@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S26A2_HUMAN: (2015-12-10 )
MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQKGVCVPNGLSLSSD
Atome Classification :
(20 SA)
-----------------------------------------------.........10........20-----..---..-....30.......---------.40........50------------.........60....--------..-----------------..70........-----------80.----------.......90--...--...--..100....------..--.110...-----..------..120.---..---....130.......140--...-------------.....150....-.....160..----.....170...------....180.......190.......200.......210.--......220.......230.......----240----------------......--...250.....-..260....----------...270.......280--.......290.------------....--------..300...-..-..310.....---..320--------------.........330.-.----.------..-----..340-------.----.---------.......350.........360...-..-------.--.370..-.....380-.......390.......400.......----410.----......420-......----..430.......--440.......450..--.....460....---------------------------.-----..470.....-------....480.-.....-------.490----..----.......500.......510.......520..------..-----------.....530..-----...-------------------..540.......550.......560.........570--------....---.-....580--....-----------------------.-----...590...--....600-..---------......610.......620.....--------..630..---.--....640-----.......650.....----..660......----.670..--..-...680.......690-....-....700........710.......720.......730.......-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------MSSE
S
K
EQHNVSPRDSAEGND-----SY---PS-
G
I
H
L
E
L
QRESSTD---------FKQFETNDQC
R
P
-------------
Y
H
R
I
L
I
E
R
QEKSDT
N
--------
F
K
-----------------
E
F
V
I
K
K
L
Q
K
NCQ-----------CSP----------A
K
A
K
N
M
I
L
G
--
F
L
P
--
V
L
Q
--
W
L
P
KY
D
L
K
K
------
N
I
--
L
G
D
V
M
S
G
-----
L
I
------
V
G
I
L
LV---
P
Q
---
S
I
A
Y
S
L
LAGQE
P
V
Y
G
L
---
Y
T
S
-------------
F
F
A
S
I
I
--
Y
F
L
L-GTSR
H
I
S
V
G
I
----
F
G
V
L
C
L
M
IG
E
T
------
V
D
R
E
L
Q
KAGYDNAHSAPSLGMVSN
G
S
T
L
LNHTSDRICD--KS
C
Y
A
I
M
VG
S
T
V
T
F
I
A
G
V
Y
Q
V
A
M
G
F
F
----
Q
------------------
V
G
F
V
S
V
--
Y
L
S
D
A
L
L
S
G
F
V-TG
A
S
F
T
I
L
T----------SQ
A
K
Y
L
L
GLNLPRTNG--
V
G
S
L
I
T
T
W
I
H
V
------------
F
R
N
I
--------
H
K
T
N
L
C
D
L
-
I
T
-
S
L
L
C
L
L
V
LLP---
T
K
E
----------------
L
N
E
H
F
K
S
KLKAPI-P----
I
------
E
L
-----
V
V
V
---------
V
----
A
---------
A
T
L
A
S
H
F
G
--
K
L
H
E
NYNSSIAGHIP-TG-------F--MPPKVP-EWNL
I
P
S
V
-
A
V
D
A
I
A
I
S
I
I
G
F
A
I
T
V
S
L
S
E
M
F
A
K
KH
G
----
Y
T
V
K----ANQ
E
M
Y
A
I
--
G
F
C
N
I
I
----
P
S
F
F
H
C
FT
T
S
A
A
--
L
A
K
T
L
V
K
ESTGC
H
T
Q
--
L
S
G
V
V
T
A
L
V
L
L
L
---------------------------
V
-----
L
L
V
--
I
A
P
L
F
-------
Y
S
L
Q
K
S
V
L
-
G
V
I
T
I
-------
V
N
------
L
R
----
G
A
L
R
K
F
R
D
L
P
K
M
W
S
I
S
R
M
D
T
V
I
W
F
V
T
M
L
--
S
S
------
A
L
-----------
L
S
T
E
I
G
L
L
V
G
-----
V
C
F
-------------------
S
I
F
C
V
I
LRTQKP
K
S
S
L
L
G
L
V
E
E
S
--
E
V
F
E
S
V
S
A
YK----------N
L
Q
I---K-PG
I
K
I
F
---
R
F
V
A
-----------------------
P
-----
L
Y
Y
I
N
K
E
C
F
--
K
S
A
L
Y
K
--QT---------VN
P
I
L
I
K
V
A
W
K
K
A
A
K
R
K
I
K
E
K
V
V
T--------LGGIQD
E
---
M
--
S
V
Q
LSHD-----P
L
E
L
H
T
I
V
I
DCS
A
I
Q
----
F
L
D
TAG
I
H
T
L
K
----
E
V
R
R
D
Y
--
E
A
-
I
G
I
Q
V
L
L
AQCNPTVR--DSLT-N
G
E
Y
CK-KEEE
N
L
L
F
Y
S
V
Y
E
A
M
A
F
A
E
VSKNQK
G
V
CVPNGLSLSSD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
91.64
22%
-127
- C2 -
5DA0
2
?
