@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LAT1_HUMAN: (2015-12-08 )
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
Atome Classification :
(20 SA)
.........10........20........30.....---------...40........50........60........70-........80........90..--...--...100---........110........120------......-.130-.........140.......150.----.....-.160.......170.......180........-190....-..-.200.......210.......220--..----..--.----....-230---...-.-.--..240.---....-..250.......260.......270.......280.......290......---.300..---------------..--.--.-.310..----.....320.---.......330..-...---..340.......350.......360.....----..370.......380.......----390-.........400.......410---------...----....420.......430----.........440.......450.......460.......470.......480.......490.......500.....-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGAGPKRRALAAPA
A
E
E
K
E
E
A
R
E
K
M
L
AAKSADGSA---------PAGEGE
G
V
T
L
Q
R
N
I
T
L
LN
G
V
A
I
I
V
G
T
I
IGS
G
I
F
VT-P
T
G
V
L
KEAGSPG
L
A
L
V
V
W
A
A
C
G
--
V
F
S
--
I
V
G
A
L
----
C
Y
A
E
LGTTIS-KSGG
D
Y
A
Y
M
L
E
------
V
YGS
L
P
-
A
F
---
L
K
L
W
I
E
L
L
I
IRPSS
Q
Y
I
V
A
L
V
F
A
----
T
Y
L
L
K
-PLFPTCPV
P
E
E
A
A
K
L
V
A
C
L
C
V
L
-
L
L
TAVNCYS-V
K
A
A
T
R
V
-
Q
D
-
A
F
A
A
A
K
L
L
A
L
A
L
I
I
L
L
G
F
V
QIG----KG----DV--S----NLDP-NFS---FEG-T-K--L
D
V
G
N
I
---
V
L
A
L
-
Y
S
G
L
F
A
YGG
W
N
Y
L
N
F
V
T
E
E
M
I
N
P
YRNL
P
L
A
I
I
IS
L
P
I
V
T
L
V
Y
V
L
T
N
L
A
Y
F
T
---TL
S
T
E
Q
---------------ML--S--S-E
A
V
A
V
D----FGN
Y
H
L
G
-
V
---
M
S
W
I
I
P
V
F
V
G
L
S
-
C
FG---SVNG
S
L
F
TS
S
R
L
F
F
V
GSREG
H
L
P
S
I
L
S
M
I
H
----
P
Q
LLTP
V
P
S
L
V
F
T
C
V
M
T
L
L
Y
A
F
----
S
---
K
D
I
F
S
V
I
N
F
F
S
F
F
N
W
L
C
V
A
L
A
I
---------
I
G
M
----
I
W
L
RHRKPELER
P
I
K
------
V
N
L
A
L
P
V
F
F
I
L
A
C
L
F
L
I
A
V
S
F
WKT
P
V
ECGI
G
F
T
I
I
LSGL
P
V
Y
F
F
G
V
W
WKNK
P
K
W
L
L
Q
G
I
F
S
T
T
V
L
C
Q
K
L
M
Q
VVPQET-----
10
PsiBlast_PDB
85.96
22%
-154
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-431]
---------------------------------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
--
V
Y
E
Y
-
P
T
-----
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
--
I
P
V
G
L
----
C
A
A
E
M
A
T
V
D
G
W---
G
V
F
A
W
V
S
N
------
T
L
G
P
R
W
-
G
F
---
A
A
I
S
F
G
Y
L
Q
I
--
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
----
T
K
T
I
A
A
L
I
I
L
-
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
-
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
-------------------
T
F
F
P
-
D
F
S
---
K
V
G
-
T
-------------
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
---
V
I
P
G
N
E
---------------
I
N
--
L
--
S
-
A
G
V
M
Q
T
----
F
T
V
L
M
S
H
-
V
APE
I
E
W
T
V
R
V
I
S
A
L
L
-
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
----
K
N
G
V
-
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
----
I
---
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
----
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
GGK
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
---------------
9
PsiBlast_PDB
84.96
22%
-150
- C3 -
4DJI
-
GADC_ECOLI
A:
[11-431]
--------------------------------------------------------
K
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
--
V
Y
E
Y
-
P
T
-----
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
--
I
P
V
G
L
----
C
A
A
E
M
A
T
V
D
G
W
E
E
G
G
V
F
A
W
V
S
N
------
T
L
G
P
R
W
-
G
F
---
A
A
I
S
F
G
Y
L
Q
I
--
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
----
T
K
T
I
A
A
L
I
I
L
-
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
-
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
----
S
G
AIEM
D
S
--
K
----
T
F
F
P
-
D
F
S
---
K
V
G
-
T
-------------
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
---
V
I
P
G
N
E
---------------
I
N
--
L
--
S
-
A
G
V
M
Q
T
----
F
T
V
L
M
S
H
-
V
APE
I
E
W
T
V
R
V
I
S
A
L
L
-
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
----
K
N
G
V
-
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
----
I
---
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
----
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
IPGG
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
V
T
L
E
P
I
N
S
Q
N
A
P
K
G
H
-----
15
HHSearch
84.24
20%
-142
- C3 -
3GIA
7
Y609_METJA
A:
[3-432]
