@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RSCA1_HUMAN: (2015-12-08 )
MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------.....------....10........20........30.....-------------...40........50.......-.60.......--.70........80--------.........90.----------.......100.......-110.----------......120.------......130..-.....140.-------...-...150-----........160.......170.......180---........190....---...200.......210.......220---.....-------..230.......240.......250.......260.--------...--------...270.......280.......290.......300.......310.......320.......330.......340.......350........360.......370.......380---.......390--------------...---......400.......410..--.....420---------------...-----.....430.......440.......450.......460.......-470.......480.......490...----------....500-........----------.510.......520.......530----.........540--------.........550.....-----..560.......570.-......580-...--.-...590.......-600-.......610.....--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------MSSLP------TSDGFNHPARSSGQSPDVG
N
P
M
S
L
A
R
S
VSAS-------------VCPIKPSDSDRI
E
P
K
A
V
K
A
L
KA-S
A
E
F
Q
LNS
E
K
--
K
EHL
S
L
Q
D
L
S
D
H---------ASSADHAPTDQS----------PAMPMQNSSE
E
I
T
V
AGN-L
E
K
S
----------AERSTQG
L
K
F
------
H
L
H
TRQEA
S
L
S
-
V
T
STRMHE
P
-------
Q
M
F-LGEKD------WHPENQNLSQVSD
P
Q
QHEEPGN
E
Q
Y
E
V
A
Q
Q
----KASH
D
Q
E
Y
L
CNIGDL---EL
P
E
E
R
QQNQ
H
K
I
V
D
L
E
A
TMKGNGLP---QNVDP-------PSAKKSIP
S
S
ECSGCSNS
E
T
F
M
E
I
D
T
A
Q
Q
S
L
V
T
L
L
N
--------STG--------RQNANV
K
N
I
G
A
L
D
L
TLDNP
L
M
E
V
ETSKCN
P
S
S
E
I
LNDSISTQDLQPPET
N
V
EIPGTNKEYGHYSSPSLCGSCQP
S
V
E
S
A
E
ESC
P
S
-
I
T
A
A
L
K
E
L
H
E
L
L
VVSSKPASENTSE
E
V
I
CQS---ETIAEG
Q
T
----------------
S
I
K
---
D
L
S
E
R
WTQNEHLTQNEQCPQV--
S
F
H
Q
A
I
S
----------------
V
S
V
-----
E
T
E
K
LTGTSSDT
G
R
E
A
V
E
NVNFRSLGDGLSTDKEGVPK
S
R
E
SINK-NR
S
V
T
V
T
SAKTS
N
Q
L
H
C
T
LGVEI
S
P
K
----------LLAG
E
---
E
D
A
L
N
Q
T
S
----------
E
Q
T
K
SLSS
N
F
I
L
V
K
D
L
G
Q
G
I
Q
N
------SVTDRPE
T
R
E----------NVCPDASRPLLEYEPPT-----SHPSSSPAILPPLIFP-A
