H
QSR--
G
L
T
A
W
V
S
S
LSM
G
I
T
L
I
V
G
P
F
I
G
L
F
I
NTCGC
R
Q
T
A
I
I
---
G
G
L
V
N
S
L
G
W
V
L
S
A
Y
---A---A----N
V
---
H
Y
L
F
I
T
FGV
A
A
GLGS
G
M
A
Y
L
P
A
V
V
M
V
G
R
Y
F
-
Q
---
K
R
R
A
L
A
-QGL-STTGT--
G
F
G
T
-
F
L
M
T
V
L
L
K
Y
L
C
A
--------------------------EYG-WR-
N
A
M
L
I
QGAV
S
L
N
L
C
V
C
G
A
L
MRPLSPGK-----NPND-PGEKDVRGLPAHS
T
E
S
V
K
STGQQGRTEEKDGGLGN
E
E
--
T
L
C
D
L
Q
--------
A
Q
EC
P
D
QAGH
R
K
N
M
C
A
L
R
I
L
K
T
V
----------
S
W
L
T
M
R
V
R
K
G
F
E
D
W
Y
SGYF
G
T
A
S
L
F
TN
R
M
F
V
A
F
I
F
W
A
L
F
A
Y
S
S
F
V
I
P
F
I----H
L
P
E
I
V
N
L
--YNLSE--------QNDV---
F
P
L
T
S
I
I
A
I
V
H
I
F
G
K
V
I
L
G
V
IADL
P
----
C
-
I
S
V
W
N
V
F
L
L
-
A
N
F
T
L
V
L
S
I
F
I
L
-
P
L
M
----
H
T
Y
A
G
L
A
V
I
C
A
L
I
GFSS
G
Y
F
-
S
L
-
M
P
V
V
T
E
D
L
V
G
I
E
H
L
A
NA
Y
G
I
I
-
I
-CAN
G
I
S
A
-
L
LGPPF
A
G
W
I
Y
D
I
T
Q
KY-------------------------------------D
F
S
F
Y
I
C
G
L
L
Y
M
I
G
I
L
F
L
L
---
I
Q
P
C
I
R
I
---------
I
E
Q
S
R
R
K
YMDGAHV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
80.25
16%
-109
* C4 *
4WW4
1
?
A:
[3-458]
----
Q
I
S
E
V
R
G
N
T
R
D
H
R
T
A
---
A
H
T
H
I
K
G
L
G
L
N
S
S
G
I
A
E
K
Q
A
----------
A
G
-
F
V
--------
G
Q
C
A
A
R
E
A
C
G
V
V
--
V
D
-
L
I
K
A
H
--
K
M
A
G
------
R
G
V
L
L
A
G
G
P
---------
G
T
G
K
T
A
L
A
---
L
A
I
S
Q
E
L
G
-------------
T
----
K
I
---
P
F
C
P
I
T
----------------------------------
G
-
S
E
I
-
Y
S
T
E
V
--
K
K
T
E
-
V
L
M
E
N
F
R
R
A
I
G
L
--------------------------
R
V
--
R
E
-
T
K
D
V
Y
E
G
E
V
S
T
L
L
------------------------
I
G
L
K
S
A
R
G
Q
K
L
D
Q
K
E
R
V
Q
-
V
G
D
V
I
Y
I
E
T
N
T
G
A
C
R
S
D
A
YA
T
E
F
D
L
E
--------
A
E
E
Y
V
P
I
P
K
G
E
--------
V
H
K
K
----------
K
E
I
V
Q
D
V
T
L
H
D
L
D
V
A
N
A
R
P
D
I
I
S
M
M
G
Q
L
M
K
P
K
M
T
----------
E
I
T
D
K
----
L
R
M
E
I
N
K
V
--
V
Q
K
Y
I
--------
N
Q
G
V
---
A
E
L
I
P
--
G
V
L
F
I
D
E
A
H
M
L
----
D
I
E
----
C
-
F
T
Y
L
N
K
A
L
E
-
S
P
I
A
P
I
V
V
L
A
S
N
-
R
G
I
----
A
T
I
R
G
A
D
D
L
K
A
A
H
G
I
P
P
D
F
L
-
Q
R
-
L
L
I
I
P
T
H
P
Y
E
P
D
E
I
R
R
I
V
R
I
R
-
A
-
Q
T
E
G
V
Q
---
L
T
D
A
A
V
D
R
V
A
E
H
G
V
R
I
-------------------------------------
S
L
R
Y
C
L
-
Q
L
L
A
P
A
S
I
L
A
R
V
N
GR
T
Q
V
D
V
Q
D
---------
I
A
E
A
E
E
L
F
L
D
A
R
R
S
A
N
I
L
T
S
TGGLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
71.77
12%
-131
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-421]
-----------------------------------
R
S
Y
I
I
P
F
----------
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
--
Q
A
-
F
T
L
T
N
--
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
---
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
---
A
A
E
I
M
----
N
Y
---
T
L
F
L
V
-
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
-
P
E--
S
S
G
H
F
R
-
L
N
L
-
A
Q
T
F
N
--
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
-
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
-
I
M
L
T
-
K
F
P
A
L
-----
Q
--
S
--
D
N
H
S
-
D
A
K
-----------------------------------------------------------------
Q
G
---------------
S
F
S
A
----------
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
----
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
--------
G
F
A
A
---
N
-
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
----
A
-
P
H
K
--
V
L
A
A
-
Y
A
L
I
A
M
A
L
C
L
I
S
-
A
F
A
----
G
G
H
V
G
L
-
I
A
L
T
L
C
S
A
F
M
S
I
Q
-
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
---
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
-------------------------------------
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
---
F
R
S
Q
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
71.15
11%
-144
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
------------
F
K
P
A
P
H
K
---
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
----------
L
G
-
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
--
V
E
-
Q
G
F
S
R
--
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
---
G
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
---
P
----
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
---
K
E
R
G
G
I
-
V
S
V
-
W
N
C
A
H
--
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
-
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
-----
C
G
L
P
-
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
--------------------------------------------------------------------------------------------
