@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AG_HUMAN: (2015-12-09 )
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......---.190..-.....200----------------..---.----.-.....210-----------.......220---.......------.-230...---------....240.....----..----250--.......260-.--..----.-----------.--------------------------..-.----270.......280-..-.----.---.----...---.290.......300.......310.......320.......330....--...340.......-350.....-----..360....-----...--370.-----......-.-380.-..--------.---.---.----..390.......--------400.----------......---410.....-----..---420----..---.....430.---.-...-..440----.........450.......---460.......470.......480.....------...490.----.....-.--------.500--.......510.......520.-......530.......540.......550.......560.......570.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGS
R
H
F
E
G
I
Y
D
HV
G
H
F
G
R
F
Q
R
V
L
Y
F
I
C
A
FQNI
S
C
G
I
H
Y
L
A
S
V
F
MGVT
P
H
HVCRPPGN
V
S
Q
V
V
F
HNHSNWSL
E
D
T
G
A
L
L
SSGQK
D
Y
V
T
V
Q
LQNG
E
I
W
E
L
S
R
CSRNKRENTSSLG
Y
E
YTGSKKEFPCVD
G
Y
I
YDQNTWKS
T
A
V
T
Q
W
N
L
VC
D
R
K
W
L
A
M
L
I
Q
P
L
F
M
F
G
V
L
L
G
S
V
T
F
G
Y
F
S
DRLG
R
R
V
V
L
W
AT---SSS
M
F
L
-
F
G
I
A
A
A
------------------
F
A
---
V
----
D
-
Y
Y
T
F
M
A
A
R
-----------
F
F
L
A
M
V
AS
G
----
Y
L
V
V
G
F
V
------
Y
-
V
M
E
F
IG---------MKSR
T
W
A
S
V
H
L
H
----
S
F
----
F
A
V
--
G
T
L
L
V
A
L
T
G
--
Y
--
L
V
----
R
-----------
T
--------------------------
W
W
-
L
----
Y
Q
M
I
L
S
T
V
T
V
P
---
F
I
-
L
----
C
---
C
----WVL---PET
P
F
W
L
LSEG
R
Y
E
E
A
Q
K
I
V
D
I
M
A
KWNRASSC
K
L
S
E
L
L
S
LDLQGPVSN--SPTE
V
Q
KHN
L
S
Y
L
-
F
Y
N
W
S
I
T
K
-----
R
T
L
T
V
W
L
I
W
-----
F
TG--S-L
G
-----
F
Y
S
F
S
L
-
N
-
S
V
-N-LG--------
G
---
N
---
E
----
Y
L
N
L
F
L
L
G
VVEI--------P
A
Y
T
----------
F
V
C
I
A
M---DKVGRR
T
V
-----
L
A
---
Y
S
L
----
F
C
---
S
A
L
AC
G
V
V
M
---
V
-IPQ-K
H
Y
------
I
L
G
V
V
T
A
M
V
G
K
F
A
I
G
A
A
F
G
---
L
I
Y
L
Y
T
A
E
L
Y
P
T
I
V
R
S
L
AVGS
G
-
S
M
V
C
R
------
L
A
S
I
-LA----PFSV
D
-
L
--------
S
S
I
W
--
I
F
I
P
Q
L
F
V
G
T
M
A
L
L
S
G
V
L
T
LK-
L
P
E
T
L
G
K
R
L
A
T
T
W
E
E
A
A
KLESENESKS
S
K
L
L
L
TTNNSGLEKTEAITPRDSGLGE
22
Fugue
89.37
16%
-116
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
----------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
------------------------------------
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
-------------------------------------------------
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
-
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
-----------
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
------
Y
-
I
A
E
L
A
P
---------
A
H
I
R
G
K
L
V
S
F
N
Q
----
F
A
----
I
I
F
--
G
Q
L
L
V
Y
C
V
N
--
Y
--
F
I
----
A
R
S
GD
A
S
W
L
N
T
D
G
--------------------------
W
R
-
Y
----
M
F
A
S
E
C
I
P
A
L
L
---
F
L
-
M
----
L
---
L
----
Y
T
V
---
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
-
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
--
G
R
L
L
M
F
G
V
G
V
I
V
I
-
G
V
M
L
S
I
F
Q
-----
Q
F
V
G
I
N
V
V
L
-----
Y
Y
A
--
P
-
E
V
-----
F
K
T
L
G
A
-
S
-------
T
--------
D
---
I
---
A
----
L
L
Q
T
I
I
V
G
V
I
N
L
--------
T
F
T
V
----------
L
A
I
M
T
V
---
D
K
F
G
R
K
P
L
-----
Q
I
---
I
G
A
----
L
G
---
M
A
I
G
M
F
S
L
G
---
T
-
A
F
Y
-
T
Q
A
------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
------
L
A
N
Y
-
F
V
S
---
W
T
F
P
M
-
M
--------
D
K
N
S
--
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
-
A
A
L
F
M
W
K
F
V
P
E
T
----------------------
K
G
K
T
L
E
E
L
E
A
L
W
E
-------
9
PsiBlast_PDB
85.68
21%
-123
- C2 -
4ZW9
4
?