A:
[14-484]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
E
W
F
A
------
N
P
--
R
K
D
V
L
A
G
-----
I
V
------
V
A
L
A
L
I
---
P
E
---
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
---
Y
A
S
-------------
F
I
I
A
L
I
--
T
A
F
L
-
G
G
R
P
G
M
I
S
A
A
----
T
G
A
M
A
L
L
M
T
G
L
------
V
K
D
----------------------------------------
H
G
I
Q
Y
L
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
------------------
L
A
R
Y
L
K
--
F
V
P
R
S
V
M
V
G
F
V
-
N
A
L
A
I
L
I
F
M
----------
A
Q
L
P
Q
F
V
G
A
N
---------------------------------------------
W
Q
M
Y
A
M
-
V
A
-
A
G
L
A
I
I
Y
L
L
P
---
L
V
------------------
F
K
A
M
P
S
A
L
V
A
I
V
-
V
----
L
------
T
V
-----
V
A
V
---------
V
----
T
---------
G
A
D
V
K
T
V
G
--
D
M
-----
G
T
L
P
T
A
L
P
-
H
F
-------
Q
--
F
P
Q
V
P
L
-
T
F
E
T
L
A
I
I
-
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
----
T
T
S
D
----
K
N
V
E
S
R
G
Q
--
G
V
A
N
I
V
----
T
G
F
F
G
G
M
A
G
C
A
M
--
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
--
L
S
T
F
V
A
G
A
F
L
M
V
---------------------------
L
-----
I
L
A
--
L
Q
P
L
L
-------
V
Q
I
---
P
M
-
A
A
L
V
A
-------
V
M
------
M
V
----
V
A
I
S
T
F
D
-----
W
G
S
L
R
F
P
K
G
E
T
V
V
M
L
A
--
T
V
------
A
V
-----------
T
V
F
T
H
D
L
S
L
G
-----
V
L
I
-------------------
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
L
S
Q
V
T
P
V
D
--
E
V
---------------------------
D
G
T
R
T
Y
---
R
V
R
G
-----------------------
Q
-----
L
F
F
V
S
T
H
D
F
--
L
H
Q
F
--------------------------------------------------------------
D
F
T
H
P
-----
A
---
R
R
V
V
I
D
L
S
D
A
H
----
F
W
D
G
S
A
V
G
A
L
D
----
K
V
M
L
K
F
--
M
R
-
Q
G
T
S
V
E
L
R
G
L
N
A
A
S
A
--
T
L
V
E
-
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.27
22%
-126
- C2 -
5DA0
2
?
A:
[14-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QREWFA
N
P
--
R
K
D
V
L
A
G
-----
I
V
------
V
A
L
A
L
I
---
P
E
---
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
---
Y
A
S
-------------
F
I
I
A
L
I
T
-
A
F
L
G
-
G
R
P
G
M
I
S
A
A
T
----
G
A
M
A
L
L
M
T
G
L
V
------
K
D
H
G
I
Q
Y
-----------------------------------
L
F
A
------
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
------------------
L
A
R
Y
L
K
--
F
V
P
R
S
V
M
V
G
F
V
-
N
A
L
A
I
L
I
F
M
----------
A
Q
L
P
Q
F
V
G
A
N
---------------
W
------------------------------
Q
M
Y
A
M
-
V
A
-
A
G
L
A
I
I
Y
L
L
P
---
L
V
---------------------
F
K
A
M
P
S
A
L
V
-
A
----
I
------
V
V
-----
L
T
V
---------
V
----
A
---------
V
V
T
G
A
D
V
K
--
T
V
G
D
------
M
G
T
L
P
-
T
A
LPH----
F
--
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
-
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
----
T
T
S
D
----
K
N
V
E
S
R
G
Q
--
G
V
A
N
I
V
----
T
G
F
F
G
G
M
A
G
C
A
M
--
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
--
L
S
T
F
V
A
G
A
F
L
M
V
---------------------------
L
-----
I
L
A
--
L
Q
P
L
L
-------
V
Q
I
P
M
A
A
L
V
A
V
M
M
V
-------
V
A
------
I
S
T
F
DW
G
S
L
R
----
F
P
K
G
E
T
V
V
M
L
A
T
V
A
--
V
T
V
F
--
T
H
------
D
L
--------------
S
L
G
V
L
I
G
-----
V
V
L
-------------------
S
A
L
F
F
A
R
K
V
S
