@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO2B1_HUMAN: (2015-12-12 )
MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMAIFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
Atome Classification :
(20 SA)
.........10........20........30........40........50.......---.60........70....-.-...80........90........100.......110......-.120--........130-.........140.......150.......160.......170.......180....---...190.......200---.-.......210....----...220.......230.----......-.240.......250.......-260...-....---270--.......280.......290.......300.......310.......320.......330.......340.......350...---.-...360.-......370.......380.--......390.......400.-......-.410.......420.......430.......440.......450.......460.......470----.......480.......490-.......500----.......510.---......520.......530.........540.......550.......560.......570.....---..580--........590.......600.......610.......620.......630.......640-----.........650.......660.......670.......680.......690.......700---.........-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASP
D
P
Q
DV
R
P
S
V
F
H
N
I
K
L
F
V
L
C
H
S
L
L
---
Q
L
A
Q
L
M
I
S
G
Y
L
K
S
S
I
S
T
-
V
-
E
K
R
FGLSSQTS
G
L
L
A
S
F
N
EVG
N
T
A
L
I
V
F
V
S
Y
F
G
SRVHRPRMI-
G
Y
G
---
A
I
L
V
A
L
A
G
L
---
L
M
T
L
P
H
F
ISEPYRYDNT
S
P
E
D
M
P
Q
D
F
K
A
SLCLPTTSAPASAPSNGNCSSYTE
T
Q
H
L
---
S
V
V
G
I
M
F
V
A
Q
T
L
LGV----G-GVPIQPF
G
I
S
Y
I
D
D
----
F
AHNSNS
P
L
Y
L
G
I
L
-
F
A
----
V
T
MMG
P
-
G
L
A
F
G
L
G
S
L
M
L
R
L
Y
V
D
I
NQMP-EG
G
I
S
L
-
T
IKD---PR
W
--
V
G
A
W
W
L
G
F
L
I
A
A
G
A
V
A
L
A
A
I
P
Y
F
FF
P
K
EM
P
K
E
K
R
E
L
Q
F
R
R
K
V
L
A
VTDSPARKGKDSPSKQSPGESTKKQD
G
L
V
Q
IAPN
L
T
V
I
Q
---
F
-
I
K
V
F
P
R
V
-
L
L
Q
T
LR
H
P
I
F
L
L
V
V
L
S
Q
V
C
L
--
S
S
M
A
A
G
M
A
I
F
L
P
K
F
L
E
R
Q
-
F
-
S
I
T
A
S
Y
-
A
N
L
L
I
G
C
LS
F
P
S
V
I
V
G
I
V
V
G
G
V
L
V
K
R
LHLGPV
G
C
G
A
L
C
L
L
G
M
L
L
C
L
F
F
S
L
P
L
F
F
IGCSSH
Q
I
A
G
----
I
THQTSAHPGLEL
S
P
S
C
M
E
A
-CSCPLDGFNP----VCDPST
R
V
E
Y
I
---TPCHAG
C
S
S
W
V
V
Q
DALD--NS
Q
V
F
Y
TN
C
S
C
V
VEGN
P
V
L
AGSC
D
S
T
C
S
H
L
V
V
P
F
L
L
L
V
S
L
G
S
A
L
A
C
L
---THT
P
---
S
F
M
L
I
L
RGVKKEDK
T
L
A
V
G
I
Q
F
M
F
L
R
I
L
A
WMPSPVIHGSA
I
D
T
T
C
V
H
W
A
L
S
C
G
R
R
A
V
C
R
-------
Y
YN
N
D
L
L
R
N
R
F
I
G
L
Q
F
F
FKT
G
S
V
I
C
F
A
L
V
L
A
V
L
R
QQ
D
K
E
ARTKESRSSP
A
V
E
Q
Q
LLVSGP-----GKKPEDSRV-
1
PsiBlast_PDB
60.33
33%
13
- C1 -
2K7P
-
FLNA_HUMAN
A:
[1847-1905]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
N
M
H
I
P
G
S
P
L
Q
F
Y
V
D
-
Y
V
NCG
H
V
T
A
Y
G
P
-
G
L
T
H
G
V
V
N
K
P
A
T
F
T
V
N
T
K
D
A
G
-
E
G
G
L
S
L
-
A
I
E
G
---
P
S
K
--
A
E
I
S
C
T
D
N
Q
D
G
T
C
S
V
S
Y
L
P
V
L
P
G
D
Y
S
I
L
V
K
Y
N
E
Q
H
V
P
G
S
P
F
T
A
R
V
T
G
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
55.67
22%
-63
- C2 -
4U1F
-
EIF3B_YEAST
A:
[17-496]
--------------
P
S
S
S
L
K
S
W
L
M
D
D
K
V
R
D
Q
F
V
L
Q
D
--
D
V
K
T
S
V
F
W
N
----------------------
S
M
F
N
E
E
D
S
L
-
V
-
E
S
R
E
N
W
S
T
N
----
Y
V
R
F
S
P
K
G
T
Y
----
L
F
S
Y
-----
H
Q
Q
G
V
T
-
A
W
G
---
G
------
P
N
---
F
D
R
L
R
R
F
Y
H
P
D
V
R
N
S
S
V
S
P
N
E
-------
K
Y
L
V
T
F
S
T
E
P
I
I
V
E
E
D
N
E
F
S
P
F
T
K
K
N
E
G
---
H
Q
L
C
I
W
D
I
A
S
G
L
L
M
A
----
T
F
P
V
I
K
S
P
Y
L
K
W
P
L
V
R
----
W
S
Y
N
D
K
---------
Y
C
----
A
R
M
V
G
D
---------------------------
S
L
-
I
V
H
D
----------
A
T
K
N
F
M
P
L
E
A
K
A
L
K
P
S
G
I
R
D
F
S
F
A
P
E
---------------
G
V
K
L
Q
P
F
R
N
G
D
E
P
S
V
L
L