A:
[91-485]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
----------
N
S
M
L
I
-
V
N
L
L
A
V
------------------
T
G
---
G
----
C
-
F
M
G
L
C
K
V
A
-----------
K
S
V
E
M
L
I
L
G
----
R
L
V
I
G
L
F
C
G
L
C
T
G
F
-
V
P
M
Y
I
G
---------
E
I
S
P
T
A
L
R
G
A
F
G
----
T
L
N
Q
L
G
I
V
V
--
G
I
L
V
A
Q
I
F
G
LE
F
--
I
L
----
G
-----------
S
--------------------------
E
E
-
L
----
W
P
L
L
L
G
F
T
I
L
P
---
A
I
-
L
----
Q
---
S
----
A
A
L
PFC
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
-
L
Q
R
L
W
G
-------
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
--
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
-----
Q
P
I
I
I
S
I
V
L
-------------------
Q
L
S
Q
Q
L
-
S
-
G
I
-
N
-
A
V
--------
F
---
Y
---
Y
----
S
T
G
I
F
K
D
A
G
V
Q
E
--------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-----
H
M
---
I
G
L
G
G
M
A
F
C
---
S
T
L
M
--
T
V
S
---
L
-
L
L
K
-
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
-
P
---
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--
C
S
N
W
T
S
N
F
L
V
G
L
-
L
F
----
P
S
A
A
H
-
Y
--------
L
G
A
Y
--
V
F
I
--
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
-
V
P
E
T
R
G
R
----
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------
10
PsiBlast_PDB
85.35
21%
-124
- C2 -
4ZWB
1
?
A:
[91-485]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
----------
N
S
M
L
I
-
V
N
L
L
A
V
------------------
T
G
---
G
----
C
-
F
M
G
L
C
K
V
A
-----------
K
S
V
E
M
L
I
L
G
----
R
L
V
I
G
L
F
C
G
L
C
T
G
F
-
V
P
M
Y
I
G
---------
E
I
S
P
T
A
L
R
G
A
F
G
----
T
L
N
Q
L
G
I
V
V
--
G
I
L
V
A
Q
I
F
G
LE
F
--
I
L
----
G
-----------
S
--------------------------
E
E
-
L
----
W
P
L
L
L
G
F
T
I
L
P
---
A
I
-
L
----
Q
---
S
----
A
A
L
PFC
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
-
L
Q
R
L
W
G
-------
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
--
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
-----
Q
P
I
I
I
S
I
V
L
-------------------
Q
L
S
Q
Q
L
-
S
-
G
I
-
N
-
A
V
--------
F
---
Y
---
Y
----
S
T
G
I
F
K
D
A
G
V
Q
E
--------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-----
H
M
---
I
G
L
G
G
M
A
F
C
---
S
T
L
M
--
T
V
S
---
L
-
L
L
K
-
D
N
Y
NG
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
-
P
---
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--
C
S
N
W
T
S
N
F
L
V
G
L
-
L
F
----
P
S
A
A
H
-
Y
--------
L
G
A
Y
--
V
F
I
--
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
-
V
P
E
T
R
G
R
----
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------
12
PsiBlast_PDB
84.30
21%
-117
- C2 -
5C65
8
?