Q
L
S
Q
V
T
P
V
D
E
V
D
G
--
T
R
T
Y
R
V
R
G
Q
L
----------
F
F
V
S
---
T
-
H
D
F
L
H
Q
---
F
D
F
T
-----------------------
H
-----
P
A
R
R
V
V
I
D
L
--
S
D
A
H
F
W
--
D
G
---------
S
A
V
G
A
L
D
K
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
--------
L
N
A
A
S
A
T
---
L
--
V
E
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
71.33
13%
-87
- C4 -
3B8E
2
AT1A1_PIG
A:
[1-998]
-------------------------------------AKKERDMDEL
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
-----
T
D
---
L
S
R
G
L
T
P
A
R
A
A
E
I
L
A
R
---------
D
G
P
N
A
L
T
P
P
P
T
T
PEWVKFCRQLFGG
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
--------
Y
G
IQAATEEEPQND
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
-----------
F
S
Y
YQEAKSSKIM
E
S
F
K
N
M
V
P
Q
--
Q
A
L
--
V
I
R
N
G
E
K
M
S
I
N
A
E
E
------
V
V
--
V
G
D
L
V
E
V
K
G
GDR
I
P
------
A
D
L
R
I
I
---
S
A
NG
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
---
S
P
D
F
T
N
ENPLETRNIA
F
F
S
T
N
C
--
V
E
G
T
-
A
R
G
I
V
V
Y
T
G
D
RT
V
-
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
E
Y
T
W
L
E
A
V
--
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
----
A
K
R
M
A
R
K
NCLVKNLE
A
V
E
T
L
G
S
T
S
T
--
I
C
S
D
K
--
T
G
T
L
-
T
Q
N
R
M
T
V
A
H
MWSDN
Q
I
H
E
A
D
T
T
E
N
Q
S
G
V
S
F
D
K
T
S
A
--
T
W
L
A
L
S
R
I
A
G
L
CNR
A
V
F
Q
A
NQEN
L
P
I
L
--------
K
R
A
V
A
G
D
A
-
S
E
-
S
A
L
L
K
C
I
E
L
C
CGS
V
K
E
----------------
M
R
E
R
Y
T
K
I
V
E
I
P
F
-
N
STN
K
Y
------
Q
L
-----
S
I
H
K
N
PNTAEPR
H
----
L
---------
L
V
M
K
G
A
P
E
--
R
I
L
D
R
C
S
S
I
L
I
H
G
-
K
-
E
Q
-------
P
--
L
D
E
E
L
K
-
D
A
F
Q
N
A
Y
L
-
E
L
G
G
L
G
E
R
V
L
G
F
C
H
L
F
L
P
D
E
Q
F
P
E
G
F
Q
----
F
D
T
D
DVNF
P
L
D
N
L
C
F
V
--
G
L
I
S
M
I
DPPR
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
---
T
G
D
H
P
I
--
T
A
K
A
I
A
K
G
V
G
I
I
SEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
-----
C
V
V
--
H
G
S
D
L
-------
K
D
M
T
S
E
Q
L
-
D
D
I
L
K
-------
Y
H
------
T
E
----
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
--
G
D
G
VND
S
P
A
S
-----------
K
K
A
D
I
G
V
A
M
G
IAGSD
V
S
K
-------------------
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
--
L
I
F
D
N
L
K
K
S
I
----------
A
Y
T
L
TS
N
I
-
P
E
I
T
P
F
---
L
I
F
I
I
ANIPLPLG
T
V
T
I
L
C
I
DLGTD
M
V
P
-----
A
I
S
L
A
Y
E
Q
A
--
E
S
D
I
M
K
--
R
Q
PRNPKTDKL
V
N
E
Q
L
I
S
M
A
Y
G
Q
I
G
M
I
Q
A
L
G
G
F
F
T
--------
Y
F
V
I
L
A
E
N
GF
L
--
P
I
H
L
L
G
L
-----
R
V
N
W
D
D
R
W
I
N
D
V
E
D
S
----
Y
G
Q
Q
W
T
Y
E
Q
R
K
----
I
V
E
F
T
C
--
H
T
-
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
K
T
R
R
-
N
S
V
F
Q
Q
-
G
M
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
C
P
G
M
G
V
A
L
R
M
Y
P
L
K
P
TWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
67.99
13%
-77
- C3 -
3S28
3
SUSY1_ARATH
A:
[27-807]
-----------------------------N
E
V
L
A
L
L
S
R
V
E
A
K
G
K
G
I
L
Q
Q
N
Q
I
I
A
E
F
E
A
L
P
E
Q
T
R
K
K
L
E
-----
G
G
---
P
F
-
F
D
L
L
K
S
T
Q
E
A
I
V
L
P
P
W
V
-----
A
L
A
V
R
P
R
P
G
V
W
E
-------------
Y
L
R
V
N
L
H
A
L
V
V
E
E
L
Q
--------
P
A
-----------------
E
F
-
L
H
F
K
E
E
L
V
D
-----------
