@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MPCP_HUMAN: (2015-12-08 )
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTQ
Atome Classification :
(20 SA)
---------------------------------------...--......10....---....20......-..30.-..--------------.....40.......---.50...------.---....60...-...--..70-......----...80----------....-----.--....90..---...--------.--------.-----------.100....-----...110-.---......120...---------..--...130-----.........140...---------..--....150.------..---.-.-..160-.......170------......---------..180-----------........-190--..-------...-----.------.---..------200-----..----------------------.---.....--210........-----.220..----------.....--230..------------.-....240...-------....250......----.260-----......-...270.....-..280-.-------------.--.--....290------------.---.-..------------...300.------------......310.---......320...-...-------..330.......340.-......350.......360------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------MF
S
--
S
V
A
H
L
ARANPFN---TP
H
L
Q
L
V
H
D
G
L
G
-
D
LRSS-SP--------------GPTGQPRRP
R
N
L
A
A
---
A
A
V
E
E
Q
------Y---SCDYGS
G
R
F
-
F
I
L
--CGL--GGIISC----GTT
H
-----------
T
A
L
V-----
P
--
L
D
L
V
K
C
R
M---QV
D
--------
P
--------
Q
-----------
K
Y
K
G
I
FNG-----
F
S
V
T
L
K
-E---D
G
V
R
G
L
A
K-GW
A
---------
P
T
--
F
L
G
Y
-------
S
M
Q
G
L
C
K
F
G
F
--
Y
E
V
---------
F
K
--
V
L
Y
S
N
MLG------EE---N-
T
-
Y
L
W
R
T
-
S
L
Y
L
AASAS-------
A
E
F
F
A
D
---------IALA------------PM
E
A
A
K
V
R
-
I
----
Q
T-------QPG-----Y------
A
---
N
T
------
L
R
------
D
A
----------------------
A
---
P
K
M
Y
K
--
E
--
E
G
L
K
A
F
Y
K
-----
G
V
A
P
L
W
----------
M
R
QI
P
--
Y
T
M
M
K
------------
F
-
A
C
F
E
R
T
V
E
A
L
-------
Y
K
F
VVPKP
R
S
ECS----K
P
-------
E
Q
L
V
V
T
-
F
V
A
G
Y
I
A
G
V
F
C
-
A
I
VSH-P-------------
A
--
D
--
S
V
V
S
V
L
N
------------K---E-KG------------
S
S
A
S
L
V
L
------------
K
R
LG
F
K
G
V
W
K
---
G
L
F
A
R
I
I
-
M
I
G
T
-
L
T
A
-------
L
Q
W
F
I
YD
S
V
K
V
Y
F
RLP-RPPPP
E
M
P
E
S
L
K
K
KLGLTQ------------------------------------------------------------
17
Fugue
86.41
20%
-71
- C6 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
---
G
G
V
A
A
A
------
I
---
S
K
T
A
V
-------------------------------------------
A
-----
P
--
I
E
R
V
K
L
L
L
---
Q
V
Q
--------
H
ASKQISAE
K
-----------
Q
Y
K
G
I
I
D
C
-----
V
V
R
I
P
K
-
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
---------
A
N
--
V
I
R
Y
-------
F
P
T
Q
A
L
N
F
A
F
--
K
D
K
---------
Y
K
--
Q
I
F
L
G
G
V
D
------
R
H
---
K
-
Q
-
F
W
R
Y
F
-
A
G
N
L
A
S
G
G
A
-------
A
G
A
T
S
L
---------
C
F
V
Y
------------
P
L
D
F
A
R
T
R
-
L
----
A
A
-------
D
V
G
-----
K
------
G
---
A
A
QREFTG
L
G
------
N
C
----------------------
I
---
T
K
I
F
K
--
S
--
D
G
L
R
G
L
Y
Q
-----
G
F
N
V
S
V
----------
Q
G
I
I
I
--