A:
[69-463]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
----------
N
S
M
L
I
-
V
N
L
L
A
V
------------------
T
G
---
G
----
C
-
F
M
G
L
C
K
V
A
-----------
K
S
V
E
M
L
I
L
G
----
R
L
V
I
G
L
F
C
G
L
C
T
G
F
-
V
P
M
Y
I
G
---------
E
I
S
P
T
A
L
R
G
A
F
G
----
T
L
N
Q
L
G
I
V
V
--
G
I
L
V
A
Q
I
F
G
LE
F
--
I
L
----
G
-----------
S
--------------------------
E
E
-
L
----
W
P
L
L
L
G
F
T
I
L
P
---
A
I
-
L
----
Q
---
S
----
A
A
L
PFC
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
-
L
Q
R
L
W
G
-------
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
--
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
-----
Q
P
I
I
I
S
I
V
L
-------------------
Q
L
S
Q
Q
L
-
S
-
G
I
-
N
-
A
V
--------
F
---
Y
---
Y
----
S
T
G
I
F
K
D
A
------------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-----
H
M
---
I
G
L
G
G
M
A
F
C
---
S
T
L
M
--
T
V
S
---
L
-
L
L
K
-
D
--M
S
F
V
--
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
-
P
---
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--
C
S
N
W
T
S
N
F
L
V
G
L
-
L
F
----
P
S
A
A
H
-
Y
--------
L
G
A
Y
--
V
F
I
--
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
-
V
P
E
T
R
G
R
----
T
F
E
D
I
T
R
A
F
E
G
Q
A
------------------------------
11
PsiBlast_PDB
81.98
21%
-120
- C2 -
4ZWC
3
?
A:
[91-485]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
----------
N
S
M
L
I
-
V
N
L
L
A
V
------------------
T
G
---
G
----
C
-
F
M
G
L
C
K
V
A
-----------
K
S
V
E
M
L
I
L
G
----
R
L
V
I
G
L
F
C
G
L
C
T
G
F
-
V
P
M
Y
I
G
---------
E
I
S
P
T
A
L
R
G
A
F
G
----
T
L
N
Q
L
G
I
V
V
--
G
I
L
V
A
Q
I
F
G
LE
F
--
I
L
----
G
-----------
S
--------------------------
E
E
-
L
----
W
P
L
L
L
G
F
T
I
L
P
---
A
I
-
L
----
Q
---
S
----
A
A
L
PFC
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
-
L
Q
R
L
W
G
-------
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
--
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
-----
Q
P
I
I
I
S
I
V
L
-------------------
Q
L
S
Q
Q
L
-
S
-
G
I
-
N
-
A
V
--------
F
---
Y
---
Y
----
S
T
G
I
F
K
D
A
G
V
Q
E
--------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
-----
H
M
---
I
G
L
G
G
M
A
F
C
---
S
T
L
M
--
T
V
S
---
L
-
L
L
K
-
D
N
Y
NGM
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
-
P
---
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--
C
S
N
W
T
S
N
F
L
V
G
L
-
L
F
----
P
S
A
A
H
-
Y
--------
L
G
A
Y
--
V
F
I
--
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
-
V
P
E
T
R
G
R
----
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------
1
PsiBlast_PDB
81.10
22%
-126
- C2 -
4LDS
-
?
A:
[51-427]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
---
A
I
V
F
I
I
-
G
A
L
I
L
A
------------------
A
S
---
T
----
N
-
L
A
L
L
I
I
G
R
-----------
L
I
I
G
L
A
V
G
G
----
S
M
S
T
V
P
V
------
Y
-
L
S
E
M
A
P
---------
T
E
Y
R
G
S
L
G
S
L
N
Q
----
L
M
----
I
T
I
--
G
I
L
A
A
Y
L
V
N
--
Y
--
A
F
----
A
-----------
D
--------------------------
I
E
-
G
----
W
R
W
M
L
G
L
A
V
V
P
---
S
V
-
I
----
L
L
V
G
I
----
Y
F
M
---
P
E
S
P
R
W
L
L
-
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
N
---
A
I
S
E
--
S
---------------
T
W
T
V
I
K
SP
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
IN
A
-
V
I
-----
F
Y
S
S
S
I
F
A
-
K
A
-
G
-
L
G
E-------
A
---
A
---
S
----
I
L
G
S
V
G
I
G
T
I
N
V
--------
L
V
T
I
----------
V
A
I
F
V
V
---
D
K
I
D
R
K
K
L
-----
L
V
G
G
N
I
G
M
----
I
A
---
S
L
L
I
M
A
I
L
I
W
T
I
G
-
I
A
S
-
S
A
W
------
I
I
I
V
C
L
S
L
F
I
V
F
-
F
G
I
S
W
G
P--
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
-
A
L
V
L
N
------
I
G
T
L
-
I
V
S
L
FF
P
I
L
S
D
A
L
--------
S
T
E
W
--
V
F
L
I
F
A
F
I
G
V
L
A
M
---
I
F
V
I
K
F
L
P
E
T
R
G
------------------------------------------------
2
PsiBlast_PDB
68.88
22%
-135
- C2 -
4J05
-
?