A
Y
W
T
P
E
T
N
N
S
A
C
--------
T
A
T
---
I
-
A
E
V
P
R
G
R
-
V
L
K
T
V
N
-----
L
V
Q
V
S
N
V
T
L
--
H
W
Q
--
N
Q
A
E
F
L
C
F
N
V
E
R
H
-
T
K
S
G
K
T
Q
F
-
S
N
L
Q
I
C
R
L
T
E
R
D
I
P
V
E
K
V
E
L
K
D
S
V
F
E
F
G
W
E
P
H
G
N
R
------------------
F
V
T
I
S
V
H
E
V
A
D
----
M
N
Y
A
I
---------------------------------
P
A
N
T
I
R
F
Y
---
A
P
E
T
K
K
R
W
S
L
V
K
E
I
P
K
T
FA
N
T
V
S
W
S
P
A
G
R
F
V
V
V
G
A
L
V
G
P
N
M
R
R
S
D
L
Q
F
Y
D
M
D
Y
-----------------------------
P
G
E
K
N
I
N
D
N
N
D
V
S
A
S
L
----------
K
D
V
A
H
P
T
Y
S
A
A
T
N
I
T
W
D
P
S
-
G
R
Y
--
V
T
-------
A
W
S
S
S
L
K
H
K
V
E
H
G
Y
K
I
F
N
I
A
G
N
----------
L
V
K
E
D
I
I
A
G
F
K
N
F
A
W
R
P
------------------
R
P
------
21
Fugue
53.33
16%
-84
- C3 -
2OCC
-
COX1_BOVIN
A:
[1-514]
----------------------
M
F
I
N
R
W
L
F
S
T
N
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
---
I
R
A
E
L
G
Q
P
G
T
L
L
G
-------------------
D
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
F
F
M
----
V
M
P
I
M
I
G
G
F
G
---
N
W
L
V
P
L
M
I
G
---
A
P
D
M
A
F
-----
P
R
M
N
N
M
S
F
W
L
L
P
P
S
F
L
L
L
L
A
S
S
M
V
E
-----
A
G
A
G
T
----------------------------------
G
W
T
V
Y
P
---
P
L
A
G
N
----
L
A
H
A
---------------------
G
A
-
S
V
D
L
T
I
F
S
L
H
L
A
G
V
S
S
I
L
G
A
I
-
N
F
I
T
T
I
-
I
N
M
K
---
P
P
A
--
M
S
Q
Y
Q
T
P
L
F
V
W
S
--
V
M
I
T
A
V
L
L
L
L
S
L
P
V
L
A
A
G
I
T
M
L
L
T
D
R
N
L
N
T
T
F
F
D
P
A
G
G
G
D
-----------------------------------
P
I
L
Y
Q
H
-
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
P
G
F
G
M
--
I
S
H
I
V
T
Y
Y
S
G
K
K
E
------------------
P
F
G
Y
M
G
M
V
W
A
M
M
S
I
G
F
L
G
F
I
V
W
A
H
H
M
F
T
V
G
------
M
D
V
D
T
R
A
Y
F
T
S
A
T
M
I
I
A
I
P
T
G
V
K
V
-----
F
S
W
L
A
T
L
H
G
G
-------------------------------
N
I
K
W
S
---
P
A
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
--
L
T
G
I
V
L
A
N
----
S
S
L
D
I
V
L
H
D
T
-----
Y
Y
V
V
A
H
F
H
Y
V
L
S
M
G
A
V
F
A
I
M
---
G
G
F
V
---
H
W
F
P
L
F
S
G
Y
T
L
N
D
T
W
A
K
I
H
F
A
I
M
F
V
G
V
N
M
T
F
F
-----------
P
Q
H
F
L
G
L
S
G
M
P
R
R
Y
S
D
-------
Y
P
D
A
Y
T
M
W
N
T
I
S
S
M
G
S
F
I
S
L
T
A
V
M
L
M
V
F
I
I
W
E
A
F
A
S
K
R
E
V
L
---
T
V
D
L
T
T
T
N
L
E
W
L
N
G
C
P
PPYHT
F
E
E
P
T
Y
V
N
L
K
18
Fugue
50.84
12%
-100
- C3 -
4BKW
6
A:
[1-530]
-
A
M
N
L
I
P
E
D
G
L
P
P
I
L
I
S
T
Y
A
V
E
E
K
P
S
Q
I
S
V
M
Q
Q
L
E
D
P
D
P
L
V
F
V
L
N
A
N
L
L
S
M
V
K
I
V
N
Y
--------------------------------------------
V
N
R
K
C
W
C
F
T
T
K
------
G
M
H
A
V
-
G
Q
S
---
E
I
V
I
L
L
Q
-------------------
C
L
P
D
E
K
C
L
P
K
D
I
F
N
H
F
V
Q
L
Y
R
D
A
L
A
G
N
V
V
S
N
L
G
H
S
F
F
S
Q
S
F
L
GSK
E
H
G
G
F
L
Y
V
T
S
T
Y
Q
S
L
----
Q
-
D
L
V
L
P
T
P
P
----------------------
Y
L
-
F
G
----
I
L
I
Q
K
W
---------------------------------
E
---
T
P
W
--
A
K
V
F
P
I
R
L
M
L
R
L
G
A
E
Y
----
R
L
Y
P
C
P
L
F
S
V
R
F
R
K
P
L
F
G
E
T
G
H
T
I
M
N
L
L
A
D
F
R
N
Y
Q
Y
T
L
P
V
V
Q
G
L
V
V
D
M
E
V
R
----------------------------------
K
T
S
I
K
I
P
S
N
R
Y
--
N
E
M
M
K
A
M
N
K
S
N
E
H
V
L
A
G
G
-
A
-
C
F
N
E
K
A
-
D
S
H
L
V
C
V
Q
N
D
D
G
N
Y
Q
T
Q
A
I
S
I
H
N
Q
P
R
K
V
T
G
A
S
---------------------
F
F
V
F
S
G
A
L
--
A
----
K
S
S
I
V
E
D
G
V
M
V
Q
I
T
A
E
N
M
D
S
-
L
R
Q
A
L
R
E
M
K
D
----
F
T
I
E
H
I
H
I
Q
W
V
D
D
D
K
N
V
S
K
G
V
V
S
P
I
D
G
K
S
M
E
--
T
I
T
N
V
K
I
F
H
E
Y
K
A
N
G
--------------
K
V
I
R
W
T
E
V
F
F
L
E
S
R
L
T
E
H
---
V
A
K
A
---
F
C
L
A
L
C
P
H
L
K
L
L
K
E
D
---
G
M
T
K
L
G
L
R
V
T
L
------------
D
S
D
Q
V
G
Y
Q
