@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPT2B_HUMAN: (2015-12-08 )
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
Atome Classification :
(14 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30.......--.40...-.....50.....---...60........70........80........-90....--....100.......-------------110.......120.------......130.......140......---------.150.......160.......---170...--------....180......-.190.-------------------------......200.....-----..210......--------------.220---------.--..-....230.......240......-.250..-.....260.-......270.--......-------------------------------280....------...290.......300.......310.......320.......330.......340.--......350.......-360.......------370.....-.-----.-380...-....390.......400.......410...----....420.....----------..430.......440...----------....450.......460.....---..470.......480.......------490.......500.......510.--------------....-..520.......530---....----------------------------------....540.......550.......560.......570-----.....---..580..--------.....590....----...600.......--610.-----......620..--------.....630.......640........650-------....-----------.....660...-....670..---.....680.......690----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAPWPELGDAQP
N
P
D
K
Y
LEGAAGQQPTAPDKSKETNKT--DNTEAP-
V
T
K
I
E
L
LPSYST---ATLIDEPTEVDDPWNLPTLQDSGIKWSERDTK
G
-
K
I
L
C
F
F
--
Q
G
I
G
R
L
I
L
L
L
G
F
L
Y
-------------
F
F
V
C
S
L
D
I
L
S
S
A
F
Q
------
L
V
G
G
K
M
A
G
Q
FFSNSSIMSN
P
L
L
G
L
V
---------
I
G
V
L
V
T
V
L
VQSSSTSTS
I
V
V
S
---
M
V
S
S
S
L
--------
L
T
V
R
AA
I
P
I
I
MGA-NIG
T
S
-------------------------
I
T
N
T
I
V
A
L
M
QVG
D
R
-----
S
E
F
R
R
A
FAG
A
T
--------------
V
H
D
F
---------
F
--
N
W
-
L
S
V
L
V
L
L
P
V
E
V
A
T
H
Y
L
E
I
I
T
Q
L
I
-
V
E
S
FHF-KNGED
A
P
D
L
-
L
K
V
I
T
K
P
F
T
K
--
L
I
V
Q
L
D
-------------------------------
K
K
V
I
S
Q
I
------AMN
D
E
KAKN
K
S
L
V
K
I
W
C
K
TFTNK
T
Q
I
N
V
TVPSTANCTSPS
L
C
W
TDGIQNWTMKNV
T
Y
--
K
E
N
I
A
K
C
Q
H
I
F
V
N
FHL-
P
D
L
A
V
G
T
I
L
L
------
I
L
S
L
L
V
L
C
-
G
-----
C
-
L
I
M
I
V
K
-
I
L
G
S
V
L
K
G
Q
V
A
T
V
I
K
K
T
INTDFPF
P
F
A
W
L
T
----
G
Y
L
A
I
L
VGA
G
M
T
----------
F
I
V
QSS
S
V
F
T
S
A
L
T
P
L
I
G
----------
I
G
V
I
T
I
ERAY
P
L
TLGSNIG
T
T
T
---
T
A
I
L
A
A
LASP
G
N
A
L
R
S
S
L
Q
I
A
L
------
C
H
F
F
F
NIS
G
I
L
L
W
YPIPFTR
L
P
I
R
--------------
M
A
K
G-LGNI
S
A
K
Y
R
W
F
A
V
F
----
Y
L
I
I
----------------------------------
F
F
F
L
I
P
L