G
V
K
----------
N
G
N
F
T
L
E
L
D
--
F
E
P
--
F
N
A
--
S
I
P
R
P
T
L
H
K
------
Y
I
--
G
N
-------------------
G
V
D
F
L
---
N
R
---
H
L
S
A
K
L
F
H
D
K
E
S
L
L
P
L
---
L
K
F
-------------
L
R
L
H
S
H
QG
K
N
L
M
-
L
S
E
K
I
Q
N
L
N
T
----
L
Q
H
T
L
R
K
A
E
E
Y
------
L
A
E
L
K
S
E
T
L
Y
E
E
F
E
A
K
F
E
E
I
G
L
E
R
G
---
W
G
D
N
A
E
R
V
L
D
M
I
R
L
L
L
D
L
L
E
A
P
D
P
C
T
L
E
T
F
L
G
R
V
P
M
V
F
----
N
------------------
V
V
I
L
S
P
HG
Y
F
A
Q
D
N
V
L
G
Y
P
D
T
G
G
Q
V
V
Y
I
L
----------
D
Q
V
R
A
L
E
I
E
M
L
Q
R
I
K
Q
--
Q
G
L
N
I
K
P
R
I
L
I
------------
L
T
R
L
L
PDAVGTT
C
G
E
R
L
E
R
V
-
Y
D
-
S
E
Y
C
D
I
L
R
V
P
---
F
R
T
EKGIVR
K
W
I
S
RFEVWP
Y
L
E
T
Y
T
E
D
A
A
V
E
L
-
S
----
K
------
E
L
NGKPD
L
I
I
---------
G
N
Y
S
D
G
---------
N
L
V
A
S
L
L
A
--
H
K
L
G
V
T
Q
C
T
I
A
H
A
L
E
-
K
T
K
Y
PDSDI
Y
--
W
K
K
L
D
D
-
K
Y
H
F
S
C
Q
F
-
T
A
D
I
F
A
M
N
H
T
D
F
I
I
T
S
T
F
Q
E
I
A
G
S
K
E
T
----
V
G
Q
Y
----
E
S
H
T
A
F
T
L
------------
P
G
L
Y
R
V
V
H
G
I
D
V
--
F
D
P
K
F
N
I
V
S
P
G
A
D
M
S
IY
F
P
Y
T
E
E
K
R
R
L
T
K
---------------------------
F
-----
H
S
E
--
I
E
E
L
L
-------
Y
S
D
V
E
N
K
---------------
E
------
H
L
----
C
V
L
K
D
-
K
K
K
P
I
L
F
T
M
A
R
L
D
R
V
K
N
L
S
G
L
V
--
E
W
------
Y
G
-----------
K
N
T
R
L
R
E
L
A
----------------------------
N
L
V
V
V
G
G
D
R
R
K
E
S
K
D
N
E
E
K
A
E
M
K
--
K
M
Y
D
L
I
E
E
Y
K
LNGQ
F
R
W
I
S
S
Q
M
D
R
---
V
-
R
N
G
E
L
Y
---
R
Y
I
C
-----------------------
D
T
K
G
A
F
V
Q
P
A
L
Y
E
A
F
--
G
L
T
V
V
E
--
A
M
---------
T
C
G
L
P
T
F
A
T
C
K
G
G
P
A
E
I
I
V
H
G
K
---------------
S
G
---
F
--
H
I
D
P
Y
H
G
-----
D
Q
A
A
D
T
L
A
D
F
F
T
K
C
K
E
D
P
S
H
W
D
E
I
S
K
G
G
L
Q
----
R
I
E
E
K
Y
TW
Q
I
-
Y
S
Q
R
L
L
T
L
T
G
V
Y
G
F
W
--
K
H
V
S
-
N
----
L
-
D
R
L
E
A
R
R
Y
L
E
M
F
Y
A
L
K
Y
R
P
L
A
Q
A
---------
V
P
L
A
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
65.43
14%
-93
- C4 -
2DFS
-
MYO5A_CHICK
A:
[5-1080]
ELYTKY
A
R
V
W
I
P
D
PEEV
W
K
S
A
E
L
LKDYKPGDK
V
L
Q
L
R
L
EE
G
K
D
L
E
Y
C
L
D
P
K
T
K
E
L
P
P
L
R
N
P
D
I
L
V
G
E
N
DLTAL
S
Y
LH
E
P
A
-
V
L
H
N
L
K
V
R
F
I
D
S
K
LIYTYCGI
V
L
V
A
I
N
P
Y
E
Q
L
P
I
-------------
Y
G
E
D
I
I
N
A
Y
S
G
Q
N
M
G
DMDPH
I
F
A
V
A
-----------------
E
E
A
Y
K
Q
M
A
R
D
E
R
N
Q
S
I
I
V
S
G
E
S
G
A
G
K
----------
T
V
S
A
K
Y
A
M
R
--
Y
F
A
T
-
V
S
G
--
S
A
S
E
A
N
V
E
E
------
K
V
--
L
A
S
N
P
I
M
-----
E
S
------
I
G
N
A
K
T
---
T
R
---
N
D
N
S
S
R
F
-
G
K
Y
I
E
I
G
F
D
KR
Y
R
I
-------------
I
G
A
N
M
R
--
T
Y
L
L
-
E
K
S
R
V
V
F
Q
A
E
EERN
Y
H
I
F
Y
Q
L
C
A
S
A
------
A
L
P
E
F
K
T
L
R
L
G
N
A
N
Y
F
H
Y
T
K
Q
G
G
S
P
V
I
D
G
I
D
D
A
K
E
M
V
N
--
T
R
Q
A
C
T
L
L
G
I
S
D
S
Y
Q
M
G
I
F
R
I
L
A
G
I
L
----
H
------------------
L
G
N
V
E
F
--
A
S
R
D
---
S
D
S
C
-
A
I
P
P
K
H
D
P
L
----------
T
I
F
C
D
L
M
G
V
D
Y
E
E
M
A
H
W
L
C
H
R
K
L
A
T
Y
I
K
P
------------
I
S
K
L
--------
H
A
I
N
A
R
D
A
-
L
A
K
H
I
Y
A
N
L
F
N
W
I
---
V
D
H
----------------
V
N
K
A
L
H
S
T
V
K
Q
H
S
-
F
----
I
------
G
V
-----
L
D
I
---------
Y
----
G
FETFEINS
F
E
Q
F
C
I
N
Y
A
N
E
K
L
Q
Q
Q
F
N
M
H
V
F
K
L
E
Q
-
E
E
-------
Y
--
M
K
E
Q
I
P
--
W
T
L
I
D
F
Y
D
N