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
----
W
S
P
T
Y
L
K
E
--
V
K
H
F
A
--------
L
D
K
S
---
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
FRGN
R
-
G
A
T
G
V
F
F
M
T
-
L
V
T
I
A
T
I
V
Y
W
M
N
-
P
A
G
----
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
-
M
L
-
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
-
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
-------------------------------------
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
---
V
M
I
G
E
K
R
---------
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
70.25
10%
-114
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
-------------------------------
M
Y
Y
L
K
N
T
N
F
W
M
----------
F
G
-
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
--
D
I
-
N
H
I
S
K
--
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
---
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
---
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
-
E
---
K
V
S
R
R
S
N
F
E
F
-
G
R
A
R
M
--
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
--------------------------
T
I
N
-
N
Q
-
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
-----
A
T
V
A
-
N
A
V
G
A
N
H
S
A
F
S
----------------------------------------------
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
----------
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
----
F
A
P
L
I
I
N
R
--
I
G
---------------------------------------------------
G
K
N
A
L
L
L
-
A
G
T
I
M
S
V
R
I
I
G
S
-
S
F
A
----
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
-
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
-------------------------------------
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
---
T
L
S
G
P
G
P
---------
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
70.10
12%
-133
- C3 -
2CFQ
-
LACY_ECOLI
A:
[24-393]
------------------------------------------------------------------
G
A
Y
F
P
F
F
P
I
W
L
--
H
D
I
N
H
I
S
K
--
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
---
G
---
P
----
L
L
Q
--
Y
N
I
L
V
-
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
-
E
K
V
S
R
R
S
N
F
E
-
F
G
R
-
A
R
M
F
G
--
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
-
N
Q
-
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
--------
A
--
T
V
A
--
N
A
V
G
--
A
-------------------------------------------------------------
N
H
-------------
S
A
F
S
L
K
----------
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
--
G
E
Q
G
T
--------
R
V
F
G
---
Y
-
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
----
G
-
G
K
N
--
A
L
L
L
-
A
G
T
I
M
S
V
R
I
I
G
S
-
S
F
A
----
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
-
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
-
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
-------------------------------------
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
---
F
T
L
S
G
P
G
---------
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
69.75
12%
-141
- C3 -
1PW4
-
GLPT_ECOLI
A:
[19-430]
----------------------------
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
----------
G
I
-
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
---
E
-
Q
G
F
S
R
--
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
---
G
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
---
P
W
A
T
S
S
I
---
A
V
M
F
V
-
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
-
S
Q--
K
E
R
G
G
I
-
V
S
V
-
W
N
C
A
H
--
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
-
W
H
-
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
-----
C
G
L
P
-
P
I
E
E
Y
--
K
N
D
---------------------------------------------------------------------------------
T
A
K
Q
-
I
--------
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
----
W
S
P
T
Y
L
K
E
V-
K
H
F
A
L
--------
D
K
S
S
---
W
-
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
----
F
-
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
-
W
M
N
PA--
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
-
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
-
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
-------------------------------------
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
---
V
V
M
I
G
E
K
---------
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
67.04
13%
-136
- C3 -
3WDO
-
?