A:
[130-506]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
R
V
L
T
W
I
T
---
I
C
R
V
F
L
G
I
G
I
G
G
D
------------------
Y
P
---
M
----
S
-
A
-
T
V
V
S
D
R
ANIHR
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
----
S
F
V
G
S
L
V
------
T
-
I
V
T
I
S
G
---------
F
K
H
R
L
-
K
S
G
H
T
H
----
D
V
----
D
K
A
--
W
R
I
L
I
G
L
S
------
L
I
----
P
-----------
A
--------------------------
F
G
T
L
----
Y
Q
R
----------------------------------------------------------------------------------------
W
Q
E
F
-
V
A
Y
--
F
S
T
W
N
H
F
R
-----
N
L
L
G
S
M
L
G
W
-----
F
L
V
--
D
-
I
A
-----
F
Y
G
I
N
L
-
N
Q
S
V
-
V
-
L
A
Q
I
G
FAGKT
G
---
D
---
V
----
Y
D
K
L
F
Q
L
A
T
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
----------
F
T
L
F
L
I
---
D
I
V
G
R
K
K
L
Q
F
M
G
F
I
M
---
S
G
L
----
F
L
---
A
I
L
A
G
E
I
D
H
---
I
---
G
-
K
G
P
------
L
L
A
C
F
T
F
M
Q
F
F
F
N
F
G
A
N
-
T
---
T
T
F
I
V
A
A
E
L
F
P
T
R
I
R
A
S
A
H
G
I
S
-
A
A
A
G
K
------
C
G
A
I
-
L
S
----
S
L
V
F
N
-
Q
L
K
A
K
IG
T
S
A
V
L
W
--
I
F
F
S
T
C
I
L
G
F
I
S
------
T
F
L
-
I
D
E
T
M
G
V
D
P
D
E
K
D
L
E
E
R
R
A
R
----------------------------------
32
HHSearch
64.31
14%
-136
- C2 -
3WDO
-
?
A:
[39-360]
---------------------------------------------------------------------------------------------------------------------------------------------
A
L
Q
G
A
S
---
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
-
G
S
V
I
A
A
------------------
L
S
---
D
----
S
-
I
W
G
I
I
L
G
R
-----------
A
L
Q
G
S
G
A
------
I
A
A
A
V
M
A
------
L
-
L
S
D
L
T
R
---------
E
Q
N
R
T
K
A
M
A
F
I
G
----
V
S
----
F
G
I
--
T
F
A
I
A
M
V
L
G
--
P
--
I
I
----
T
-----------
H
--------------------------
K
L
-
G
----
L
H
A
L
F
W
M
I
A
I
L
---
A
T
-
T
G
I
A
L
T
---
I
----
W
V
V
---
P
N
S
S
T
H
V
L
N
R
----
E
-------------------------------------
S
G
M
V
K
G
S
F
S
K
V
-
L
A
E
P
R
L
L
K
-----
L
N
F
G
I
M
C
L
H
-----
M
L
L
--
M
-
S
T
-----
F
V
A
L
P
G
-
Q
-
L
A
-
D
-
A
G
--------
F
---
P
A
A
-
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
--------
V
P
F
I
----------
I
Y
A
E
V
K
---
R
K
M
K
Q
--
V
-----
F
V
---
F
C
V
----
G
L
---
I
V
V
A
E
I
V
L
W
---
N
-
A
Q
--
T
Q
F
------
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
---
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
------
L
G
V
A
-
I
G
----
G
S
L
G
G
-
W
--------
I
D
G
M
--
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
-
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
33
HHSearch
58.53
15%
-128
- C2 -
1PW4
-
GLPT_ECOLI
A:
[56-428]
---------------------------------------------------------------------------------------------------------------------------------------------
V
E
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
-
V
M
L
F
M
G
------------------
F
V
---
P
W
A
T
S
S
-
I
A
V
M
F
V
L
L
-----------
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
------
T
-
M
V
H
W
W
S
---------
Q
K
E
R
G
G
I
V
S
V
W
N
----
C
A
----
H
N
V
--
G
G
G
I
P
P
L
L
F
--
L
--
L
G
----
M
-----------
A
W-------------------------
F
N
-
D
----
W
H
A
A
L
Y
M
P
A
F
C
---
A
I
-
L
V
A
L
F
A
---
F
----
A
M
M
---
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
-----------------------------------
T
A
K
Q
I
F
M
Q
Y
V
-
L
P
N
K
L
L
W
Y
-----
I
A
I
A
N
V
F
V
Y
-----
L
L
R
--
Y
-
G
I
-----
L