Q
P
C
I
N
L
I
E
A
K
M
G
V
L
D
L
L
D
E
E
C
K
M
P
K
G
----
S
D
D
T
----
W
A
Q
K
L
Y
N
T
HL
N
K
C
A
L
F
E
K
--
P
R
L
S
N
K
A
F
I
I
K
H
--
F
A
D
K
V
E
Y
Q
C
E
G
F
L
E
K
--
N
K
D
T
V
Y
E
E
Q
I
K
V
---------------------------
L
K
S
SKK
F
K
L
--
L
P
E
L
F
QHKKT
V
G
H
Q
F
R
N
S
L
H
-
L
L
M
E
T
-------
L
N
A
T
T
P
H
Y
V
R
----
C
I
K
P
N
D
F
K
F
P
F
T
F
D
E
K
R
A
V
Q
Q
L
R
A
C
G
V
L
--
E
T
------
I
R
-----------
I
S
A
A
-
G
F
P
S
R
-----
W
T
Y
-------------------
Q
E
F
F
S
R
Y
R
V
L
M
K
Q
K
D
V
L
S
D
R
K
Q
T
C
K
N
V
L
E
K
L
I
L
D
K
----------
D
K
Y
Q
---
F
-
G
K
T
K
I
F
F
R
A
G
Q
V
A
-----------------------
Y
-----
L
E
K
I
R
A
D
K
L
--
R
A
A
C
I
R
I
Q
K
T
---------
I
R
G
W
L
M
R
K
K
Y
M
R
M
R
R
A
A
I
T
I
Q
R
Y
V
--------
R
G
H
Q
A
R
C
---
Y
--
A
T
F
L
R
R
T
R
A
A
I
I
I
Q
K
F
Q
R
M
Y
V
V
R
K
R
Y
Q
----
C
M
R
D
A
T
I
A
L
Q
A
----
L
L
R
G
Y
L
--
V
R
-
N
K
Y
Q
M
M
L
R
E
H
K
S
I
I
I
--
Q
K
H
V
-
R
G
W
L
A
R
-
V
H
Y
H
R
T
L
K
A
I
V
Y
L
Q
C
C
Y
R
R
M
M
A
K
R
E
L
K
K
L
M
N
N
L
E
I
T
Y
S
T
E
T
E
K
L
R
S
D
V
E
R
L
R
M
S
E
E
E
A
K
N
A
T
N
R
V
L
S
L
Q
E
E
I
A
K
L
R
K
E
L
H
Q
T
Q
T
E
K
K
T
I
E
E
W
A
D
K
Y
K
H
E
T
E
Q
L
V
S
E
L
K
E
Q
N
T
L
L
K
T
E
K
E
E
L
N
R
R
I
H
D
Q
A
K
E
I
T
E
T
M
E
K
K
L
V
E
E
T
K
Q
L
E
L
D
L
N
D
E
R
L
R
Y
Q------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
64.97
32%
-94
- C2 -
3LLO
1
A:
[1-143]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Y
T
V
L
G
Q
L
P
D
T
--
D
V
Y
I
D
I
D
A
Y
E
----------
E
V
K
E
---
I
-
P
G
I
K
I
F
---
Q
I
N
A
-----------------------
P
-----
I
Y
Y
A
N
S
D
L
Y
--
S
S
A
N
---------------------------------------------------------------------------
I
H
T
V
I
L
D
F
T
Q
V
N
----
F
M
D
S
V
G
V
K
T
L
A
----
G
I
V
K
E
Y
--
G
D
-
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
--
N
D
L
T
-
S
N
R
F
F
E
N
P
A
L
K
E
L
L
F
H
S
I
H
D
A
V
L
G
S
Q
V
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
58.11
15%
-109
- C2 -
3QE7
2
URAA_ECOLI
A:
[12-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
P
L
--
L
Q
T
I
P
L
S
-----
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
---
P
V
---
L
F
H
------
I
N
P
A
T
V
L
---
L
F
N
-------------
G
I
G
T
L
L
--
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
----
S
F
A
F
I
S
P
V
L
L
L
------
L
P
-----------------------------------------
L
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
------------------
T
G
W
L
D
V
--
L
F
P
P
A
A
M
G
A
I
V
-
A
V
I
G
L
E
L
A
G
----------
V
A
A
G
M
A
G
L
L
--
P
A
-
E
G
-------------------------------------
Q
T
P
D
S
K
T
I
-
I
I
-
S
I
T
T
L
A
V
T
V
L
---
G
S
V
----------------
L
F
R
G
-----
F
L
A
I
-
I
----
P
------
I
L
-----
I
G
V
---------
L
----
V
---------
G
Y
A
L
S
F
A
M
--
G
I
V
---
D
T
T
P
I
I
N
A
H
W
F
A
-------
L
--
P
T
L
Y
T
P
-
R
F
E
--
W
F
A
-
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
KDLL
R
D
P
G
----
L
H
R
S
M
F
A
N
--
G
L
S
T
V
I
----
S
G
F
F
G
S
T
P
N
T
T
Y
--
G
E
N
I
G
V
M
A
I
T
R
V
Y
S
T
--
W
V
I
G
G
A
A
I
F
A
I
L
---------------------------
L
-----
S
C
V
G
K
L
A
A
A
I
-------
Q
M
I
P
L
P
V
M
-
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
------
G
I
----
R
V
L
I
E