T
D
I
D
R
I
L
R
-AG
F
--
T
-
L
Q
E
A
L
G
A
L
H
RVGG-
N
A
D
-
L
A
L
L
V
L
L
A
K
NIVVPT--------
23
Fugue
72.18
15%
34
- C3 -
4XR7
-
PAN2_YEAST
A:
[1-758]
----------------------------------------------------------------------------------------------
M
L
A
Y
P
DYFNDI
T
S
D
G
P
I
S
V
D
D
E
T
Y
P
L
S
S
V
G
M
P
Y
Y
L
D
K
L
L
S
A
W
P
P
V
V
F
KSEGTIPQ
L
L
A
V
I
S
S
Q
N
E
K
L
S
T
Q
E
F
P
L
L
R
Y
D
R
T
K
Y
G
M
R
N
A
I
--
P
D
Y
V
C
L
R
D
I
R
K
Q
---------
I
T
S
G
L
E
T
S
D
I
Q
T
YTSINKYEVP
P
A
Y
S
R
L
P
L
T
F
D
F
T
P
F
N
N
-
T
E
Y
S
G
L
D
PDVDNH
Y
T
N
A
I
I
Q
L
Y
R
F
I
P
E
M
F
N
F
V
V
G
C
L
K
D
E
N
F
-
E
T
T
L
L
T
D
L
G
-------
Y
L
F
-
D
M
M
E
R
------
S
H
G
K
I
C
S
S
S
N
F
Q
A
S
L
K
S
L
T
D
K
L
E
S
L
C
I
R
E
S
I
EDS
S
E
S
I
K
R
N
M
P
Q
K
F
N
R
F
L
L
S
Q
L
I
K
E
E
A
Q
T
V
N
H
N
I
T
L
N
Q
C
F
---
G
L
E
---
T
E
I
R
T
E
C
S
CDH
Y
D
T
T
V
K
L
L
P
S
L
S
I
S
G
I
N
K
Q
N
I
L
P
Y
I
E
Y
A
M
K
N
V
T
Q
K
N
S
ICPTCGKT
E
T
I
--------
T
Q
E
C
T
V
K
N
L
P
S
V
-
L
S
L
E
L
S
L
L
D
T
E
F
S
N
I
R
S
S
K
N
W
L
T
S
E
F
Y
G
S
I
I
K
---
N
K
A
V
L
R
S
T
A
S
E
L
K
--------
G
T
S
H
I
F
K
Y
E
L
N
G
Y
V
A
K
-
I
T
D
N
N
N
E
T
R
L
V
T
Y
V
K
K
Y
N
P
K
E
N
C
F
K
W
L
M
F
N
D
Y
L
V
V
E
I
T
E
E
E
A
L
KMTYPW
K
T
P
E
I
I
I
Y
C
D
A
E
---
E
L
R
K
P
F
F
S
V
D
T
Y
S
I
N
Y
D
I
L
F
R
--
D
Y
F
A
N
A
R
----------------
R
E
Y
-----
K
L
L
T
H
D
E
A
P
K
S
G
T
L
V
A
I
D
A
E
F
V
S
L
Q
S
E
L
C
E
I
D
H
Q
G
I
---
R
S
I
I
R
P
-
K
R
T
A
L
A
R
I
S
I
I
R
G
E
E
G
E
L
Y
G
V
P
F
V
D
D
----------
Y
V
V
N
T
NHI
E
D
Y
L
T
R
Y
S
GILPGDLDPE
K
S
T
K
R
L
V
R
R
N
V
V
Y
R
K
V
W
L
L
M
Q
L
G
C
----
V
F
V
G
H
G
L
N
N
D
----------
F
K
H
I
N
I
N
V
P
R
N
Q
I
R
D
T
A
-----
I
Y
F
L
Q
G
K
R
Y
L
S
L
R
Y
L
A
-
Y
V
L
L
G
M
N
I
Q
-
E
G
N
HD
S
-
I
E
D
A
H
T
A
L
I
L
Y
K
K
-
Y
L
H
-
L
K
E
K
A
I
F
E
K
V
L
N
S
----------
27
Fugue
55.89
14%
18
- C3 -
4J5T
4
CWH41_YEAST
A:
[1-811]
A
E
F
M
E
E
Y
Q
K
F
T
N
E
S
L
LWAPYRSNCY
F
G
M
R
P
R
YVHESPL
I
M
G
I
M
W
F
N
SLSQDGLHSLRHFATPQDKLQ
K
Y
G
W
EVYDPR
I
G
G
K
E
V
F
I
D
EKNNLN
L
T
V
Y
F
V
K
------
S
K
N
G
E
N
W
S
V
R
V
Q
G
E
P
L
D
P
K
R
P
S
T
A
S
V