A
G
S
N
G
Q
P
L
P
S
-------
Q
Y
M
N
D
L
D
S
A
L
V
P
V
I
H
--------
V
V
M
E
L
I
F
Y
I
L
E
N
I
---------------------------------------
20
Fugue
49.37
10%
-104
- C3 -
1ON3
4
12S_PROFR
A:
[7-523]
------
K
L
A
S
T
M
E
G
R
V
E
Q
L
A
E
Q
R
Q
V
I
E
A
G
G
G
E
R
R
V
E
K
Q
H
S
Q
----
G
K
Q
T
A
R
E
R
L
N
N
L
L
---
D
P
H
S
F
D
E
V
G
A
F
R
K
H
R
T
T
-
L
-
F
G
M
D
K
A
V
V
P
A
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
--------
V
-
M
G
G
---
S
A
G
E
T
Q
S
T
K
---
V
V
E
T
M
E
Q
A
L
L
T
-------------------------------------------
G
T
---
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
----
G
-
I
D
S
L
S
G
Y
G
K
M
F
F
A
N
----
V
K
L
S
G
V
V
P
-
Q
I
A
I
I
-
A
G
----
P
C
A
G
G
A
-
S
Y
S
P
A
L
T
D
F
I
I
M
T
-------
K
-
K
A
H
M
F
I
-
T
G
P
Q
---
V
I
K
--
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
---
F
L
P
Q
N
N
T
E
E
A
S
F
V
N
P
N
N
D
V
S
P
N
T
E
L
R
D
I
V
P
I
---------------------
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
--
W
G
--------------
D
Y
-
L
-
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
-
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
-------
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
-
A
Y
S
E
---------------------------------------------------------------------
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
CNR
D
L
G
A
---
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
G
A
A
N
V
I
F
R
K
E
I
K
A
A
D
D
P
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
F
N
T
-
P
Y
V
A
A
A
R
-------
G
Q
V
D
D
V
I
D
----------
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
C
-------------------------
19
Fugue
48.27
11%
-100
- C3 -
3RKO
4
?
B:
[1-612]
----
M
N
M
L
A
L
T
I
I
L
P
L
I
G
F
V
L
L
A
F
S
R
G
R
W
S
E
N
V
S
A
I
V
G
V
G
S
V
G
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
N
GE
Q
T
Y
S
Q
P
L
W
T
W
M
S
V
G
D
F
N
-
I
-
G
F
N
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
E
E
G
Y
S
R
F
F
-
A
Y
T
---
N
L
F
I
A
S
M
V
V
---
L
V
L
A
D
N
L
--------------------------------------------
L
L
M
Y
L
---
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
------------------------
Y
Y
T
D
P
K
N
G
A
A
A
M
K
A
-
F
V
----
V
T
R
V
G
----
D
V
F
L
A
F
A
L
F
I
L
Y
N
E
L
G
T
L
N
-
F
R
E
M
V
E
-
L
A
P
A
HFA
D
G
N
--
N
M
L
M
W
A
T
L
M
L
L
G
G
A
V
G
K
S
A
---------------
Q
L
P
L
Q
T
W
L
A
D
A
M
A
G
P
--------------------------
T
P
V
S
A
L
I
H
---
A
A
T
M
V
T
A
G
V
-
Y
L
I
A
R
T
H
G
L
F
L
M
T
P
E
V
L
H
L
V
--
G
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
Q
-
T
-
D
I
K
R
V
L
-
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
---------------
V
Q
A
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
A
C
H
HEQN
I
F
K
M
G
G
L
R
K
S
I
P
L
V
Y
L
C
F
L
V
-
G
G
A
A
L
S
A
L
P
L
VT
A
G
F
F
S
K
D
E
I
L
A
G
A
---
M
A
N
G
H
I
N
L
M
V
A
G
L
V
G
A
F
--
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
H
G
K
E
Q
I
H
A
H
A
V
K
G
V
T
H
S
L
P
L
I
V
L
L
I
L
S
T
F
V
G
A
L
---
I
V
P
P
LQG
V
L
P
Q
T
T
E
L
A
H
G
S
M
L
T
L
E
I
T
S
G
V
V
A
V
V
G
I
L
L
A
A
W
L
W
L
G
K
R
T
L
V
T
S
I
A
N
S
A
P
G
R
L
L
S
T
W
W
Y
N
AWG
F
D
W
L
Y
D
K
V
F
V
K
P
F
L
G
I
A
W
L
L
K
R
D
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
L
L
L
S
E
N
G
Y
L
R
W
Y
V
A
S
M
S
I
G
A
V
-----
V
V
L
A
L
L
M
V
L
-
16
Fugue
47.07
10%
-77
* C3 *
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
---
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
-
Y
-
L
V
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