D
W
S
P
T
-
Y
-
L
K
-
E
V
K
H
FA
L
-----
D
---
K
---
S
----
S
W
A
Y
F
L
Y
E
Y
A
G
I
--------
P
G
T
L
----------
L
C
G
W
M
S
---
D
K
V
F
R
G
N
R
-----
G
A
---
T
G
V
----
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
---
M
-
N
P
A
-
G
N
P
------
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
---
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
------
L
G
G
S
V
A
A
----
S
A
I
V
G
-
Y
--------
T
V
D
F
FG
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
-
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------
34
HHSearch
57.61
12%
-121
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[47-405]
--------------------------------------------------------------------------------------------------------------------------------------
I
L
L
P
Q
F
Q
Q
A
F
T
L
T
---
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
-
G
A
A
L
F
W
------------------
P
A
A
E
I
M
----
N
-
Y
T
L
F
L
V
G
L
-----------
F
I
I
A
A
G
L
G
C
----
L
E
T
A
A
N
P
------
F
-
V
T
V
L
G
P
---------
E
S
S
G
H
F
R
L
N
L
A
Q
----
T
F
----
N
S
F
--
G
A
I
I
A
V
V
F
G
--
Q
--
S
L
----
I
-----------
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
-
S
----
V
Q
T
P
Y
M
I
I
V
A
I
---
V
L
L
V
----
A
L
--
L
----
I
M
L
---
T
K
F
P
A
L
-----
Q
S
D
N
H
S
D
--------------------------------
A
K
Q
G
S
F
S
A
S
L
S
R
L
-
A
R
I
R
H
W
R
W
-----
A
V
L
A
Q
F
C
Y
V
-----
G
A
Q
--
T
A
C
W
-----
S
Y
L
I
R
Y
-
A
-
V
E
-
E
I
P
G
--------
M
T
A
G
F
---
A
----
A
N
Y
L
T
G
T
M
V
C
F
F
--------
I
G
R
F
----------
T
G
T
W
L
I
---
S
R
F
A
P
H
K
V
-----
L
A
---
A
Y
A
----
L
I
---
A
M
A
L
C
L
I
S
A
---
F
-
A
G
---
G
H
------
V
-
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
---
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
M
T
I
------
I
G
G
G
-
I
V
----
T
P
V
M
G
-
F
--------
V
S
D
A
--
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
-
A
R
F
R
S
Q
T
-----------------------------------------------
35
HHSearch
57.46
16%
-110
- C2 -
2GFP
-
EMRD_ECOLI
A:
[32-358]
-----------------------------------------------------------------------------------------------------------------------------------------
A
D
M
A
R
D
L
N
V
R
---
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
-
A
T
L
V
A
V
------------------
T
T
---
S
----
S
-
L
T
V
L
I
A
A
S
-----------
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
T
------
L
-
P
R
D
L
Y
E
---------
R
T
Q
L
R
H
A
N
S
L
L
N
----
M
G
----
I
L
V
--
S
P
L
L
A
P
L
I
G
--
G
--
L
L
----
D
-----------
T
--------------------------
M
W
-
N
----
W
R
A
C
Y
L
F
L
L
V
L
---
C
A
-
G
----
V
---
T
FSMA
R
W
M
---
P
E
T
R
P
V
--------
D
A
P
-----------------------------------
R
T
R
L
L
T
S
Y
K
T
L
-
F
G
N
S
G
F
N
C
-----
Y
L
L
M
L
I
G
G
L
-----
A
G
I
--
A
-
A
F
-----
E
A
C
S
G
V
-
L
M
G
A
-
V
-
L
G
--------
L
---
S
S
M
T
V
----
S
I
L
F
I
L
P
I
P
A
A
F
--------
F
G
A
W
----------
F
A
G
R
P
N
---
K
R
F
S
T
L
M
W
-----
Q
S
---
V
I
C
----
C
L
---
L
A
G
L
L
M
W
I
P
---
D
W
F
G
V
-
M
N
V
------
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
---
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
L
Q
N
------
I
G
S
G
-
V
L
----
A
S
L
S
A
-
M
--------
L
P
Q
T
--
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
-
P
L
----------------------------------------------------
8
PsiBlast_PDB
52.02
25%