T
V
F
GLSLAG
W
R
V
L
V
GV
G
V
P
V
V
F
I
I
I
L
V
L
C
L
-----
R
L
L
Q
S---RC
P
R
V
L
P
--------
K
K
LQNWN
F
L
P
L
W
----
M
R
SLK
P
W
D
A
V
V
S
K
--
F
T
G
C
-----
F
Q
M
R
C
C
C
C
C
R
V
--------
C
C
R
A
C
C
L
LCD
C
P
K
C
C
R
C
-
S
K
C
C
E
D
L
E
E
---------
A
QEG-----------QDVPVKAPETF-D
N
I
T
ISREA---QGEVPASDSKTECTAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
83.03
17%
-91
- C6 -
4U1C
-
EIF3C_YEAST
C:
[6-549]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
F
T
R
L
Q
T
I
I
D
S
R
G
K
K
T
V
N
Q
Q
S
L
I
--
S
T
L
E
E
L
-
L
T
V
A
E
K
P
Y
E
F
I
M
---
A
Y
L
T
L
I
P
S
R
F
D
A
S
A
N
L
S
-----------
Y
Q
P
I
D
-
Q
W
K
S
S
F
--
N
D
I
S
K
L
L
S
I
L
D
Q
T
-----------------------------------
I
D
T
Y
Q
V
N
E
F
A
D
P
I
D
F
I
E
D
E
P
K
E
D
S
---------
D
G
V
----------------------------------------------------
K
R
-------------------------
I
L
G
S
I
F
S
F
V
E
R
L
D
D
------
E
F
M
K
S
L
L
N
I
D
--------------
P
H
S
----------------
S
D
Y
L
I
R
L
R
D
E
Q
S
I
Y
N
L
I
L
R
T
Q
L
Y
-
F
E
A
T
L
-----
K
D
E
H
D
L
-
E
R
A
L
T
R
P
F
V
K
--
R
L
D
H
I
Y
-------------------------------
Y
K
S
E
N
L
I
------
K
I
M
E
T
A
A
W
N
I
-
I
P
A
Q
F
K
S
K
F
T
S
K
D
Q
L
D
-------------------------
S
A
D
Y
V
--
D
N
L
I
D
G
L
S
T
I
L
S
K
Q
N
N
-
I
A
V
Q
K
R
A
I
L
Y
------
N
I
Y
Y
T
A
L
N
-
K
-----
D
-
F
Q
T
A
K
D
-
M
L
L
T
S
---
Q
V
Q
T
N
I
N
Q
-----
F
D
S
S
L
Q
I
L
F
----
N
R
V
V
V
Q
L
G
L
S
A
F
KLC-------
L
I
E
E
C
H
Q
I
L
N
D
L
L
S
S
S
H
L
----------
R
E
I
L
G
Q
Q
S
L
H
R
I
S
L
N
S
----
S
N
---
N
A
S
A
D
E
R
A
R
Q
C
L
P
Y
H
Q
H
I
N
L
D
L
------
I
D
V
V
F
L
T
C
S
L
L
I
E
I
P
R
M
T
A
F
Y
S
-------------------
G
-
I
K
V
K
R
I
P
Y
S
----------------------------------------------------
P
K
S
-
I
R
R
S
L
E
H
Y
D
K
L
S
F
Q
G
P
P
E
T
L
R
D
Y
V
L
F
A
A
-----
K
S
M
Q
K
GNW
R
D
S
V
K
Y
L
--------
R
E
I
K
S
W
A
L
L
P
N
M
----
E
T
V
L
N
S
L
T
E
R
V
Q
V
ES
L
K
T
Y
-----
F
F
S
F
K
R
F
Y
S
S
F
--------
S
V
A
K
L
A
E
L
F
D
L
P
----
E
-
N
K
V
V
E
V
L
Q
S
---------
V
I
A
E
-----------
L
E
I
P
A
K
L
N
D
E
K
-
T
I
F
V
V
E
K
G
D
-------
E
I
T
K
L
E
E
A
M
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
71.53
12%
-90
- C2 -
2YIC
2
KGD_MYCS2
A:
[7-868]
------------------------------------------------------------------------------------------------------------------------------------------------------------------K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
D
N
T
R
F
R
S
T
L
W
D
L
D
R
E
F
Q
R
K
--
K
L
R
D
I
L
-
S
V
L
R
D
A
Y
C
R
H
V
G