V
L
Y
F
S
-------------
Q
N
G
G
E
I
D
G
K
S
S
L
A
M
I
G
H
D
G
-
P
N
-
D
M
K
F
F
G
Y
S
K
E
L
G
E
Y
H
L
T
V
K
D
N
F
G
H
Y
F
KNPEYET
M
E
V
A
P
G
S
D
C
S
K
T
----------
S
H
L
S
L
Q
I
P
D
K
E
V
W
K
A
R
D
V
F
Q
S
L
----------
V
S
D
S
I
R
D
I
L
E
------
R
P
A
D
L
I
P
S
V
L
T
-
I
R
N
L
Y
N
F
N
P
GN
F
H
Y
I
Q
K
T
F
D
L
T
K
K
D
G
F
Q
F
D
I
T
Y
N
K
L
G
T
T
Q
S
I
S
T
R
E
Q
V
T
E
--
L
I
T
W
S
L
N
E
I
----
N
A
R
F
D
K
Q
F
S
F
G
E
G
P
D
---
S
I
E
S
V
E
V
K
R
R
F
A
L
E
T
L
S
N
L
L
G
G
I
G
Y
F
Y
G
N
Q
L
I
D
R
-------
E
T
E
F
D
E
S
Q
F
T
E
I
K
L
L
N
A
K
E
E
------
G
P
F
E
L
F
T
S
V
P
--------
S
R
G
FFPRGF
Y
W
D
E
G
F
H
L
L
Q
I
M
E
Y
D
F
D
L
A
F
E
I
L
A
S
W
F
E
M
I
E
D
D
S
G
W
I
A
R
E
I
I
L
G
N
E
A
R
S
K
V
P
Q
E
F
Q
V
Q
N
P
N
I
A
N
--
P
P
T
L
L
L
A
F
S
E
M
L
S
R
A
I
E
N
I
G
D
F
M
T
N
N
L
E
A
N
P
G
L
L
T
E
Y
A
K
K
I
Y
P
K
L
L
K
H
Y
N
W
F
R
---
K
S
Q
T
G
L
I
D
----------------
E
Y
E
---
E
I
L
E
D
E
G
I
W
D
K
I
H
K
N
E
V
Y
R
W
V
GR
T
F
T
H
C
L
P
SGMDDYPRAQPPDVAE
L
N
V
-----
D
A
L
A
W
V
G
V
M
T
R
S
M
K
Q
I
A
H
V
L
K
-------
L
T
Q
D
E
Q
R
Y
A
Q
I
E
Q
E
V
V
E
-
N
L
D
L
L
H
W
S
--
E
N
D
N
C
Y
C
D
I
S
I
D
P
E
D
D
E
I
R
E
F
VCHEG
Y
V
S
V
L
---
P
F
A
L
K
L
I
P
----------
K
N
S
P
K
L
E
K
V
V
A
L
M
S
D
P
E
K
I
F
S
D
YGLLSL
S
R
Q
D
D
Y
F
G
K
D
ENYWR
G
P
I
W
M
N
I
N
Y
L
C
L
D
A
M
R
Y
Y
Y
P
E
V
ILDVA
G
E
A
S
N
A
K
K
L
Y
Q
S
L
K
I
N
L
S
N
N
I
Y
K
V
W
E
-
E
Q
G
--
Y
-
C
Y
E
N
Y
S
P
I
D
G
H
G
T
-
G
A
E
H
F
T
G
W
T
A
L
V
V
N
I
L
G
R
F
RS
H
H
H
H
HH
26
Fugue
54.74
24%
-76
* C4 *
1WR1
-
DSK2_YEAST
B:
[316-373]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
G
I
S
G
G
G
G
G
I
L
D
P
E
E
R
Y
-
E
H
Q
L
R
Q
L
N
D
-
M
G
F
--
F
D
F
D
R
N
V
A
A
L
R
R
S
G
G
-
S
V
Q
-
G
A
L
D
S
L
L
N
G
D
V
------------
28
Fugue
54.06
12%
16
- C3 -
3LGD
5
CECR1_HUMAN
A:
[3-484]
---------------------------------------------------------------------------------------------------------
S
I
D
E
T
R
A
H
L
L
L
K
E
K
M
M
R
L
G
G
R
L
V
L
-----------------------------
N
T
K
E
E
L
A
N
E
R
L
M
T
-
L
K
I
A
E
M
K
E
A
M
--
R
T
L
---------------------------
I
F
P
----------
P
S
M
H