-145
- C2 -
4PYP
1
GTR1_HUMAN
A:
[52-227]
----------------------------------------------------------------------------------------------------------------------------------
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
----------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
---
N
L
L
A
F
V
-
S
A
V
L
M
G
------------------
F
S
KLG
K
----
S
-
F
E
M
L
I
L
G
R
-----------
F
I
I
G
V
Y
C
G
------
L
T
T
G
F
V
P
M
----
Y
-
V
G
E
-
V
S
---------
P
T
A
L
R
G
A
L
G
T
L
H
----
Q
L
G
---
I
V
V
--
G
I
L
I
A
Q
V
F
G
--
L
DS
I
M
----
G
-----------
N
--------------------------
K
D
-
L
----
W
P
L
L
L
S
I
I
F
I
P
---
A
L
-
L
----
Q
---
C
----
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
--
K
V
T
I
L
E
L
F
R
S
P
A
Y
-
R
Q
P
I
L
I
A
V
-----
V
L
Q
L
S
Q
Q
L
S
-----
G
I
N
--
A
-
V
F
-----
Y
Y
S
T
S
I
-
F
-
E
K
-
A
-
G
V
--------
Q
---
Q
---
P
----
V
Y
A
T
I
G
S
G
I
V
N
T
--------
A
F
T
V
----------
V
S
L
F
V
V
---
Q
R
A
G
R
R
T
L
-----
H
L
---
I
G
L
----
A
G
---
M
A
G
C
A
I
L
M
T
---
I
-
A
L
A
-
L
L
E
------
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
---
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
-
P
A
A
I
A
------
V
A
G
F
-
S
N
----
W
T
S
N
F
-
I
--------
V
G
M
C
--
F
Q
Y
V
E
Q
L
C
G
P
Y
V
F
I
I
F
T
V
L
L
V
-
L
F
F
I
F
T
Y
F
K
V
P
E
T
-----------------------------------------
36
HHSearch
47.62
13%
-114
- C2 -
2CFQ
-
LACY_ECOLI
A:
[37-374]
----------------------------------------------------------------------------------------------------------------------------------------------
I
N
H
I
S
---
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
-
P
F
F
I
F
I
------------------
F
G
---
P
----
L
L
Q
Y
N
I
L
V
G
S
-----------
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
E
A
------
F
-
I
E
K
V
S
R
-----------
R
S
N
F
E
F
G
R
A
R
----
M
F
----
G
C
V
--
G
W
A
L
G
A
S
I
V
--
G
--
I
M
----
F
-----------
T
---------------------------
I
-
N
----
N
Q
F
V
F
W
L
G
S
G
C
---
A
L
-
I
LAV-
L
---
L
----
F
F
A
---
K
T
D
A
P
-----
S
S
A
T
V
A
N
A
---------------------------
V
G
A
--
N
H
S
A
F
S
L
K
L
A
L
E
L
-
F
R
Q
P
K
L
W
F
-----
L
S
L
Y
V
I
G
V
S
-----
C
T
Y
--
D
-
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
-
A
T
G
E
-
Q
G
--------
T
R
--
V
---
F
----
G
Y
V
T
T
M
G
E
L
L
N
A
--------
S
I
M
F
----------
F
A
P
L
I
I
---
N
R
I
G
G
K
N
A
-----
L
L
---
L
A
G
----
T
I
---
M
S
V
R
I
I
G
S
S
---
F
-
A
T
---
S
A
------
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
---
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
------
L
A
M
I
-
F
M
----
S
V
L
A
G
-
N
--------
M
Y
E
S
--
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
-
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------
6
PsiBlast_PDB
47.33
25%
-115
- C2 -
4JA3
-
XYLE_ECOLI
A:
[65-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
-
S
G
V
G
S
A
------------------
W
P
---
E
----
L
-
G
F
T
S
I
N
P
D
-----------
N
T
V
P
V
Y
L
A
G
----
Y
V
P
E
F
V
I
------
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
--
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
--
F
I
A
R
S
G
D
-----------
A
--------------------------
S
W
-
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
----
L
---
L
----
Y
T
V
---
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
G
V
I
V
--
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-