---
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
-
V
A
E
Q
K
-
Y
I
L
S
K
L
--
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
VGQKRFSLEGAET
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
GLD
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
SEFEDVKYH
L
G
A
T
G
T
Y
I
Q
M
F
G
D
N
D
I
E
V
S
L
T
---
A
N
P
S
H
L
EAV
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
T
G
-
E
E
G
S
D
-------------------------
N
R
F
S
V
V
P
L
M
L
H
G
D
A
-----
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
LLRGYRTG
G
T
I
H
I
V
---------
V
N-
N
Q
-
I
G
F
T
T
A
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
-
G
A
P
I
F
H
-
V
N
G
D
D
-
P
E
A
-
C
A
W
V
A
R
L
A
V
D
--
F
R
Q
A
F
K
-------------------------------
K
D
V
V
I
D
M
L
C
Y
R
RR
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
---
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
--
L
E
R
V
F
N
E
V
R
E
L
E
K
H
L
A
-
T
A
V
D
K
A
M
L
Q
R
------
I
G
D
A
H
L
A
L
-
P
-----
E
-
G
F
T
V
H
P
-
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
RGTFTQRHA
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
NPDGTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
NP
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
FISSG
E
A
K
W
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
G
--------------------
Q
G
-
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
WAEG
S
M
T
I
----------------------------------
A
M
P
S
T
P
A
N
Y
F
--
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
---------
S
M
L
R
N
---
K
A
A
V
S
D
I
--------
R
D
F
T
E
S
K
F
R
S
V
L
EEPM
Y
T
D
G
E
G
D
R
N
K
V
T
R
--
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
N
--------
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
-
R
R
L
A
E
T
L
D
R
Y
PNVKEKFW
V
Q
E
E
PANQGA
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
-
T
G
L
K
R
I
S
R
R
---
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
67.81
9%
-97
- C6 -
4IFQ
-
NU192_YEAST
A:
[2-956]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------SLKWSA
I
P
F
Q
T
L
Y
R
S
I
E
S
G
E
F
D
F
D
L
F
K
E
V
L
P
D
L
Q
N
L
N
L
N
T
D
K
L
K
N
N
A
--
S
R
S
Q
L
E
-
K
G
E
I
E
L
S
D
G
S
T
F
K
V
N
Q
E
F
I
F
E
A
I
S
L
S
D
E
L
N
L
D
E
I
V
A
C
E
L
I
L
S
G
D
T
T
A
N
N
G
K
V
Q
Y
F
--
L
R
R
Q
Y
I
L
Q
I
V
S
F
I
V
-------------
N
C
F
H
E
D
T
E
L
Y
Q
E
L
I
------
K
N
G
-
A
L
V
S
N
I
L
S
A
F
K
F
I
H
T
Q
L
S
E
I
K
---------
Q
Q
I
N
K
A
Q
I
L
E
N
Y
N
A
L
F
Q
Q
N
I
K
---
F
R
R
D
F
L
--------
L
R
E
Y
D