F
F
Q
A
K
H
L
I
E
-
R
S
Q
-
V
F
N
I
----------
L
R
M
M
P
K
G
A
A
L
------
H
L
H
D
I
G
I
V
T
M
D
W
L
V
R
N
V
T
Y
R
P
-------
H
C
H
-
I
C
F
---------
T
P
R
G
I
M
Q
F
R
F
A
H
P
T
P
R
P
S
E
K
C
S
K
W
I
L
L
E
D
----
Y
R
K
-----------------
R
V
Q
N
V
T
E
F
D
D
S
L
L
R
N
F
T
L
V
T
Q
H
P
E
---
V
I
Y
T
-----------------------
N
Q
N
V
V
W
S
K
F
E
T
I
F
F
T
I
S
G
L
I
H
--------------------------
Y
A
P
V
F
R
D
Y
V
F
R
S
M
Q
E
F
Y
E
-----------
D
N
V
L
Y
M
E
I
R
A
R
L
L
P
V
----
Y
E
L
S
G
E
H
H
D
E
E
W
S
V
K
T
Y
Q
E
V
A
Q
K
F
V
E
T
H
P
E
-
F
I
G
-----
I
K
I
I
Y
S
D
H
R
S
K
D
V
A
V
I
A
E
S
I
R
M
A
---
M
G
L
R
I
K
F
P
----------------
T
V
V
A
G
F
D
L
V
G
H
E
D
T
G
H
S
L
H
D
Y
K
E
A
L
M
I
--
P
A
K
D
G
V
K
----------------
L
P
Y
FFHAG
E
T
D
W
-
Q
G
T
S
I
D
R
N
I
L
D
A
L
M
L
N
T
T
R
I
G
H
G
F
A
L
S
K
H
--
P
A
V
R
T
Y
S
W
K
K
D
I
P
I
E
V
C
--------------
P
I
S
N
Q
----------
V
L
K
L
V
---
S
D
L
R
N
H
P
V
----------
A
T
L
M
A
T
G
H
P
M
V
I
S
-----------------
S
D
D
P
A
M
F
G
------------
A
K
G
L
S
Y
D
F
Y
E
V
F
M
G
I
-----
G
G
M
K
A
D
L
R
T
L
K
Q
L
A
M
N
-
S
I
K
-----
Y
-
S
T
L
--
L
-
E
S
E
K
N
T
F
M
E
I
W
K
K
-
R
W
D
-
K
F
I
A
D
V
A
T
---------------
5
HHSearch
51.48
31%
-37
- C4 -
1Z96
-
MUD1_SCHPO
A:
[297-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
K
I
A
Q
L
V
S
-
M
G
F
--
D
-
P
L
E
A
A
Q
A
L
D
A
A
N
G
-
D
L
D
-
V
A
A
S
F
L
-----------------
6
HHSearch
51.38
20%
-38
- C4 -
1WGN
-
A:
[17-57]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
E
-
R
Q
C
V
E
T
V
V
N
-
M
G
Y
--
S
-
Y
E
C
V
L
R
A
M
K
K
K
G
E
-
N
I
E
-
Q
I
L
D
Y
L
F
A
H
S
G
P
S
S
G
--------
11
HHSearch
50.51
23%
-51
- C4 -
2LBC
-
A:
[77-119]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
-
E
E
I
V
A
I
I
T
S
-
M
G
F
--
Q
-
R
N
Q
A
I
Q
A
L
R
A
T
N
N
-
N
L
E
-
R
A
L
D
W
I
F
S
H
P
E
F
E
E
D
--------
17
HHSearch
50.25
28%
-32
- C4 -
1WR1
-
DSK2_YEAST
B:
[333-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
Q
L
R
Q
L
N
D
-
M
G
F
--
F
D
F
D
R
N
V
A
A
L
R
R
S
G
G
-
S
V
Q
-
G
A
L
D
S
L
L
N
G
D
-------------
18
HHSearch
49.31
21%
-39
- C4 -
1VEJ
-
?