Y
R
A
A
Y
------------
F
-
G
V
Y
D
T
A
K
G
M
L
-------
P
D
----------
P
----
K
N
-------
V
H
I
I
V
S
-
W
M
I
A
Q
T
V
T
A
V
A
-
G
L
V
S
Y
-
P
-------------
F
--
D
--
T
V
R
R
R
M
M
M
Q
SGRKGADIMY
T
---
G
-
T
V
------------
D
C
W
R
K
I
A
------------
K
D
E
G
P
K
A
F
F
K
---
G
A
W
S
N
V
L
-
R
-
G
M
-
G
G
A
-------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------------------------------
8
HHSearch
83.84
21%
-71
- C6 -
1OKC
10
ADT1_BOVIN
A:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------
S
-
F
L
K
--
D
F
L
--
A
G
G
V
A
A
----
A
I
S
K
-----------
T
A
V
A
-----
P
--
I
E
R
V
K
L
L
L
---
Q
V
Q
--------
H
--------
A
SKQISAEK---
Q
Y
K
G
I
I
D
C
-----
V
V
R
I
P
K
-
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
---------
A
N
--
V
I
R
Y
-------
F
P
T
Q
A
L
N
F
A
F
--
K
D
K
---------
Y
K
--
Q
I
F
L
G
G
V
D
------
R
H
---
K
-
Q
-
F
W
R
Y
F
-
A
G
N
L
A
S
G
G
A
-------
A
G
A
T
S
L
---------
C
F
V
Y
------------
P
L
D
F
A
R
T
R
-
L
----
A
A
-------
D
V
G
-----
K
GAAQRE
F
---
T
G
------
L
G
------
N
C
----------------------
I
---
T
K
I
F
K
--
S
--
D
G
L
R
G
L
Y
Q
-----
G
F
N
V
S
V
----------
Q
G
I
I
I
--
Y
R
A
A
Y
------------
F
-
G
V
Y
D
T
A
K
G
M
L
-------
P
D
P
K
--------------
N
-------
V
H
I
I
V
S
-
W
M
I
A
Q
T
V
T
A
V
A
-
G
L
V
S
Y
-
P
-------------
F
--
D
--
T
V
R
R
R
M
M
------------
M
---
Q
-
S
G
RKGADIMYTG
T
V
D
C
W
R
K
I
A
------------
K
D
E
G
P
K
A
F
F
K
---
G
A
W
S
N
V
L
-
R
G
M
G
--
G
A
-------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------------------------------
20
Fugue
82.33
20%
-58
* C3 *
4RKS
2
MV3K_THEAC
A:
[21-337]
-----------------------TYR
S
I
G
S
T
A
Y
P
T
I
G
VV
L
L
G
--
G
I
A
N
P
V
T
R
T
P
L
H
---
T
S
A
G
I
A
Y
S
D
S
C
G
-
S
I
R
S
E
-
T
R
I
Y
A
D
E
A
T
H
I
Y
F
NGT
E
S
T
D
D
N
R
S
V
R
R
V
L
D
R
Y
S
S
V
F
E
E
A
------
F
GTK
T
V
S
Y
S
S
Q
N
F
-
G
I
L
--
S
G
S
S
D
A
G
A
A
S
I
----
G
A
A
I
-----------
L
G
L
K
-----
P
-------------
D
L
D
--------
P
--------
H
-----------
D
V
E
N
D
L
R
A
-----
V
S
E
S
A
G
-
R
---
S
L
F
G
G
L
T
I
-
T
W
S
---------
D
G
--
F
H
A
Y
-------
T
E
K
I
L
D
P
E
A
F
SG
Y
S
I
---------
V
A
--
F
A
F
D
Y
Q
R
N
------
P
-----------
S
D
-
V
I
H
Q
N
I
V
R
S
-------
D
L
Y
P
A
R
---------
K
K
H
A
------------
D
E
H
A
H
M
I
K
-
E
----
Y
A
-------
K
T
N
-----
D
------
I
---
K
G
------
I
F
------
D
L
----------------------
A
----------
Q
--
E
D
T
E
E
Y
H
S
-----
I
L
R
G
V
G
----------
V
N
V
I
R
--
E
N
M
Q
K
------------
L
-
I
S
Y
L
K
L
I
R
K
D
-------
Y
----------------------------
W
N
A
-
Y
I
V
T
G
G
S
N
V
Y
V
-
A
V
E
S
E
-
N
-------------
A
--
D
--
R
L
F
S
I
E
N
------------
T
-------------------------------------------------------------------------------
F
G
S
K
K
K
M
L
R
I
V
-
G
G
A
W
H
R
R
P
E
----------------------------------------------------------------------
18
Fugue
82.00
20%
-51
- C2 -
1ZR6
3
?