I
L
S
Q
I
L
Y
G
-
L
V
D
K
G
AIMKNK
D
F
I
L
S
L
L
H
H
V
S
E
LDSNDFF
I
I
Y
Y
T
P
A
F
F
H
L
F
A
S
-----
L
R
V
L
P
D
A
D
V
K
L
--------------
L
H
S
Q
F
M
K
D
L
K
DDS
I
--
Y
T
-
K
P
V
K
V
A
L
I
F
I
F
F
A
Y
F
I
G
W
C
K
E
D
P
-
K
R
R
A
D
T
M
D
F
K
T
D
V
D
E
P
M
T
S
A
V
E
L
G
A
I
E
--
Q
I
L
I
F
A
A
D
T
SIVEQDKSMELFYD
I
R
S
L
L
E
RH
I
P
R
L
I
P
K
Q
L
L
D
S
Y
------
T
T
I
V
L
S
D
Q
T
Q
E
F
F
L
S
S
F
D
D
V
L
Q
T
I
-
I
T
D
C
A
F
L
L
T
K
I
K
D
A
E
E
D
S
L
L
S
G
E
D
L
T
L
D
D
I
S
L
--
K
A
D
L
E
R
F
F
L
S
I
Y
F
F
Y
A
-
S
R
P
E
Y
S
C
T
F
W
SDKES
N
A
Y
G
F
I
E
W
C
-
S
R
CND
N
L
M
R
S
C
F
Y
L
M
V
S
S
L
S
F
G
P
E
N
A
L
N
V
Y
H
Y
F
G
E
N
S
S
I
S
W
K
N
I
A
----
Q
C
L
S
D
Y
T
K
K
I
S
N
----------
F
--
N
S
N
E
E
A
V
I
F
L
S
S
L
L
T
----------
L
V
G
S
V
T
Y
Q
V
-
D
E
D
V
K
S
S
L
S
K
V
F
---
S
D
V
L
F
E
F
T
K
I
N
T
P
L
V
G
A
A
F
K
V
I
------
S
N
L
V
P
K
L
E
S
S
R
T
K
F
W
S
F
L
D
S
L
I
F
K
DSSLNYS
S
E
S
Y
R
N
A
F
T
N
V
-
L
T
K
Y
S
D
V
L
G
F
L
Q
L
F
----
H
N
L
I
SIHSRENNSEYMVFGKLAFPTRLGQGYRKVGI
W
P
Y
F
D
Y
I
F
N
D
I
L
A
H
V
D
Q
I
V
D
I
R
N
K
R
A
V
Q
L
P
I
L
K
I
I
Y
T
G
L
C
SFDY
S
V
I
L
N
---
N
F
F
N
Y
V
Q
E
CP
A
I
P
I
F
N
Y
I
F
T
E
K
I
Y
K
S
I
----
F
N
V
V
D
V
G
V
D
G
G
K
N
--
Q
A
E
L
-----
L
Q
L
A
V
K
I
I
N
K
V
--------
L
D
Y
Q
E
T
Y
V
E
E
L
F
P
I
V
K
K
-
H
G
K
T
D
Y
F
L
P
---------
K
N
Y
S
-----------
L
H
G
L
R
S
F
Y
D
A
I
F
F
N
I
P
L
V
A
H
L
---
G
L
Y
V
G
V
D
D
Q
I
L
A
T
N
S
L
R
I
L
A
K
L
S
E
RSNG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
63.33
18%
-67
- C4 -
2B39
1
CO3_BOVIN
A:
[30-1661]
TPN
I
L
R
L
E
S
E
E
T
V
V
L
E
A
H
GGQG
T
I
Q
V
S
V
T
V
H
D
FPAKKQVLSN
E
N
T
Q
L
N
S
NNGY
L
S
T
V
T
I
K
I
P
ASKELKSDK
G
H
K
F
V
T
V
VATFGN
V
Q
V
E
K
VVLISLQS
G
Y
L
F
I
Q
T
DKTIYTPG
S
T
V
L
Y
R
V
F
T
V
D
HKLLPVG
Q
T
V
F
I
T
I
E
T
PD
G
I
P
V
K
R
D
S
K
S
SQNQF
G
I
L
T
L
S
W
NIPE
L
V
N
M
G
V
W
K
I
K
A
Y
Y
E
D
S
P
Q
Q
V
F
S
A
--------------
E
F
E
V
--
K
E
Y
V
L
P
-
S
F
E
V
Q
L
E
P
E
----------
E
K
F
Y
Y
I
D
D
P
D
G
L
K
V
N
I
I
A
R
F
L
Y
G
E
Q
-
V
D
G
-
T
A
F
V
I
F
G
V
Q
D
G
D
R
R
I
------------------------
S
L
T
H
S
L
T
R
V
P
------
I
N
D
G
N
--
G
E
A
I
L
K
R
Q
V
L
L
N
G
V
Q
P
S
R
---------
A
D
A
L
V
G
---
K
S
I
Y
V
S
A
T
V
I
L
Q
---
S
G
S
D
M
V
--------
E
A
E
R
T
G
I
P
I
V
T
S
P
Y
Q
I
H
F
T
-------------------------
K
T
P
K
F
F
K
P
A
M
P
F
D
--------------------------------------------------
L
M
V
Y
V
T
N
P
D
G
S
P
A
R
H
I
P
V
V
T
Q
G
S
N
V
Q
S
L
T
Q
-
D
D
G
V
A
K
L
S
I
-
N
T
Q
N
K
R
D
P
L
T
--
I
T
V
R
T
K
-------------------------------