-
P
A
G
---
L
I
L
A
A
A
V
M
L
---
F
M
G
F
V
P
W
A
T
S
S
I
A
-------
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
--
W
W
S
Q
K
E
R
G
---
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
----
I
-
P
P
L
L
F
L
L
G
M
A
W
F
N
D
WHAA
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
-
A
F
----
A
M
M
R
D
T
-
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
-
M
Q
Y
V
-
L
-
P
N
K
L
---
L
W
Y
--
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
---
M
-
N
P
A
G
N
P
T
-
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
--
G
L
H
A
L
E
L
A
---------------
P
K
K
A
-
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
----
L
L
Q
E
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
46.86
16%
-102
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[34-325]
---------------------------------------------------------
L
---
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
-
F
-
Q
Q
A
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
-
I
T
G
---
L
F
L
Y
A
L
G
A
A
---
L
F
W
P
A
A
E
I
-----------------------------------------------
M
---
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
----
G
-
L
G
C
L
E
T
A
A
N
P
F
V
T
V
----
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
----
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
---
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
-
K
F
-
P
A
L
Q
S
D
N
H
S
D
A
-
K
----------------------------------------------
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
--
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
-
G
M
T
A
G
F
-
A
A
N
Y
L
T
G
T
M
-
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
----
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
-
T
K
Y
G
S
S
F
I
V
M
----
T
I
I
G
G
G
I
V
T
P
V
---
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
--
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
39.93
15%
-141
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
--
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
-
A
-
F
-
T
L
T
N
F
Q
-
A
G
L
I
Q
S
A
F
Y
-
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
--
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
---
P
A
--
A
E
--------------------------------------------------------------------------------------------------------
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
---
L
E
T
A
---
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
-------
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
-----
R
I
R
H
W
R
W
A
V
-
26
HHSearch
39.69
14%
-95
- C3 -
1PW4
-
GLPT_ECOLI
A:
[40-319]
---------------------------------------------------------------
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
-
L
-
V
-
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
-
P
A
G
---
L
I
L
A
A
A
V
M
L
---
F
M
G
F
V
P
W
A
T
----------------------------------------------
S
---
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
----
F
-
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
----
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
----
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
----------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
----------------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
--
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
-
H
F
A
L
D
K
-
S
S
W
A
Y
F
L
Y
E
-
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
----
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