A:
[3-481]
-------------------------------------EA
E
F
N
--
S
I
N
A
C
L
A
A
A
D
V
E
F
H
E
E
D
S
E
G
W
D
M
D
G
T
A
F
N
L
R
V
D
Y
D
P
--------------
A
A
I
A
I
P
R
S
T
E
D
I
A
A
---
A
V
--------------
Q
C
G
L
D
A
G
V
Q
-
I
S
A
--
K
G
G
--
G
H
S
Y
G
S
YGFG
G
E
D
G
-----------
H
L
M
L
-----
E
--
L
D
R
M
Y
-
R
V
---
S
V
D
--------
D
--------
N
-----------
N
V
A
T
I
Q
G
G
AR
L
G
Y
T
A
L
E
L
L
-
D
---
Q
G
N
R
A
L
S
H
-
G
T
C
---------
P
A
VG
V
G
G
H
-------
V
L
G
G
G
Y
G
F
A
T
--
H
T
H
GLTLDWLI
G
A
T
--
V
V
L
A
D
A
S
I
------
V
H
---
V
-
S
-
E
T
E
N
A
-
D
L
F
W
A
L
R
G
G
GGGFAIV
S
E
F
E
F
N
---------
T
F
E
A
------------
P
E
I
I
T
T
Y
Q
-
V
----
T
T
TWN
R
K
Q
H
V
A
G
-----
L
------
K
---
A
L
------
Q
D
------
W
A
----------------------
Q
---
N
T
M
P
R
--
E
--
L
S
M
R
L
E
I
N
-----
A
N
A
L
N
W
E
G
N
F
FGN
A
K
D
L
K
K
I
L
--
Q
P
I
M
K
------------
K
-
A
G
G
K
S
T
I
S
K
L
-------
V
E
T
D
W
Y
G
Q
I
N
T
Y
L
----
Y
G
-------
A
D
L
N
I
T
-
Y
N
Y
D
V
H
E
Y
F
Y
A
-
N
S
L
T
A
-
P
-------------
R
LS
D
--
E
A
I
Q
A
F
V
------------
D
---
Y
-
K
F
------------
D
N
S
S
-
V
R
------------
P
G
R
G
W
W
I
Q
W
D
FHG
G
K
N
S
A
L
A
-
A
V
S
N
D
E
T
A
YAHRDQL
W
L
W
Q
F
Y
D
S
I
Y
D
Y
E
N
N
T
-
S
P
Y
P
E
S
G
F
E
F
M
Q
G
F
V
A
T
I
E
DTLPEDR
K
G
K
Y
FNYADTTLT
K
E
E
A
Q
K
L
Y
WRGN
L
E
K
L
Q
A
I
K
A
K
Y
DPEDVFGNVVSVEPIAY
3
PsiBlast_PDB
76.81
20%
-59
- C6 -
2C3E
4
ADT1_BOVIN
A:
[12-293]
------------------------------------------------------------------------------------------------------------------------------------------------
L
--
A
G
G
V
A
A
----
A
I
S
K
-----------
T
A
V
A
-----
P
--
I
E
R
V
K
L
L
L
---
Q
V
Q
HASKQISA
E
--------
K
-----------
Q
Y
K
G
I
I
D
C
-----
V
V
R
I
P
K
-
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
---------
A
N
--
V
I
R
Y
-------
F
P
T
Q
A
L
N
F
A
F
--
K
D
K
---------
Y
K
--
Q
I
F
L
G
G
V
-------
D
R
---
H
-
K
-
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
-------
A
G
A
T
S
L
---------
C
F
V
Y
------------
P
L
D
F
A
R
T
R
-
L
----
A
A
-------
D
V
G
-----
K
------
G
---
A
A
------
Q
R
EFTG
L
G
N
C
----------------------
I
---
T
K
I
F
K
--
S
--
D
G
L
R
G
L
Y
Q
-----
G
F
N
V
S
V
----------
Q
G
I
I
I
--
Y
R
A
A
Y
------------
F
-
G
V
Y
D
T
A
------------
K
G
M
L
P
D
P
---------
K
N
-------
V
H
I
I
V
S
-
W
M
I
A
Q
T
V
T
A
V
A
-
G
L
V
S
Y
-
P
-------------
F
--
D
--
T
V
R
R
R
M
M
------------
M
---
Q
-
S
G
------------
R
K
G
A
D
I
M
YTG
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
---
G
A
W
S
N
V
L
-
R
-
G
M
-
G
G
A
-------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.82
21%
-82
- C6 -
4C9H
4
ADT2_YEAST
A:
[23-251]
-----------------------------------------------------------------------------------------------------------------------------------------
F
L
I
--
D
F
L
--
M
G
G
V
S
A
----
A
V
A
K
-----------
T
A
A
S
-----
P
--
I
E
R
V
K
L
L
I
---
Q
N
Q
--------
D
--------
E
M
L
K
Q
GTLDR--
K
Y
A
G
I
L
D
C
-----
F
K
R
T
A
T
-
Q
---
E
G
V
I
S
F
W
R
-
G
N
T
---------
A
N
--
V
I
R
Y
-------
F
P
T
Q
A
L
N
F
A
F
--
K
D
K
---------
I
K
--
A
M
F
G
--
F
K
------
K
E
---
E
-
G
-
Y
A
K
W
F
-
A
G
N
L
A
S
G
G
A
-------
A
G
A
L
S
L
---------
L
F
V
Y
------------
S
L
D
Y
A
R
T
R
-
L
A
A
DS------------------------
A
RQF
N