A:
[28-379]
-------------------------------------------------------------------
M
V
L
P
V
L
T
T
Y
G
M-
A
L
-
Q
G
A
S
E
--
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
---
G
L
A
V
F
A
A
G
S
V
I
A
A
L
---
S
---
D
----
S
I
---
W
G
I
I
L
-
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
-
R
E--
Q
N
R
T
K
A
-
M
A
F
-
I
G
V
S
F
--
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
-
L
H
-
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
--------
V
--
L
N
R
--
E
S
G
-----------------------------------------------------------------
M
V
--------------
K
G
S
---
F
----------
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
----
A
L
P
G
Q
L
A
D
--
A
G
F
P
A
--------
A
E
H
W
K
V
Y
L
-
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
-------
K
Q
--
V
F
V
F
-
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
----
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
-
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
-
T
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
-------------------------------------
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
---
T
M
K
E
P
P
Y
---------
V
S
S
L
R
I
E
I
P
A
D
I
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
66.58
15%
-108
- C2 -
1JB0
13
PSAA_THEEB
A:
[13-755]
R
V
V
V
D
N
D
P
V
P
T
S
F
E
K
W
A
K
P
GHF
D
R
T
L
A
R
G
P
Q
-
T
T
T
W
I
W
N
L
H
A
L
A
HDFDTHTS
D
L
-
E
D
I
S
R
K
I
F
S
A
H
F
G
H
L
A
V
V
F
I
W
L
S
G
M
Y
-
F
H
G
A
K
FS
N
Y
E
A
W
L
A
D
P
T
G
-----
I
K
P
S
A
Q
V
V
W
P
I
V
G
---
Q
G
I
L
---
N
G
D
V
G
G
-
G
F
H
G
I
Q
I
---
T
---
S
----
G
L
---
F
Q
L
W
R
A
S
G
I
-----
T
N
E
F
Q
L
Y
C
T
A
I
G
G
L
V
M
-
A
---
G
L
M
L
F
A
-
G
W
F
-
H
Y
H
K
R
--
A
P
K
L
-
E
W
F
Q
N
V
E
S
M
L
N
H
--------------------------
H
L
A
-
G
L
-
L
G
L
G
S
L
A
W
A
G
H
Q
I
H
V
S
L
P
I
N
K
L
L
D
A
G
V
-----
A
A
K
D
I
P
L
P
H
E
F
I
L
N
P
S
L
M
A
E
L
Y
P
K
V
D
W
G
F
F
S
P
F
F
T
F
N
W
A
A
Y
S
--
D
F
L
T
F
N
GGLNPVTG
G
L
W
L
S
D
T
A
H
H
H
L
A
I
A
V
L
F
I
I
A
G
H
MYRTNWGIGH
S
L
K
E
I
L
E
A
H
K
G
P
F
T
G
A
G
H
K
G
L
Y
E
V
L
T
T
S
-
W
H
A
Q
L
A
I
N
L
A
M
M
G
S
L
S
I
I
V
A
----
Q
H
M
Y
A
M
P
P
--
Y
P
Y
L
A
--------
T
D
Y
P
---
T
Q
L
S
L
F
T
H
H
M
W
I
G
G
F
L
V
V
G
G
A
A
H
G
A
----
I
-
F
M
V
R
D
Y
D
P
A
-
M
N
Q
N
N
V
L
D
R
V
L
R
-
H
R
D
----
A
I
I
S
H