--
S
K
V
D
Y
N
--
K
A
Q
N
L
I
L
T
S
V
I
L
I
--
I
G
------
V
S
GAKVNIGAAEL
K
G
M
A
L
A
T
I
V
G
-----
I
G
L
-------------------
S
L
I
F
K
L
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
56.73
11%
-67
- C1 -
3A6P
3
XPO5_HUMAN
A:
[2-1136]
------------------------AMDQ
V
N
A
L
C
E
Q
L
V
K
A
V
T
V
M
M
DPN
S
T
Q
R
Y
R
L
E
A
L
K
F
C
E
E
F
K
E
K
C
P
-----
I
C
---
V
P
-
C
G
L
R
L
A
E
K
T
Q
V
A
I
---------
V
R
H
F
G
L
Q
I
L
E
H
V
-------------
V
K
F
R
W
N
G
M
S
R
L
E
K
V
Y
--------
L
K
-----------------
N
S
V
M
E
L
I
A
N
G
T
L
-----------
N
I
L
----------
E
E
E
N
H
I
K
D
A
--
L
S
R
--
I
V
V
--
E
M
I
K
R
E
W
P
Q
------
H
W
PD
M
L
I
E
L
D
T
-----
L
S
------
K
Q
G
E
T
Q
---
T
E
---
L
V
M
F
I
L
L
R
L
A
E
D
V
V
T
F
---
Q
T
L
-------------
P
-
P
Q
R
R
--
R
D
I
Q
-
Q
T
L
T
Q
N
M
E
R
I
----
F
S
F
L
L
N
T
L
Q
E
N
------
V
N
K
Y
Q
Q
V
K
T
-
D
T
S
Q
E
S
K
A
Q
A
N
C
R
V
G
V
A
A
L
N
T
L
A
G
Y
I
D
W
--
V
S
M
S
H
I
T
A
E
N
C
K
L
L
E
I
L
C
L
L
L
N
E
Q
E
L
----
Q
------------------
L
G
A
A
E
C
--
L
L
I
A
V
S
R
K
G
K
L
-
E
D
R
K
P
L
M
V
L
----------
F
G
D
V
A
M
H
Y
I
L
S
A
A
Q
T
A
--
D
G
G
G
L
V
E
K
H
Y
V
------------
F
L
K
R
--------
L
C
Q
V
L
C
A
L
-
G
N
-
Q
L
C
A
L
L
G
A
D
S
---
D
V
E
----------------
T
P
S
N
F
G
K
Y
L
E
S
F
L
-
A
----
F
T
T
HPS
Q
F
L
-----
R
S
S
---------
T
----
Q
---------
M
T
W
G
A
L
F
R
--
H
E
I
L
S
R
D
P
L
L
L
A
I
I
P
-
K
Y
-------
L
R
A
S
M
T
N
L
V
-
K
M
G
F
P
S
K
T
-
D
S
P
S
C
E
Y
S
R
F
D
F
D
S
D
E
D
F
N
A
F
F
N
S
S
R
A
----
Q
Q
G
E
----
V
M
R
L
A
C
R
L
------------
D
P
K
T
S
F
Q
M
A
G
E
W
--
L
K
Y
Q
L
S
T
F
S
L
C
S
V
F
S
--
P
S
F
V
Q
W
E
A
M
T
L
F
---------------------------
L
-----
E
S
V
--
I
T
Q
M
F
-------
R
T
L
N
R
E
E
I
-
P
V
N
D
G
-------
I
E
------
L
L
----
Q
M
V
L
N
F
D
T
K
D
P
L
I
L
S
C
V
L
T
N
V
S
A
L
F
P
F
V
TY
R
P
------
E
F
-----------
L
P
Q
V
F
S
K
L
F
S
-----
S
V
T
FETVEESKAPRT
R
A
V
R
N
V
R
R
H
A
C
S
S
I
I
K
M
C
R
D
Y
P
Q
L
V
L
P
N
F
D
--
M
L
Y
N
H
V
K
Q
L
L
----------
S
N
E
L
---
L
L
T
Q
M
E
K
C
---
A
L
M
E
-----------------------
A
-----
L
V
L
I
S
N
Q
F
K
--
N
Y
E
R
Q
K
--
V
F
---------
L
E
E
L
M
A
P
V
A
-
S
I
W
L
S
Q
D
M
H
R
V
L
S
D
--------
V
D
A
F
I
A
Y
---
V
--
G
T
D
Q
K
D
P
-----
G
L
E
D
P
C
G
L
N
R
A
R
M
S
F
----
C
V
Y
S
I
L
G
V
V
K
R
TCWP
T
D
L
E
E
A
--
K
A
-
G
G
F
V
V
G
Y
T
S
S
G
N
P
I
F
--
R
N
P
C
-
T
E
Q
I
L
K
-
L
L
D
N
L
L
A
L
I
R
T
H
N
T
L
Y
A
P
E
M
L
A
K
M
A
E
P
F
T
K
A
L
D
M
L
D
A
E
KSAILGL
P
Q
P
L
L
E
LNDSPVFKT
V
L
E
R
M
Q
R
F
F
S
T
L
Y
E
N
C
F
H
I
L
G
K
AGPSMQ
Q
D
F
Y
T
VED
L
A
T
Q
L
L
S
SAFVNLNNIP
D
Y
R
L
R
P
M
L
R
VF
V
K
P
L
V
L
F
CPPEHYEAL
V
S
P
I
L
G
P
L
F
T
Y
L
H
M
R
L
S
Q
K
W
Q
V
I
N
Q
RE
S
Q
E
M
L
E
E
Q
L
V
R
M
L
T
R
E
V
M
D
L
I
T
V
C
CVSELT
D
L
G
K
C
L
M
K
HE
D
V
C
T
A
L
L
I
T
A
F
N
S
L
A
WKDTLS
C
Q
R
T
T
SQLCW
P
L
L
K
Q
V
LSGTLL
A
D
A
V
T
W
L
F
T
S
V
L
K
G
L
Q
M
HGQH
D
G
C
M
A
S
L
V
H
L
A
F
Q
I
Y
E
A
L
RPRYLE
I
R
A
V
M
E
Q
IPEIQ
K
D
S
L
D
Q
F
D
C
K
L
L
N
P
34
Fugue
56.42
9%
-82
- C3 -
1L1L
-
RTPR_LACLE
A:
[4-724]
--------------------------------------------------
E
I
S
L
S
A
E
F
I
D
R
V
K
A
S
V
K
P
-----
H
W
---
G
K
-
L
G
W
V
T
Y
K
R
T
Y
A
R
W
---------
L
P
E
K
G
R
S
E