G
------
L
I
------
D
V
----------------------
Y
---
K
K
T
L
K
--
S
--
D
G
V
A
G
L
Y
R
-----
G
F
L
P
S
V
----------
V
G
I
V
V
--
Y
R
G
L
Y
------------
F
-
G
M
Y
D
S
L
-----------------
K
----------------------
L
A
S
-
F
L
L
G
W
V
V
T
T
G
A
-
S
T
C
S
Y
-
P
-------------
L
--
D
--
T
V
R
R
R
M
M
------------
M
---
T
-
S
G
------------
Q
A
V
K
Y
D
G
------------
A
F
D
C
L
R
K
I
V
A
---
A
E
G
V
G
S
L
-
F
K
G
C
-
G
A
N
-------
I
L
R
G
V
A
G
A
G
V
I
S
M
Y
D
Q
-
L
Q
M
I
L
F
G
K
K
F
K
--------------------------------------------------------------------
2
PsiBlast_PDB
74.72
20%
-61
- C6 -
1OKC
10
ADT1_BOVIN
A:
[12-293]
------------------------------------------------------------------------------------------------------------------------------------------------
L
--
A
G
G
V
A
A
----
A
I
S
K
-----------
T
A
V
A
-----
P
--
I
E
R
V
K
L
L
L
---
Q
V
Q
HASKQISA
E
--------
K
-----------
Q
Y
K
G
I
I
D
C
-----
V
V
R
I
P
K
-
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
---------
A
N
--
V
I
R
Y
-------
F
P
T
Q
A
L
N
F
A
F
--
K
D
K
---------
Y
K
--
Q
I
F
L
G
G
V
-------
D
R
---
H
-
K
-
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
-------
A
G
A
T
S
L
---------
C
F
V
Y
------------
P
L
D
F
A
R
T
R
-
L
----
A
A
-------
D
V
G
-----
K
------
G
---
A
A
------
Q
R
EFTG
L
G
N
C
----------------------
I
---
T
K
I
F
K
--
S
--
D
G
L
R
G
L
Y
Q
-----
G
F
N
V
S
V
----------
Q
G
I
I
I
--
Y
R
A
A
Y
------------
F
-
G
V
Y
D
T
A
------------
K
G
M
L
P
D
P
---------
K
N
-------
V
H
I
I
V
S
-
W
M
I
A
Q
T
V
T
A
V
A
-
G
L
V
S
Y
-
P
-------------
F
--
D
--
T
V
R
R
R
M
M
------------
M
---
Q
-
S
G
------------
R
K
G
A
D
I
M
YTG
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
---
G
A
W
S
N
V
L
-
R
-
G
M
-
G
G
A
-------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------------------------------
21
Fugue
71.96
15%
-90
* C4 *
4XGC
-
ORC5_DROME
E:
[1-458]
---------------------------------------
M
E
A
--
I
C
S
S
L
E
P
L
F
P
C
R
---
E
A
A
I
E
T
L
G
E
L
I
G
-
D
S
S
E
T
-
Y
P
S
A
I
Y
L
F
G
H
------
S
G
T
G
K
T
A
L
T
R
A
F
L
K
---
E
C
G
K
R
Q
N
V
R
T
A
H
L
---
N
A
I
E
C
Y
T
T
K
-
I
M
L
--
E
I
L
--
L
D
S
L
A
P
----
D
Q
G
D
-----------
A
L
K
V
-----
D
N
M
L
D
F
V
E
Q
L
R
---
R
Q
A
--------
A
--------
T
-----------
R
V
E
D
--
Q
G
-----
F
L
I
A
V
D
N
A
---
E
R
L
R
D
M
D
A
-
N
V
L
---------
P
V
--
L
L
---------
R
L
Q
E
L
T
N
L
N
-----
L
---------
C
V
--
I
L
L
S
Q
L
P
F
------
E
K
FYN
K
-
T
-
G
L
S
E
I
-
V
C
L
H
L
A
Q
Y
N
-------
K
A
E
T
Q
R
---------
I
L
G
S
------------
D
F
Q
Q
V
R
N
Q
-
L
----
L
E
-------
Q
K
K
-----
R
------
L
---
E
I
------
C
Q
------
E
A
----------------------
V
---
T
E
D
F
Y
--
N
--
N
Y
L
N
L
F
L
S
-----
V
F
Y
K
A
-----------
C
R
D
V
P
--
E
L
Q
L
T
------------
A
R
K
C
L
S
T
Y
L
E
P
V
LDGTSRL
W
R
H
I
A
G
P
L
R
S
A
L
T
Q
IYM
R
I
-------
E
S
L
E
L
P
-
Y
Y
A
K
F
L
L
-
I
A
A
-
F
L
A
S
H
-
N
-------------
A
--
A
--
K
Q
D
K
R
L
F
------------
S
---
T
-
T
L
------------
G
P
K
S
F
S
I
------------
D
R
L
--
L
A
I
F
Y
---
A
I
L
E
E
K
V
G
L
T
C
N
-
L
L
S
-------
Q
I
S
T
L
V
H
L
N
L
L
S
F
V
S
G
-
E
Q
N
I
M
E
G
S
A
R
L
Q
C
T
I
G
L
E
F
V
L
Q
I
G
K
V
V
GFNVRQYLCD------------------------------------------
19
Fugue
69.11
14%
-83
* C5 *
4C0E
-
?