-----------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
-
R
-
N
L
P
E
T
F
I
L
S
G
--
I
Y
A
--
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
------
A
I
G
D
N
I
I
T
G
---
A
L
S
I
L
L
-
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
----
G
Y
F
L
P
-
L
I
N
A
P
--
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
-
E
F
-
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
----
P
---------
S
----
Y
V
I
---
P
D
---
L
A
----
P
--
S
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
E
---------------
L
I
--
K
A
S
E
-
N
A
L
A
-
V
----
A
A
K
P
F
L
G
N
L
---
G
F
L
L
I
S
I
G
A
L
F
S
-
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
-----
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
----
L
---
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
---------
L
S
H
----
Y
I
L
I
D
E
V
G
G
R
K
E
-
I
---------
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------
24
Fugue
83.01
19%
-138
- C3 -
3GIA
7
Y609_METJA
A:
[3-435]
-----------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
--
R
N
L
P
E
T
F
I
L
S
G
--
I
Y
A
--
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
------
A
I
G
D
N
I
-
I
T
---
G
A
L
S
I
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
----
G
Y
F
L
P
-
L
I
N
A
--
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
-
E
F
-
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
----
P
S
----
Y
V
--
I
----
P
D
L
A
-------------
P
--
S
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
E
---------------
L
I
K
A
S
--
E
-
N
A
L
A
V
A
----
A
K
P
F
L
G
N
-
L
---
G
F
L
L
I
S
I
G
A
L
F
S
-
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
----
N
---
M
E
G
V
A
S
I
T
S
A
V
F
M
--
V
I
Y
L
F
V
I
---------
L
S
H
----
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
------
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
------------------------
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
MYVKS
16
HHSearch
79.32
18%
-139
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-435]
-------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
T
G
G
---
I
A
I
Y
G
W
L
V
T
I
--
I
G
A
--
L
G
L
S
M
----
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
------
C
F
G
P
F
L
-
G
Y
---
Q
T
N
V
L
Y
-
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
----
G
Y
L
S
Y
-
F
F
P
I
L
--
K
D
P
W
V
L
T
I
T
C
V
V
V
L
W
-
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
-
Q
A
-
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
----
G
---------
E
----
T
Y
M
---
A
-----------------
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
A
---------------
L
R
--
V
--
S
A
S
P
F
G
-
D
----
A
A
R
M
A
L
G
D
T
---
A
G
A
I
V
S
F
C
A
A
A
G
-
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
SSIS
P
NAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
---------
A
A
L
----
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
------
L
--
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
---
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
------------------------
8
PsiBlast_PDB
75.33
25%
-146
- C3 -
3LRC
-
ADIC_ECO57
A:
[18-341]
------------------------------------------------------------------
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
--
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
------
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
-----
G
N
I
A
M
V
V
I
G
----
V
G
Y
L
S
-
Y
F
F
P
I
L
K
D
P
L
--
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
-
Q
------
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
WFWF
R
G
----
E
T
--
Y
----
M
A
A
W
-
N
V
S
---
G
L
G
-
T
------
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
------------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
----
S
---
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
---------
V
P
Y
----
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
------
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
---------------------------
7
PsiBlast_PDB
75.24
25%
-142
- C3 -
3LRB
-
ADIC_ECO57
A:
[18-341]
------------------------------------------------------------------
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
--
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
------
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
-----
G
N
I
A
M
V
V
I
G
----
V
G
Y
L
S
-
Y
F
F
P
I
L