N
W
D
E
-------------
T
V
K
R
V
V
E
G
N
I
N
L
D
P
R
--------
L
Q
-----------------
D
S
P
S
L
E
L
K
Q
S
L
T
-----------
E
E
A
----------
E
R
L
Y
K
L
I
Y
G
LG
A
T
P
S
G
R
N
L
--
W
I
S
G
T
D
Y
Q
R
------
R
T
--
G
D
S
L
N
N
C
-----
W
F
------
V
A
I
R
P
Q
KYG
D
S
---
K
I
V
P
S
Y
L
G
K
Q
E
K
A
V
S
M
---
P
F
S
-------------
F
L
F
D
E
L
--
M
K
G
G
-
G
V
G
F
S
V
A
R
S
N
----
I
S
Q
I
P
R
V
D
F
A
I
------
D
L
Q
L
V
V
D
E
T
S
E
S
Y
D
A
S
V
K
V
G
A
V
G
K
N
E
L
V
Q
--------
D
--
A
D
S
I
Y
Y
R
L
P
D
T
---
R
E
G
W
V
L
A
N
A
L
L
I
----
D
------------------
L
H
F
A
Q
T
--
N
P
D
R
----
K
Q
K
-
L
I
L
D
L
S
D
I
R
----------
P
Y
G
A
E
I
H
G
F
G
-
G
T
A
S
G
--
P
M
P
L
I
S
M
L
L
D
V
------------
N
E
V
L
--------
N
N
K
A
G
G
R
L
T
A
V
-
D
A
A
D
I
C
N
L
I
G
---
K
A
V
----------------
V
A
G
N
A
----------------------------
E
L
A
---------
L
----
G
---------
S
N
D
D
Q
D
F
I
--
S
M
K
Q
D
Q
E
K
L
M
H
H
R
W
A
-
S
N
-------
N
--
S
V
A
V
D
S
-
A
F
S
G
Y
Q
P
I
-
A
A
G
I
R
E
N
G
E
P
G
I
V
N
L
D
L
S
K
N
Y
G
R
I
V
D
G
----
Y
Q
A
G
----
I
D
G
D
V
E
G
T
--
N
P
C
G
E
I
----
S
L
A
N
G
E
P
C
N
L
F
E
--
V
F
P
L
I
A
E
E
Q
G
W
D
L
Q
E
--
V
F
A
L
A
A
R
Y
A
K
R
V
---------------------------
T
F
SPYD
W
E
I
--
S
R
E
I
I
-------
Q
K
N
R
R
I
G
I
-
S
M
S
G
I
-------
Q
D
------
W
L
----
L
T
R
L
G
N
R
V
V
T
G
F
K
D
D
F
D
P
E
T
H
E
A
I
K
V
P
V
--
Y
D
------
K
R
-----------
A
I
K
M
V
D
Q
L
Y
K
-----
A
V
V
-------------------
K
A
D
Q
D
Y
S
K
T
L
G
C
N
E
S
I
K
H
T
T
------
V
K
P
S
G
T
V
A
K
----------
L
A
G
A
---
S
-
E
G
M
H
------
F
H
Y
-----------------------
G
-----
A
Y
L
I
Q
R
I
R
F
Q
D
S
D
P
L
L
P
--
A
L
---------
K
A
C
G
Y
R
T
E
A
D
I
Y
T
E
N
T
T
C
V
E
F
P
I
K
--------
A
V
G
A
D
N
P
---
N
--
F
A
S
A
G
T
V
-----
S
I
A
E
Q
F
A
T
Q
A
F
L
Q
T
Y
----
W
S
D
N
A
V
S
C
T
I
T
----
F
Q
D
S
E
G
--
D
Q
-
V
E
S
L
L
R
Q
Y
R
F
I
T
K
S
T
--
S
L
L
P
Y
F
G
G
S
L
Q
-
Q
A
P
K
E
P
I
D
K
E
T
Y
E
K
R
S
Q
E
I
T
G
N
V
E
E
V
F
S
Q
L
N
S
D
V
K
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
55.17
22%
-66
- C2 -
1SBO
-
Y1442_THEMA
A:
[10-110]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
Q
-
D
D
K
A
I
V
---
R
V
Q
G
-----------------------
D
-----
I
D
A
Y
N
S
S
E
L
--
K
E
Q
L
R
N
--
F
I
---------
S
--------------------------------------------------------
T
T
S
K
K
K
I
V
L
D
L
S
S
V
S
----
Y
M
D
S
A
G
L
G
T
L
V
----
V
I
L
K
D
A
--
K
I
-
N
G
K
E
F
I
L
S
S
L
K
E
S
I
S
--
R
I
L
K
-
L
T
H
L
D
K
----
I
F
K
I
T
D
T
V
E
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
54.20
17%
-105
* C3 *
4D5T
-
A49R_VACCW
A:
[2-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
Y
V
S
D
M
H
T
E
L
A
S
I
S
Q
L
V
I
A
--
K
I
E
T
I
----
D
N
D
I
L
N
K
D
I
V
N
F
I
M
C
R
S
----
N
---------------------------
L
D
N
P
F
I
S
F
L
---
D
T
V
Y
T
I
I
D
----------
Q
E
N
Y
Q
T
E
L
I
N
---
S
L
D
--
D
N
E
I
I
D
C
I
V
N
K
------------
F
M
S
F
--------
Y
K
D
N
L
E
N
I
-
V
D
-
A
I
I
T
L
K
Y
I
M
N
---
N
P
D
----------------
F
K
T
T
Y
A
E
V
L
G
S
R
I
A
D
----
I
------
D
I
-----
K
Q
V
---------
I
----
R
---------
E
N
I
L
Q
L
S
N
--
D
I
R
E
R
Y
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
52.94
14%
-50
- C2 -
3T6O
-
?
