@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35D1_HUMAN: (2015-12-10 )
MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSDLAFDLEGYAFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGDAQKAVEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV
Atome Classification :
(16 SA)
--....-----.....10........20........-30........40..-......50..------..----....60.-------......------.70-----...-.---------..---..80..-----......90--------------.......------.100------......--...110...-------....120--------------.........130....-..----.140.......150------......-------------...160......-------.170.......180--------...------.------...190--.---------...----....200...----------...-----.210..-....---------------.220.....----..230----------.----......-..240.......250--....---....260....---------------...270.......280....-...290..----.....300....--------------------------------..--------.310--------..--------......--320...--..---------..330..-----.-.....340.......350...--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MA
E
V
-----
H
R
R
Q
H
ARVKGEAPAKSSTLR
D
E
E
E
L-GMA
S
A
E
T
L
T
V
F
L
K
L
-
L
A
A
G
F
Y
G
V
S
S
------
F
L
----
I
V
V
VN
K
S
-------
V
L
TNYR------F
P
S
-----
S
L
C
-
V
---------
G
L
---
G
Q
M
V
A
T
-----
V
A
V
L
W
V
G
K
--------------
A
L
R
V
V
KF------PD--------LDRNVP--RKTFPL
P
L
L
-------
Y
FGNQ----------------
I
T
G
L
F
STKKLN
L
P
M
F
T
-
V
L
----
R
R
F
S
I
L
F
T
M
F
AE--------
G
V
L
L
KK-------------TFSWG
I
K
M
T
V
F
A
-------
M
I
I
G
A
F
V
AASS
D
L
A
--------
F
DL------E------
G
Y
A
F
I
---
L
---------
I
N
D
----
V
L
TAAN
G
A
Y
V
----------
K
Q
K-----L
D
S
K
E
L
-
G
K
Y
G
---------------
L
L
Y
Y
N
A
L
F
M
----
I
L
P
------------
T
----
L
A
I
A
YF-TGDAQ
K
A
V
EFEGW
A
---
D
T
L
F
---
L
L
Q
F
T
L
S
C
V
M
G
---------------
F
I
L
M
Y
A
T
V
L
C
TQYN
S
A
L
T
T
T
-
I
V
G
C
I
K
N
I
----
L
I
T
Y
I
G
M
V
FGG
D
--------------------------------
Y
I
--------
F
T
W
---------
T
N
--------
F
I
G
L
N
I
--
S
I
A
G
S
L
--
V
Y
---------
S
Y
I
-TF
T
-----
E
-
E
Q
L
S
K
QSEANN
K
L
D
IKGKGAV--------------
15
Fugue
88.01
21%
-101
- C3 -
4IWS
-
?
A:
[23-515]
--
M
N
R
S
A
L
D
F
R
H
F
V
D
H
L
R
R
Q
G
D
L
V
D
V
H
T
E
V
D
A
N
L
E
I
-
G
A
I
T
R
R
V
Y
E
R
--
R
A
-
P
A
P
L
F
H
N
I
R
D
------
S
L
PG
A
R
V
L
G
A
P
A
G
-------
L
R
A
D
R
A
------
R
A
H
-----
S
R
L
-
A
L
H
F
GLPEHS
G
P
---
R
D
I
V
A
M
-----
L
R
A
A
M
R
A
E
--------------
P
I
A
P
R
R
L
------
E
R
GPVQE
N
V
W
L
G
E
Q
V
D
--
L
T
R
F
P
V
P
L
L
HEQDGGR
Y
F
G
T
Y
----------------
G
F
H
V
V
Q
T
P
D
G
S
W
D
S
W
S
-
V
G
----
R
L
M
L
V
D
R
N
T
L
A
G
P
T
I
PTQ
H
I
G
I
I
R
E
Q
-------------