K
D
N
I
P
E
----------
G
R
Q
A
T
R
T
M
Q
A
L
P
Y
N
T
Q
G
N
S
N
N
Y
L
H
L
S
V
P
----------------------------
R
V
E
L
K
P
G
E
T
L
N
V
N
F
H
L
R
T
D
P
G
E
Q
A
K
I
R
------
Y
Y
T
Y
M
I
M
N
K
G
-----
K
-
L
L
K
V
G
R
-
Q
Y
R
E
--
P
G
Q
D
L
V
V
L
P
L
T
I
T
S
D
F
I
P
S
F
R
L
V
A
----
Y
Y
--
T
L
I
N
A
K
G
Q
----------
R
E
V
V
A
D
S
V
W
V
D
V
K
D
S
--
C
----------
M
G
T
L
V
V
K
N
G
G
K
E
E
K
H
H
R
P
G
Q
Q
I
---
T
L
K
I
E
A
--------
D
Q
G
A
R
V
G
L
------
V
A
V
D
K
G
V
F
V
L
N
K
K
N
K
L
T
Q
R
K
I
W
D
V
--------------
V
E
K
A
D
I
G
C
T
P
G
S
G
R
N
Y
A
G
V
----
F
T
D
-------------------------------------------------
A
G
L
T
L
K
T
S
Q
G
L
E
T
Q
--------------
Q
R
A
D
P
---
Q
C
P
---------------
Q
S
V
Q
L
M
E
K
R
----
M
D
K
A
G
Q
Y
S
S
----------------
D
L
R
K
C
C
E
D
G
M
RDNPMKFP
C
Q
R
R
A
Q
F
I
L
Q
G
D
A
C
V
K
A
F
L
D
C
C
E
Y
I
T
Q
---------
L
R
Q
Q
-----------
H
S
----
R
D
G
A
L
-
D
D
D
I
I
P
E
E
D
I
I
S
R
S
Q
F
P
E
S
W
L
W
T
V
I
E
D
L
KQADKNG
I
S
T
K
L
M
N
V
F
L
K
DSITT
W
E
I
L
A
V
S
L
S
DKK
G
I
C
V
A
D
P
Y
E
V
T
VMQD
F
F
I
D
L
R
L
P
YSVVRNEQVE
I
R
A
I
L
Y
N
YREAENLK
V
R
V
E
L
L
Y
NPAFCSLATAK
K
R
H
Q
Q
T
I
T
I
P
A
R
S
S
V
A
V
P
Y
V
I
V
P
L
K
I
G
L
H
E
V
E
V
K
A
A
V
YNHF
I
S
D
G
V
K
K
T
L
K
V
V
P
E
G
V
R
V
N
K
TV
A
V
R
T
L
N
PEHLGQGG
V
Q
R
E
E
V
P
A
A
DLSDQVPD
T
E
S
E
T
K
I
L
L
Q
GTPV
A
Q
M
T
E
D
A
I
D
G
E
R
L
K
H
LIQTPSGCGEQNMIGM
T
P
T
V
I
A
V
H
Y
L
D
S
T
DQWEKFGLE
K
R
Q
E
S
L
E
L
I
R
K
G
Y
T
Q
Q
L
A
F
RQKSSAYAAFQYRPPS
T
W
L
T
A
Y
V
V
K
V
F
A
L
A
A
NLIAID
S
K
D
L
C
E
T
V
K
W
L
I
L
EKQKPDG
I
F
Q
E
DGPVIHQEMIGGFRDTREKD
V
S
L
T
A
F
V
L
I
A
L
H
E
A
K
DICEAQVNS
L
G
R
S
I
A
K
A
G
D
F
L
E
N
H
YRELRR
P
Y
T
V
A
I
A
A
Y
A
L
A
L
L
GKLEG
D
R
L
T
K
F
L
N
T
AKEKN
R
W
E
E
P
NQ
K
L
Y
N
V
E
A
T
S
Y
A
L
L
A
L
L
A
R
KDYDTT
P
P
V
V
R
W
L
N
E
QRYYGGGYGST
Q
A
T
F
M
V
F
Q
A
L
A
Q
Y
Q
K
D
VPDHKE
L
N
L
D
V
S
I
Q
L
PSRNS
A
V
R
H
R
I
L
WESASL
L
R
S
E
E
T
KEN
E
R
F
T
V
K
A
E
G
K
G
Q
G
T
L
S
V
V
T
V
Y
H
A
K
L
KGKVSCKK
F
D
L
R
V
S
I
R
P
A
P
ETVKKPQDAK
G
S
M
I
L
D
I
C
T
K
Y
LGDQDA
T
M
S
I
L
D
I
S
M
M
TGFSPD
V
E
D
L
K
T
L
S
TGVDRYIS
K
Y
E
M
N
R
DSNKN
T
L
I
I
Y
L
DKVSHT
V
E
D
C
L
S
F
K
V
H
Q
YFNVGL
I
Q
P
G
A
V
K
V
Y
S
YYNLDE
T
C
I
R
F
Y
H
P
D
KEDGMLSKLCHK
D
T
C
R
C
A
EENCFT
L
E
D
R
L
D
K
A
C
EPGVDYVYKTRLI
Q
K
K
L
E
DDFDEY
I
M
V
IENIIKSGSD
E
V
Q
V
K
Q
E
R
K
F
I
S
H
IKCREALKLKEG
A
H
Y
L
V
W
G
V
SSDLWGEKP
K
I
S
Y
I
IGKD
T
W
V
E
LWPEAEECQD
E
E
N
Q
K
Q
C
E
D
L
A
N
F
T
E
N
M
V
V
FGCPN
18
Fugue
58.72
15%
-75
* C6 *
3ZPJ
-
?