A:
[24-67]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
E
G
R
Y
-
Q
Q
E
L
E
E
L
K
A
-
L
G
F
--
A
N
R
D
A
N
L
Q
A
L
V
A
T
D
G
-
D
I
H
-
A
A
I
E
M
L
L
G
A
S
G
P
S
S
G
--------
15
HHSearch
48.56
26%
-30
- C4 -
2KNZ
-
A:
[11-50]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
Q
Q
Q
L
E
Q
L
N
S
-
M
G
F
I-
N
-
R
E
A
N
L
Q
A
L
I
A
T
G
G
-
D
I
N
-
A
A
I
E
R
L
L
G
S
Q
L
S
-----------
9
HHSearch
48.09
22%
-53
- C4 -
2DNA
-
A:
[17-58]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
--
S
K
E
M
E
C
L
Q
A
-
M
G
F
--
V
N
Y
N
A
N
L
Q
A
L
I
A
T
D
G
-
D
T
N
-
A
A
I
Y
K
L
K
S
S
Q
G
F
S
G
P
--------
16
HHSearch
47.56
29%
-32
- C4 -
2CPW
-
UBS3B_HUMAN
A:
[15-57]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
K
H
-
G
S
A
L
D
V
L
L
S
-
M
G
F
--
P
-
R
A
R
A
Q
K
A
L
A
S
T
G
G
R
S
V
Q
-
T
A
C
D
W
L
F
S
H
S
G
P
S
S
G
--------
21
HHSearch
46.81
22%
-44
- C4 -
1WHC
-
UBXN1_MOUSE
A:
[6-47]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
A
E
-
L
T
A
L
E
S
L
I
E
-
M
G
F
--
P
-
R
G
R
A
E
K
A
L
A
L
T
G
N
Q
G
I
E
-
A
A
M
D
W
L
M
E
H
E
D
D
P
D
V
--------
19
HHSearch
46.66
26%
-66
- C4 -
2JY5
-
UBQL1_HUMAN
A:
[543-586]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
R
F
-
Q
Q
Q
L
E
Q
L
S
A
-
M
G
F
L-
N
-
R
E
A
N
L
Q
A
L
I
A
T
G
G
-
D
I
N
-
A
A
I
E
R
L
L
G
S
--------------
8
HHSearch
45.51
27%
-48
- C4 -
1DV0
-
A:
[4-40]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
I
E
R
L
K
A
-
L
G
F
--
P
-
E
S
L
V
I
Q
A
Y
F
A
C
E
K
-
N
E
N
-
L
A
A
N
F
L
L
S
Q
N
F
D
D
E
---------
20
HHSearch
45.27
27%
-25
- C4 -
2G3Q
-
EDE1_YEAST
A:
[1342-1378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
S
L
A
V
E
E
L
S
G
-
M
G
F
--
T
-
E
E
E
A
H
N
A
L
E
K
C
N
W
-
D
L
E
-
A
A
T
N
F
L
L
----------------
25
Fugue
44.94
11%
22
- C1 -
3HOL
-
?