-
E
L
A
P
K
K
A
A
G
T
----
A
A
G
F
T
G
L
F
G
Y
L
---
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
--
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
39.27
14%
-109
- C3 -
3WDO
-
?
A:
[29-182]
-----------------------------------------------------------------------
V
L
P
V
L
T
T
Y
G
-
M
A
L
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
-
V
G
G
---
L
A
V
F
A
A
G
S
V
---
I
A
A
L
S
D
S
------------------------------------------------------
I
W
G
I
I
L
G
R
A
L
Q
G
S
----
G
-
A
--
I
A
A
A
V
M
A
L
L
S
D
----
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
----
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
-----------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
---
F
-
P
A
A
E
H
W
K
-
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
--
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
-
V
-
A
E
I
V
L
W
-
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
----
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
-
W
L
A
V
A
S
T
M
K
E
----
P
P
Y
V
S
S
L
R
I
E
I
---
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
--
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
36.72
16%
-85
- C3 -
2GFP
-
EMRD_ECOLI
A:
[22-175]
------------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
I
A
D
-
M
-
A
R
D
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
-
L
V
G
---
M
S
I
F
M
L
A
T
L
---
V
A
V
T
T
S
S
------------------------------------------------------
L
T
V
L
I
A
A
S
A
M
Q
G
M
----
G
-
T
G
V
G
G
V
M
A
R
T
L
P
R
D
----
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
----
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
-----------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
---
S
-
S
M
T
V
S
I
L
-
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
--
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
-
L
-
M
W
I
P
D
W
-
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
----
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
-
L
C
W
L
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
32.11
9%
-79
- C3 -
1PW4
-
GLPT_ECOLI
A:
[279-410]
-----------------------------------------------------------------------------
Y
-
L
-
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
-
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
------------------------------------------------
G
----
N
P
T
V
D
M
I
C
M
I
V
I
G
F
----
L
-
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
----
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
----
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
-
V
M
I
G
G
S
-
I
L
A
V
---
I
L
L
--
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
31.06
10%
-64
- C3 -
2CFQ
-
LACY_ECOLI
A:
[257-376]
---------------------------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
-
L
L
A
---
G
T
I
M
S
V
R
I
I
---
G
S
S
F
A
T
S
------------------------------------------------------
A
L
E
V
V
I
L
K
T
L
H
M
F
----
E
-
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
----
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
----
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
-
V
L
G
L
V
A
-
L
G
F
T
---
L
I
S
--
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
30.30
26%
-75
- C4 -
3KYH
-
MCE1_YEAST
C:
[109-196]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
L
P
Q
K
K
K
E
E
L
L
E
T
L
Q
D
G
T
L
L
D
GEL
V
-
I
Q
T
N
P
M
T
-
K
L
Q
E
L
R
Y
L
M
F
D
C
L
A
I
N
G
R
C