W
R
R
L
G
-
K
P
T
P
W
A
-------
M
A
L
G
A
P
P
A
A
L
A
A
A
G
--------
M
P
L
PEGVSE
A
------
G
Y
V
G
A
---
L
---------
V
G
E
P
V
E
V
V
R
T
Q
T
N
G
L
W
V
PANTE
I
V
L
E
G
E
I
S
-----
L
D
E
T
A
L
E
G
P
M
G
EYHGYSFP
I
G
K
P
Q
P
-
L
F
H
V
H
A
L
S
F
R
DQ
P
I
L
P
I
C
VAGTPPE
E
N
H
T
----
I
W
G
T
M
I
-
S
A
Q
L
L
D
V
A
Q
N
A
G
L
P
---
V
D
M
V
WCS
Y
E
A
A
T
C
W
A
V
L
S
I
D
V
Q
R
L
A
A
L
GTD
A
A
A
F
A
A
R
V
A
E
T
V
F
G
S
H
A
G
H
L
V
P
K
-
L
I
L
V
G
N
D
I
----
D
V
T
E
I
D
Q
V
V
W
A
L
--------------------------------
A
T
RAHPLHDH
F
A
F
---------
P
Q
IRDFPMVP
Y
L
D
A
E
D
--
K
A
R
G
S
G
--
G
R
---------
L
V
I
N
C
L
Y
-----
P
-
E
Q
F
A
G
Q
M
R
A
A
T
A
S
F
R
H
A
Y
P
T
A
L
R
R
R
V
E
E
R
W
SDYGF
17
Fugue
81.62
18%
-103
- C1 -
4D10
-
CSN2_HUMAN
B:
[34-447]
VD
L
E
N
Q
-----
Y
Y
N
S
K
A
L
K
E
D
D
P
K
A
A
L
S
S
F
Q
K
V
L
E
L
E
G
E
K
G
E
W
G
F
K
A
L
K
Q
M
-
I
K
I
N
F
K
L
T
N
F
------
P
E
----
M
M
N
R
Y
K
Q
-------
L
L
T
Y
I
R
SAVT
R
N
Y
S
E
-----
K
S
I
-
N
---------
S
I
---
L
D
Y
I
S
T
S
KQM
D
L
L
Q
E
F
Y
E
T
--------------
T
L
E
A
L
K
D
------
A
K
--------
N
D
R
L
W
F
--
K
T
N
T
K
L
G
K
L
-------
Y
L
E
R
E
EY
G
K
L
Q
K
I
L
R
Q
L
H
Q
S
C
Q
T
Q
L
L
E
I
Y
A
L
E
I
Q
M
Y
T
-
A
Q
----
K
N
N
K
K
L
K
A
L
Y
E
Q
--------
S
L
H
I
K
S
-------------
A
I
P
H
P
L
I
M
G
V
I
R
E
C
G
G
K
M
H
L
R
E
G
E
F
E
K
A
H
T
D
F
F
--------
E
A
F
------
K
------
N
Y
D
E
S
GSP
R
---------
R
T
T
----
C
L
K
Y
L
V
L
A
N
M
----------
L
M
K
SGINP
F
D
S
Q
E
A
-
K
P
Y
K
---------------
N
---
D
P
E
I
L
----
A
M
T
------------
N
----
L
V
S
A
Y
Q
-
N
N
D
---
I
T
E
F
E
K
I
L
---
K
T
---------
N
H
S
N
I
M
D
D
P
-------------
F
I
R
E
H
I
E
E
L
L
R
N
I
R
T
Q
V
L
I
K
-
L
I
K
P
Y
T
R
I
----
H
I
P
F
I
S
K
E
L
N
I
D
--------------------------------
V
A
--------
D
V
E
---------
S
L
--------
L
V
Q
C
I
L
D
N
T
I
H
G
R
I
DQ
V
N
---------
Q
L
L
-
E
L
D
HQKRG
G
-
A
R
Y
T
A
L
D
K
W
T
N
Q
L
N
S
L
N
Q
A
V
V
S
K
L
A----------
19
Fugue
76.18
19%
-114
- C2 -
3ALX
2
HEMA_MEASE
A:
[8-549]
------------
C
S
G
P
T
T
I
R
G
Q
F
S
N
M
S
L
S
L
L
D
L
Y
L
G
-
R
G
Y
N
V
S
S
I
V
T
M
T
S
Q
G
M
Y
G
G
T
Y
L
V
E
K
PS
M
Y
R
V
F
E
----
V
G
V
I
R
N
P
GLG
A
P
V
F
H
M
T
N
Y
L
------
E
Q
P
V
S
NDL
S
N
C
M
V
---------
A
L
---
G
E
L
--
K
-----
L
A
A
L
C
H
G
E
D
S
I
T
I
P
YQGSGK
G
V
S
F
Q
L
V
K
L
G
VWKSP
T
D
--------
M
Q
S
W
V
P
LS
T
D
D
P
V
I
D
R
L
-------
Y
L
S
S
H
-----------------
R
G
V
I
A
D
N
Q
A
K
W
A
V
P
T
-
T
R
TDDK
L
R
M
E
T
C
F
Q
Q
A
C
K
--------
G
K
I
Q
A
L
CENPEW
A
P
L
K
D
N
R
I
P
S
Y
G
V
L
S
V
D
L
S
-------
L
T
V
E
L
K
I
K
I
A
S
G
F
G
PLITHGS
G
M
D
L
------
Y
K
S
NHNN
V
Y
W
L
T
---
I
P
PMKNL
A
L
G
V
I
N
----
T
L
E
W
I
P