A:
[9-528]
L
E
A
A
H
L
L
E
Q
M
E
Y
V
F
D
E
W
I
H
L
C
N
NPHAT
E
R
A
A
M
I
F
V
H
Q
L
H
S
V
Q
--
L
V
T
N
R
D
E
F
L
L
F
L
---
R
H
A
L
D
K
S
V
E
R
F
E
-
Q
G
I
H
S
-
G
A
--------------
S
I
A
E
S
F
Q
A
V
E
A
L
V
K
---
L
I
I
I
F
V
------
K
---
S
H
S
-
A
A
V
A
F
M
D
S
I
--
L
A
L
--
G
V
L
V
A
N
----
S
H
H
V
K
RGENFN
Q
R
V
F
Y
R
F
F
-----
A
--
L
L
L
H
E
V
G
L
L
A
G
H
F
S
--------
K
--------
S
-----------
H
Y
E
Q
I
I
L
N
-----
F
A
A
R
L
F
-
D
M
RP
N
L
L
P
G
F
A
C
-
A
W
A
G
L
V
S
HRAF
L
P
V
--
I
L
G
L
PDEKG
W
A
P
F
T
K
L
L
E
Q
F
L
--
G
C
V
---------
G
E
--
L
V
K
T
F
T
V
S
------
S
L
---
G
K
E
M
Y
H
A
A
L
-
K
I
L
I
V
L
Q
H
D
-------
F
P
I
Y
L
D
K
F
R
V
Q
L
C
Q
S
L
P
L
H
------------
A
T
Q
L
V
N
L
I
-
L
----
A
A
-------
I
P
P
-----
N
------
C
---
N
S
------
L
A
------
D
P
FQAGLKVDKIPDMK
E
R
P
P
T
AFD
S
---
A
G
L
L
R
--
E
--
A
G
L
L
D
I
L
E
R
M
L
Q
N
G
P
S
E
D
G
----------
V
A
Q
I
N
--
H
A
I
N
K
STSFGYVPLGVN
R
-
R
L
I
D
A
V
V
A
R
F
-------
A
E
F
A
I
N
R
A
S
S
R
S
D
----
S
A
IFVAGA
N
D
I
K
T
L
Q
M
L
V
T
E
V
S
P
E
A
R
Y
-
Y
L
V
S
S
M
V
N
E
LRYPN
A
Y
T
N
Y
F
S
--
Q
--
A
L
L
D
I
F
G
------------
H
---
D
M
S
D
------------
P
E
E
N
L
V
R
------------
E
Q
I
V
R
V
L
L
E
R
---
V
L
G
Y
W
P
Q
-
P
W
G
L
-
I
I
T
-------
I
L
E
L
L
K
N
D
K
Y
L
F
F
E
L
P
F
I
K
A
T
P
E
V
A
E
R
F
T
A
L
A
R
S
A
A
------------------------------------------------------------
23
Fugue
66.86
13%
-78
- C3 -
2B4L
10
OPUAC_BACSU
A:
[1-268]
-----------------------------------------------------------
D
E
N
A
S
A
A
E
Q
V
N
K
-
T
I
I
G
I
-
D
P
--------------
G
S
------
G
I
M
S
L
T
---
D
K
A
M
K
D
------
Y
---
D
L
N
------------------------------------------------------------
D
W
---
T
L
I
--------
S
--------
A
-----------
S
S
A
A
M
T
A
T
-----
L
K
K
S
Y
D
-
R
---
K
K
-
P
I
I
I
T
-
G
W
T
---------
P
H
--
W
-----------
M
F
S
R
Y
K
L
K
Y
--
L
D
D
---------
P
K
--
Q
S
Y
G
S
--
A
------
E
E
---
I
-
H
-
T
I
T
R
K
-
G
F
S
K
E
Q
P
N
A
-------
A
K
L
L
S
Q
---------
F
K
W
T
------------
Q
D
E
M
G
E
I
M
-
I
----
K
V
-------
E
E
G
----------------
E
K
------
P
A
------
K
V
----------------------
A
---
A
E
Y
V
N
K
H
K
--
D
Q
I
A
E
W
T
K
-----
G
V
Q
K
V
K
----------
G
D
K
I
N
--
L
A
Y
V
A
------------
W
-
D
S
E
I
A
S
T
N
V
I
-------
G
K
V
L
E
D
L
--------------------
G
Y
E
V
T
-
L
T
Q
V
E
A
G
P
M
W
T
-
A
I
A
T
G
-
S
-------------
A
--
D
--
A
S
L
S
A
W
L
------------
P
-------------------
N
T
H
K
A
Y
A
------------
A
K
Y
K
G
K
Y
D
D
I
---
G
T
S
M
T
-------------------------
G
V
K
M
G
L
V
V
P
------
Q
Y
M
K
N
V
N
S
I
E
D
L
K
K
------------------------------------------------------------
7
HHSearch
60.69
19%
-67
- C6 -
2LCK
-
UCP2_MOUSE
A:
[14-304]
------------------------------------------------------------------------------------------------------------------------------------------
T
V
--
K
F
L
--
G
A
G
T
A
A
----
C
I
A
D
-----------
L
I
T
F
-----
P
--
L
D
T
A
K
V
R
L
---
Q
I
Q