L
N
W
V
C
I
F
L
G
F
H
S
--
F
-
G
L
-
Y
-
V
H
N
D
T
M
R
A
F
G
R
P
Q
D
M
F
--------
S
D
T
G
I
-
Q
L
Q
P
V
F
A
Q
W
V
Q
N
L
H
T
L
A
PGGTAPNAAATASVAFG
G
D
V
V
A
V
GGKVAM
M
P
I
V
L
G
T
A
D
F
M
V
H
H
I
H
A
F
T
I
H
V
T
V
L
I
L
---
L
K
G
V
L
F
A
RSSRLIPDK
A
N
L
G
F
R
F
P
C
D
G
P
G
R
GGTCQVS
G
W
D
H
V
F
L
G
L
F
W
M
Y
N
C
I
S
V
V
I
F
H
F
S
W
K
M
Q
S
D
V
W
G
T
V
A
PDG
T
V
S
H
ITGGN
F
A
Q
S
A
IT
I
N
G
W
L
RDF
L
W
A
Q
A
SQVIGSYGSAL
S
A
Y
G
L
L
F
L
G
A
H
F
I
W
A
F
S
L
M
F
L
F
S
G
R
G
Y
W
Q
E
L
I
E
S
I
V
W
A
H
N
K
L
KVAPAI
Q
P
R
A
L
S
I
I
Q
G
R
A
V
G
V
A
H
Y
L
L
G
G
I
A
T
T
W
A
F
F
L
A
R
I
ISVG
6
HHSearch
61.85
14%
-113
- C3 -
2GFP
-
EMRD_ECOLI
A:
[22-360]
---------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
--
R
D
-
L
N
V
R
E
--
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
---
G
M
S
I
F
M
L
A
T
L
V
A
V
T
---
T
---
S
----
S
L
---
T
V
L
I
A
-
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
-
E
R
--
T
Q
L
R
H
A
-
N
S
L
-
L
N
M
G
I
--
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
-
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
---
T
-----
R
P
V
D
---
A
P
---
R
T
R
-------------------------------------------------------------------------------
L
L
T
S
-------------
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
----
C
S
G
V
L
M
G
A
V
-
L
G
L
S
S
--------
M
T
V
S
---
I
-
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
----
S
-
T
L
M
-
W
Q
S
V
I
-
C
C
L
L
A
G
L
L
M
W
I
P
-
D
W
F
G
V
--
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
-
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
-
G
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
-------------------------------------
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
44.81
29%
-84
- C3 -
3DL8
-
SECY_AQUAE
G:
[268-388]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
G
V
I
P
I
I
F
A
Q
A
L
L
L
I
P
----------
S
T
L
L
N
F
V
Q
N
P
F
I
K
V
I
A
D
M
F
Q
P
G
A
I
F
Y
N
F
L
Y
V
T
F
I
V
F
F
T
Y
F
Y
T
A
V
L
I
N
P
V
----
E
L
A
E
--
N
L
--
H
K
A
G
A
FIPGVRPG
Q
D
T
V
---
K
Y
L
E
R
I
I
N
R
L
I
F
F
G
A
L
F
L
S
V
I
A
L
I
P
----
I
L
I
S
V
W
F
N
I
P
F
-
Y
F
G
G
T
T
A
L
I
V
V
G
-
V
A
L
----
D
T
F
R
Q
I
E
T
Y
L
I
Q
K
K
Y
K
S
Y
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
44.29
15%
-150
- C3 -
3WDO
-
?