A:
[1-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
T
L
E
E
I
N
L
L
V
E
R
G
Y
Y
E
E
A
L
--
A
K
V
Y
E
I
-
E
D
P
I
E
Q
V
Q
V
L
T
K
---
I
V
V
T
I
Y
Q
H
D
G
P
M
E
W
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
D
P
A
-
N
K
A
V
A
Y
--
S
I
I
A
S
T
L
A
I
M
E
Y
----------------
E
E
D
A
M
D
F
F
N
R
A
I
D
------
E
A
-----------
N
E
I
E
S
P
I
E
K
G
M
V
---------
L
S
T
L
A
Y
H
L
A
I
A
G
Y
------------
P
D
N
A
L
--------
E
I
F
N
I
A
F
D
T
I
I
G
A
-
E
--
T
S
-------------------------
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
----
E
K
A
G
D
T
L
P
S
N
E
--------------
A
M
D
F
---------
Y
--
K
M
A
F
D
I
F
D
K
L
H
V
N
Q
R
A
A
I
V
E
K
K
I
E
L
A
-
K
T
V
Y
D
V
-
G
L
----
P
Q
I
-
R
A
A
L
L
K
G
K
N
H
--
Y
A
L
A
I
I
-------------------------------
K
K
K
Y
S
----------
G
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
N
M
E
Y
L
D
V
V
D
K
A
F
E
C
C
E
S
P
R
--
F
T
D
V
N
V
Q
H
I
A
R
L
L
T
E
--
L
G
N
L
R
R
A
L
K
F
A
K
E
I
Q
N
-
I
H
K
R
S
E
A
L
K
A
------
I
A
L
E
L
V
R
R
-
K
-----
K
-
F
E
E
V
K
K
-
I
I
E
S
I
P
D
P
K
I
R
E
E
A
L
N
E
I
G
T
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
53.60
13%
-94
- C3 -
2NMT
14
NMT_YEAST
A:
[1-422]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
D
H
K
--
F
W
R
T
Q
P
-
V
K
D
F
D
--
E
K
V
V
E
---
E
G
P
I
D
K
P
K
T
P
E
D
I
S
D
K
P
L
P
L
L
S
S
F
E
W
C
S
I
D
V
D
N
------
K
--
K
Q
L
E
D
V
F
V
L
L
N
E
N
Y
VEDRDAG
F
-----
R
F
N
Y
T
K
E
F
F
N
W
A
L
K
------
S
P
G
W
K
K
D
W
H
I
G
V
R
V
K
-
E
T
Q
K
L
V
A
F
I
---------
S
A
I
P
V
T
L
G
V
R
--
G
K
Q
V
P
S
V
E
I
N
FL
C
V
H
K
Q
L
--------
R
S
K
R
L
T
P
V
L
I
K
E
I
-
T
R
R
V
N
-------------------------
K
C
D
I
W
H
A
L
Y
T
A
G
I
V
LPAPV
S
T
C
R
Y
T
H
R
P
L
N
--------------
W
K
K
L
---------
Y
E
V
D
F
-
T
G
L
P
D
G
H
T
E
E
D
M
I
A
E
N
A
L
P
A
K
T
K
-
T
A
G
L
R
K
-
L
K
K
E
D
I
D
Q
V
-
F
E
L
F
K
R
Y
Q
S
R
FE
L
I
Q
I
F
T
-------------------------------
K
E
E
F
E
H
N
------
F
I
G
-
E
E
S
L
P
L
D
K
Q
V
I
F
S
Y
V
V
E
Q
P
D
G
-
K
I
T
D
F
F
S
F
Y
S
L
P
F
T
I
L
N
N
T
K
Y
K
D
L
G
I
G
Y
L
Y
Y
Y
A
T
D
A
D
F
Q
F
K
D
R
F
D
P
K
A
T
-
K
A
L
K
T
R
L
C
E
L
------
I
Y
D
A
C
I
L
A
-
K
-----
N
-
A
N
M
D
V
F
-
N
A
L
T
S
Q
-
D
N
T
L
F
L
D
D
L
K
F
G
P
G
D
G
F
L
N
F
Y
L
F
----
N
Y
R
A
K
P
I
T
G
G
L
N
-------------
P
-
D
N
S
N
D
I
K
R
R
S
N
V
G
----------
V
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
36.54
35%
115
* C7 *
2Y1V
-
?