R
F
K
V
----------
S
P
Y
-----
R
F
T
V
P
I
-
K
E
A
G
G
D
C
H
A
P
TYLPAEVDG
D
V
K
L
S
S
N
L
V
----
I
L
P
------------
G
Q
D
L
Q
Y
V
L
A
T
Y
D
T
S
R
V
E
H
A
V
V
Y
Y
V
Y
S
PSR
S
F
S
Y
---
F
Y
P
F
R
L
P
--
I
K
---------------
G
V
P
I
E
L
Q
V
E
C
F
T
W
D
Q
K
L
W
C
R
-
H
F
C
V
L
A
D
S
ESGG
H
I
T
H
S
G
M
V
G
M
G
V
SCC
P
K
I
V
QQLGSD
V
L
L
P
LTHERINTSMNKS
I
H
I
V
--------
V
T
M
A
KSLENSVE
N
K
--------
I
V
S
L
D
P
--
S
E
A
G
P
P
--
R
Y
LKD
R
Y
R
F
Y
L
E
H
L
-
S
L
A
-----
I
-
Y
E
S
T
K
K
D
E
G
W
Y
F
M
T
L
E
K
N
I
S
V
Q
R
F
C
L
H
L
K
L
Y
E---
11
Fugue
69.07
15%
-86
* C4 *
4R8G
-
E:
[5-332]
------------
R
R
Q
S
L
A
T
K
I
Q
A
A
W
R
G
F
H
W
R
Q
K
F
L
R
-
V
K
R
S
A
I
C
I
Q
S
W
W
R
G
-
T
L
G
R
R
K
A
A
K
R
------
K
W
----
A
A
Q
T
I
R
R
-------
L
I
R
G
F
I
------
L
R
H
-----
S
P
R
-
C
---------
P
E
---
N
A
F
F
L
D
-----
H
V
R
A
S
F
L
L
--------------
N
L
R
----------
R
Q
--------
L
P
R
N
V
L
--
D
T
S
W
P
T
P
P
P
-------
A
L
R
E
A
----------------
S
E
L
L
R
E
L
C
M
K
N
M
V
W
K
Y
-
C
R
----
S
I
S
P
E
W
K
Q
Q
L
Q
Q
--------
K
A
V
A
S
E
-------------
I
F
K
-
G
K
K
D
N
Y
P
Q
-------
S
V
P
R
L
F
I
S
T
R
L
G
T
E
--------
E
I
S
------
P
------
R
V
L
Q
S
---
L
---------
G
S
E
----
P
I
Q
Y
A
V
P
V
V
K
----------
Y
D
R
-----
K
G
Y
K
P
R
-
P
R
Q
L
---------------
L
L
T
P
S
A
V
V
I
----
V
E
D
------------
A
----
K
V
K
Q
R
I
-
D
Y
A
N
L
T
G
I
S
V
S
S
L
S
---
D
S
L
F
---
V
L
H
V
Q
K
Q
-
K
G
D
---------------
V
V
L
Q
S
D
H
V
I
E
T
L
T
K
T
A
L
S
----
A
D
R
V
N
N
I
----
N
I
N
Q
G
S
I
T
F
A
G
----------------------------------------------------------------------------
G
P
G
--
R
D
---------
G
I
I
-
D
F
T
-----
S
G
S
E
L
L
I
T
K
A
K
N
G
H
L
A
V
V
A
P
R
L
---------------
1
PsiBlast_PDB
47.87
29%
-85
- C4 -
2AVD
-
CMTD1_HUMAN
A:
[120-191]
--------------------------------
E
H
K
I
-
D
L
R
L
K
P
A
L
E
T
L
D
E
L
-
L
A
A
G
E
A
G
T
F
D
------
V
A
----
V
V
D
A
D
K
E
-------
N
C
S
A
Y
---------
Y
-----
E
R
C
-
L
---------
Q
L
LRP
G
G
I
L
A
V
-----
L
R
V
L
W
R
G
K
--------------
V
L
Q
P
P
K
G
------
D
V
--------
A
A
E
C
V
R
--
N
L
N
E
R
I
R
R
D
-------
V
R
V
Y
I
----------------
S
L
L
P
L
G
D
G
L
T
L
A
F
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
38.06
15%
-180
- C- -
3B5D
1
EMRE_ECOLI
A:
[33-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
T
I
I
C
Y
---------------
C
A
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
----
L
I
S
L
L
S
W
G
F
F
G
Q
--------------------------------
R
---------
L
D
L
---------
P
A
--------
I
I
G
M
M
L
--
I
C
A
G
V
L
--
I
I
---------
N
L
L
-
S
--------------------------------------------
14
Fugue
31.77
11%
202
- C4 -
2Z5I
-
?