A:
[21-177]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
M
L
G
M
F
M
V
L
P
----
V
L
T
T
Y
G
M
A
L-
Q
G
A
S
E
--------
A
L
I
G
---
I
-
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
----
G
-
R
K
P
--
L
I
V
G
-
G
L
A
V
F
A
A
G
S
V
I
A
-
A
L
S
----
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
-
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
-
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
-------------------------------------
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
---
W
V
V
P
N
S
S
---------
T
H
V
L
N
R
E
S
G
M
V
K
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
44.08
17%
-109
- C3 -
2CFQ
-
LACY_ECOLI
A:
[257-391]
-------------------------------------------------------------------------------------
G
T
--
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
---
A
G
T
I
M
S
V
R
I
I
G
S
S
F
---
A
---
T
----
S
A
---
L
E
V
V
I
-
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
-
E
V--
R
F
S
A
T
I
-
Y
L
V
C
F
C
F
F
K
--
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
-
F
Q
-
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
-----
S
L
L
R
-
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
43.92
14%
-132
- C3 -
1PW4
-
GLPT_ECOLI
A:
[54-200]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
E
--
Q
G
F
S
R
--------
G
D
L
G
---
F
-
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
----
N
-
P
R
V
--
F
L
P
A
-
G
L
I
L
A
A
A
V
M
L
F
M
-
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
-
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
-
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
-------------------------------------
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
---
A
M
M
R
D
T
P
---------
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
39.65
15%
-118
- C3 -
2GFP
-
EMRD_ECOLI
A:
[27-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
P
----
A
I
A
D
M
A
R
D
--
L
N
V
R
E
--------
G
A
V
Q
---
S
-
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
----
G
-
R
R
P
--
V
I
L
V
-
G
M
S
I
F
M
L
A
T
L
V
A
-
V
T
T
----
S
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
-
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
-
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
-
N
W
-------------------------------------
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
---
R
W
M
P
E
T
R
---------
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
39.39
12%
-148
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[39-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
A
N
N
L
N
D
I
----
L
L
P
Q
F
Q
Q
A
--
F
T
L
T
N
--------
F
Q
A
G
---
L
-
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
----
S
-
Y
K
A
--
G
I
I
T
-
G
L
F
L
Y
A
L
G
A
A
L
F
-
W
P
A
A
E
I
-
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
-
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
-
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
-------------------------------------
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
---
S
L
V
L
S
V
Q
---------
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
38.33
17%
281
- C4 -
2C1M
-
NUP50_MOUSE
B:
[1-46]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
R
V
A
E
K
E
L
T
DR
N
W
D
E
-
E
D
E
V
E
E
M
G
T
F
S
V
A
S
E
E
V
M
K
N
R
A
V
K
K
A
K
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
37.72
32%
-45
- C3 -
4M5D
-
UTP22_YEAST
A:
[358-421]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
V
E
A
T
V
L
-
G
R
L
W
-
L
---
Q
Q
R
G
F
S
-
S
N
M
-
S
H
S
G
S
LG
G
F
G
T
-
F
E
F
T
I
L
M
A
A
L
L
N
--------------------------
G
G
G
-
I
N
S
N
K
I
L
L
H
G
F
S
S
Y
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
35.75
14%
128
- C3 -
3VEM
-
MOM1_ARATH
A:
[1732-1813]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
D
-
P
F
L
H
E
L
E
K
L
R
R
E
S
E
N
S
K
K
T
F
E
E
K
K
S
I
L
K
A
E
L
E
R
K
M
A
E
--
V
Q
A
E
F
R
--------
R
K
F
H
E
V
E
A
E
H
N
T
R
T
T
K
I
E
K
D
K
N
L
----------
V
I
M
N
K
L
L
A
N
A
F
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
32.82
11%
77
- C3 -
2L9Q
-
HSP12_YEAST
A:
[1-109]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
D
A
G
R
K
G
F
G
E
K
A
S
E
A
L
K
P
D
S
Q
K
-----
S
Y
A
E
-
Q
G
K
E
Y
I
T
D
K
A
D
K
V
A
G
K
V
Q
P
E
D
N
K
G
V
F
Q
G
V
H
D
S
A
E
K
G
K
--
D
N
A
E
G
Q
--------
G
E
S
L
A
D
Q
A
R
D
Y
M
G
A
A
K
S
K
L
N
D
A
V
----------
E
Y
V
S
G
R
V
H
G
E
E
D
P
T
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
32.36
30%
414
* C3 *
3WY9
-
RL12_PYRHO
C:
[7-32]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
K
E
E
E
E
K
E
E
E
V
S
E
E
E
--
A
L
A
G
L
S
--------
A
L
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------