A:
[153-217]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
N
T
E
A
K
P
K
I
D
K
D
F
K
G
K
A
N
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
VG
D
V
V
E
Y
E
I
V
T
K
I
P
A
L
A
N
Y
A
T
---
A
N
W
S
D
R
M
T
E
G
L
A
F
N
K
G
T
V
K
V
T
V
D
D
V
A
L
E
A
G
D
Y
A
-
L
T
E
V
A
T
--
G
F
D
L
K
L
T
D
A
G
L
A
K
V
-------------
N
D
Q
N
A
E
K
T
V
K
I
T
Y
S
------
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
---------
D
H
G
N
T
P
K
P
N
K
P
N
E
N
G
D
L
T
L
T
K
---
T
W
V
D
A
T
--------
G
A
P
I
P
A
G
A
E
A
T
F
D
-
L
V
N
A
Q
-------------------------
T
G
K
V
V
Q
T
V
T
L
T
T
D
K
-----
N
T
V
T
V
N
G
L
D
K
N
--------------
T
E
Y
K
---------
F
--
V
E
-
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
T
A
G
E
I
A
V
K
N
-
W
K
D
E
N
P
-
K
P
L
D
P
T
E
P
K
-
V
V
T
Y
G
K
K
F
V
K
--
V
N
D
K
D
N
-------------------------------
R
L
A
G
A
E
F
------
V
I
A
N
A
D
N
A
G
Q
Y
L
A
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
Q
Q
T
Q
Q
E
K
E
K
V
--
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
-
A
F
E
W
V
A
D
K
D
N
------
E
N
V
V
K
L
V
S
-
D
-----
A
-
Q
G
R
F
E
I
-
T
G
L
L
A
G
T
Y
Y
L
E
E
T
K
Q
P
A
G
Y
A
L
L
T
S
R
Q
K
F
E
V
----
T
A
T
S
Y
S
A
T
G
Q
G
I
----------
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
K
K
----------
I
T
I
P
Q
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
36.15
35%
100
- C7 -
3RPK
-
?
A:
[181-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
N
T
E
A
K
P
K
I
D
K
D
F
K
G
K
A
N
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
VG
D
V
V
E
Y
E
I
V
T
K
I
P
A
L
A
N
Y
A
T
---
A
N
W
S
D
R
M
T
E
G
L
A
F
N
K
G
T
V
K
V
T
V
D
D
V
A
L
E
A
G
D
Y
A
-
L
T
E
V
A
T
--
G
F
D
L
K
L
T
D
A
G
L
A
K
V
-------------
N
D
Q
N
A
E
K
T
V
K
I
T
Y
S
------
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
---------
D
H
G
N
T
P
K
P
N
K
P
N
E
N
G
D
L
T
L
T
K
---
T
W
V
D
A
T
--------
G
A
P
I
P
A
G
A
E
A
T
F
D
-
L
V
N
A
Q
-------------------------
T
G
K
V
V
Q
T
V
T
L
T
T
D
K
-----
N
T
V
T
V
N
G
L
D
K
N
--------------
T
E
Y
K
---------
F
--
V
E
-
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
T
A
G
E
I
A
V
K
N
-
W
K
D
E
N
P
-
K
P
L
D
P
T
E
P
K
-
V
V
T
Y
G
K
K
F
V
K
--
V
N
D
K
D
N
-------------------------------
R
L
A
G
A
E
F
------
V
I
A
N
A
D
N
A
G
Q
Y
L
A
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
Q
Q
T
Q
Q
E
K
E
K
V
--
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
-
A
F
E
W
V
A
D
K
D
N
------
E
N
V
V
K
L
V
S
-
D
-----
A
-
Q
G
R
F
E
I
-
T
G
L
L
A
G
T
Y
Y
L
E
E
T
K
Q
P
A
G
Y
A
L
L
T
S
R
Q
K
F
E
V
----
T
A
T
S
Y
S
A
T
G
Q
G
I
----------
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
K
K
----------
I
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
32.94
44%
219
- C5 -
4KW2
-
?