K
D
P
L
--
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
-
Q
------
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
----
E
T
--
Y
----
M
A
A
W
-
N
V
S
---
G
L
G
-
T
------
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
------------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
----
S
---
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
---------
V
P
Y
----
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
------
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
---------------------------
26
Fugue
75.09
15%
-117
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-501]
----
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
V
Y
E
Y
P
T
F
A
T
S
-----------------------------------------------------------
G
F
S
L
V
F
F
L
L
L
G
G
I
--
L
W
F
--
I
P
V
G
L
----
C
A
A
E
M
A
T
--
V
-
D
G
W
G
V
F
A
W
V
S
N
------
T
L
G
P
R
W
-
G
F
---
A
A
I
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
----
A
L
S
Y
I
-
L
K
W
P
A
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
-
A
L
A
L
T
Q
F
G
G
-
T
K
Y
T
A
R
I
A
K
V
-
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
---------------
H
----
T
F
F
P
-
D
F
S
---
K
V
G
-
T
-------------
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
---
V
I
P
G
N
E
INLSA
G
---------
V
M
--
Q
--
T
-
F
T
V
L
M
S
----
H
V
A
P
E
I
E
-
W
---
T
V
R
V
I
S
A
L
L
L
L
G
-
V
L
A
---
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
KN
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
----
G
---
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
---------
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
------
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
--
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
-------
3
PsiBlast_PDB
73.79
24%
-131
- C3 -
3NCY
-
ADIC_SALTY
A:
[18-341]
------------------------------------------------------------------
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
---
A
A
T
G
G
I
A
I
Y
G
W
L
V
T
I
--
I
G
A
--
L
A
L
S
M
----
V
Y
A
K
M
S
S
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
------
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
-----
G
N
I
A
M
V
V
I
G
----
V
G
Y
L
S
-
Y
F
F
P
I
L
K
D
P
L
--
V
L
T
L
T
C
V
A
V
L
W
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
-
Q
------
A
V
A
T
V
L
A
L
V
P
I
V
G
I
A
V
F
G
WFWF
K
G
----
E
-----------
W
-
N
V
S
---
G
M
N
-
T
------
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
A
---------------
L
R
--
V
--
S
-
A
S
P
F
G
D
----
A
A
R
M
A
L
G
-
D
---
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
----------
T
P
V
A
G
L
L
I
V
G
V
L
M
T
I
F
Q
F
----
S
---
S
M
S
P
N
A
A
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
---------
V
P
Y
----
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
------
G
K
A
R
P
L
Y
L
L
I
T
F
V
A
F
V
Y
C
I
W
A
V
I
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
L
Y
A
L
N
Y
N
R
I
H
K
N
P
Y
P
L
D
A
P
---------------------
6
PsiBlast_PDB
73.57
25%
-139
- C3 -
3L1L
2
ADIC_ECO57
A:
[18-341]
------------------------------------------------------------------
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
--
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
------
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
-----
G
N
I
A
M
V
V
I
G
----
V
G
Y
L
S
-
Y
F
F
P
I
L
K
D
P
W
--
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
-
Q
------
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
----
E
T
--
Y
----
M
A
----------------------
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
A
---------------
L
R
--
V
--
S
-
A
S
P
F
G
D
----
A
A
R
M
A
L
G
-
D
---
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
----
S
---
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
---------
V
P
Y
----
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
------
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------
5
PsiBlast_PDB
73.46
25%
-135
- C3 -
3OB6
1
ADIC_ECOLI
A:
[18-341]
------------------------------------------------------------------
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
--
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
------
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
-----
G
A
I
A
M
V
V
I
G
----
V
G
Y
L
S
-
Y
F
F
P
I
L
K
D
P
L
--