--------
G
--------
E
SQG
L
V
R
T
A
ASA
Q
Y
R
G
V
L
G
T
-----
I
L
T
M
V
R
-
T
---
E
G
P
R
S
L
Y
N
-
G
L
V
---------
A
G
--
L
Q
R
Q
-------
M
S
F
A
S
V
R
I
G
L
--
Y
D
S
---------
V
K
--
Q
F
Y
T
K
G
S
----------------
E
H
A
G
I
-
G
S
R
L
L
A
G
S
T
-------
T
G
A
L
A
V
---------
A
V
A
Q
------------
P
T
D
V
V
K
V
R
-
F
----
Q
A
-------
Q
A
R
AGGGR
R
------
Y
---
Q
S
------
T
V
------
E
A
----------------------
Y
---
K
T
I
A
R
--
E
--
E
G
I
R
G
L
W
K
-----
G
T
S
P
N
V
----------
A
R
N
A
I
--
V
N
C
A
E
------------
L
-
V
T
Y
D
L
I
K
D
T
L
-------
L
K
A
N
L
------------
M
T
-------
D
D
L
P
C
H
-
F
T
S
A
F
G
A
G
F
C
T
-
T
V
I
A
S
-
P
-------------
V
--
D
--
V
V
K
T
R
Y
M
------------
N
---
S
-
A
L
GQYHS
A
G
-----
H
C
A
L
T
M
L
------------
R
K
E
G
P
R
A
F
Y
K
---
G
F
M
P
S
F
L
-
R
L
G
S
-
W
N
V
-------
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
-
Y
Q
S
R
E
A
P
F
-----------------------------------------------------------------------
10
HHSearch
58.86
22%
-53
- C6 -
1OKC
9
ADT1_BOVIN
A:
[111-293]
---------------------------------------------------------------------------------------------------------------------------------------
Y
-
F
A
G
--
N
L
A
--
S
G
G
A
A
G
----
A
T
S
L
-----------
C
F
V
Y
-----
P
--
L
D
F
A
R
T
R
L
---
A
A
D
--------
V
--------
G
KGAAQR-----
E
F
T
G
L
G
N
C
-----
I
T
K
I
F
K
-
S
---
D
G
L
R
G
L
Y
Q
-
G
F
N
---------
V
S
--
V
Q
G
I
-------
I
I
Y
R
A
A
Y
F
G
V
--
Y
D
T
---------
A
K
--
G
M
L
P
D
P
K
-----------------
N
V
H
I
-
I
V
S
W
M
I
A
Q
T
-------
V
T
A
V
A
G
---------
L
V
S
Y
------------
P
F
D
T
V
R
R
R
-
M
----
M
M
-------
Q
S
G
-----
R
KGADIM
Y
---
T
G
------
T
V
------
D
C
----------------------
W
---
R
K
I
A
K
--
D
--
E
G
P
K
A
F
F
K
-----
G
A
W
S
N
V
----------
L
R
G
M
G
---
G
A
F
V
------------
L
-
V
L
Y
D
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
58.18
14%
-47
- C4 -
1XKT
-
FAS_HUMAN
A:
[2217-2502]
----------------------------------------------------------------------
V
-
N
L
R
S
L
-
L
V
--------------
N
P
E
G
P
T
L
M
R
L
N
S
V
Q
---
S
S
E
R
P
L
------
F
---
L
V
H
P
I
E
G
S
T
-
T
V
F
--
H
S
L
--
A
S
R
L
S
-----------------------
I
-----
P
--
T
Y
G
L
Q
C
T
R
---
A
A
P
--------
L
--------
D
-----------
S
I
H
S
L
A
A
Y
-----
Y
I
D
C
I
R
-
Q
---
V
Q
P
E
G
------
P
---------
Y
R
--
V
A
G
Y
-------
S
Y
G
A
C
V
A
F
E
M
--
C
S
Q
---------
L
Q
--
A
Q
-----------------------
H
N
S
-
L
F
L
F
D
G
S
P
T
-------
Y
P
G
C
E
A
---------
E
A
E
T
------------
E
A
I
C
F
F
V
Q
-
Q
----
F
T
-------
D
M
E
-----
H
------
N
---
R
V
------
L
E
------
A
L
----------------------
L
---
P
L
K
G
L
--
E
--
E
R
V
A
A
A
V
D
-----
L
I
I
K
S
H
----------
Q
G
L
D
R
--
Q
E
L
S
F
------------
A
-
A
R
S
F
Y
Y
K
L
R
A
-------
A
E
Q
Y
T
P
K
A
-------------------------------------------
K
-------------
Y
--
Y
--
G
N
V
M
L
L
R
------------
A
---
K
-
T
G
------------
L
G
A
D
Y
-----------------
N
L
S
Q