A:
[10-120]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
---
E
-
A
Q
V
T
V
I
---
S
F
P
A
VFQ--------------------
R
-----
L
R
E
T
E
V
E
Q
I
--
A
S
T
F
L
A
--
A
M
---------
Q
--------------------------------------------------------
G
A
Q
P
R
K
V
L
I
D
L
E
G
V
E
----
F
F
G
S
S
F
I
E
L
L
V
----
R
G
W
K
R
I
--
K
E
D
Q
Q
G
V
F
A
L
C
S
V
S
P
Y
C
V
--
E
V
L
Q
-
V
T
H
I
D
E
----
V
W
P
R
Y
S
T
K
Q
E
A
L
L
A
M
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
52.57
15%
-67
- C2 -
1TH8
-
SP2AA_GEOSE
B:
[8-114]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
---
K
-
Q
D
V
L
I
V
---
R
L
S
G
-----------------------
E
-----
L
D
H
H
T
A
E
E
L
--
R
E
Q
V
T
D
--
V
L
---------
E
--------------------------------------------------------
N
R
A
I
R
H
I
V
L
N
L
G
Q
L
T
----
F
M
D
S
S
G
L
G
V
I
L
----
G
R
Y
K
Q
I
--
K
N
-
V
G
G
Q
M
V
V
C
A
V
S
P
A
V
K
--
R
L
F
D
-
M
S
G
L
F
K
----
I
I
R
V
E
A
D
E
Q
F
A
L
Q
A
L
G
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
50.15
16%
-56
- C2 -
1H4X
1
SP2AA_LYSSH
A:
[8-112]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
T
-
R
E
T
V
V
I
---
R
L
F
G
-----------------------
E
-----
L
D
H
H
A
V
E
Q
I
--
R
A
K
I
S
T
--
A
I
---------
F
--------------------------------------------------------
Q
G
A
V
T
T
I
I
W
N
F
E
R
L
S
----
F
M
D
S
S
G
V
G
L
V
L
----
G
R
M
R
E
L
--
E
A
-
V
A
G
R
T
I
L
L
N
P
S
P
T
M
R
--
K
V
F
Q
-
F
S
G
L
G
P
-
W
---
M
-
M
D
A
T
E
E
E
A
I
D
R
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
49.73
16%
-30
- C2 -
3AGD
-
?
A:
[323-447]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
G
D
R
V
F
L
---
H
L
Q
G
-----------------------
V
-----
I
R
F
G
G
A
E
A
V
--
L
D
A
L
T
D
--
L
R
---------
T
-------
G
W
D
A
A
V
Y
P
R
W
Q
E
A
A
A
D
R
A
A
L
S
A
A
T
G
G
G
A
V
H
E
---
A
A
A
A
A
A
---
N
-----
D
G
P
I
R
T
V
V
L
N
L
A
R
V
D
----
R
I
D
D
V
G
R
R
L
I
A
----
E
G
V
R
R
L
--
Q
A
-
D
G
V
R
V
E
V
E
D
P
E
R
I
L
P
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
48.19
14%
-62
* C2 *
2KA5
-
Y1081_THEMA
A:
[4-124]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
K
I
H
H
H
H
H
H
M
F
----------
P
Y
K
I
---
V
-
D
D
V
V
I
L
---
M
P
N
K
-----------------------
E
-----
L
N
I
E
N
A
H
L
F
--
K
K
W
V
F
D
--
E
F
---------
L
--------------------------------------------------------
N
K
G
Y
N
K
I
F
L
V
L
S
D
V
E
----
S
I
D
S
F
S
L
G
V
I
V
----
N
I
L
K
S
I
--
S
S
-
S
G
G
F
F
A
L
V
S
P
N
E
K
V
E
--
R
V
L
S
-
L
T
N
L
D
R
----
I
V
K
I
Y
D
T
I
S
E
A
M
E
E
V
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
47.86
13%
-59
- C2 -
3NY7
2
?
A:
[14-118]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
P
-
D
D
V
L
V
L
---
R
V
I
G
-----------------------
P
-----
L
F
F
A
A
A
E
G
L
--
F
T
D
L
E
S
--
R
L
-------------------------------------------------------------------
E
G
K
R
I
V
I
L
K
W
D
A
V
P
----
V
L
D
A
G
G
L
D
A
F
Q
----
R
F
V
K
R
L
--
P
--
E
G
C
E
L
R
V
C
N
V
E
F
Q
P
L
--
R
T
M
A
-
R
A
G
I
Q
P
-
I
P
G
R
L
A
F
F
P
N
R
R
A
A
M
A
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
46.99
21%
-4
- C2 -
2KLN
-
?
A:
[1-124]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
----------
Q
A
K
R
---
V
-
P
G
L
V
V
Y
---
R
Y
D
A
-----------------------
P
-----
L
C
F
A
N
A
E
D
F
--
R
R
R
A
L
T
--
V
V
---------
D
-------------------------------------------------
Q
D
-----
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
----
E
V
D
L
T
A
L
D
A
L
D
----
Q
L
R
T
E
L
--
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
--
E
S
L
R
-
A
A
S
L
L
D
-
K
I
G
E
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
46.35
20%
-1
- C2 -
2KLN
-
?
A:
[1-124]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
----------
Q
A
K
R
---
V
-
P
G
L
V
V
Y
---
R
Y
D
A
-----------------------
P
-----
L
C
F
A
N
A
E
D
F
--
R
R
R
A
L
T
--
V
V
----------------------------------------------------------
D
Q
D
-----
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
----
E
V
D
L
T
A
L
D
A
L
D
----
Q
L
R
T
E
L
--
L
R
-
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
--
E
S
L
R
-
A
A
S
L
L
D
-
K
I
G
E
D
H
I
F
M
T
L
P
T
A
V
Q
A
F
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
44.29
29%
-6
- C2 -
4DGH
1
?
A:
[52-117]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
L
R
L
K
W
V
P
----
F
M
D
I
T
G
I
Q
T
L
E
----
E
M
I
Q
S
F
--
H
K
-
R
G
I
K
V
L
I
S
G
A
N
S
R
V
S
--
Q
K
L
V
-
K
A
G
I
V
K
L
V
G
E
Q
N
V
--
Y
P
V
F
E
G
A
L
S
A
A
L
T
E
I
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------