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
-
Q
------
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
WFWF
R
G
----
E
T
--
Y
----
M
A
A
W
-
N
V
S
---
G
L
G
-
T
------
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
A
---------------
L
R
--
V
--
S
-
A
S
P
F
G
D
----
A
A
R
M
A
L
G
-
D
---
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
---
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
----
S
---
S
I
S
P
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
---------
C
A
A
----
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
------
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------------
1
PsiBlast_PDB
70.80
25%
-127
- C3 -
3GI9
-
Y609_METJA
C:
[5-309]
-------------------------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
-
E
T
F
I
L
S
G
--
I
Y
A
--
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
IGDN
I
I
T
G
A
L
S
------
I
L
L
W
M
S
Y
V
I
----
S
I
A
L
F
A
K
G
F
A
----
G
Y
F
L
--
P
L
I
--
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
-
E
F
-
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
----
P
S
----
Y
V
I-
P
----
D
L
A
P
-
S
---------------
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
E
---------------
L
I
K
A
S
--
E
-
N
A
L
A
V
A
A
KPF
L
G
N
--
L
G
-
F
---
L
--
L
I
S
I
G
A
L
F
S
-
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
----
N
---
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
---------
H
Y
I
----
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
------
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
L
E
S
-----------------------
2
PsiBlast_PDB
70.42
25%
-131
- C3 -
3GIA
5
Y609_METJA
A:
[5-309]
-------------------------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
-
E
T
F
I
L
S
G
--
I
Y
A
--
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
IGDN
I
I
T
G
A
L
S
------
I
L
L
W
M
S
Y
V
I
----
S
I
A
L
F
A
K
G
F
A
----
G
Y
F
L
--
P
L
I
-
N
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
-
E
F
-
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
----
P
S
----
Y
V
I-
P
----
D
L
A
P
-
S
---------------
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
E
---------------
L
I
K
A
S
--
E
-
N
A
L
A
V
A
A
KPF
L
G
N
--
L
G
-
F
---
L
--
L
I
S
I
G
A
L
F
S
-
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
----
N
---
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
---------
H
Y
I
----
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
------
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------------
4
PsiBlast_PDB
69.24
25%
-127
- C3 -
3GI8
-
Y609_METJA
C:
[5-309]
-------------------------------------------------------
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
-
E
T
F
I
L
S
G
--
I
Y
A
--
L
L
V
A
Y
----
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
AIGDNI
I
T
G
A
L
S
------
I
L
L
W
M
S
Y
V
I
----
S
I
A
L
F
A
K
G
F
A
----
G
Y
F
L
--
P
L
I
-
N
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
-
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
-
E
F
-
F
I
V
L
V
A
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
----
P
S
----
Y
V
I-
P
----
D
L
A
P
-
S
---------------
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
E
---------------
L
I
KA
S
--
E
-
N
A
L
A
V
A
AKPF
L
G
N
--
L
G
-
F
---
L
--
L
I
S
I
G
A
L
F
S
-
I
S
S
---
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
----
N
---
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
---------
H
Y
I
----
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
------
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------------
13
PsiBlast_PDB
41.66
30%
-132
- C4 -
4IHH
1
LPXD_ECOLI
A:
[108-193]
----------------------------
A
P
S
A
V
I
D
A
---------
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
-
K
N
S
K
I
G
-
A
G
S
R
-----
L
W
A
N
V
T
--
I
Y
H
E
I
Q
I
G
Q
N
----
C
L
I
Q
S
G
T
V
V
G
-
A
D
G
F
G
Y
A
N
D
R
G
------
N
W
V
K
I
P
-
Q
I
---
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
----
D
T
I
I
G
-
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
-
V
A
G
G
V
I
M
A
G
-
S
L
K
I
G
R
Y
-
C
M
-
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
----
G
M
----
V
M
--
R
----
P
I
T
E
-
P
G
V
---
Y
S
S
-
G
-
I
--
P
L
Q
P
N
K
---
V
W
R
K
-
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
41.44
11%
-77
- C3 -
3DH4
1
?