V
C
D
---
G
K
V
S
V
H
V
-
I
E
G
D
----------------------
H
R
T
L
L
-
E
S
G
L
E
S
I
I
S
I
I
H
S
S
L
A
---------------------------------------------------------------
25
Fugue
57.40
19%
-89
- C5 -
4D10
-
CSN8_HUMAN
H:
[14-212]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
K
K
-
L
L
D
Q
C
E
N
Q
E
-------
L
E
A
P
G
G
---------
I
A
T
P
------------
P
V
Y
G
Q
L
L
A
-
L
----
Y
L
-------
L
H
N
-----
D
------
M
---
N
N
------
A
R
------
Y
L
----------------------
W
K
R
I
P
P
A
I
K
--
S
A
N
S
E
L
G
G
I
W
S
-----
V
G
Q
R
I
W
----------
Q
R
D
F
P
G
I
Y
T
T
I
N
------------
A
-
H
Q
W
S
E
T
V
Q
P
I
-------
M
E
A
L
R
D
A
T
R
R
R
A
--------------
F
A
L
V
S
Q
-
A
Y
T
S
I
I
A
D
D
F
A
-
A
F
V
G
L
-
P
-------------
V
--
E
--
E
A
V
K
G
I
L
------------
E
Q
G
W
Q
-
A
D
------------
S
T
T
R
M
V
L
------------
P
R
K
P
E
Q
Q
L
A
R
---
L
T
D
Y
V
A
F
-
L
E
N
------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
54.94
24%
-51
- C6 -
2LCK
-
UCP2_MOUSE
A:
[115-298]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
I
--
G
S
R
L
L
A
----
G
S
T
T
-----------
G
A
L
A
V
A
V
A
Q
P
--
T
D
V
V
K
V
R
F
---
Q
A
Q
--------
A
--------
R
AGGGR------
R
Y
Q
S
T
V
E
A
-----
Y
K
T
I
A
R
-
E
---
E
G
I
R
G
L
W
K
-
G
T
S
---------
P
N
--
V
A
R
N
-------
A
I
V
N
C
A
E
L
V
T
--
Y
D
L
---------
I
K
D
T
L
L
K
A
N
L
M
T
------
D
D
-----------
L
-
P
C
H
F
T
S
A
F
G
-------
A
G
F
C
T
T
---------
V
I
A
S
------------
P
V
D
V
V
K
T
R
Y
M
----
N
S
-------
A
L
G
-----
Q
------
Y
---
H
S
------
A
G
------
H
C
----------------------
A
---
L
T
M
L
R
--
K
--
E
G
P
R
A
F
Y
K
-----
G
F
M
P
S
F
----------
L
R
L
G
S
--
W
N
V
V
M
------------
F
-
V
T
Y
E
Q
L
K
R
A
L
-------
M
A
A
Y
Q
S
R
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
53.16
14%
-36
- C1 -
3J6V
-
RT05_BOVIN
E:
[89-430]
---------------------------------------
F
F
T
KL
T
A
D
E
L
W
K
G
A
-----------
L
A
E
T
G
A
G
-
A
R
K
G
R
-
G
K
--------------
R
T
K
R
K
R
R
K
D
L
N
R
G
Q
---
I
I
G
E
G
R
------
R
---
G
F
L
W
P
G
L
N
A
-
P
L
M
KS
G
A
I
--
Q
T
I
T
Q
R
----
S
K
E
E
-----------
Q
E
K
V
-----
E
--
A
D
M
V
Q
Q
R
E
---
E
W
D
--------
R
--------
K
-----------
R
K
M
K
V
K
R
E
-----
R
G
W
S
G
N
-
S
---
W
G
G
I
S
L
G
P
P
D
P
G
---------
P
N
--
G
E
T
Y
-------
D
D
F
D
T
R
I
L
E
V
--
R
N
V
---------
F
N
--
M
T
A
K
E
G
R
K
------
R
S
---
V
-
R
-
V
L
V
A
V
-
G
N
G
R
G
A
A
G
F
-------
A
I
G
K
A
T
---------
E
R
A
D
------------
A
F
R
K
A
K
N
R
-
A
----
V
H
-------
Y
L
H
-----
Y
------
I
---
E
R
------
Y
E
------
D
H
----------------------
T
-----
I
Y
H
--
D
--
I
S
L
T
F
K
R
T
-----
H
I
K
-------------
M
K
K
Q
P
--
R
G
Y
G
L
------------
R
-
C
--
H
R
A
I
T
T
I
-------
C
R
L
I
G
I
K
D
M
Y
A
K
V
----
S
G
-------
S
V
N
M
L
S
-
L
T
R
G
L
F
Q
G
L
S
R
Q
E
T
H
Q
Q
-
L
-------------
A
--
D
KK
S
L
H
V
V
E
F
------------
R
---
E
-
E
C
------------
G
P
L
P
I
V
V
------------
A
S
P
------
Q
---
G
A
L
R
K
D
P
-
E
P
E