L
TQ
S
P
T
S
S
R
L
A
H
L
G
K
E
F
F
K
P
Y
-
F
-
D
L
R
A
A
Y
-
P
N
R
---
C
T
T
F
P
F
K
I
S
M
K
H
M
D
F
S
Y
Q
L
V
K
V
A
K
S
L
D
K
L
P
H
L
S
D
G
L
I
F
T
P
V
K
A
P
Y
T
A
G
G
K
D
S
L
L
L
K
W
K
----
P
E
Q
E
N
T
V
D
F
K
L
I
L
D
I
P
Y
D
V
K
-
P
V
F
S
L
Y
V
W
Q
G
----
G
A
D
V
N
S
R
L
K
H
F
---
D
Q
P
F
D
R
K
E
F
E
I
L
E
R
T
Y
R
--
K
F
A
E
L
S
V
S
D
E
E
W
Q
N
L
K
N
L
E
Q
P
L
N
G
R
I
V
E
C
A
K
N
Q
E
T
G
A
W
E
M
L
R
F
R
D
D
K
---
L
N
G
N
---
H
T
S
V
V
Q
K
V
L
E
S
I
N
D
S
V
S
L
E
D
L
E
E
I
V
G
D
I
K
R
C
W
D
E
R
R
A
N
M
------------------------------------------------------------------------------------------------------
30
HHSearch
29.65
9%
-84
- C3 -
2CFQ
-
LACY_ECOLI
A:
[24-163]
---------------------------------------------------------------------
G
A
Y
F
P
F
F
P
I
-
W
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
-
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
---
I
F
I
F
G
P
L
-----------------------------------------------------
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
YLGF
C
-
F
N
A
G
A
P
A
V
E
A
F
I
E
K
----
V
S
R
--
R
S
N
F
E
F
G
R
A
-
R
M
----
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
N
N
Q
F
V
F
W
L
-
G
S
G
C
A
L
-
I
L
A
V
---
L
L
F
--
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
---
E
-
L
L
N
A
S
I
M
-
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
--
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
-
V
-
V
I
L
K
T
L
-
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
----
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
-
L
S
L
L
R
R
Q
V
N
E
----
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
29.48
31%
-99
- C4 -
3RZE
-
ENLYS_BPT4 (first)
A:
[11-84]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
V
L
S
T
I
C
L
--
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
-
L
-
H
---
T
V
-
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
------
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
----
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
-
T
K
T
R
A
S
A
T
I
L
----
G
A
W
F
L
S
F
L
W
V
I
---
P
I
L
G
W
N
H
R
R
E
D
K
C
E
T
D
F
--
Y
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
---
G
L
R
L
---
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-------
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
-----
K
S
R
W
Y
N
Q
T
P
-
33
HHSearch
29.43
20%
-36
- C3 -
2GFP
-
EMRD_ECOLI
A:
[233-359]
-----------------------------------------------------------------------------
L
-
M
-
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
-
S
V
I
---
C
C
L
--
L
A
G
L
---
L
M
W
I
P
D
W
F
G
V
---------------------------------------------
M
----
N
V
W
T
L
L
V
P
A
A
L
F
F
F
----
G
-
A
G
M
L
F
P
L
A
T
S
G
A
M
E
----
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
----
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
-
M
T
L
M
G
L
-
L
I
V
L
---
C
W
L
--
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
27.68
26%
159
- C2 -
1CGJ
-
ISK1_HUMAN
I:
[7-38]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
C
Y
N
E
L
N
G
C
T
L
-
E
Y
R
P
----
V
C
G
T
D
-
G
D
T
Y
P
---
N
E
C
V
L
C
F
E
N
R
K
R
Q
T
S
I
L
--
I
Q
K
S
G
P
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
26.79
33%
275
- C2 -
2LEO
-
ISK7_HUMAN
A:
[43-66]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
C
P
I
-
T
Y
L
P
----
V
C
G
S
D
-
Y
I
T
Y
G
---
N
E
C
H
L
C
T
E
S
L
K
S
N
G
R
V
Q
--
F
L
H
D
G
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------