A:
[22-46]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
V
G
I
Q
T
W
T
F
H
N
L
T
L
--
M
E
T
L
D
K
T
Q
Q
L
G
M
G
Y
A
E
-
A
F
F
F
Q
E
L
G
A
P
------
F
P
K
E
T
Y
L
N
-
Y
-----
D
-
L
S
D
D
N
C
-
A
L
L
R
H
E
F
K
I
R
G
I
K
P
I
A
F
G
V
A
S
Y
G
T
N
E
E
W
D
K
----
F
F
A
F
A
H
K
I
G
A
H
I
----------
V
T
V
E
P
E
L
N
Q
L
D
Y
I
E
S
L
A
K
----------
K
Y
D
M
E
V
A
I
H
N
H
P
A
S
A
E
V
V
E
K
A
L
---
K
G
R
S
P
L
M
G
V
C
A
D
I
G
H
W
K
R
V
G
E
D
------
P
L
K
N
L
Q
K
L
S
G
R
I
K
V
A
H
L
K
D
L
T
D
K
M
--------------
E
D
A
T
-
W
G
T
G
I
L
P
V
K
A
F
V
N
E
----
L
K
R
Q
----------------------------------
H
F
N
G
L
I
S
I
E
Y
D
D
F
K
S
D
I
Q
E
I
R
N
S
L
E
F
L
Q
K
C
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
31.43
14%
227
- C5 -
2LE3
-
CPT1A_HUMAN
A:
[1-42]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
A
E
A
H
Q
A
V
A
F
-
Q
F
T
V
T
P
D
--
G
--
I
D
L
R
L
S
-------------------------------
H
E
A
L
R
Q
I
------
Y
L
S
G
L
H
S
W
K
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
25.71
26%
156
- C5 -
2LOR
-
TM141_HUMAN
A:
[48-78]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
F
I
Q
R
K
F
P
Y
P
L
Q
W
S
-----
L
L
V
A
V
V
A
G
S
V
V
S
----------
Y
G
V
T
R
V
E
S
E
K
C
N
N
L
W
L
F
L
----------
E
T
G
Q
L
P
K
D
R
S
T
D
Q
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
20.58
29%
1013
- C1 -
1GIB
-
CM3B_CONGE
A:
[8-21]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
C
K
D
R
R
C
K
--
M
K
C
C
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
14.90
31%
256
* C5 *
2OAR
-
MSCL_MYCTA
A:
[40-68]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
V
A
V
V
I
G
T
A
F
T
----------
A
L
V
T
K
--
F
T
D
S
I
I
T
P
L
I
N
----------
R
I
G
V
N
A
Q
S
D
V
G
I
L
R
I
G
I
G
G
G
Q
T
---
I
D
L
N
V
L
L
S
A
A
I
N
F
F
L
I
A
F
A
V
Y
F
------
L
V
V
L
P
Y
N
T
L
R
K
K
G
E
V
E
Q
P
G
D
T
Q
V
V
--------------
L
L
T
E
-
I
R
D
L
L
A
Q
T
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
3.24
38%
868
- C5 -
2LUG
-
A:
[9-21]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
P
V
------
V
H
F
F
K
N
I
V
T
P
R
T
P
P
P
S
Q
G
K
G
R
G
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------