D
-
E
V
P
-------
D
I
K
L
D
W
D
D
V
K
A
V
Q
G
M
K
-
R
S
V
W
S
G
L
K
R
A
A
T
-------------------------------------------------------------------
9
HHSearch
52.92
21%
-57
- C6 -
2LCK
-
UCP2_MOUSE
A:
[115-303]
---------------------------------------------------------------------------------------------------------------------------------------
G
-
I
G
S
--
R
L
L
--
A
G
S
T
T
G
----
A
L
A
V
-----------
A
V
A
Q
-----
P
--
T
D
V
V
K
V
R
F
---
Q
A
Q
--------
A
--------
R
AGGGR------
R
Y
Q
S
T
V
E
A
-----
Y
K
T
I
A
R
-
E
---
E
G
I
R
G
L
W
K
-
G
T
S
---------
P
N
--
V
A
R
N
-------
A
I
V
N
C
A
E
L
V
T
--
Y
D
L
---------
I
K
--
D
T
L
L
K
A
N
L
------
M
---------
T
D
D
L
-
P
C
H
F
T
S
A
F
G
-------
A
G
F
C
T
T
---------
V
I
A
S
------------
P
V
D
V
V
K
T
R
-
Y
----
M
N
-------
S
A
L
-----
G
Q-----
Y
---
H
S
------
A
G
------
H
C
----------------------
A
---
L
T
M
L
R
--
K
--
E
G
P
R
A
F
Y
K
-----
G
F
M
P
S
F
----------
L
R
L
G
S
--
W
N
V
V
M
------------
F
-
V
T
Y
E
Q
L
K
R
A
L
-------
M
A
A
Y
Q
S
R
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.26
21%
-40
- C6 -
4C9Q
5
ADT3_YEAST
A:
[151-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
L
D
F
A
R
T
R
L
---
A
A
D
--------
A
--------
K
SAR--------
Q
F
N
G
L
T
D
V
-----
Y
K
K
T
L
K
-
S
---
D
G
I
A
G
L
Y
R
-
G
F
M
---------
P
S
--
V
V
G
I
-------
V
V
Y
R
G
L
Y
F
G
M
--
F
D
S
---------
L
K
-------------------------------
P
L
----------------
F
L
A
S
---------
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
-
M
----
M
M
-------
T
S
G
-----
Q
------
A
VKY
N
G
------
A
I
------
D
C
----------------------
L
---
K
K
I
V
A
--
S
--
E
G
V
G
S
L
F
K
-----
G
C
G
A
N
I
----------
L
R
S
V
A
--
G
A
G
V
I
------------
S
-
M
Y
D
Q
L
Q
M
I
L
F
-------
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
52.26
21%
-21
- C6 -
4C9J
4
ADT3_YEAST
A:
[151-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
L
D
F
A
R
T
R
L
---
A
A
D
--------
A
--------
K
SAR--------
Q
F
N
G
L
T
D
V
-----
Y
K
K
T
L
K
-
S
---
D
G
I
A
G
L
Y
R
-
G
F
M
---------
P
S
--
V
V
G
I
-------
V
V
Y
R
G
L
Y
F
G
M
--
F
D
S
---------
L
K
--------------------------------------------------------------
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
-
M
----
M
M
-------
T
S
G
-----
Q
------
A
VKY
N
G
------
A
I
------
D
C
----------------------
L
---
K
K
I
V
A
--
S
--
E
G
V
G
S
L
F
K
-----
G
C
G
A
N
I
----------
L
R
S
V
A
--
G
A
G
V
I
------------
S
-
M
Y
D
Q
L
Q
M
I
L
F
-------
G
K
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
48.89
13%
-52
- C6 -
3F2E
1
?
A:
[8-90]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
A
E
Q
-----
V
S
A
V
L
S
-
Q
---
Y
G
I
T
G
P
N
R
-
A
I
Y
---------
Q
G
--
F
G
L
K
-------
V
A
R
A
L
N
R
L
G
G
--
G
P
A
---------
L
V
--
N
M
I
N
G
L
K
A
Y
Y
I
S
AF
N
A
---
N
-
P
-
T
V
L
D
A
-
V
T
D
I
I
T
G
S
P
-------
T
G
Y
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------