I:
[5-40]
--
M
D
A
I
-----
K
K
K
M
Q
M
L
K
L
D
K
E
N
A
L
D
R
A
E
Q
L
E
N
E
V
-
A
R
L
K
K
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
31.11
25%
265
- C4 -
1L4A
-
CPLX_DORPE
E:
[49-76]
----
E
R
-----
R
K
E
K
H
R
K
M
E
E
E
R
E
E
M
R
Q
T
I
R
D
K
Y
G
L
-
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
Fugue
27.77
29%
232
- C4 -
2RMI
-
?
A:
[13-41]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
--
L
R
---------
E
V
L
-
E
A
R
-----
A
-
E
Q
L
A
Q
E
A
H
K
N
R
K
L
E
I
I
-------------------
18
Fugue
25.57
30%
303
- C4 -
3WY9
-
RL12_PYRHO
C:
[7-32]
------------------
E
K
K
E
E
E
E
K
E
E
E
V
S
E
E
E
A
L
-
A
G
L
S
A
L
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
24.67
4%
-34
- C- -
3B5D
1
EMRE_ECOLI
A:
[30-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
W
P
S
V
G
T
I
I
C
-------
Y
C
A
S
F
----------------
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
----
S
G
V
G
I
V
L
I
S
L
L
S
--------
W
G
F
F
G
Q
-------------
R
L
D
L
P
A
I
I
G
M
M
L
-------
I
C
A
G
V
L
I
I
N
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
22.81
28%
190
- C4 -
2RME
-
?
A:
[1-38]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--------
P
I
S
L
D
L
--
T
---
H
L
--
L
R
---------
E
V
L
-
E
A
R
-----
A
-
E
Q
L
A
Q
Q
E
H
S
K
R
K
L
E
I
I
-------------------
9
HHSearch
11.67
5%
247
- C4 -
3L1L
-
ADIC_ECO57
A:
[411-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
S
F
V
T
--
L
M
V
I
T
A
--
M
Y
---------
A
L
N
-
Y
N
R
-----
L
-
H
K
N
P
Y
P
L
D
A
--------------------------
6
HHSearch
6.46
22%
362
- C4 -
2JP3
-
FXYD4_RAT
A:
[25-42]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
--
C
I
A
G
I
A
--
L
A
---------
L
S
G
-
K
C
K
-----
C
-
R
R
N
H
T
P
S
S
L
P
E
K
V
T
P
L
I
T
P
G
S
--------------
8
HHSearch
5.46
19%
341
- C4 -
2JO1
-
PLM_HUMAN
A:
[24-39]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
I
L
--
F
I
L
G
I
L
--
I
V
---------
L
S
R
-
R
C
R
-----
C
-
K
F
N
Q
Q
Q
R
T
G
E
P
D
E
E
E
G
T
F
R
S
S
--------------
7
HHSearch
0.22
11%
504
- C4 -
3WGU
1
?
G:
[34-48]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
A
--
F
I
V
G
L
I
--
I
I
---------
L
S
K
----------------------------------------------