A:
[53-349]
-------------------------------------------------------
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
--
L
A
-
I
A
S
Y
E
W
M
S
A
--
I
T
L
--
I
I
V
G
K
----
Y
F
L
P
I
F
I
E
K
--
G
I
Y
T
I
P
E
F
V
E
K
------
R
F
N
K
K
L
-
K
T
---
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
----
L
A
L
E
T
-
I
L
G
I
----
P
L
M
--
Y
S
I
L
G
L
A
L
F
-
A
L
V
Y
S
I
-------
V
V
W
T
-
D
V
-
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
----
G
T
----
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
FEM
I
L
D
Q
S
N
P
QY
M
N
L
P
G
I
AVL
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLPS
A
A
--
N
--
A
-
D
K
A
Y
P
W
----
L
T
-
Q
F
L
P
V
G
---
V
K
G
V
V
F
A
A
L
A
A
A
-
I
V
S
---
S
L
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
----
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
----
L
---
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
---------
A
V
F
----
L
L
G
L
F
W
K
K
T
T
S
K
G
A
I
------
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
-----
12
PsiBlast_PDB
41.43
30%
-131
- C4 -
4IHF
1
LPXD_ECOLI
A:
[108-193]
----------------------------
A
P
S
A
V
I
D
A
---------
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
-
K
N
S
K
I
G
-
A
G
S
R
-----
L
W
A
N
V
T
--
I
Y
H
E
I
Q
I
G
Q
N
----
C
L
I
Q
S
G
T
V
V
G
-
A
D
G
F
G
Y
A
N
D
R
G
------
N
W
V
K
I
P
-
Q
I
---
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
----
D
T
I
I
G
-
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
-
V
A
G
G
V
I
M
A
G
-
S
L
K
I
G
R
Y
-
C
M
-
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
----
G
M
----
V
M
--
R
----
P
I
T
E
-
P
G
V
---
Y
S
S
-
G
-
I
--
P
L
Q
P
N
K
---
V
W
R
K
-
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
41.32
30%
-124
* C4 *
3EH0
-
LPXD_ECOLI
A:
[101-186]
----------------------------
A
P
S
A
V
I
D
A
---------
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
-
K
N
S
K
I
G
-
A
G
S
R
-----
L
W
A
N
V
T
--
I
Y
H
E
I
Q
I
G
Q
N
----
C
L
I
Q
S
G
T
V
V
G
-
A
D
G
F
G
Y
A
N
D
R
G
------
N
W
V
K
I
P
-
Q
I
---
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
----
D
T
I
I
G
-
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
-
V
A
G
G
V
I
M
A
G
-
S
L
K
I
G
R
Y
-
C
M
-
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
----
G
M
----
V
M
--
R
----
P
I
T
E
-
P
G
V
---
Y
S
S
-
G
-
I
--
P
L
Q
P
N
K
---
V
W
R
K
-
T
A
A
L
V
M
N
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
N
Q
Q
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
40.38
19%
221
- C3 -
2KK9
-
A:
[1-55]
---
K
G
L
R
R
D
L
D
A
S
R
E
A
K
K
Q
L
E
A
E
Q
Q
K
L
E
E
Q
N
K
I
S
E
A
SRKGLRRDL
D
A
S
R
E
A
K
K
Q
V
E
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
40.14
25%
278
- C3 -
1Y03
-
ANP3_MYOSC
A:
[1-35]
--------
G
S
M
N
A
P
A
R
A
A
A
K
T
A
A
D
A
L
A
A
A
K
K
T
A
A
D
A
---------
A
A
A
A
A
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------