A:
[24-528]
---------------------------------------------------------------------------------------------E
E
Y
K
D
V
------
E
T
A
K
K
E
K
E
Q
L
G
E
L
M
E
P
A
L
G
Y
V
V
K
V
P
V
S
-
S
F
E
-------------
N
K
K
V
D
I
S
D
I
E
V
I
T
N
G
N
L
D
D
V
P
Y
-
K
A
N
S
S
K
Y
N
Y
P
--
D
I
K
T
K
D
S
S
L
Q
Y
V
---------
R
S
G
---------------------
Y
V
I
D
G
E
H
S
G
S
N
E
K
G
Y
-
V
Y
Y
K
----------
G
N
S
P
A
K
E
L
P
V
------
N
Q
L
L
T
Y
T
G
S
W
D
-
F
T
S
N
--------------
A
-
N
L
N
N
E
------
E
G
R
P
N
Y
L
N
D
D
Y
Y
T
K
F
I
G
K
R
V
G
L
V
S
G
D
A
K
P
A
----
K
H
K
Y
T
S
Q
F
E
V
D
F
A
T
K
---
K
M
T
G
K
L
S
D
K
E
K
T
I
Y
T
V
N
A
D
I
R
G
N
R
F
T
---
G
A
A
T
A
-------
S
D
K
N
K
G
----------
K
G
E
S
Y
N
F
F
S
A
D
S
Q
S
L
E
G
G
F
Y
--------
G
P
-------------
K
A
E
E
M
A
G
K
F
V
A
N
D
K
S
L
F
A
V
F
S
A
K
H
N
G
S
N
V
D
T
V
R
I
I
D
A
S
K
I
D
L
T
N
F
S
I
S
E
L
N
N
F
G
D
A
S
----------------------------
V
L
I
I
D
G
K
K
I
K
L
A
G
S
G
F
T
N
K
H
T
I
E
I
N
G
K
T
---
M
V
A
V
A
C
C
S
----------------
N
L
E
---
Y
M
K
F
G
Q
L
W
Q
Q
A
-
E
G
G
K
P
E
N
N
S
--
L
F
L
Q
G
E
R
----------------
T
A
T
-----
D
K
M
P
K
G
G
-----------
N
Y
K
Y
I
G
T
W
D
A
Q
V
S
------------
K
E
-
N
N
W
V
A
T
A
D
D
D
R
K
A
G
Y
R
T
E
F
D
V
D
F
G
N
K
----------
N
L
S
G
K
------
L
F
D
K
N
----------
G
V
N
P
V
F
T
V
D
P
K
I
D
---
G
N
G
F
T
G
------
K
A
K
-------------------
T
S
D
A
G
F
A
L
D
S
G
S
S
R
Y
-----
E
N
V
K
F
N
D
V
A
V
S
G
G
F
Y
G
-
P
T
A
----------------
A
E
L
G
G
Q
F
H
H
K
S
-
E
N
G
-
S
V
G
A
V
F
G
A
K
Q
Q
V
K
K
---------
1
HHSearch
44.50
21%
-22
- C4 -
2D9S
-
CBL_MOUSE
A:
[5-46]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
G
Q
L
-
S
S
E
I
E
R
L
M
S
-
Q
G
Y
--
S
-
Y
Q
D
I
Q
K
A
L
V
I
A
H
N
-
N
I
E
-
M
A
K
N
I
L
R
E
F
S
G
P
S
S
G
--------
14
HHSearch
43.87
23%
-23
- C4 -
1IFY
-
RD23A_HUMAN
A:
[162-200]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
-
E
T
M
L
T
E
I
M
S
-
M
G
Y
--
E
-
R
E
R
V
V
A
A
L
R
A
S
Y
N
-
N
P
H
-
R
A
V
E
Y
L
L
T
---------------
7
HHSearch
43.04
18%
-48
- C4 -
2CP9
-
EFTS_HUMAN
A:
[3-48]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
S
G
S
S
-
K
E
L
L
M
K
L
R
R
K
T
G
Y
--
S
-
F
V
N
C
K
K
A
L
E
T
C
G
G
-
D
L
K
-
Q
A
E
I
W
L
H
K
E
A
Q
K
E
G
W
--------