I
N
V
V
L
Y
Y
A
-----
P
E
V
S
T
D
I
A
L
-----
L
Q
T
--
I
-
I
V
-----
G
V
I
N
L
T
-
F
-
T
V
-
L
-
A
I
--------
M
---
T
---
V
----
D
K
F
G
R
K
P
L
Q
I
I
G
--------
A
L
G
M
----------
A
I
G
M
F
S
---
L
G
T
A
F
Y
T
Q
-----
A
P
---
G
I
V
----
A
L
---
L
S
M
L
F
Y
V
A
A
---
F
-
A
M
S
-
W
G
P
------
V
C
W
V
L
L
S
E
A
L
A
I
A
V
A
A
Q
W
L
---
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
H
N
G
F
S
Y
-
W
I
Y
G
C
------
M
G
V
L
-
A
A
----
L
F
M
W
K
-
F
--------
V
P
E
-------------------------------------------------------------------------------
5
PsiBlast_PDB
45.95
25%
-121
- C2 -
4GC0
3
XYLE_ECOLI
A:
[65-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
-
S
G
V
G
S
A
------------------
W
P
---
E
----
L
-
G
F
T
S
I
N
P
D
-----------
N
T
V
P
V
Y
L
A
G
----
Y
V
P
E
F
V
I
------
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
--
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
--
F
I
A
R
S
G
D
-----------
A
--------------------------
S
W
-
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
----
L
---
L
----
Y
T
V
---
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
--
R
L
L
M
F
G
V
G
V
I
V
I
G
-
V
M
L
S
I
F
Q
Q
-----
F
V
G
I
N
V
V
L
Y
-----
Y
A
P
--
E
-
V
F
-----
K
T
L
G
A
S
-
T
-
D
I
-
A
-
L
L
--------
Q
---
T
---
I
----
I
V
G
V
I
N
L
T
F
T
V
L
--------
A
I
M
T
----------
V
D
K
F
G
R
---
K
P
L
Q
I
I
G
A
-----
L
G
---
M
A
I
----
G
M
---
F
S
L
G
T
A
F
Y
T
---
Q
-
A
P
G
-
I
V
A
------
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
---
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
-
A
Q
W
L
A
------
N
Y
F
V
-
S
W
----
T
F
P
M
M
-
D
--------
K
N
S
W
--
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------------------
3
PsiBlast_PDB
45.15
25%
-117
- C2 -
4GBY
3
XYLE_ECOLI
A:
[65-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
-
S
G
V
G
S
A
------------------
W
P
---
E
----
L
-
G
F
T
S
I
N
P
D
-----------
N
T
V
P
V
Y
L
A
G
----
Y
V
P
E
F
V
I
------
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
--
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
--
F
I
A
R
SG
D
-----------
A
--------------------------
S
W
-
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
----
L
---
L
----
Y
T
V
---
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
--
R
L
L
M
F
G
V
G
V
I
V
I
G
-
V
M
L
S
I
F
Q
Q
-----
F
V
G
I
N
V
V
L
Y
-----
Y
A
P
--
E
-
V
F
-----
K
T
L
G
A
S
-
T
-
D
I
-
A
-
L
L
--------
Q
---
T
---
I
----
I
V
G
V
I
N
L
T
F
T
V
L
--------
A
I
M
T
----------
V
D
K
F
G
R
---
K
P
L
Q
I
I
G
A
-----
L
G
---
M
A
I
----
G
M
---
F
S
L
G
T
A
F
Y
T
---
Q
-
A
P
G
-
I
V
A
------
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
---
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
-
A
Q
W
L
A
------
N
Y
F
V
-
S
W
----
T
F
P
M
M
-
D
--------
K
N
S
W
--
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------------------
4
PsiBlast_PDB
43.12
25%
-118
- C2 -
4GBZ
3
XYLE_ECOLI
A:
[65-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
-
S
G
V
G
S
A
------------------
W
P
---
E
----
L
-
G
F
T
S
I
N
P
D
-----------
N
T
V
P
V
Y
L
A
G
----
Y
V
P
E
F
V
I
------
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
--
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
--
F
I
A
R
S
G
D
-----------
A
--------------------------
S
W
-
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
----
L
---
L
----
Y
T
V
---
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
--
R
L
L
M
F
G
V
G
V
I
V
I
G
-
V
M
L
S
I
F
Q
Q
-----
F
V
G
I
N
V
V
L
Y
-----
Y
A
P
--
E
-
V
F
-----
K
T
L
G
A
S
-
T
-
D
I
-
A
-
L
L
--------
Q
---
T
---
I
----
I
V
G
V
I
N
L
T
F
T
V
L
--------
A
I
M
T
----------
V
D
K
F
G
R
---
K
P
L
Q
I
I
G
A
-----
L
G
---
M
A
I
----
G
M
---
F
S
L
G
T
A
F
Y
T
---
Q
-
A
P
G
-
I
V
A
------
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
---
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
-
A
Q
W
L
A
------
N
Y
F
V
-
S
W
----
T
F
P
M
M
-
D
--------
K
N
S
W
--
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------------------
7
PsiBlast_PDB
41.65
25%
-124
- C2 -
4JA4
-
XYLE_ECOLI
A:
[65-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
-
S
G
V
G
S
A
------------------
W
P
---
E
----
L
-
G
F
T
S
I
N
P
D
-----------
N
T
V
P
V
Y
L
A
G
----
Y
V
P
E
F
V
I
------
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
--
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
--
F
I
A
RSG
D
-----------
A
--------------------------
S
W
-
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
----
L
---
L
----
Y
T
V
---
P
E
S
P
R
W
L
M
----
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
M
F
G
V
G
--
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-
F
V
G
I
N
V
V
L
-----
Y
Y
A
P
E
V
L
L
Q
-----
T
I
I
--
V
-
G
V
-----
I
N
L
T
F
T
-
V
-
L
A
-
I
-
M
T
--------
V
---
D
---
K
----
F
G
R
K
P
L
Q
I
I
G
A
L
--------
G
M
A
I
----------
G
M
F
S
L
G
---
T
A
F
Y
T
Q
A
P
-----
G
I
---
V
A
L
----
L
S
---
M
L
F
Y
V
A
A
F
A
---
M
-
S
W
G
-
P
V
C
------
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
---
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
-
S
W
N
G
F
------
S
Y
W
I
-
Y
G
----
C
M
G
V
L
-
A
--------
A
L
F
M
--
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------------------
20
PsiBlast_PDB
38.66
34%
33
- C2 -
3DHG
-
TMOA_PSEME
A:
[245-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
E
N
G
K
R
E
E
A
Q
K
K
V
D
-
M
A
I
W
------
R
A
W
R
L
F
A
V
-
L
T
G
P
V
M
D
YY
T
P
L
E
D
R
S
Q
S
F
K
E
F
-
M
Y
E
W
I
I
G
Q
-----
F
E
R
S
L
I
D
L
G
-----
L
D
K
--
P
-
W
Y
-----
W
D
L
F
L
K
-
D
-
I
D
-
E
-
L
H
--------
H
---
S
---
Y
----
H
M
G
V
W
Y
W
R
T
T
A
W
--------
W
N
P
A
----------
A
G
V
T
P
E
---
E
R
D
W
L
E
E
K
-----
Y
P
---
G
W
N
----
K
R
---
W
G
R
C
W
D
V
I
T
---
E
-
N
V
L
-
N
D
R
------
M
D
L
V
S
P
E
T
L
P
S
V
C
N
M
S
Q
I
P
---
L
V
G
V
P
G
D
D
W
N
I
E
V
F
S
L
E
H
N
G
R
L
-
Y
H
F
G
S
------
E
V
D
R
-
W
V
----
F
Q
Q
D
P
-
V
--------
Q
Y
Q
N
--
H
M
N
I
V
D
R
F
L
A
G
Q
I
Q
P
M
T
L
E
G
A
-
L
K
Y
M
G
F
Q
S
I
E
E
M
G
K
D
A
H
D
F
A
W
A
D
K
C
-----------------------------
37
HHSearch
38.63
14%
-100
* C2 *
3O7Q
1
FUCP_ECOLI
A:
[63-175]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
G
L
I
Q
S
A
F
Y
F
G
Y
F
--------
I
I
P
I
----------
P
A
G
I
L
M
---
K
K
L
S
Y
K
A
G
-----
I
I
---
T
G
L
----
F
L
---
Y
A
L
G
A
A
L
F
W
---
P
-
A
A
E
I
M
N
Y
------
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
---
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
------
F
G
A
I
-
I
A
----
V
V
F
G
Q
-
S
--------
L
I
L
S
--
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
-
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L